JP2023506488A - 家族性自律神経失調症を処置するための化合物 - Google Patents

家族性自律神経失調症を処置するための化合物 Download PDF

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Publication number
JP2023506488A
JP2023506488A JP2022535707A JP2022535707A JP2023506488A JP 2023506488 A JP2023506488 A JP 2023506488A JP 2022535707 A JP2022535707 A JP 2022535707A JP 2022535707 A JP2022535707 A JP 2022535707A JP 2023506488 A JP2023506488 A JP 2023506488A
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Japan
Prior art keywords
methyl
chloro
pyrimidin
amine
thieno
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JP2022535707A
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Japanese (ja)
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JP2023506488A5 (https=
Inventor
ナンジン ジャン
マイケル エー アーノルド
アマル ダッカ
ギャリー ミッチェル カープ
トム トゥアン ルオン
クリスティ モリル
ジャナ ナラシムハン
ニコライ エー ナリシュキン
アンソニー ターポフ
ジャシ ワン
シャオヤン ジャン
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ピーティーシー セラピューティクス， インコーポレイテッド
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Publication of JP2023506488A publication Critical patent/JP2023506488A/ja
Publication of JP2023506488A5 publication Critical patent/JP2023506488A5/ja
Priority to JP2025097641A priority Critical patent/JP2025133750A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
JP2022535707A 2019-12-12 2020-12-07 家族性自律神経失調症を処置するための化合物 Pending JP2023506488A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025097641A JP2025133750A (ja) 2019-12-12 2025-06-11 家族性自律神経失調症を処置するための化合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962947049P 2019-12-12 2019-12-12
US62/947,049 2019-12-12
PCT/US2020/063612 WO2021118929A1 (en) 2019-12-12 2020-12-07 Compounds for treating familial dysautonomia

Related Child Applications (1)

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JP2025097641A Division JP2025133750A (ja) 2019-12-12 2025-06-11 家族性自律神経失調症を処置するための化合物

Publications (2)

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JP2023506488A true JP2023506488A (ja) 2023-02-16
JP2023506488A5 JP2023506488A5 (https=) 2023-12-15

Family

ID=74046197

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JP2022535707A Pending JP2023506488A (ja) 2019-12-12 2020-12-07 家族性自律神経失調症を処置するための化合物
JP2025097641A Pending JP2025133750A (ja) 2019-12-12 2025-06-11 家族性自律神経失調症を処置するための化合物

Family Applications After (1)

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JP2025097641A Pending JP2025133750A (ja) 2019-12-12 2025-06-11 家族性自律神経失調症を処置するための化合物

Country Status (14)

Country Link
US (1) US20230057568A1 (https=)
EP (1) EP4072677A1 (https=)
JP (2) JP2023506488A (https=)
KR (1) KR20220113700A (https=)
CN (1) CN115209955A (https=)
AU (1) AU2020402717A1 (https=)
BR (1) BR112022011364A2 (https=)
CA (1) CA3160053A1 (https=)
CL (1) CL2022001523A1 (https=)
CO (1) CO2022008195A2 (https=)
IL (1) IL293764A (https=)
MX (1) MX2022007094A (https=)
PE (1) PE20221581A1 (https=)
WO (1) WO2021118929A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202108519TA (en) 2019-02-13 2021-09-29 Ptc Therapeutics Inc Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia
WO2020167624A1 (en) 2019-02-13 2020-08-20 Ptc Therapeutics, Inc. Pyrrolo[2,3-d]pyrimidine compounds for treating familial dysautonomia
MX2024002887A (es) * 2021-09-07 2024-05-28 Ptc Therapeutics Inc Metodos para tratar enfermedades neurodegenerativas.

Citations (7)

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WO2005007083A2 (en) * 2003-06-18 2005-01-27 Smithkline Beecham Corporation Chemical compounds
JP2009007341A (ja) * 2007-06-01 2009-01-15 Mitsubishi Tanabe Pharma Corp 医薬組成物
WO2009007422A1 (en) * 2007-07-12 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Thienopyrimidylamines as modulators of the ep2 receptor
WO2016115434A1 (en) * 2015-01-16 2016-07-21 The General Hospital Corporation Compounds for improving mrna splicing
WO2018151326A1 (ja) * 2017-02-20 2018-08-23 国立大学法人京都大学 スプライシング異常に起因する遺伝性疾病のための医薬組成物及び治療方法
WO2020167624A1 (en) * 2019-02-13 2020-08-20 Ptc Therapeutics, Inc. Pyrrolo[2,3-d]pyrimidine compounds for treating familial dysautonomia
JP2022520822A (ja) * 2019-02-13 2022-04-01 ピーティーシー セラピューティクス， インコーポレイテッド 家族性自律神経失調症を処置するためのチオエノ［３，２－ｂ］ピリジン－７－アミン化合物

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
EP1028964A1 (en) * 1997-11-11 2000-08-23 Pfizer Products Inc. Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
EP2611812A1 (en) * 2010-09-01 2013-07-10 Ambit Biosciences Corporation Thienopyridine and thienopyrimidine compounds and methods of use thereof
CN103242341B (zh) * 2013-04-19 2015-12-09 中国科学院广州生物医药与健康研究院 噻吩并2，4取代嘧啶类化合物及其药物组合物与应用
GB201700814D0 (en) * 2017-01-17 2017-03-01 Liverpool School Tropical Medicine Compounds

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005007083A2 (en) * 2003-06-18 2005-01-27 Smithkline Beecham Corporation Chemical compounds
JP2009007341A (ja) * 2007-06-01 2009-01-15 Mitsubishi Tanabe Pharma Corp 医薬組成物
WO2009007422A1 (en) * 2007-07-12 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Thienopyrimidylamines as modulators of the ep2 receptor
WO2016115434A1 (en) * 2015-01-16 2016-07-21 The General Hospital Corporation Compounds for improving mrna splicing
WO2018151326A1 (ja) * 2017-02-20 2018-08-23 国立大学法人京都大学 スプライシング異常に起因する遺伝性疾病のための医薬組成物及び治療方法
WO2020167624A1 (en) * 2019-02-13 2020-08-20 Ptc Therapeutics, Inc. Pyrrolo[2,3-d]pyrimidine compounds for treating familial dysautonomia
JP2022520822A (ja) * 2019-02-13 2022-04-01 ピーティーシー セラピューティクス， インコーポレイテッド 家族性自律神経失調症を処置するためのチオエノ［３，２－ｂ］ピリジン－７－アミン化合物

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"RN 1349123-32-5 REGISTRY", DATABASE REGISTRY [ONLINE] RETRIEVED FROM STN, JPN7024004355, 5 December 2011 (2011-12-05), ISSN: 0005627542 *
"RN 1349454-03-0 REGISTRY", DATABASE REGISTRY [ONLINE] RETRIEVED FROM STN, JPN7024004356, 6 December 2011 (2011-12-06), ISSN: 0005627543 *
"RN 1914470-24-8 REGISTRY", DATABASE REGISTRY [ONLINE] RETRIEVED FROM STN, JPN7024004358, 20 May 2016 (2016-05-20), ISSN: 0005627539 *
"RN 1967539-15-6 REGISTRY", DATABASE REGISTRY [ONLINE] RETRIEVED FROM STN, JPN7024004357, 5 August 2016 (2016-08-05), ISSN: 0005627538 *
"RN 1967610-91-8 REGISTRY", DATABASE REGISTRY [ONLINE] RETRIEVED FROM STN, JPN7024004349, 5 August 2016 (2016-08-05), ISSN: 0005627536 *
"RN 1981326-49-1 REGISTRY", DATABASE REGISTRY [ONLINE] RETRIEVED FROM STN, JPN7024004346, 28 August 2013 (2013-08-28), pages 27 - 2024, ISSN: 0005627535 *
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TERRY PANCHAL, NICK BAILEY, MARK BAMFORD, EMMANUEL DEMONT, RICHARD ELLIOTT, IRENE FARRE-GUTIERREZ, N: "Evaluation of basic, heterocyclic ring systems as templates for use as potassium competitive acid bl", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19(23), JPN6024041543, 4 July 2009 (2009-07-04), NL, pages 6813 - 6817, ISSN: 0005627533 *

Also Published As

Publication number Publication date
AU2020402717A1 (en) 2022-06-23
BR112022011364A2 (pt) 2022-08-23
WO2021118929A1 (en) 2021-06-17
KR20220113700A (ko) 2022-08-16
JP2025133750A (ja) 2025-09-11
CO2022008195A2 (es) 2022-07-29
CL2022001523A1 (es) 2023-03-31
US20230057568A1 (en) 2023-02-23
CA3160053A1 (en) 2021-06-17
PE20221581A1 (es) 2022-10-06
MX2022007094A (es) 2022-07-11
IL293764A (en) 2022-08-01
CN115209955A (zh) 2022-10-18
EP4072677A1 (en) 2022-10-19

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