JP2023183349A - Solid composition for external use - Google Patents

Abstract

To provide a solid composition for external use.SOLUTION: A solid composition for external use contains (A) a solid wax with a melting point of 40°C or higher, (B) a water-soluble vitamin, and (C) a polyhydric alcohol, with a water content of 2 mass% or less.SELECTED DRAWING: None

Description

The present invention relates to solid external compositions.

External compositions containing water-soluble vitamins are useful for treating, preventing, and/or improving skin diseases, symptoms, and conditions. Attempts have been made to incorporate water-soluble vitamins into solid compositions for external use, but there have been many problems in realizing solid compositions for external use that can be molded into a solid form and have an excellent feel when used.

Attempts have been made to uniformly disperse nicotinic acid amide and achieve stability over time in oily skin external preparations or oily cosmetics containing nicotinic acid amide, liquid oil, oily thickeners, and silica (Patent Documents 1) When a composition containing solid particles of silica was applied to the skin, the moisturizing of the skin by the composition was insufficient.

JP 2019-131538 Publication

An object of the present invention is to provide a solid composition for external use that has good moldability and is comfortable to use.

The present inventor has formulated a combination of (A) a solid wax with a melting point of 40°C or higher, (B) a water-soluble vitamin, and (C) a polyhydric alcohol, and has developed a method for external use with a water content of 2% by mass or less. The present inventors have discovered that by forming a composition, the external composition can be formed into a solid shape, and the feeling of use when applied to the skin is enhanced, and the present invention has been completed.

That is, the present invention
[1] A solid composition for external use containing (A) a solid wax with a melting point of 40° C. or higher, (B) a water-soluble vitamin, and (C) a polyhydric alcohol, and having a water content of 2% by mass or less ;
[2] (D) The solid external composition according to [1], containing a glycerin fatty acid ester;
[3] (E) The solid external composition according to [1] or [2], containing a terpenoid;
[4] (F) The solid external composition according to [1] to [3], which contains a liquid oil;
[5] (G) The solid external composition according to [1] to [4], containing paste oil;
[6] The above (A) is one or more selected from the group consisting of paraffin wax, microcrystalline wax, polyethylene wax, Fischer-Tropsch wax, carnauba wax, and candelilla, and the above (B) is nicotinamide, thiamine hydrochloride. , thiamine phosphate, riboflavin, folic acid (pteroyl monoglutamic acid), pyridoxine hydrochloride, cyanocobalamin, biotin, pantothenic acid, ascorbic acid, ascorbyl glucoside, ascorbyl phosphate, ascorbyl magnesium phosphate, ethyl ascorbate, ascorbyl palmitate The solid external composition according to [1] to [5], containing one or more selected from the group consisting of phosphate, isostearyl ascorbyl phosphate, and caprylyl 2-glyceryl ascorbic acid;
[7] The solid external composition according to [2], wherein (D) is polyglyceryl diisostearate;
[8] The solid external composition according to [3], wherein (E) is a cyclic terpene;
[9] The solid external composition according to [8], wherein (E) is one or more selected from the group consisting of menthol, glycyrrhetinic acid, retinol palmitate, and cymen-5-ol;
[10] The solid external composition according to [1] to [9], wherein the total content of component (B) is 0.001 to 5 parts by mass relative to 1 part by mass of component (A). thing;
[11] The solid external composition according to [1] to [10], wherein the total content of component (C) is 0.005 to 2 parts by mass with respect to 1 part by mass of component (A). thing;
[12] The solid external composition according to [1] to [11], wherein the total content of component (C) is 0.05 to 10 parts by mass relative to 1 part by mass of component (B). thing;
[13] The solid external composition according to [1] to [12], which has a hardness of 5 g or more at 25°C;
[14] The solid external composition according to [1] to [13], which is for use on the lips.

The solid composition for external use of the present invention contains (A) a solid wax having a melting point of 40°C or higher, (B) a water-soluble vitamin, and (C) a polyhydric alcohol, and has a water content of 2% by mass or less. Therefore, it has excellent moldability and usability.

EMBODIMENT OF THE INVENTION Hereinafter, the form for implementing this invention is demonstrated in detail. However, the present invention is not limited to the following embodiments.

[1. Solid external composition]
The solid composition for external use according to the present embodiment contains (A) a solid wax having a melting point of 40° C. or higher, (B) a water-soluble vitamin, and (C) a polyhydric alcohol, and has a water content of 2 mass % or less.

<(A) component>
The solid wax used in the present invention with a melting point of 40°C or higher (hereinafter also simply referred to as component (A)) has waxy physical properties (specifically, water resistance, plasticity, gloss and/or It refers to a substance that exhibits opacity, etc.), has a melting point of 40°C or higher, is solid at room temperature, and is not particularly limited as long as it is medicinally, pharmacologically (pharmacologically) or physiologically acceptable. . The melting point of the solid wax used in the present invention is not particularly limited as long as it is 40°C or higher, as long as the effects of the present invention can be achieved, but it is usually about 40 to 150°C, preferably about 40 to 130°C, more preferably about 40 to 130°C. The temperature is about 100°C. Specifically, petroleum-derived waxes such as paraffin wax and microcrystalline wax; synthetic waxes such as polyethylene wax, Fischer-Tropsch wax, hydrogenated castor oil, and polypropylene wax; (stearoxymethicone/dimethicone) copolymer, cetearylmethicone, alkyl (C30-45) Silicone wax such as cetearyl dimethicone crosspolymer; carnauba wax, candelilla wax, wood wax, rice bran wax, hazel wax, sumac wax, sugar cane wax, palm wax, orange peel wax, orange flower wax, staghorn flower wax, cuticle wax Plant-derived waxes such as daffodil flower wax, white bayberry fruit wax, sweet acacia flower wax, and tuberose flower wax; Animal-derived waxes such as beeswax, beeswax, spermaceti, shellac wax, lanolin; Montan wax, ozokerite, ceresin wax solid higher alcohols such as cetyl alcohol (also referred to as cetanol, palmityl alcohol, etc.), stearyl alcohol, and behenyl alcohol; and the like, but are not limited to these. Among component (A), petroleum-derived waxes, plant-derived waxes, and higher alcohols are preferred, petroleum-derived waxes and plant-derived waxes are more preferred, and paraffin waxes, More preferred is microcrystalline wax. In the solid external composition of the present invention, only one type of the above-mentioned (A) components may be used alone, or two or more types may be used in combination. Preferably, by using two or more types of component (A) in combination, even higher effects of the present invention can be expected. As component (A), commercially available products can be used.

The content of component (A) in the solid external composition according to the present embodiment is not particularly limited, and includes the type of component (A), the type and content of other ingredients, the use and formulation form of the solid external composition, etc. It is set as appropriate depending on the situation. The content of component (A) should be, for example, from 0.1 to 60% by mass based on the total amount of the solid topical composition, from the viewpoint of achieving more remarkable effects of the present invention. %, preferably from 0.5 to 50% by weight, more preferably from 1 to 46% by weight, more preferably from 2 to 41% by weight, and from 4 to 36% by weight. It is even more preferable that the amount be present, and particularly preferably 6 to 30% by weight.

<(B) component>
The water-soluble vitamin used in the present invention (hereinafter also simply referred to as component (B)) has a solubility in water of 3 [g/100g water] or more at 25°C, and has a pharmaceutically and pharmacologically There are no particular limitations as long as it is (pharmaceutically) or physiologically acceptable. The solubility of the water-soluble vitamins used in the present invention in water is not particularly limited as long as it is 3 [g/100 g water] or more, as long as the effects of the present invention can be achieved, but it is usually about 5 to 100 [g/100 g water]. , preferably about 10 to 95 [g/100g water], more preferably about 20 to 90 [g/100g water]. Specific examples include water-soluble vitamin B, water-soluble vitamin C, and the like. Water-soluble vitamin B includes vitamin B1 such as thiamine hydrochloride and thiamine phosphate; vitamin B2 such as riboflavin; vitamin B6 such as pyridoxine hydrochloride; vitamin B12 such as cyanocobalamin; niacin such as nicotinamide; Examples include, but are not limited to, monoglutamic acid); pantothenic acid; biotin, and the like. Examples of water-soluble vitamin C include ascorbic acid, ascorbyl glucoside, ascorbyl phosphate, magnesium ascorbyl phosphate, ethyl ascorbate, ascorbyl palmitate phosphate, isostearyl ascorbyl phosphate, and caprylyl 2-glyceryl ascorbic acid. However, it is not limited to these. Among component (B), niacin and water-soluble vitamin C are preferred, and nicotinic acid amide is more preferred, from the viewpoint of achieving even more remarkable effects of the present invention. In the solid external composition of the present invention, one type of the above-mentioned component (B) may be used alone, or two or more types may be used in combination. Preferably, by using two or more types of component (B) in combination, even higher effects of the present invention can be expected. As component (B), commercially available products can be used.

The content of component (B) in the solid external composition according to the present embodiment is not particularly limited, and includes the type of component (B), the type and content of other ingredients, the use and formulation form of the solid external composition, etc. It is set as appropriate depending on the situation. The content of component (B) should be, for example, from 0.01 to 20% by mass based on the total amount of the solid external composition, from the viewpoint of achieving more remarkable effects of the present invention. %, more preferably 0.05 to 18% by mass, even more preferably 0.1 to 16% by mass, even more preferably 0.15 to 14% by mass, Particularly preferred is 0.2 to 12% by weight.

<(C) component>
The polyhydric alcohol used in the present invention (hereinafter also simply referred to as component (C)) refers to a polyhydric alcohol with a valence of 2 or more, which is medicinally, pharmacologically (pharmacologically) or physiologically acceptable. There is no particular restriction as long as it is carried out. The polyhydric alcohol used in the present invention is not particularly limited as long as it can achieve the effects of the present invention, and examples thereof include glycols, glycerin, and the like. Specifically, glycols include alkylene glycols such as ethylene glycol, propylene glycol, 1,3-butylene glycol, and pentylene glycol; dialkylene glycols such as diethylene glycol and dipropylene glycol; tripropylene glycol, hexylene glycol, Examples include polyalkylene glycols such as caprylyl glycol, polyethylene glycol, and polypropylene glycol. Examples of glycerin include glycerin, diglycerin, polyglycerin, and the like. Among component (C), glycerin is preferable from the viewpoint of exhibiting the effects of the present invention even more markedly. In the solid external composition of the present invention, only one type of the above-mentioned component (C) may be used alone, or two or more types may be used in combination. Preferably, by using two or more types of component (C) in combination, even higher effects of the present invention can be expected. As component (C), commercially available products can be used.

The content of component (C) in the solid external composition according to the present embodiment is not particularly limited, and includes the type of component (C), the type and content of other ingredients, the use and formulation form of the solid external composition, etc. It is set as appropriate depending on the situation. The content of component (C) is, for example, from 0.001 to 10% by mass based on the total amount of the solid topical composition, from the viewpoint of achieving more remarkable effects of the present invention. %, more preferably 0.005 to 8% by mass, even more preferably 0.01 to 7% by mass, even more preferably 0.05 to 6% by mass, Particularly preferred is 0.1 to 5% by weight.

<(D) component>
The solid composition for external use according to the present embodiment may further contain (D) glycerin fatty acid ester (also simply referred to as "component (D)"). The glycerin fatty acid ester used in the present invention includes both monoglycerin fatty acid ester and polyglycerin fatty acid ester, and is not particularly limited as long as it is medicinally, pharmacologically (pharmacologically) or physiologically acceptable. Specifically, monoglycerin fatty acid esters include glyceryl monocaprylate, glyceryl monocaprate, glyceryl monolaurate, glyceryl monomyristate, glyceryl monopalmitate, glyceryl monostearate, glyceryl monoisostearate, glyceryl monobehenate, and monoglyceryl monostearate. Examples include glyceryl oleate, glyceryl monoerucate, glyceryl sesquioleate, glyceryl distearate, glyceryl diisostearate, glyceryl diarachate, and the like. Polyglycerin fatty acid esters include diglyceryl monocaprylate, decaglyceryl monocaprylate, hexaglyceryl monocaprate, tetraglyceryl monolaurate, hexaglyceryl monolaurate, decaglyceryl monolaurate, poly(4-10)glyceryl monolaurate, and monoglyceryl monolaurate. Decaglyceryl myristate, Decaglyceryl monostearate, Decaglyceryl monoisostearate, Poly(2-10)glyceryl monostearate, Diglyceryl monooleate, Hexaglyceryl monooleate, Diglyceryl sesquioleate, Poly(2-10) diisostearate. 2-10) glyceryl, poly(6-10) glyceryl distearate, diglyceryl triisostearate, and poly(10) glyceryl tristearate. Among component (D), diglyceryl diisostearate is preferable from the viewpoint of exhibiting the effects of the present invention more markedly. When the solid external composition further contains component (D), the effects of the present invention are more significantly exhibited. In the solid external composition of the present invention, one type of the above-mentioned component (D) may be used alone, or two or more types may be used in combination. Preferably, by using two or more types of component (D) in combination, even higher effects of the present invention can be expected. As component (D), commercially available products can be used.

The content of component (D) in the solid external composition according to the present embodiment is not particularly limited, and includes the type of component (D), the type and content of other ingredients, the use and formulation form of the solid external composition, etc. It is set appropriately depending on the situation. The content of component (D) should be, for example, from 0.01 to 15% by mass based on the total amount of the solid external composition, from the viewpoint of achieving more remarkable effects of the present invention. %, more preferably 0.05 to 12% by mass, even more preferably 0.05 to 9% by mass, even more preferably 0.05 to 7% by mass, Particularly preferred is 0.1 to 5% by weight.

<(E) component>
The solid composition for external use according to the present embodiment further exhibits the effects of the present invention by further containing (E) terpenoid (also simply referred to as "component (E)"). The terpenoids used in the present invention include both cyclic terpenes, which are terpenoids that have at least one ring structure in their molecules, and acyclic terpenes, which are terpenoids that do not have a ring structure in their molecules. There are no particular limitations as long as it is pharmaceutically (pharmaceutically) or physiologically acceptable. Specifically, menthol, menthone, camphor, carvone, borneol, cineole, anethole, eugenol, terpineol, carvacrol, limonene, pinene, cinnamyl aldehyde, thymol, cymen-5-ol, glycyrrhetinic acid, retinol, glycyrrhetinic acid, and cyclic terpenes such as derivatives thereof; acyclic terpenes such as geraniol, citronellol, linalool, linalyl acetate, nerol, citral, and derivatives thereof, and the like, but are not limited to these. Among component (E), cyclic terpenes are preferable, and menthol, cymen-5-ol, glycyrrhetinic acid, retinol, and derivatives thereof are more preferable, from the viewpoint of more significantly exerting the effects of the present invention.

Terpenoids may be d-, l-, or dl-menthol, and examples thereof include l-menthol, d-menthol, and dl-menthol. However, some terpenoids, such as geraniol, do not have optical isomers. As component (E), commercially available products can be used. Component (E) may be used alone or in combination of two or more. , any part may be used.

The content of component (E) in the solid external composition according to the present embodiment is not particularly limited, and includes the type of component (E), the type and content of other ingredients, the use and formulation form of the solid external composition, etc. It is set as appropriate depending on the situation. The content of component (E) should be, for example, from 0.001 to 5% by weight based on the total amount of the solid topical composition, from the viewpoint of exhibiting the effects of the present invention more markedly. %, more preferably 0.005 to 4% by mass, even more preferably 0.01 to 3% by mass, even more preferably 0.05 to 2% by mass, Particularly preferred is 0.1 to 1% by weight.

<(F) component>
When the solid composition for external use according to the present embodiment further contains (F) liquid oil (also simply referred to as "component (F)"), the effects of the present invention are more prominently exhibited. The liquid oil used in the present invention is fluid at room temperature, contains oil-soluble ultraviolet absorbers and tocopherol, and is pharmaceutically, pharmacologically (pharmacologically) or physiologically acceptable. If so, there are no particular restrictions. Specifically, one or more oil-soluble UV absorbers selected from the group consisting of para-methoxycinnamate 2-ethylhexyl, dimethicodiethyl benzalmalonate, octocrylene, and octyl salicylate; paraffin, isoparaffin, squalane, etc. Hydrocarbon oils; vegetable oils such as jojoba oil, olive oil, macadamia nut oil, avocado oil, coconut oil, corn oil, soybean oil, rapeseed oil, and sunflower oil; animal oils such as lanolin; higher alcohols such as octyldodecanol and isostearyl alcohol; Examples include ester oils such as macadamia nut fatty acid phytosteryl, diisostearyl malate, tri(caprylic/capric) glyceryl, cetyl ethylhexanoate, and hydrogenated pentaerythyl rosinate. Among component (F), 2-ethylhexyl paramethoxycinnamate, paraffin, squalane, olive oil, and diisostearyl malate are preferable from the viewpoint of more significantly exerting the effects of the present invention. When the solid composition for external use further contains component (F), the effects of the present invention are more prominently exhibited. In the solid external composition of the present invention, only one type of the above-mentioned (F) components may be used alone, or two or more types may be used in combination. Preferably, by using two or more types of component (F) in combination, even higher effects of the present invention can be expected. As component (F), commercially available products can be used.

The content of component (F) in the solid external composition according to the present embodiment is not particularly limited, and includes the type of component (F), the type and content of other ingredients, the use and formulation form of the solid external composition, etc. It is set as appropriate depending on the situation. The content of component (F) is, for example, from 1 to 60% by mass, based on the total amount of the solid topical composition, from the viewpoint of achieving more remarkable effects of the present invention. It is preferably from 3 to 60% by mass, even more preferably from 5 to 60% by mass, even more preferably from 5 to 50% by mass, and from 7 to 45% by mass. is particularly preferred.

<(G) component>
The solid composition for external use according to the present embodiment further exhibits the effects of the present invention by further containing (G) paste oil (also simply referred to as "component (G)"). The paste oil used in the present invention has no fluidity at room temperature, and is medicinally, pharmacologically (pharmacologically) or physiologically derived, such as petroleum-derived, mineral-derived, plant-derived, or animal-derived. If so, there are no particular restrictions. Specifically, hydrocarbons such as petrolatum and isoparaffin, plant-derived products such as shea butter, cocoa butter, avocado butter, and aloe butter, lanolin, di(phytosteryl octyldodecyl) lauroylglutamate, and dimer dilinoleyl dilinoleate. , (polyglyceryl-2 isostearate/dimer dilinoleic acid) copolymer, hexa(hydroxystearic acid/stearic acid/stearic acid/rosin acid) dipentaerythrityl, diglyceryl adipate mixed fatty acid ester, fatty acid (C10-30) (cholesterol/lanosterol) ) esters such as esters. Among component (G), vaseline, isoparaffin, shea butter, and lanolin are preferred from the viewpoint of achieving even more remarkable effects of the present invention. When the solid external composition further contains component (G), the effects of the present invention are more significantly exhibited. In the solid external composition of the present invention, one type of the above-mentioned (G) components may be used alone, or two or more types may be used in combination. Preferably, by using two or more types of component (G) in combination, even higher effects of the present invention can be expected. As component (G), commercially available products can be used.

The content of component (G) in the solid external composition according to the present embodiment is not particularly limited, and includes the type of component (G), the type and content of other ingredients, the use and formulation form of the solid external composition, etc. It is set as appropriate depending on the situation. The content of component (G) is, for example, from 5 to 70% by mass based on the total amount of the solid topical composition, from the viewpoint of achieving more remarkable effects of the present invention. It is preferably from 8 to 65% by mass, even more preferably from 10 to 60% by mass, even more preferably from 12 to 55% by mass, and even more preferably from 20 to 50% by mass. is particularly preferred.

The hardness at 25°C of the solid composition for external use according to the present embodiment is preferably 5 g or more, more preferably 7 g or more, even more preferably 10 g or more, even more preferably 12 g or more, and even more preferably 17 g or more, from the viewpoint of moldability. More preferably, 20 g or more is particularly preferable. The hardness at 25° C. of the solid external composition is preferably 60 g or less, more preferably 50 g or less, even more preferably 45 g or less, even more preferably 38 g or less, even more preferably 35 g or less, and even more preferably 33 g or less. is particularly preferred. The hardness of the solid topical composition at 25°C is determined by heating and melting the cosmetic main body at 90°C or higher, filling it into a lipstick container (approximately 12 mm in diameter, and approx. 40 mm in height), and then cooling and solidifying it at 4°C for 2 hours. Then, leave it at 25℃ overnight to cool. After leaving it at 25℃ for more than 4 hours, cut off about 10mm from the top, and use a rheometer manufactured by Rheotec to obtain a table speed of 2mm using a jig with a diameter of 1mm. It can be measured by reading the maximum value when the jig is inserted to a depth of 10 mm at a speed of /s.

The water used in the solid external composition according to the present embodiment can be ion-exchanged water, distilled water, or the like. As for the water content, from the viewpoint of achieving more remarkable effects of the present invention, for example, the total water content is preferably 2% by mass or less based on the total amount of the solid external composition, and 1. It is more preferably 5% by mass or less, even more preferably 1.2% by mass or less, even more preferably 1% or less, even more preferably 0.8% by mass or less, and even more preferably 0.8% by mass or less. It is particularly preferably 6% by mass or less, particularly preferably 0.4% by mass or less, particularly preferably 0.2% by mass or less, and most preferably substantially 0% by mass. If it exceeds 2% by mass, moldability may be unfavorable.

In the solid external composition according to the present embodiment, the content ratio of component (B) to component (A) is not particularly limited, and the types of component (A) and (B), and the types and contents of other ingredients , is appropriately set depending on the use and formulation form of the solid external composition. The content ratio of component (B) to component (A) is, for example, the total content of component (A) contained in the oil-in-water cosmetic according to the present embodiment, from the viewpoint of achieving more remarkable effects of the present invention. The total content of component (B) per 1 part by mass is preferably 0.001 to 5 parts by mass, more preferably 0.001 to 3 parts by mass, and 0.005 to 2 parts by mass. 1 part by weight is more preferable, and 0.005 to 1 part by weight is particularly preferable. If the content ratio of component (B) to component (A) is small, the usability will be poor, and if the content ratio of component (B) to component (A) is large, moldability will be poor.

In the solid external composition according to the present embodiment, the content ratio of component (C) to component (A) is not particularly limited, and the types of component (A) and (C), and the types and contents of other ingredients. , is appropriately set depending on the use and formulation form of the solid external composition. The content ratio of component (C) to component (A) is, for example, the total content of component (A) contained in the oil-in-water cosmetic according to the present embodiment, from the viewpoint of achieving more remarkable effects of the present invention. The total content of component (C) per 1 part by mass is preferably 0.005 to 2 parts by mass, more preferably 0.01 to 1 part by mass, and 0.02 to 0. It is more preferably 8 parts by weight, even more preferably 0.025 to 0.6 parts by weight, and particularly preferably 0.05 to 0.5 parts by weight. If the content ratio of component (C) to component (A) is small, the usability will be poor, and if the content ratio of component (C) to component (A) is large, moldability will be poor.

In the solid external composition according to the present embodiment, the content ratio of component (C) to component (B) is not particularly limited, and the types of component (B) and (C), and the types and contents of other ingredients , is appropriately set depending on the use and formulation form of the solid external composition. The content ratio of component (C) to component (B) is, for example, the total content of component (B) contained in the oil-in-water cosmetic according to the present embodiment, from the viewpoint of achieving more remarkable effects of the present invention. The total content of component (C) is preferably 0.05 to 10 parts by weight, more preferably 0.1 to 8 parts by weight, and 0.2 to 7 parts by weight per 1 part by weight. parts by weight, even more preferably from 0.3 to 6 parts by weight, and particularly preferably from 1 to 5 parts by weight. If the content ratio of component (C) to component (B) is small, the dissolution and dispersion of component (C) will be insufficient, and if the content ratio of component (C) to component (B) is large, the usability will be poor.

The solid composition for external use according to the present embodiment can contain known ingredients used in cosmetics, quasi-drugs, and pharmaceuticals, as long as they do not impede the effects of the present invention. In addition to the above ingredients (A) to (G), for example, antioxidants, whitening ingredients, moisturizers, anti-inflammatory ingredients, antibacterial agents, vitamins, amino acids, biological extracts, various pharmacologically active ingredients, and physiological ingredients. It may contain a suitable amount of a combination of active ingredients (excluding components (A) to (G) above). Additionally, additives such as surfactants, preservatives, pH adjusters, chelating agents, stabilizers, buffers, thickeners, gelling agents, irritation reducers, preservatives, colorants, fragrances, minerals, etc. One kind can be added alone or two or more kinds can be added in combination (excluding the above-mentioned components (A) to (G)). Moreover, one type of base or carrier can be used alone, or two or more types can be included. These can be used by appropriately selecting known ones, and can be manufactured using conventional methods. Commercially available ones can also be used.

The solid external composition according to the present embodiment is not particularly limited as long as it has a shape that can be applied to the application site, and can be cylindrical, elliptical, triangular, square, polygonal, modified cylindrical (petal-shaped, (animal-shaped, etc.), or filled in a dome-shaped container.

The inner diameter (diameter) of the container filled with the solid external composition according to the present embodiment is preferably 3 to 60 mm, more preferably 4 to 55 mm, from the viewpoint of achieving more remarkable effects of the present invention. , more preferably 5 to 50 mm, particularly preferably 6 to 45 mm. The inner diameter is the length of the shortest straight line passing through the center of gravity in the shape of the plane of the part that comes into contact with the application part when the solid external composition filled in the container is taken out of the container accommodating part. When the solid external composition filled in the container is cylindrical, it is the diameter of the circle, and when it is a regular square prism, it is the length of one side of the square.

In the container to be filled with the solid external composition according to the present embodiment, the depth of the accommodating portion relative to the inner diameter (diameter) is preferably 0.3 to 20, from the viewpoint of more prominently achieving the effects of the present invention. It is more preferably from 0.8 to 12, even more preferably from 1.2 to 9, even more preferably from 1.4 to 6, and particularly preferably from 1.6 to 3. In the case where the bottom surface of the housing part is not flat but sloped, the depth of the housing part refers to the longest distance in the depth direction.

The solid external composition according to this embodiment can be applied to the skin. Skin is not only the surface of the body (e.g., face, head, ears, neck, chest, armpits, abdomen, waist, back, buttocks, arms, legs, hands, fingers, sensitive areas (genital areas), etc.), but also the mucous membranes. It is an inclusive concept.

The solid external composition according to the present embodiment is not particularly limited in the form of a drug, and may take any known form as a cosmetic, a quasi-drug, or a pharmaceutical. Among such known forms, examples include creams, gels, liniments, ointments, poultices, and sticks such as lipsticks. It can also be used in the form of basic cosmetics such as emulsions, creams, body lotions, body creams, and sunscreens, and in the form of makeup cosmetics such as foundations, lipsticks, blushers, eye makeup, face powder, manicures, and pedicures. Preferred are lipsticks, stick antiperspirants, and stick sunscreens. The solid composition for external use according to the present embodiment can be prepared by mixing and stirring each component according to a conventional method.

The present invention will be specifically explained below based on test examples, but the present invention is not limited thereto. Moreover, the compounding amounts in the following examples and the like indicate mass %.

[Test Example 1]
A solid composition for external use having the composition shown in Tables 1 and 2 below was prepared according to a conventional method and filled into a retractable lipstick container (made of polypropylene). Inside the container, the solid external composition has a cylindrical shape with a diameter of 12 mm and a length of 40 mm. Shape retention, peeling phenomenon, sweating, and feeling of use were evaluated using the following evaluation criteria, and the results are shown in Tables 1 and 2.

(Evaluation criteria for shape retention)
The solid composition for external use was drawn out of the lipstick container so that the length of the solid composition for external use was 30 mm, and the shape retention of the solid composition for external use was observed after it was tilted horizontally at 45 degrees and left at rest for 5 seconds.
〇: The solid topical composition is held in a shape tilted at 45 degrees in the horizontal direction △: The solid topical composition is tilted a little more than 45 degrees in the horizontal direction, and the shape is slightly bent ×: The solid topical composition is kept in the horizontal direction tilts more than 45 degrees and the shape bends

(Evaluation criteria for peeling phenomenon)
Eight solid external compositions filled in lipstick containers were drawn out of the container to a length of 30 mm, and the sides of the solid external compositions were visually observed to evaluate the presence or absence of peeling phenomenon. When thin peeling or chipping was observed on the side surface of the solid external composition, it was evaluated that there was a peeling phenomenon.
◎: All 8 pieces have no peeling phenomenon ○: 1 to 2 out of 8 pieces have peeling phenomenon △: 3 to 5 out of 8 pieces have peeling phenomenon ×: 6 to 8 out of 8 pieces have peeling phenomenon There is a phenomenon

(Evaluation criteria for sweating)
The solid external composition was drawn out of the lipstick container to a length of 30 mm, and the side surface of the solid external composition was visually observed to evaluate the presence or absence of liquid droplets.
〇: There are no liquid droplets ×: There are liquid droplets

(Evaluation criteria for usability)
Five subjects used the solid external composition filled in a lipstick container and applied it to their lips for two days, and gave an evaluation score between 0 and 5 depending on the degree of improvement in the peeling condition of the lips. A score of 0 was given when there was no change in the state of peeling, and a score of 5 was given when the state of peeling improved and the peeling disappeared. The average score of the five test subjects was calculated and evaluated based on the following criteria. The subjects were those who felt that their lips were more likely to get chapped or peeled by wearing a non-woven fabric mask that covered their mouth and nose on a daily basis.
◎: 3.5 points or more ○: 2.0 points or more, less than 3.5 points △: 0 points or more, less than 2.0 points

[Test Example 2]
The hardness of the solid external composition used in Test Example 1 at 25°C was measured. After filling a lipstick container (diameter 12 mm, height 40 mm) up to the top with a solid external composition heated and melted at 90 ° C. or higher, it was cooled and solidified at 4 ° C. for 2 hours, and left to stand at 25 ° C. overnight. After leaving it at 25° C. for 4 hours or more, 11 mm was cut off from the top surface. Using a rheometer manufactured by Rheotech, the maximum value of hardness was read when a jig with a diameter of 1 mm was inserted to a depth of 10 mm at a table speed of 2 mm/s. Each composition was measured three times, and the average values are shown in Tables 1 and 2.

なお、表１中のジイソステアリン酸ジグリセリルの原料は、ＥＭＡＬＥＸ ＤＩＳＧ―2（日本エマルジョン株式会社）である。

The raw material for diglyceryl diisostearate in Table 1 is EMALEX DISG-2 (Nippon Emulsion Co., Ltd.).

なお、表２中のジイソステアリン酸ジグリセリルの原料は、ＥＭＡＬＥＸ ＤＩＳＧ―2（日本エマルジョン株式会社）である。

The raw material for diglyceryl diisostearate in Table 2 is EMALEX DISG-2 (Nippon Emulsion Co., Ltd.).

As shown in Table 1, the solid topical composition containing solid wax with a melting point of 40°C or higher, water-soluble vitamins, and polyhydric alcohol has good shape retention, no peeling phenomenon or sweating, and good moldability. (Example 1). A solid external composition containing a solid wax with a melting point of 40°C or higher, water-soluble vitamins, and no polyhydric alcohol has shape retention, but cracks are observed in slightly curved parts. Peeling phenomenon occurred and moldability was poor (Comparative Example 1). Furthermore, in terms of feeling of use, the test subjects evaluated that it felt rough and irritating when applied to the lips, which was unfavorable for peeling skin (Comparative Example 1). A solid external composition containing solid wax with a melting point of 40°C or higher, water-soluble vitamins, and polyhydric alcohol, and containing 2.1% by mass of water has very poor shape retention and poor moldability. Hardness, peeling, perspiration, and feeling of use could not be evaluated (Comparative Example 2). It was considered that Comparative Example 1 and Comparative Example 2 may be due to non-uniformity in the formulation.
A solid external composition containing a solid wax with a melting point of 40°C or higher, a water-soluble vitamin, a polyhydric alcohol, and further containing a glycerin fatty acid ester has good shape retention, does not cause peeling or sweating, and has good moldability. was good (Example 2). Furthermore, the feeling of use was very good, and the test subjects reported that the solid topical composition adhered to the areas where the skin had peeled off and it covered the lips like a film, which lasted for a long time, and the hard skin of the lips softened. I received the opinion that The solid topical composition enters the outer surface of peeled skin and the raised gaps and protects the entire epithelium from drying due to the adhesion of wax, and penetrates into the dry and hardened epithelium due to the medicinal properties of water-soluble vitamins and the water-retaining properties of polyhydric alcohol. The composition has a highly uniform composition of oily and aqueous components due to glycerin fatty acid ester, so the functions of the wax, water-soluble vitamins, and polyhydric alcohol are quickly exerted at the application site, improving peeling effects. was considered high. Furthermore, since it can be applied very smoothly to lips that are uneven due to peeling, we received the opinion that the application process can be done more quickly and in a shorter time.

[Test Example 3]
A solid external composition shown in Table 3 below was prepared according to a conventional method and filled into a retractable lipstick container (made of polypropylene). Inside the container, the solid external composition has a cylindrical shape with a diameter of 12 mm and a length of 40 mm. Examples 7 to 12 are solid external compositions with good evaluations of shape retention, peeling, and perspiration, and good moldability. The usability was evaluated using the following evaluation criteria, and the results are shown in Table 3.

(Evaluation criteria for usability)
Five subjects applied the solid external composition filled in a lipstick container to their lips, and evaluated the moisturizing feeling after 3 hours using the following criteria. Table 3 shows the average evaluation scores of the five subjects.
◎: Feels moisturizing.
○: Feels a little moisturizing.
×: No moisturizing feeling. I feel dry.

As shown in Table 3, the solid external compositions of Examples 7 to 12 had a good moisturizing feeling.

Claims (6)

A solid composition for external use, which contains (A) a solid wax having a melting point of 40° C. or higher, (B) a water-soluble vitamin, and (C) a polyhydric alcohol, and has a water content of 2% by mass or less. (D) The solid composition for external use according to claim 1, which contains glycerin fatty acid ester. (E) The solid external composition according to claim 1 or 2, containing a terpenoid. The solid composition for external use according to claim 1 or 2, wherein the total content of component (B) is 0.001 to 5 parts by mass relative to 1 part by mass of component (A). The solid composition for external use according to claim 1 or 2, which has a hardness of 5 g or more at 25°C. The above (A) is one or more selected from the group consisting of paraffin wax, microcrystalline wax, polyethylene wax, Fischer-Tropsch wax, carnauba wax, and candelilla, and the above (B) is nicotinamide, thiamine hydrochloride, thiamine phosphorus. Acid salt, riboflavin, folic acid (pteroyl monoglutamic acid), pyridoxine hydrochloride, cyanocobalamin, biotin, pantothenic acid, ascorbic acid, ascorbyl glucoside, ascorbyl phosphate, ascorbyl magnesium phosphate, ethyl ascorbate, ascorbyl palmitate phosphate , isostearyl ascorbyl phosphate, and caprylyl 2-glyceryl ascorbic acid.