JP2023516653A - 予測可能な液体と液体の相分離を有するタンパク質 - Google Patents

予測可能な液体と液体の相分離を有するタンパク質 Download PDF

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JP2023516653A
JP2023516653A JP2022552436A JP2022552436A JP2023516653A JP 2023516653 A JP2023516653 A JP 2023516653A JP 2022552436 A JP2022552436 A JP 2022552436A JP 2022552436 A JP2022552436 A JP 2022552436A JP 2023516653 A JP2023516653 A JP 2023516653A
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seq
ratio
polypeptide
protein
idp
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JP2023516653A5 (https=
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マイケル ズリッキー
アシュトッシュ チルコティ
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Duke University
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Duke University
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Publication of JP2023516653A publication Critical patent/JP2023516653A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2022552436A 2020-03-04 2021-03-03 予測可能な液体と液体の相分離を有するタンパク質 Pending JP2023516653A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062985179P 2020-03-04 2020-03-04
US62/985,179 2020-03-04
PCT/US2021/020591 WO2021178483A2 (en) 2020-03-04 2021-03-03 Proteins with predictable liquid-liquid phase separation

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JP2023516653A true JP2023516653A (ja) 2023-04-20
JP2023516653A5 JP2023516653A5 (https=) 2024-03-12

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US (1) US20230086188A1 (https=)
EP (1) EP4087856A4 (https=)
JP (1) JP2023516653A (https=)
AU (1) AU2021231786A1 (https=)
WO (1) WO2021178483A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12269847B2 (en) 2018-08-16 2025-04-08 Donaldson Company, Inc. Genetically encoded polypeptide for affinity capture and purification of biologics
CN114712487B (zh) * 2022-05-17 2024-09-03 清华大学 无序蛋白序列在抗生物污染中的用途
WO2025060384A1 (zh) * 2023-09-22 2025-03-27 小熊猫有限公司 一种基于合成细胞器的目标产物回收方法、dna构建体和表达系统

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120121709A1 (en) * 2010-09-24 2012-05-17 Ashutosh Chilkoti Phase transition biopolymers and methods of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6013763A (en) * 1996-06-04 2000-01-11 Genentech, Inc. Peptide variants of protein A
US20050255554A1 (en) * 2000-03-20 2005-11-17 Ashutosh Chilkoti Fusion peptides isolatable by phase transition
CN108884458A (zh) * 2016-03-31 2018-11-23 味之素株式会社 丝心蛋白样蛋白质改造体及细胞培养方法
CN110914386A (zh) * 2017-06-12 2020-03-24 杜克大学 用于生产生物分子的组合物、系统和方法
US12269847B2 (en) * 2018-08-16 2025-04-08 Donaldson Company, Inc. Genetically encoded polypeptide for affinity capture and purification of biologics
GB201815285D0 (en) * 2018-09-19 2018-10-31 Univ London Queen Mary Self-assembly graphene oxide-protein matrix

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120121709A1 (en) * 2010-09-24 2012-05-17 Ashutosh Chilkoti Phase transition biopolymers and methods of use

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Publication number Publication date
EP4087856A2 (en) 2022-11-16
WO2021178483A3 (en) 2021-11-18
AU2021231786A1 (en) 2022-09-08
WO2021178483A2 (en) 2021-09-10
EP4087856A4 (en) 2024-03-06
US20230086188A1 (en) 2023-03-23

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