CN115279407A - 用于在哺乳动物中刺激嵌合抗原受体介导的免疫应答的方法中的包含pd-l1和/或pd-l2的靶向模块 - Google Patents

用于在哺乳动物中刺激嵌合抗原受体介导的免疫应答的方法中的包含pd-l1和/或pd-l2的靶向模块 Download PDF

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CN115279407A
CN115279407A CN202180021083.0A CN202180021083A CN115279407A CN 115279407 A CN115279407 A CN 115279407A CN 202180021083 A CN202180021083 A CN 202180021083A CN 115279407 A CN115279407 A CN 115279407A
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阿尔明·恩宁格尔
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Avenzel Europe Ltd
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CN202180021083.0A 2020-03-16 2021-03-16 用于在哺乳动物中刺激嵌合抗原受体介导的免疫应答的方法中的包含pd-l1和/或pd-l2的靶向模块 Pending CN115279407A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20163257.7 2020-03-16
EP20163257.7A EP3881866A1 (en) 2020-03-16 2020-03-16 A targeting module comprising pd-l1 and/or pd-l2 for use in a method for stimulating a chimeric antigen receptor mediated response in a mammal
PCT/EP2021/056625 WO2021185807A1 (en) 2020-03-16 2021-03-16 A targeting module comprising pd-l1 and/or pd-l2 for use in a method for stimulating a chimeric antigen receptor mediated immune response in a mammal

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CN115279407A true CN115279407A (zh) 2022-11-01

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CN202180021083.0A Pending CN115279407A (zh) 2020-03-16 2021-03-16 用于在哺乳动物中刺激嵌合抗原受体介导的免疫应答的方法中的包含pd-l1和/或pd-l2的靶向模块

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US (1) US20230183351A1 (https=)
EP (2) EP3881866A1 (https=)
JP (1) JP2023527621A (https=)
CN (1) CN115279407A (https=)
AU (1) AU2021237694A1 (https=)
CA (1) CA3170250A1 (https=)
WO (1) WO2021185807A1 (https=)

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Publication number Priority date Publication date Assignee Title
WO2021234006A1 (en) * 2020-05-20 2021-11-25 Miltenyi Biotec B.V. & Co. KG Compositions and methods for treating cancer expressing cd90 and cd326
WO2025219955A1 (en) * 2024-04-17 2025-10-23 BioNTech SE Soluble tcrs and methods of use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3255060A1 (en) * 2008-12-09 2017-12-13 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
US9233125B2 (en) 2010-12-14 2016-01-12 University Of Maryland, Baltimore Universal anti-tag chimeric antigen receptor-expressing T cells and methods of treating cancer
WO2013044225A1 (en) 2011-09-22 2013-03-28 The Trustees Of The University Of Pennsylvania A universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens
CN105829349B (zh) * 2013-10-15 2023-02-03 斯克利普斯研究所 肽嵌合抗原受体t细胞开关和其用途
EP2990416B1 (en) 2014-08-29 2018-06-20 GEMoaB Monoclonals GmbH Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders
US11091546B2 (en) * 2015-04-15 2021-08-17 The Scripps Research Institute Optimized PNE-based chimeric receptor T cell switches and uses thereof
EP3315511A1 (en) * 2016-10-29 2018-05-02 Miltenyi Biotec GmbH Adapter chimeric antigen receptor expressing cells for targeting of multiple antigens
DK3592769T3 (da) * 2017-03-09 2024-08-12 Genmab As Antistoffer mod pd-l1
WO2018224660A1 (en) * 2017-06-09 2018-12-13 Armin Ehninger Targeting modules for universal chimeric antigen receptor expressing immune cells and use in the treatment of cancer infections and autoimmune disorders

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EP3881866A1 (en) 2021-09-22
AU2021237694A1 (en) 2022-09-22
EP4121107A1 (en) 2023-01-25
US20230183351A1 (en) 2023-06-15
JP2023527621A (ja) 2023-06-30
CA3170250A1 (en) 2021-09-23
WO2021185807A1 (en) 2021-09-23

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