JP2023511471A5 - - Google Patents

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Publication number
JP2023511471A5
JP2023511471A5 JP2022523943A JP2022523943A JP2023511471A5 JP 2023511471 A5 JP2023511471 A5 JP 2023511471A5 JP 2022523943 A JP2022523943 A JP 2022523943A JP 2022523943 A JP2022523943 A JP 2022523943A JP 2023511471 A5 JP2023511471 A5 JP 2023511471A5
Authority
JP
Japan
Application number
JP2022523943A
Other languages
Japanese (ja)
Other versions
JP2023511471A (ja
JPWO2021086785A5 (https=
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/057356 external-priority patent/WO2021086785A1/en
Publication of JP2023511471A publication Critical patent/JP2023511471A/ja
Publication of JP2023511471A5 publication Critical patent/JP2023511471A5/ja
Publication of JPWO2021086785A5 publication Critical patent/JPWO2021086785A5/ja
Pending legal-status Critical Current

Links

JP2022523943A 2019-10-28 2020-10-26 二官能性化合物 Pending JP2023511471A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19205545 2019-10-28
EP19205545.7 2019-10-28
PCT/US2020/057356 WO2021086785A1 (en) 2019-10-28 2020-10-26 Bifunctional compounds

Publications (3)

Publication Number Publication Date
JP2023511471A JP2023511471A (ja) 2023-03-20
JP2023511471A5 true JP2023511471A5 (https=) 2023-10-31
JPWO2021086785A5 JPWO2021086785A5 (https=) 2023-10-31

Family

ID=68382246

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022523943A Pending JP2023511471A (ja) 2019-10-28 2020-10-26 二官能性化合物

Country Status (5)

Country Link
US (1) US20230002367A1 (https=)
EP (1) EP4054724A4 (https=)
JP (1) JP2023511471A (https=)
CN (1) CN114599428A (https=)
WO (1) WO2021086785A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019140380A1 (en) 2018-01-12 2019-07-18 Kymera Therapeutics, Inc. Protein degraders and uses thereof
WO2020010227A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Protein degraders and uses thereof
WO2020251972A1 (en) 2019-06-10 2020-12-17 Kymera Therapeutics, Inc. Smarca degraders and uses thereof
WO2021133917A1 (en) 2019-12-23 2021-07-01 Kymera Therapeutics, Inc. Smarca inhibitors and uses thereof
BR112022012410A2 (pt) 2019-12-23 2022-08-30 Kymera Therapeutics Inc Degradadores smarca e usos dos mesmos
WO2021207291A1 (en) * 2020-04-06 2021-10-14 Foghorn Therapeutics Inc. Compounds and uses thereof
EP4192458A4 (en) 2020-08-05 2024-09-04 C4 Therapeutics, Inc. COMPOUNDS FOR TARGETED DEGRADATION OF RET
EP4259144A4 (en) * 2020-12-09 2025-08-20 Kymera Therapeutics Inc SMARCA DEGRADING AGENTS AND THEIR USES
US11993599B2 (en) 2021-08-09 2024-05-28 Genentech, Inc. Therapeutic compounds
WO2023129506A1 (en) * 2021-12-28 2023-07-06 Board Of Regents, The University Of Texas System Potent and selective smarca2 degrading chimeric molecules as cancer therapeutics
EP4476225A4 (en) * 2022-02-09 2026-01-14 Aurigene Oncology Ltd PYRIDAZINE 3-SUBSTITUTED COMPOUNDS USED AS SMARCA2 AND/OR SMARCA4 DEGRADING AGENTS
KR20250023362A (ko) * 2022-06-15 2025-02-18 씨4 테라퓨틱스, 인코포레이티드 Smarca2의 표적화된 분해를 위한 화합물
CN119384414A (zh) * 2022-06-30 2025-01-28 甘李药业股份有限公司 一种用作smarca2/4抑制剂的化合物及其应用
WO2024064316A1 (en) 2022-09-23 2024-03-28 Regents Of The University Of Michigan Compounds and compositions as smarca2/4 inhibitors and uses thereof
WO2024064328A1 (en) 2022-09-23 2024-03-28 Regents Of The University Of Michigan Compounds and compositions as smarca2/4 degraders and uses thereof
WO2024073507A1 (en) 2022-09-28 2024-04-04 Theseus Pharmaceuticals, Inc. Macrocyclic compounds and uses thereof
WO2024137742A1 (en) 2022-12-20 2024-06-27 Blueprint Medicines Corporation Compounds and compositions as fgfr3 degraders and uses thereof
WO2025096976A1 (en) * 2023-11-01 2025-05-08 Cornell University Arid1a is a prognostic marker for aggressive lymphoma transformation and presents a vulnerability to pharmacological inhibition of smarca4/2
WO2025129116A1 (en) * 2023-12-14 2025-06-19 C4 Therapeutics, Inc. Compounds for the targeted degradation of smarca2

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190300521A1 (en) * 2018-04-01 2019-10-03 Arvinas Operations, Inc. Brm targeting compounds and associated methods of use
US12371426B2 (en) * 2018-04-26 2025-07-29 Aurigene Discovery Technologies Limited Pyridazine derivatives as SMARCA2/4 degraders
WO2019213005A1 (en) * 2018-04-30 2019-11-07 Dana-Farber Cancer Institute, Inc. Small molecule degraders of polybromo-1 (pbrm1)
PH12022550578A1 (en) * 2019-09-12 2024-02-19 Aurigene Discovery Tech Ltd Method for identifying responders to smarca2/4 degraders

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