JP2023516692A5 - - Google Patents

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Publication number
JP2023516692A5
JP2023516692A5 JP2022552816A JP2022552816A JP2023516692A5 JP 2023516692 A5 JP2023516692 A5 JP 2023516692A5 JP 2022552816 A JP2022552816 A JP 2022552816A JP 2022552816 A JP2022552816 A JP 2022552816A JP 2023516692 A5 JP2023516692 A5 JP 2023516692A5
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JP
Japan
Prior art keywords
polypeptide
domain
target
sequence
template rna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022552816A
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English (en)
Japanese (ja)
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JP2023516692A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/020933 external-priority patent/WO2021178709A1/en
Publication of JP2023516692A publication Critical patent/JP2023516692A/ja
Publication of JP2023516692A5 publication Critical patent/JP2023516692A5/ja
Pending legal-status Critical Current

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JP2022552816A 2020-03-04 2021-03-04 ゲノムを調節するための方法及び組成物 Pending JP2023516692A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062985291P 2020-03-04 2020-03-04
US62/985,291 2020-03-04
US202063035638P 2020-06-05 2020-06-05
US63/035,638 2020-06-05
PCT/US2021/020933 WO2021178709A1 (en) 2020-03-04 2021-03-04 Methods and compositions for modulating a genome

Publications (2)

Publication Number Publication Date
JP2023516692A JP2023516692A (ja) 2023-04-20
JP2023516692A5 true JP2023516692A5 (https=) 2024-03-13

Family

ID=77612784

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022552816A Pending JP2023516692A (ja) 2020-03-04 2021-03-04 ゲノムを調節するための方法及び組成物

Country Status (7)

Country Link
US (1) US20230242899A1 (https=)
EP (1) EP4114940A4 (https=)
JP (1) JP2023516692A (https=)
AU (1) AU2021232005A1 (https=)
BR (1) BR112022017713A2 (https=)
CA (1) CA3174537A1 (https=)
WO (1) WO2021178709A1 (https=)

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EP3676376B1 (en) 2017-08-30 2025-01-15 President and Fellows of Harvard College High efficiency base editors comprising gam
EP3844272A1 (en) 2018-08-28 2021-07-07 Flagship Pioneering Innovations VI, LLC Methods and compositions for modulating a genome
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WO2020092453A1 (en) 2018-10-29 2020-05-07 The Broad Institute, Inc. Nucleobase editors comprising geocas9 and uses thereof
US12351837B2 (en) 2019-01-23 2025-07-08 The Broad Institute, Inc. Supernegatively charged proteins and uses thereof
WO2020191233A1 (en) 2019-03-19 2020-09-24 The Broad Institute, Inc. Methods and compositions for editing nucleotide sequences
US12473543B2 (en) 2019-04-17 2025-11-18 The Broad Institute, Inc. Adenine base editors with reduced off-target effects
CN114981409A (zh) 2019-09-03 2022-08-30 美洛德生物医药公司 用于基因组整合的方法和组合物
US12435330B2 (en) 2019-10-10 2025-10-07 The Broad Institute, Inc. Methods and compositions for prime editing RNA
RU2724470C1 (ru) * 2019-11-11 2020-06-23 Автономная некоммерческая образовательная организация высшего образования Сколковский институт науки и технологий Применение cas9 белка из бактерии pasteurella pneumotropica для модификации геномной днк в клетках
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CN116209756A (zh) 2020-03-04 2023-06-02 旗舰先锋创新Vi有限责任公司 调控基因组的方法和组合物
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WO2023069948A1 (en) 2021-10-18 2023-04-27 Flagship Pioneering Innovations Vii, Llc Dna compositions and related methods
EP4419669A1 (en) * 2021-10-19 2024-08-28 Massachusetts Institute Of Technology Genomic editing with site-specific retrotransposons
CN118556119A (zh) * 2021-11-19 2024-08-27 埃门多生物公司 新型omni crispr核酸酶
WO2023108153A2 (en) 2021-12-10 2023-06-15 Flagship Pioneering Innovations Vi, Llc Cftr-modulating compositions and methods
WO2023141602A2 (en) * 2022-01-21 2023-07-27 Renagade Therapeutics Management Inc. Engineered retrons and methods of use
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WO2024077267A1 (en) * 2022-10-07 2024-04-11 The Broad Institute, Inc. Prime editing methods and compositions for treating triplet repeat disorders
JP2025538855A (ja) * 2022-10-19 2025-12-02 メタゲノミ，インク． 逆転写酵素を含む遺伝子編集系
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TW202449159A (zh) 2023-04-19 2024-12-16 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 用於產生文庫之組合物及方法
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WO2025074310A2 (en) * 2023-10-06 2025-04-10 Exsilio Therapeutics Ltd Engineered retrotransposable element proteins for gene delivery and insertion
WO2025085519A1 (en) * 2023-10-16 2025-04-24 Typewriter Therapeutics, Inc. R2 retrotransposons for gene writing
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JP2021530212A (ja) * 2018-07-13 2021-11-11 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California レトロトランスポゾンベースの送達媒体及びその使用方法
EP3844272A1 (en) * 2018-08-28 2021-07-07 Flagship Pioneering Innovations VI, LLC Methods and compositions for modulating a genome

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