JP2023524627A5 - - Google Patents
Info
- Publication number
- JP2023524627A5 JP2023524627A5 JP2022559477A JP2022559477A JP2023524627A5 JP 2023524627 A5 JP2023524627 A5 JP 2023524627A5 JP 2022559477 A JP2022559477 A JP 2022559477A JP 2022559477 A JP2022559477 A JP 2022559477A JP 2023524627 A5 JP2023524627 A5 JP 2023524627A5
- Authority
- JP
- Japan
- Prior art keywords
- genomic regions
- tables
- methylated
- methylation
- methylated genomic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063002878P | 2020-03-31 | 2020-03-31 | |
| US63/002,878 | 2020-03-31 | ||
| PCT/US2021/024604 WO2021202351A1 (en) | 2020-03-31 | 2021-03-29 | Methods and systems for detecting colorectal cancer via nucleic acid methylation analysis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023524627A JP2023524627A (ja) | 2023-06-13 |
| JP2023524627A5 true JP2023524627A5 (enExample) | 2024-04-02 |
Family
ID=77929568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022559477A Pending JP2023524627A (ja) | 2020-03-31 | 2021-03-29 | 核酸のメチル化分析による結腸直腸癌を検出するための方法およびシステム |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20230101485A1 (enExample) |
| EP (1) | EP4127215A4 (enExample) |
| JP (1) | JP2023524627A (enExample) |
| KR (1) | KR20230017169A (enExample) |
| CN (2) | CN115667554B (enExample) |
| AU (1) | AU2021245992A1 (enExample) |
| CA (1) | CA3178302A1 (enExample) |
| WO (1) | WO2021202351A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019060716A1 (en) | 2017-09-25 | 2019-03-28 | Freenome Holdings, Inc. | SAMPLE EXTRACTION METHODS AND SYSTEMS |
| KR20220015367A (ko) | 2019-05-31 | 2022-02-08 | 프리놈 홀딩스, 인크. | 메틸화된 핵산의 고심도 시퀀싱 방법 및 시스템 |
| AU2021245992A1 (en) | 2020-03-31 | 2022-11-10 | Freenome Holdings, Inc. | Methods and systems for detecting colorectal cancer via nucleic acid methylation analysis |
| US12467096B2 (en) | 2020-05-15 | 2025-11-11 | Universal Diagnostics, S.A. | Methods and systems for identifying methylation biomarkers |
| CN116670510A (zh) | 2020-10-05 | 2023-08-29 | 福瑞诺姆控股公司 | 用于结肠细胞增殖性病症的早期检测的标志物 |
| CA3202255A1 (en) | 2020-12-21 | 2022-06-30 | Hayley WARSINSKE | Markers for the early detection of colon cell proliferative disorders |
| US11788152B2 (en) | 2022-01-28 | 2023-10-17 | Flagship Pioneering Innovations Vi, Llc | Multiple-tiered screening and second analysis |
| WO2023164017A2 (en) * | 2022-02-22 | 2023-08-31 | Flagship Pioneering Innovations Vi, Llc | Intra-individual analysis for presence of health conditions |
| EP4499877A4 (en) * | 2022-03-25 | 2026-04-08 | Freenome Holdings Inc | TCR/BCR Profiling for Cell-Free Nucleic Acid Cancer Detection |
| JP2025517309A (ja) | 2022-05-17 | 2025-06-05 | ガーダント ヘルス， インコーポレイテッド | 創薬可能な標的を特定するための方法およびがんを処置するための方法 |
| WO2024031097A2 (en) * | 2022-08-05 | 2024-02-08 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for cancer screening |
| CN115497561B (zh) * | 2022-09-01 | 2023-08-29 | 北京吉因加医学检验实验室有限公司 | 一种甲基化标志物分层筛选的方法及装置 |
| TW202417642A (zh) * | 2022-09-16 | 2024-05-01 | 大陸商江蘇鵾遠生物科技股份有限公司 | 鑑別癌症的甲基化標誌物及應用 |
| WO2024105132A1 (en) * | 2022-11-16 | 2024-05-23 | Universal Diagnostics, S.A. | Methods for stratification and early detection of advanced adenoma and/or colorectal cancer using dna methylation markers |
| US12606872B2 (en) | 2022-11-16 | 2026-04-21 | Universal Diagnostics, S.A. | Methods for stratification and early detection of advanced adenoma and/or colorectal cancer using DNA methylation markers |
| CN116298295B (zh) * | 2023-05-18 | 2023-09-01 | 上海秤信生物科技有限公司 | 用于结直肠癌早期检测的肿瘤自身抗原/抗体组合及应用 |
| WO2024243375A1 (en) | 2023-05-23 | 2024-11-28 | Yale University | Compositions and methods of determining lupus nephritis class |
| CN120164523B (zh) * | 2023-12-07 | 2026-04-21 | 深圳华大三箭齐发科技有限责任公司 | 蛋白测序数据的处理方法、相关方法及装置 |
| WO2025129061A1 (en) * | 2023-12-14 | 2025-06-19 | Grail, Inc. | Systems and methods for masking treatment-affected regions in the genome to improve classifier performance |
| EP4589022A1 (en) * | 2024-01-19 | 2025-07-23 | Royal College of Surgeons in Ireland | Compositions and methods relating to colorectal cancer |
| CN118366547B (zh) * | 2024-06-19 | 2024-08-23 | 南京世和基因生物技术股份有限公司 | 基因标志物在多癌种早筛中的应用、早筛模型构建方法以及检测装置 |
| CN119639894A (zh) * | 2024-12-10 | 2025-03-18 | 深圳市艾斯基因科技有限公司 | 结直肠癌相关的甲基化标志物、引物探针组合及其应用 |
Family Cites Families (46)
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|---|---|---|---|---|
| US5786146A (en) | 1996-06-03 | 1998-07-28 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US7270960B2 (en) | 2001-08-29 | 2007-09-18 | Pacific Northwest Research Institute | Diagnosis of ovarian carcinomas |
| US7727720B2 (en) | 2002-05-08 | 2010-06-01 | Ravgen, Inc. | Methods for detection of genetic disorders |
| US7393665B2 (en) | 2005-02-10 | 2008-07-01 | Population Genetics Technologies Ltd | Methods and compositions for tagging and identifying polynucleotides |
| DK2302070T3 (da) | 2005-06-23 | 2012-11-26 | Keygene Nv | Strategier til identifikation og detektion af polymorfismer med højt gennemløb |
| US20080194414A1 (en) * | 2006-04-24 | 2008-08-14 | Albert Thomas J | Enrichment and sequence analysis of genomic regions |
| WO2008115185A2 (en) * | 2006-04-24 | 2008-09-25 | Nimblegen Systems, Inc. | Use of microarrays for genomic representation selection |
| US8383338B2 (en) * | 2006-04-24 | 2013-02-26 | Roche Nimblegen, Inc. | Methods and systems for uniform enrichment of genomic regions |
| US7754429B2 (en) | 2006-10-06 | 2010-07-13 | Illumina Cambridge Limited | Method for pair-wise sequencing a plurity of target polynucleotides |
| EP1975252A1 (en) | 2007-03-29 | 2008-10-01 | INSERM (Institut National de la Santé et de la Recherche Medicale) | Methods for the prognosis or for the diagnosis of a thyroid disease |
| US9115386B2 (en) | 2008-09-26 | 2015-08-25 | Children's Medical Center Corporation | Selective oxidation of 5-methylcytosine by TET-family proteins |
| EP2364368B1 (en) | 2008-11-07 | 2014-01-15 | Sequenta, Inc. | Methods of monitoring conditions by sequence analysis |
| US9080210B2 (en) | 2010-06-09 | 2015-07-14 | Keygene N.V. | High throughput screening using combinatorial sequence barcodes |
| US20130022974A1 (en) * | 2011-06-17 | 2013-01-24 | The Regents Of The University Of Michigan | Dna methylation profiles in cancer |
| EP2613278A2 (en) | 2011-12-05 | 2013-07-10 | Koninklijke Philips Electronics N.V. | Retroactive extraction of clinically relevant information from patient sequencing data for clinical decision support |
| US9267117B2 (en) | 2012-03-15 | 2016-02-23 | New England Biolabs, Inc. | Mapping cytosine modifications |
| CA2902916C (en) * | 2013-03-14 | 2018-08-28 | Mayo Foundation For Medical Education And Research | Detecting neoplasm |
| US20160040248A1 (en) * | 2013-03-14 | 2016-02-11 | Genekey Corporation | Method to improve expression and other biological analysis |
| CA2951141C (en) * | 2014-06-04 | 2021-11-30 | Quest Diagnostics Investments Incorporated | Methylated markers for colorectal cancer |
| US9710606B2 (en) | 2014-10-21 | 2017-07-18 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for neurological health issues |
| US10388407B2 (en) | 2014-10-21 | 2019-08-20 | uBiome, Inc. | Method and system for characterizing a headache-related condition |
| US9984201B2 (en) * | 2015-01-18 | 2018-05-29 | Youhealth Biotech, Limited | Method and system for determining cancer status |
| EP3250708B1 (en) | 2015-01-30 | 2021-08-11 | BGI Shenzhen | Biomarkers for colorectal cancer related diseases |
| US11514289B1 (en) | 2016-03-09 | 2022-11-29 | Freenome Holdings, Inc. | Generating machine learning models using genetic data |
| TW201816645A (zh) | 2016-09-23 | 2018-05-01 | 美商德萊福公司 | 用於生物樣本的自動化處理及分析、臨床資訊處理及臨床試驗配對之整合系統及方法 |
| WO2019060716A1 (en) | 2017-09-25 | 2019-03-28 | Freenome Holdings, Inc. | SAMPLE EXTRACTION METHODS AND SYSTEMS |
| CN111742062B (zh) * | 2017-10-06 | 2023-11-17 | 优美佳肿瘤技术有限公司 | 用于诊断癌症的甲基化标志物 |
| WO2019100024A1 (en) | 2017-11-20 | 2019-05-23 | Freenome Holdings, Inc. | Methods for reduction in required material for shotgun sequencing |
| WO2019147663A1 (en) | 2018-01-24 | 2019-08-01 | Freenome Holdings, Inc. | Methods and systems for abnormality detection in the patterns of nucleic acids |
| EP3785269A4 (en) | 2018-03-29 | 2021-12-29 | Freenome Holdings, Inc. | Methods and systems for analyzing microbiota |
| DE202019005627U1 (de) * | 2018-04-02 | 2021-05-31 | Grail, Inc. | Methylierungsmarker und gezielte Methylierungssondenpanels |
| JP7455757B2 (ja) * | 2018-04-13 | 2024-03-26 | フリーノーム・ホールディングス・インコーポレイテッド | 生体試料の多検体アッセイのための機械学習実装 |
| CA3107948A1 (en) | 2018-10-08 | 2020-04-16 | Freenome Holdings, Inc. | Transcription factor profiling |
| KR20220015367A (ko) | 2019-05-31 | 2022-02-08 | 프리놈 홀딩스, 인크. | 메틸화된 핵산의 고심도 시퀀싱 방법 및 시스템 |
| AU2021245992A1 (en) | 2020-03-31 | 2022-11-10 | Freenome Holdings, Inc. | Methods and systems for detecting colorectal cancer via nucleic acid methylation analysis |
| JP2023524016A (ja) | 2020-04-29 | 2023-06-08 | フリーノム ホールディングス，インク． | 結腸細胞増殖性障害を特定するためのｒｎａマーカと方法 |
| CN116670510A (zh) | 2020-10-05 | 2023-08-29 | 福瑞诺姆控股公司 | 用于结肠细胞增殖性病症的早期检测的标志物 |
| CA3202255A1 (en) | 2020-12-21 | 2022-06-30 | Hayley WARSINSKE | Markers for the early detection of colon cell proliferative disorders |
| WO2022204358A1 (en) | 2021-03-26 | 2022-09-29 | Freenome Holdings, Inc. | Methods and systems for detecting cancer via nucleic acid methylation analysis |
| EP4352745A4 (en) | 2021-06-10 | 2025-03-26 | Freenome Holdings, Inc. | Diagnostic data feedback loop and methods of use thereof |
| EP4373967A4 (en) | 2021-07-20 | 2025-06-11 | Freenome Holdings, Inc. | Compositions and methods for improved resolution of 5-hydroxymethylated cytosine in nucleic acid sequencing |
| WO2023147472A1 (en) | 2022-01-28 | 2023-08-03 | Freenome Holdings, Inc. | Methods and systems for risk stratification of colorectal cancer |
| EP4499877A4 (en) | 2022-03-25 | 2026-04-08 | Freenome Holdings Inc | TCR/BCR Profiling for Cell-Free Nucleic Acid Cancer Detection |
| CA3257890A1 (en) | 2022-06-03 | 2023-12-07 | Freenome Holdings, Inc. | MARKERS FOR THE EARLY DETECTION OF PROLIFERATIVE COLONIC CELL DISORDERS |
| EP4536845A1 (en) | 2022-06-13 | 2025-04-16 | Freenome Holdings, Inc. | Sequence process validation methods and compositions |
| WO2023250441A2 (en) | 2022-06-23 | 2023-12-28 | Freenome Holdings, Inc. | Methods and compositions of nucleic acid molecule enrichment for sequencing |
-
2021
- 2021-03-29 AU AU2021245992A patent/AU2021245992A1/en active Pending
- 2021-03-29 WO PCT/US2021/024604 patent/WO2021202351A1/en not_active Ceased
- 2021-03-29 CN CN202180039398.8A patent/CN115667554B/zh active Active
- 2021-03-29 CA CA3178302A patent/CA3178302A1/en active Pending
- 2021-03-29 EP EP21780407.9A patent/EP4127215A4/en active Pending
- 2021-03-29 KR KR1020227037982A patent/KR20230017169A/ko active Pending
- 2021-03-29 JP JP2022559477A patent/JP2023524627A/ja active Pending
- 2021-03-29 CN CN202511382220.XA patent/CN121610573A/zh active Pending
-
2022
- 2022-09-28 US US17/954,576 patent/US20230101485A1/en active Pending
-
2023
- 2023-02-01 US US18/163,138 patent/US12410480B2/en active Active
-
2025
- 2025-08-08 US US19/294,628 patent/US20260028680A1/en active Pending
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