JP2023502943A - エアロアレルゲン関連アレルギーと炎症とを治療するナノエマルジョン組成物 - Google Patents

エアロアレルゲン関連アレルギーと炎症とを治療するナノエマルジョン組成物 Download PDF

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Publication number
JP2023502943A
JP2023502943A JP2022528047A JP2022528047A JP2023502943A JP 2023502943 A JP2023502943 A JP 2023502943A JP 2022528047 A JP2022528047 A JP 2022528047A JP 2022528047 A JP2022528047 A JP 2022528047A JP 2023502943 A JP2023502943 A JP 2023502943A
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Japan
Prior art keywords
oil
nanoemulsion
chloride
cells
mice
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JP2022528047A
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Japanese (ja)
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JP2023502943A5 (https=
Inventor
ルカーチ，ニコラス
アール．，ジュニア ベイカー，ジェームス
オコネク，ジェシカ
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University of Michigan System
University of Michigan Ann Arbor
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University of Michigan System
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Publication of JP2023502943A publication Critical patent/JP2023502943A/ja
Publication of JP2023502943A5 publication Critical patent/JP2023502943A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A61K39/36—Allergens from pollen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2022528047A 2019-11-13 2020-11-13 エアロアレルゲン関連アレルギーと炎症とを治療するナノエマルジョン組成物 Pending JP2023502943A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962934878P 2019-11-13 2019-11-13
US62/934,878 2019-11-13
PCT/US2020/060362 WO2021097174A1 (en) 2019-11-13 2020-11-13 Nanoemulsion compositions for treating aeroallergen associated allergy and inflammation

Publications (2)

Publication Number Publication Date
JP2023502943A true JP2023502943A (ja) 2023-01-26
JP2023502943A5 JP2023502943A5 (https=) 2023-11-21

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ID=75912616

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Application Number Title Priority Date Filing Date
JP2022528047A Pending JP2023502943A (ja) 2019-11-13 2020-11-13 エアロアレルゲン関連アレルギーと炎症とを治療するナノエマルジョン組成物

Country Status (5)

Country Link
US (1) US20220387316A1 (https=)
EP (1) EP4058059B1 (https=)
JP (1) JP2023502943A (https=)
CN (1) CN114929271A (https=)
WO (1) WO2021097174A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240042016A1 (en) * 2020-12-30 2024-02-08 The Regents Of The University Of Michigan Nanoemulsion vaccine compositions and methods for suppressing reactivity to multiple food allergens

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002506648A (ja) * 1998-03-16 2002-03-05 アルク−アベーロ アクティーゼルスカブ 突然変異体組換えアレルゲン
JP2006520184A (ja) * 2002-11-01 2006-09-07 アルカベロ アクチェセルスカプ 組換えタンパク質変種
JP2017534608A (ja) * 2014-10-10 2017-11-24 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン アレルギー性疾患および炎症性疾患を、予防するため、抑制するためおよび排除するための、ナノエマルション組成物
JP2018148907A (ja) * 2012-06-13 2018-09-27 アンギャニー・ジェネティクスＡｎｇａｎｙ Ｇｅｎｅｔｉｃｓ 植物における高品質の組み換えアレルゲンの生産方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006099574A2 (en) * 2005-03-16 2006-09-21 Tai June Yoo Cockroach allergen gene expression and delivery systems and uses
KR102233251B1 (ko) * 2013-04-03 2021-03-26 엔-폴드 엘엘씨 신규 나노입자 조성물

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002506648A (ja) * 1998-03-16 2002-03-05 アルク−アベーロ アクティーゼルスカブ 突然変異体組換えアレルゲン
JP2006520184A (ja) * 2002-11-01 2006-09-07 アルカベロ アクチェセルスカプ 組換えタンパク質変種
JP2018148907A (ja) * 2012-06-13 2018-09-27 アンギャニー・ジェネティクスＡｎｇａｎｙ Ｇｅｎｅｔｉｃｓ 植物における高品質の組み換えアレルゲンの生産方法
JP2017534608A (ja) * 2014-10-10 2017-11-24 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン アレルギー性疾患および炎症性疾患を、予防するため、抑制するためおよび排除するための、ナノエマルション組成物

Also Published As

Publication number Publication date
EP4058059A1 (en) 2022-09-21
WO2021097174A1 (en) 2021-05-20
EP4058059A4 (en) 2023-06-21
CN114929271A (zh) 2022-08-19
US20220387316A1 (en) 2022-12-08
EP4058059B1 (en) 2024-10-09

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