JP2023152964A - センサ較正のための方法 - Google Patents
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- A61B5/1495—Calibrating or testing of in-vivo probes
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- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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Abstract
Description
Claims (12)
- フロースルーセンサ経路(211)に配置され、較正のために少なくとも1つの酸素化較正流体(221’’)を必要とするセンサ(212)を較正する自動化された方法であって、
流体供給源(220)から、流体選択弁(230)と前記センサ経路(211)との間にある、内壁を有する流体ライン(213)内に所定量の脱酸素化較正流体(221)を移送することと、
前記較正流体を移送する前後に、周囲空気(232’)を前記流体ライン(213)内に移送し、それによって周囲空気(232’)の2つのゾーンの間に位置する較正流体の隔離されたプラグ(221’)を形成することと、
前記較正流体のプラグ(221’)を、前記弁(230)と前記センサ経路(211)との間に含まれる前記流体ライン(213)の所定の長さ内で所定の回数および所定の速度で前後に振動させること(241)であって、それによって、前記流体ライン(213)の前記内壁に沿ってテーリングする流体膜(225)を往復運動させ、それによって、前記流体ライン(213)内の前記周囲空気(232’)からの前記テーリング流体膜(225)による酸素取り込みを介した前記較正流体(221’)の酸素化を促進することと、
前記センサ(212)が配置される位置にて前記酸素化較正流体(221’’)を前記センサ経路(211)内に移送し、前記センサ(212)を較正することと
を含む、方法。 - 前記脱酸素化較正流体(221、221’)の所定量が、前記センサ経路(211)内の許容位置範囲内で較正されるべき前記センサ(212)を完全に覆うのに十分な最小体積である、請求項1に記載の方法。
- 周囲空気(232’)および/または前記較正流体(221、221’、221’’)を前記流体ライン(213)内に移送するため、前記流体ライン(213)内の前記較正流体(221’)を振動させる(241)ため、ならびに周囲空気(232’)および/または前記較正流体(221’、221’’)を前記センサ経路(211)内に移送するためにポンプ(240)を使用することを含む、請求項1または2に記載の方法。
- 前記流体ライン(213)内の前記較正流体(221’)を振動させる(241)ための前記所定の速度が、前記ポンプ(240)が可能なほぼ最大の速度である、請求項3に記載の方法。
- 前記較正流体(221’)が内部で振動する(241)前記流体ライン(213)の前記所定の長さが、前記流体ライン(213)のほぼ全長である、すなわち、前記流体選択弁(230)と前記センサ経路(211)との間、または、さらなる導管(214)を介して前記流体選択弁(230)の出口ポート(231)に流体接続されたポート(40)と前記センサ経路(211)との間の長さである、請求項1から4のいずれか一項に記載の方法。
- 第1のステップとして、前記流体ライン(213)および前記センサ経路(211)を脱酸素化較正流体(221)によって洗浄することを含む、請求項1から5のいずれか一項に記載の方法。
- 前記洗浄ステップが、前記流体ライン(213)および前記センサ経路(211)を通って、周囲空気(232’)の複数のゾーンによって交互に配置された、複数の較正流体のプラグ(221’)を所定の時間および所定の速度で連続的に移送することを含む、請求項6に記載の方法。
- 第2のステップとして、前記流体ライン(213)および前記センサ経路(211)を空気(232’)によって充填することを含む、請求項6または7に記載の方法。
- フロースルーセンサ経路(211)内に配置され、較正のために少なくとも1つの酸素化較正流体(221’’)を必要とする少なくとも1つのセンサ(212)を備える体外診断IVD分析器(200)であって、前記IVD分析器(200)が、少なくとも1つの脱酸素化較正流体(221)を備える流体供給源(220)と、一度に少なくとも1つの流体(221、222、223、232)を選択するための流体選択弁(230)と、前記弁(230)と前記センサ経路(211)との間に含まれる流体ライン(213、213’)と、をさらに備え、前記IVD分析器(200)が、請求項1から8のいずれか一項に記載の少なくとも1つのセンサ(212)を較正する方法を自動的に実行するように構成されたコントローラ(250)をさらに備える、IVD分析器(200)。
- 前記少なくとも1つのセンサ(212)が、グルコースセンサおよび乳酸センサのうちの少なくとも一方を含む代謝産物センサである、請求項9に記載のIVD分析器(200)。
- 前記IVD分析器(200)がポンプ(240)をさらに備え、前記コントローラ(250)が、周囲空気(232’)および/または前記較正流体(221’、221’’)を前記流体ライン(213、213’)内に移送するため、前記流体ライン(213)内の前記較正流体(221’)を振動させる(241)ため、ならびに較正のためにそれぞれの前記センサ(212)に対応して前記酸素化較正流体(221’’)を配置することを含む、周囲空気(232’)および/または前記較正流体(221’、221’’)を前記センサ経路(211)内に移送するために、前記ポンプ(240)および前記流体選択弁(230)を制御するように構成されている、請求項9または10に記載のIVD分析器(200)。
- 前記流体ライン(213’)が、周囲空気からの酸素に対して透過性のある材料から少なくとも部分的に作られている、請求項9から11のいずれか一項に記載のIVD分析器(200)。
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EP22166263.8A EP4253965A1 (en) | 2022-04-01 | 2022-04-01 | Method for sensor calibration and in-vitro diagnostic analyzer |
EP22166263.8 | 2022-04-01 |
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EP (1) | EP4253965A1 (ja) |
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US4221567A (en) * | 1977-12-23 | 1980-09-09 | Intermountain Health Care | Sampling and determination of diffusible chemical substances |
EP1421372B1 (en) * | 2001-08-22 | 2010-11-03 | Instrumentation Laboratory Company | Method and apparatus for calibrating sensors |
US9585605B2 (en) * | 2011-05-19 | 2017-03-07 | Pepex Biomedical, Inc. | Fluid management and patient monitoring system |
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2022
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