JP2023506156A - インフルエンザを処置または予防するための組成物および方法 - Google Patents

インフルエンザを処置または予防するための組成物および方法 Download PDF

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JP2023506156A
JP2023506156A JP2022535124A JP2022535124A JP2023506156A JP 2023506156 A JP2023506156 A JP 2023506156A JP 2022535124 A JP2022535124 A JP 2022535124A JP 2022535124 A JP2022535124 A JP 2022535124A JP 2023506156 A JP2023506156 A JP 2023506156A
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amino acid
antibody molecule
acid sequence
cdrs
cdr1
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JP2023506156A5 (https=
Inventor
カルシク ビスワナサン，
ブライアン ブース，
ブーパシー ラマクリシュナン，
アンドリュー エム． ウーラコット，
グレゴリー バブコック，
ザッカリー シュリバー，
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ビステラ， インコーポレイテッド
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Publication of JP2023506156A publication Critical patent/JP2023506156A/ja
Publication of JP2023506156A5 publication Critical patent/JP2023506156A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2022535124A 2019-12-11 2020-12-11 インフルエンザを処置または予防するための組成物および方法 Pending JP2023506156A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962946772P 2019-12-11 2019-12-11
US62/946,772 2019-12-11
US202062985623P 2020-03-05 2020-03-05
US62/985,623 2020-03-05
US202063028938P 2020-05-22 2020-05-22
US63/028,938 2020-05-22
PCT/US2020/064573 WO2021119467A1 (en) 2019-12-11 2020-12-11 Compositions and methods for treating and preventing influenza

Publications (2)

Publication Number Publication Date
JP2023506156A true JP2023506156A (ja) 2023-02-15
JP2023506156A5 JP2023506156A5 (https=) 2023-12-18

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JP2022535124A Pending JP2023506156A (ja) 2019-12-11 2020-12-11 インフルエンザを処置または予防するための組成物および方法

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Country Link
US (1) US20230257449A1 (https=)
EP (1) EP4073107A1 (https=)
JP (1) JP2023506156A (https=)
KR (1) KR20220113749A (https=)
CN (1) CN115551885A (https=)
AU (1) AU2020403133A1 (https=)
BR (1) BR112022011350A2 (https=)
CA (1) CA3164230A1 (https=)
CL (1) CL2022001545A1 (https=)
IL (1) IL293804A (https=)
MX (1) MX2022007207A (https=)
WO (1) WO2021119467A1 (https=)

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US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
AU2017222564A1 (en) 2016-02-24 2018-09-06 Visterra, Inc. Formulations of antibody molecules to influenza virus
US11230593B2 (en) 2019-03-25 2022-01-25 Visterra, Inc. Compositions and methods for treating and preventing influenza
CN118388650B (zh) * 2024-06-28 2024-08-27 杭州赛基生物科技有限公司 一种抗CD235a单克隆抗体及其制备方法和应用
CN119901847B (zh) * 2025-04-01 2025-06-27 天津辰欣药物研究有限公司 一种抗病毒新药中间体中相关异构体杂质的质量控制方法

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JP2011506344A (ja) * 2007-12-06 2011-03-03 ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド インフルエンザウイルスに対する抗体およびその使用方法
JP2014523254A (ja) * 2011-07-18 2014-09-11 インスティテュート・フォー・リサーチ・イン・バイオメディシン Ａ型インフルエンザウイルス中和抗体及びその使用法
JP2015517492A (ja) * 2012-05-10 2015-06-22 マサチューセッツ インスティテュート オブ テクノロジー インフルエンザの中和のための薬剤
JP2015519052A (ja) * 2012-05-10 2015-07-09 ビステラ， インコーポレイテッド 新規のｈａ結合剤
JP2018518940A (ja) * 2015-04-08 2018-07-19 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド ヒト化インフルエンザモノクローナル抗体およびその使用方法

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JP2014523254A (ja) * 2011-07-18 2014-09-11 インスティテュート・フォー・リサーチ・イン・バイオメディシン Ａ型インフルエンザウイルス中和抗体及びその使用法
JP2015517492A (ja) * 2012-05-10 2015-06-22 マサチューセッツ インスティテュート オブ テクノロジー インフルエンザの中和のための薬剤
JP2015519052A (ja) * 2012-05-10 2015-07-09 ビステラ， インコーポレイテッド 新規のｈａ結合剤
JP2018518940A (ja) * 2015-04-08 2018-07-19 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド ヒト化インフルエンザモノクローナル抗体およびその使用方法

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Publication number Publication date
AU2020403133A1 (en) 2022-06-23
IL293804A (en) 2022-08-01
CL2022001545A1 (es) 2023-03-24
EP4073107A1 (en) 2022-10-19
CN115551885A (zh) 2022-12-30
KR20220113749A (ko) 2022-08-16
MX2022007207A (es) 2022-07-12
CA3164230A1 (en) 2021-06-17
BR112022011350A2 (pt) 2022-08-23
WO2021119467A1 (en) 2021-06-17
US20230257449A1 (en) 2023-08-17

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