JP2023147133A - Skin composition - Google Patents

Abstract

To provide a skin composition that allows a significant reduction in the ingredient smell of coenzyme Q10 and also a significant reduction in stickiness after its application.SOLUTION: A skin composition contains the following component A, the following component B, and the following component C. The content of the component A is more than 0.3 mass% and 1.0 mass% or less. The component A is coenzyme Q10, the component B is unsaturated fatty acid ester oil and the component C is an amino acid.SELECTED DRAWING: None

Description

The present invention relates to dermatological compositions.

One of the functions required of skin care products is ``moisturizing''. Conventionally, components that make up interkeratinocyte lipids such as ceramides, sphingolipids, and lecithin; components that exist within corneocytes such as natural moisturizing factor (NMF); and components that originally exist in the dermis such as hyaluronic acid and collagen. The formulation contains ingredients that exhibit various moisturizing effects, such as polyhydric alcohols, oils, sugars, and plant extracts.

Among these ingredients, coenzyme Q10 continues to attract attention as an ingredient with exceptionally excellent moisturizing ability. However, although coenzyme Q10 can exhibit exceptionally excellent moisturizing ability, when it is blended in high amounts with the expectation of a moisturizing effect, there are problems such as the odor of the raw material becoming noticeable and hindering formulation, and the problem of stickiness after application. There is a problem that the feeling persists.

To address the problem of raw material odor, masking the odor using fragrances may be an option, but adding fragrance to a preparation also depends on the user's preference for odor, so it cannot be said to be the best method of improvement. Therefore, there is a need to develop methods other than masking methods to suppress odors. Attempts have been made to suppress odor changes over time in preparations containing coenzyme Q10 (for example, see Patent Document 1). However, this attempt was aimed at suppressing deterioration over time and odor in oil-based skin compositions, and did not lead to a fundamental solution to suppressing the raw material odor of coenzyme Q10.

On the other hand, in order to reduce stickiness, it is necessary to incorporate a low amount of coenzyme Q10, and the desired moisturizing effect cannot be imparted. Various attempts have been made to suppress stickiness in preparations containing coenzyme Q10 (see, for example, Patent Documents 2 and 3). However, these attempts have the disadvantage that formulation requires ingenuity and preparation is time-consuming.

Japanese Patent Application Publication No. 2007-084505 Japanese Patent Application Publication No. 2007-077084 Japanese Patent Application Publication No. 2013-136545

The present invention has been made in view of the above-mentioned prior art, and even if the main function of coenzyme Q10 is highly blended to fully exhibit its main function, the raw material odor of coenzyme Q10 can be significantly reduced, and An object of the present invention is to provide a skin composition that can significantly reduce the sticky feeling after application.

That is, the present invention is characterized in that it contains the following component A, the following component B, and the following component C, and the content of the component A is more than 0.3% by mass and not more than 1.0% by mass. A skin composition is provided.
Component A: Coenzyme Q10
Component B: Unsaturated fatty acid ester oil Component C: Amino acid

It is preferable that the component C is at least one selected from the group of alanine, arginine, glycine, cysteine, serine, and ectoine.

It is preferable that the skin composition further contains the following component D.
Component D: Polyglycerin fatty acid ester type nonionic surfactant

By satisfying the above-mentioned constituent requirements, the skin composition of the present invention exhibits an odor suppressing effect that can significantly reduce the raw material odor of coenzyme Q10, which is an unprecedented method. Furthermore, the skin composition of the present invention has the effect of significantly reducing the sticky feeling after application.

The skin composition of the present invention is characterized by containing the following component A, the following component B, and the following component C.
Component A: Coenzyme Q10
Component B: Unsaturated fatty acid ester oil Component C: Amino acid

The details of each component used in the skin composition of the present invention will be explained below.

[Component A]
The above component A is coenzyme Q10. Coenzyme Q10 is a compound also known as coenzyme Q10, CoQ10, ubiquinone, and ubidecarenone. In the present invention, by using component A, it is possible to impart extremely excellent moisture to the skin after application, a so-called moisturizing effect.

In addition, the said component A is not specifically limited, even if it is a single raw material or a mixed raw material with other components. In the present invention, a commercially available product can be used as the component A. Commercially available products of coenzyme Q10 include, for example, Solfonte Q10, Phytopresome Q10, Phytopresome Lipo-Q, Presome Q10 (trade names, all manufactured by Nippon Fine Chemical Co., Ltd.), and the like.

The content of component A in the skin composition of the present invention is greater than 0.3% by mass and 1.0% by mass or less. From the viewpoint of feeling in use, the content is more preferably 0.9% by mass or less. In the present invention, even if component A is blended in a high proportion, specifically, in an amount greater than 0.3% by mass, raw material odor can be significantly reduced by combining it with the components described below. In addition, in the present invention, since a high amount of component A can be incorporated, it goes without saying that an extremely excellent moisturizing effect can be achieved. Note that the content of component A is the amount converted to pure content.

[Component B]
The above component B is an unsaturated fatty acid ester oil. Surprisingly, in the present invention, by using the component B, the raw material odor of the component A can be reduced, which is a particularly remarkable effect that has not been known in the past. Therefore, even if the content of component A in the skin composition is more than 0.3% by mass, it is possible to reduce the raw material odor.

Examples of the component B used include decyl oleate, oleyl oleate, octyldodecyl oleate, ethyl oleate, isodecyl oleate, cholesteryl oleate, dihydrocholesteryl oleate, and phytosteryl oleate. These components B may be used alone or in an appropriate combination of two or more.

In the present invention, among the component B, decyl oleate, oleyl oleate, and octyldodecyl oleate are preferably used from the viewpoint of significantly reducing the raw material odor of component A.

In addition, the said component B is not particularly limited, whether it is a single raw material or a mixed raw material with other components, as long as the desired effect is exhibited. In the present invention, a commercially available product can be used as the component B. A commercially available product of decyl oleate is, for example, CETIOL V (trade name, manufactured by BASF Japan), and a commercially available product of oleyl oleate is, for example, SR CRODAMOL OO-LQ-(JP) (trade name, manufactured by Croda Japan). Commercially available products of octyldodecyl oleate include O. O. D. (trade name, manufactured by Shin-Eikagaku Co., Ltd.).

The content of component B in the skin composition of the present invention is not particularly limited as long as the desired effect is sufficiently exhibited, but usually, from the viewpoint of significantly reducing the raw material odor of component A, Out of 100% by mass, it is preferably 0.01% by mass or more, and more preferably 0.1% by mass or more. Further, from the viewpoint of feeling in use, the content is preferably 1.0% by mass or less, more preferably 0.5% by mass or less based on 100% by mass of the composition. Note that the content of component B is the amount converted to pure content.

In the present invention, from the viewpoint of significantly reducing the raw material odor of the component A, the ratio of the content of the component B to the component A (component B/component A) is adjusted to be within the range of 0.01 to 20.0. It is preferable to satisfy the range of 0.05 to 5.0, more preferably to satisfy the range of 0.1 to 1.5.

[Component C]
The above component C is an amino acid. Surprisingly, in the present invention, by using the component C, the sticky feeling after application of the component A can be reduced, which is an extremely remarkable effect that has not been known in the past. . Therefore, even if the content of component A in the skin composition is more than 0.3% by mass, it is possible to reduce the sticky feeling.

The above component C used includes, for example, amino acids with a simple structure such as glycine and alanine; basic amino acids such as lysine, arginine, and histidine; acidic amino acids such as aspartic acid and glutamic acid; and amino acids with an amide side chain such as asparagine and glutamine. Certain amino acids; amino acids whose side chains are alcohols, such as serine and threonine; amino acids with sulfur atoms in their side chains, such as cysteine and methionine; amino acids with aromatic rings in their side chains, such as phenylalanine, tyrosine, and tryptophan; valine, leucine, Examples include hydrophobic amino acids with aliphatic side chains such as isoleucine; amino acids with ring-shaped side chains such as proline and ectoine. These components C may be used alone or in an appropriate combination of two or more.

In the present invention, from the viewpoint of reducing the excessive sticky feeling after application of the component A, among the above component C, a group consisting of alanine, arginine, glycine, cysteine, glutamic acid, glutamine, phenylalanine, leucine, serine and ectoine is selected. It is preferable to use at least one selected from the group consisting of alanine, arginine, glycine, cysteine, serine, and ectoine.

In addition, the said component C is not particularly limited, whether it is a single raw material or a mixed raw material with other components, as long as the desired effect is exhibited. In the present invention, a commercially available product can be used as the component C. Examples of commercially available alanine products include L-Alanine Kyowa (trade name, manufactured by KH Neochem); commercially available arginine products include, for example, L-Arginine C Grade (trade name, manufactured by Ajinomoto Co., Ltd.); and commercially available glycine products. Examples of commercially available cysteine products include Glycine M (trade name, manufactured by Fuso Chemical Industry Co., Ltd.), and commercially available cysteine products include, for example, L-cysteine (P) (trade name, manufactured by Nippon Protein Co., Ltd.). Commercially available serine products include, for example, L-serine (trade name, manufactured by Nippon Rikagaku Yakuhin Co., Ltd.), L-serine (trade name, manufactured by Junsei Kagaku Co., Ltd.), P. P. A. A. -C (trade name, manufactured by Seiwa Kasei Co., Ltd.) and the like. Commercially available products of ectoine include, for example, RonaCare Ection, RonaCare Cyclopeptide-5 (trade names, all manufactured by Merck & Co.), and Ectoin natural (trade name, manufactured by Bitop AG).

The content of component C in the skin composition of the present invention is not particularly limited as long as the desired effect is sufficiently exhibited, but usually from the viewpoint of reducing the excessive sticky feeling caused by the component A, It is preferably 0.01% by mass or more, more preferably 0.1% by mass or more in 100% by mass of the substance. Further, from the viewpoint of feeling in use, the content is preferably 1.0% by mass or less, more preferably 0.5% by mass or less based on 100% by mass of the composition. Note that the content of component C is the amount converted to pure content.

In the present invention, from the viewpoint of significantly reducing the excessive sticky feeling after application caused by the component A, the content ratio of the component C to the component A (component C/component A) is 0.01 to 20. It is preferable to satisfy the range of .0, more preferably to satisfy the range of 0.05 to 5.0, and even more preferably to satisfy the range of 0.1 to 1.0.

[Component D]
The skin composition of the present invention preferably contains a polyglycerin fatty acid ester type nonionic surfactant as component D from the viewpoint of further enhancing the effect of reducing the raw material odor of component A.

The number of carbon atoms in the fatty acid constituting the polyglycerol fatty acid ester of component D is not particularly limited, but is preferably 8 to 24, more preferably 10 to 20, and still more preferably 12 to 18. In addition, the fatty acid moiety may be a saturated fatty acid or an unsaturated fatty acid, but is not particularly limited as long as the desired effect is sufficiently exhibited, but the ingredient A further enhances the raw material odor reducing effect. From this point of view, unsaturated fatty acids are preferred. On the other hand, the average degree of polymerization of the polyglycerin constituting the polyglycerin fatty acid ester is not particularly limited, but is preferably 2 to 12, more preferably 5 to 10.

Examples of the polyglycerol fatty acid ester of component D include monoesters, diesters, and triesters. That is, component D includes, for example, polyglycerol fatty acid monoester, polyglycerol fatty acid diester, and polyglycerol fatty acid triester. Component D may be a mixture of these.

Examples of the component D used include hexaglyceryl monomyristate, decaglyceryl monostearate, decaglyceryl monoisostearate, decaglyceryl monooleate, decaglyceryl monolinoleate, decaglyceryl monocaprate, and decaglyceryl monolaurate. , decaglyceryl monomyristate, decaglyceryl dioleate, decaglyceryl distearate, decaglyceryl diisostearate, pentaglyceryl monolaurate, pentaglyceryl dioleate, hexaglyceryl monocaprylate, triglyceryl monocaprylate, poly(4~ 10) Glyceryl, poly(2-10) glyceryl monostearate, poly(2-10) glyceryl diisostearate, poly(2-10) glyceryl monooleate, and the like. These components D may be used alone or in an appropriate combination of two or more.

Among the above component D, from the viewpoint of further enhancing the effect of reducing raw material odor by the above component A, decaglyceryl monooleate, decaglyceryl monostearate, decaglyceryl diisostearate, decaglyceryl monolinoleate, decaglyceryl dioleate, diolein It is preferable to use pentaglyceryl acid and poly(2-10)glyceryl monooleate, and more preferably to use decaglyceryl monooleate, decaglyceryl monostearate, and decaglyceryl diisostearate.

In addition, the said component D is not particularly limited, whether it is a single raw material or a mixed raw material with other components, as long as the desired effect is exhibited. In the present invention, a commercially available product can be used as the component D. Commercially available products of decaglyceryl monooleate include, for example, Decaglyn 1-OV (trade name, manufactured by Nippon Surfactant Industries, Ltd.), Sunsoft Q-17Y-C (trade name, manufactured by Taiyo Kagaku Co., Ltd.), and the like. Commercially available products of decaglyceryl monostearate include, for example, Decaglyn 1-SV (trade name, manufactured by Nippon Surfactant Industries Co., Ltd.), Sunsoft Q-18Y-C (trade name, manufactured by Taiyo Kagaku Co., Ltd.), and the like. Examples of commercial products of decaglyceryl diisostearate include NIKKOL Decaglyn 2-ISV (trade name, manufactured by Nippon Surfactant Industries, Ltd.).

The content of component D in the skin composition of the present invention is not particularly limited as long as the desired effect is sufficiently exhibited, but usually from the viewpoint of further enhancing the effect of reducing raw material odor by the component A, It is preferably 0.1% by mass or more, more preferably 0.2% by mass or more in 100% by mass of the composition. Further, from the viewpoint of feeling in use, it is preferably 2.0% by mass or less, more preferably 1.2% by mass or less, based on 100% by mass of the composition. Note that the content of component D is the amount converted to pure content.

The skin composition of the present invention has high viscosity and high viscosity, from the viewpoint of further enhancing the stability of the formulation that can maximize the effect of reducing raw material odor and the effect of reducing the sticky feeling after application. It is preferable to include molecules. Examples of the thickening polymer include water-soluble natural polymers, semi-synthetic polymers, and synthetic polymers. In addition, in this specification, the thickening polymer may be referred to as component E.

Examples of the above component E include natural polymers such as gum arabic, gum tragacanth, guar gum, locust bean gum, karaya gum, xanthan gum, iris moss, quince seed, gelatin, shellac, rosin, and casein; sodium carboxymethyl cellulose, hydroxyethyl cellulose, and methyl cellulose. , ethylcellose, sodium alginate, ester gum, nitrocellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, crystalline cellulose, and other semisynthetic polymers; polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, (acrylates/alkyl acrylates (C10- 30)) Synthetic polymers such as crosspolymers (acrylic acid/alkyl methacrylate copolymers), polyvinyl methyl cellulose, polyamide resins, etc. can be mentioned. These components E may be used alone or in an appropriate combination of two or more.

The content of component E in the skin composition of the present invention is not particularly limited, but from the viewpoint of further improving formulation stability, it is preferably 0.01% by mass or more based on 100% by mass of the composition, and 0.01% by mass or more based on 100% by mass of the composition. More preferably, it is 1% by mass or more. Further, from the viewpoint of feeling in use, the content is preferably 1.0% by mass or less, more preferably 0.5% by mass or less based on 100% by mass of the composition. Note that the content of component E is the amount converted to pure content.

[Other ingredients]
The skin composition of the present invention may contain, in addition to the above-mentioned ingredients, such as fats and oils, waxes, hydrocarbon oils, saturated fatty acids, higher alcohols, and fatty acid ester oils, as long as they do not impair the effects of the present invention. , oil agents other than the above component B such as silicone oil; surfactants other than the above component D such as anionic surfactants, cationic surfactants, amphoteric surfactants, and nonionic surfactants; film formation A UV absorber, a whitening agent, an anti-inflammatory agent, a cooling agent, a pH adjuster, a neutralizing agent, a fragrance, etc. can be added as appropriate depending on the purpose.

Purified water is used for the remainder of the dermatological composition of the present invention. The content of purified water is not particularly limited, but from the viewpoint of exhibiting the effects of the present invention, it is preferably 30 to 95% by mass, more preferably 50 to 90% by mass.

The method for producing the skin composition of the present invention is not particularly limited, but it can be produced by, for example, a known method. Specifically, the above-mentioned components are mixed and stirred using a known method such as a disper mixer or a disper mill, or emulsified by a phase inversion emulsification method using a homomixer or the like. However, the present invention is not limited to these manufacturing methods.

The use of the skin composition according to an embodiment of the present invention is not particularly limited, but it is preferably used as a skin cosmetic, and more specifically, for example, a moisturizing cosmetic, a whitening cosmetic, an acne care cosmetic, It is preferable to use it as an anti-aging cosmetic for the purpose of suppressing wrinkles and sagging. Furthermore, the skin composition of the present invention can take the form of cosmetics, quasi-drugs, designated quasi-drugs, miscellaneous goods, and the like.

In addition, the areas to which the skin composition according to one embodiment of the present invention is applied are not particularly limited, but examples include the face (forehead, around the eyes, corners of the eyes, cheeks, mouth, etc.), arms, elbows, backs of hands, fingertips, It can be used on feet, knees, heels, neck, decollete, armpits, back, etc.

Hereinafter, the present invention will be explained in more detail based on Examples, but the present invention is not limited only to these Examples. In addition, the blending amount represents "mass %" unless otherwise specified.

(Sample preparation 1)
According to the compositions shown in Tables 1 and 2, the skin compositions of Examples 1 to 8 and Comparative Examples 1 to 5 were prepared in the form of emulsifiers according to conventional methods and subjected to the following evaluation. The results are also listed in Tables 1 and 2. In addition, all the blending amounts in the table are values converted to pure content.

(Test Example 1: Evaluation of presence or absence of raw material odor)
Each sample of the example and comparative example was sealed in a 50 mL transparent glass container and stored in a constant temperature bath at 25° C. for 4 weeks. After storage, 1 g of each sample was applied to the back of the hand, and the presence or absence of raw material odor caused by component A was sensory evaluated based on the odor emitted during spreading. The evaluation was conducted by 10 expert panelists, and the evaluation was based on whether or not they could smell the raw material odor of component A that they smelled before the evaluation. Moreover, Comparative Example 1, which does not contain component A, was not subjected to the test.

<Evaluation criteria for the presence or absence of raw material odor>
◎ (Very good): 9-10 out of 10 people answered that they did not feel the raw material odor caused by component A. ○ (Good): 6-8 out of 10 people felt the raw material odor caused by component A. △ (Insufficient): 3 to 5 out of 10 people answered that they did not feel the raw material odor caused by component A. Answer: No smell

(Test Example 2: Evaluation of sticky feeling after application)
1 g of each sample of Examples and Comparative Examples was taken in the palm of the hand and applied to both cheeks so as to be blended. 30 minutes after application, a sensory evaluation was performed on the "stickiness" of the applied area, and the evaluation was made according to the following evaluation criteria. The evaluation was carried out by 10 professional evaluators under the condition of 25°C, and the evaluation was determined by combining the evaluations of each evaluator.

<Evaluation criteria for sticky feeling after application>
◎ (Very good): Does not feel sticky at all and has an optimal feel ○ (Good): Slightly feels sticky but has a good feel △ (Insufficient): Slightly sticky and has a good feel It cannot be said that the usability is good × (Poor): It clearly feels sticky and the usability is poor.

From the results shown in Tables 1 and 2, it can be seen that the skin compositions obtained in each example had a higher content of coenzyme Q10 than those obtained in each comparative example. First, it can be seen that the raw material odor caused by coenzyme Q10 can be significantly suppressed, and the sticky feeling after application can be significantly reduced. On the other hand, it can be seen that Comparative Examples 1 to 3, which did not satisfy the essential components of the present invention, and Comparative Examples 4 to 5, in which other components were substituted, did not fully exhibit the effects of the present invention.

As is clear from these results, the skin composition of the present invention solves the problems of both raw material odor and sticky feeling in compositions with a high content of coenzyme Q10, which were difficult to solve in conventional attempts. It turns out that this is something that can be solved.

Claims (3)

Contains the following component A, the following component B, and the following component C,
A skin composition characterized in that the content of component A is more than 0.3% by mass and not more than 1.0% by mass.
Component A: Coenzyme Q10
Component B: Unsaturated fatty acid ester oil Component C: Amino acid The skin composition according to claim 1, wherein the component C is at least one selected from the group consisting of alanine, arginine, glycine, cysteine, serine, and ectoine. The skin composition according to claim 1 or 2, further comprising the following component D.
Component D: Polyglycerin fatty acid ester type nonionic surfactant