JP2023092506A - Oil-in-water type emulsion composition and method for producing the same - Google Patents

Abstract

To provide an oil-in-water type emulsion composition which comprises a sulfated polysaccharide, a carboxy vinyl polymer and a glycyrrhizic acid salt, can obtain a stable system and further has an excellent feeling of use and improves a skin moisture transpiration suppressing effect when applied to the skin.SOLUTION: There is provided an oil-in-water type emulsion composition which is excellent in stability and a feeling of use and improves a skin moisture transpiration suppressing effect and is a preparation containing a sulfated polysaccharide or a glycyrrhizic acid salt in which the viscosity is adjusted by combination of a carboxy vinyl polymer and a xanthan gum and a specific organic compound having skin affinity is blended as a feeling-improving agent.SELECTED DRAWING: None

Description

The present invention improves the stability of formulations of oil-in-water emulsified compositions containing a water-soluble polymer and glycyrrhizinate, improves the feeling of use thereof, and improves skin sensitivity when the emulsified composition is applied to the skin. The present invention relates to improving the effect of suppressing water evaporation.

Water-soluble polymers such as polysaccharides and carboxyvinyl polymers are well known as ingredients to be blended in external preparations for skin such as cosmetics. This is blended for the purpose of increasing the viscosity of the composition to ensure the stability of the formulation and expecting moisturizing power when applied to the skin. In addition, depending on the type of water-soluble polymer, the viscosity, moisturizing power, feeling of use when applied to the skin, etc. differ, and are appropriately selected at the time of development of the skin preparation for external use, and the one that meets the purpose is blended.

Carboxyvinyl polymers are widely used in external preparations for skin for the purpose of increasing the viscosity of the system and improving the stability of the emulsified composition. It is already known that the thickening action of carboxyvinyl polymer makes it easier to obtain safer and more stable formulations by reducing the amount of surfactants that sometimes cause irritation. It is known. Xanthan gum is also known to have a similar effect, and is often used in place of carboxyvinyl polymer in the presence of components such as powders that tend to agglomerate with carboxyvinyl polymer. Furthermore, sulfated polysaccharides represented by heparin-like substances have extremely useful actions such as excellent moisturizing action and blood flow increasing action, and are used for such purposes in external preparations for the skin such as cosmetics. It is also a known fact that

On the other hand, the biggest problem with the use of carboxyvinyl polymer is that when it is included in an external preparation for skin together with a sulfated polysaccharide, it tends to give a slimy feel. It is known that this can be alleviated by adding xanthan gum at the same time (Patent Document 1).

In addition, glycyrrhizinate is a component widely used in external skin preparations such as cosmetics and quasi-drugs. Since it is in the form of a salt, it is known that when used in combination with a carboxyvinyl polymer, the formulation causes a decrease in viscosity over time.

However, it is possible to improve the stability of the skin external preparation containing these water-soluble polymers and glycyrrhizinate, especially the oil-in-water emulsified composition, further improve the feeling of use, and evaporate skin moisture when applied to the skin. It has been desired to improve the inhibitory effect.

JP-A-2000-302664

The present invention contains a sulfated polysaccharide, a carboxyvinyl polymer, and a glycyrrhizinate salt, provides a stable system, is excellent in use, and improves the effect of suppressing skin moisture loss when applied to the skin. An object of the present invention is to provide a type emulsion composition.

As a result of intensive studies, the present inventors have found that an organic compound containing sulfated polysaccharide and glycyrrhizinate, combined with carboxyvinyl polymer and xanthan gum to adjust the viscosity, and having specific skin affinity is blended as a touch modifier. By doing so, the inventors have found that it is possible to provide an oil-in-water emulsion composition that is excellent in stability and feeling of use and improves the effect of suppressing skin moisture loss when applied to the skin, and completed the present invention.

The oil-in-water emulsion composition of the present invention is characterized by containing the following components.
(A) one or more selected from sulfated polysaccharides
0.01 to 0.5% by mass
(B) one or more selected from glycyrrhizic acid or salts thereof
0.01 to 0.5% by mass
(C) carboxyvinyl polymer 0.05 to 0.7 mass%
(D) xanthan gum 0.1 to 1.0% by mass
(E) one or more selected from ceramide and derivatives thereof
0.1 to 1.0% by mass
(F) Hydrogenated phospholipid 0.001 to 0.3% by mass
(G) 0.1 to 2.5% by mass of hydrocarbon oil that is liquid at 25°C
(H) water

The component (A) is characterized by containing one or more selected from sodium chondroitin sulfate, a heparin analogue, and fucoidan derived from brown algae.

The component (E) is characterized by containing one or more selected from ceramide NS, ceramide NP, ceramide AP and equine sphingolipid.

The phosphatidylcholine content of component (F) is 30 to 95% by mass.

The average emulsified particle size of the oil-in-water emulsified composition is 800 nm or less.

Further, as a method for producing the oil-in-water emulsion composition of the present invention, emulsify the system containing the component (E) ~ component (G) and polyhydric alcohol, this is component (A) ~ component (D) and It is characterized by being dispersed in a system containing component (H).

Since the oil-in-water emulsion composition of the present invention contains the above components (A) to (H), it improves the effect of suppressing moisture loss from the skin, has an excellent feeling of use with less stickiness, and has excellent emulsion stability. ing.

Water transpiration inhibition rate. It is the test result of the water|moisture-content transpiration suppression effect as described in an Example.

The present invention will be described in detail below. In this specification, "-" shall mean a range including numerical values before and after it.

<1> Component (A): Sulfated Polysaccharides Sulfated polysaccharides include, for example, D-glucosamine, D-galactosamine, D-glucosamine, D-galactosamine, D -Glucuronic acid, L-iduronic acid, D-galacturonic acid, D-glucose, D-galactose, D-xylose, etc. Sulfated polysaccharide composed of one or more of these repeating be. The sulfated polysaccharides used in the present invention also include polysulfated polysaccharides obtained by further sulfating polysaccharides that already have sulfate groups in nature.

Examples of specific sulfated polysaccharides include heparin, heparin-like substances, heparan sulfate, chitin sulfate, chitosan sulfate, ketalan sulfate, dermatan sulfate, pectin sulfate, galactan sulfate, polyglucose sulfate, chondroitin sulfate, sulfated trehalose, Examples include fucoidan and polysulfates obtained by further sulfating these. These components may be used singly or in combination of two or more.

Further, in the present invention, it can be used as a salt of the above-described sulfated polysaccharides and polysulfates obtained by further sulfation. Salts that can be used include, for example, alkali metal salts such as sodium salts and potassium salts; alkaline earth metal salts such as calcium salts and magnesium salts;

Fucoidan used in the present invention includes, for example, fucoidan derived from brown algae. The brown algae include, for example, seaweeds belonging to the order Laminariales, Laminariales, Fucusaceae, etc. Specifically, Gagome kelp, Maconbu, Tororokonbu, Wakame, Kurome, Arame, Ecklonia, Giant kelp, Lessonia nigrescens , Mozuku, Okinawa Mozuku, Fucus, Ascophyllum nodosum and the like, and among them, Wakame and Fucus are preferable because a sufficient amount of raw materials can be secured.

When fucoidan is extracted from brown algae, the method of extracting fucoidan from brown algae is not particularly limited. An extraction method, a method known per se, such as a hot water extraction method in which algal bodies are suspended in water and extracted at about 100°C may be used. After extraction, solid-liquid separation is performed, and in the case of an acid extraction method, the resulting extract may be neutralized, and an aqueous solution of calcium chloride, barium acetate, or the like may be added to the extract to remove precipitated alginic acid. Furthermore, if desired, ultrafiltration, dialysis, etc. may be performed to remove low molecular weight substances.

Specifically, sodium chondroitin sulfate: Sodium chondroitin sulfate (Maruha Nichiro Co., Ltd.), Japanese Standards for Heparin-like substances: those that conform to Japanese Pharmacopoeia Pharmaceutical Standards, Fucoidan derived from brown algae: Fucoidan derived from Fucus vesiculosus (Sigma) Aldrich Co.) and other commercial products can be used.

The amount of the sulfated polysaccharide compounded is not particularly limited, but in the oil-in-water emulsion composition of the present invention, it is preferably 0.01 to 0.5% by mass, and 0.05 to 0.2% by mass, based on the total amount of the formulation. % by mass is more preferred.

<2> Ingredient (B): Glycyrrhizic acid or its salt Glycyrrhizic acid is a component contained in a crude drug called licorice, and has excellent anti-inflammatory properties. It is used in medicine and oral antiseptic lozenges. In addition, it is a component widely used in rhinitis drugs and gastrointestinal drugs for the purpose of soothing inflammation of the nasal mucosa and gastric mucosa, and eye drops for the purpose of soothing eye inflammation.

In the present invention, a salt of glycyrrhizic acid can be added to the formulation. Examples of salts that can be used include alkali metal salts such as sodium salts and potassium salts; alkaline earth metal salts such as calcium salts and magnesium salts; and other ammonium salts.

Dipotassium glycyrrhizinate, which is one of glycyrrhizinates, can be obtained by reacting glycyrrhizic acid with potassium hydroxide (KOH) or the like. Approved as an active ingredient in medicinal cosmetics to prevent rough skin. Commercially available products listed in the Standards for Quasi-Drug Ingredients can be used.

The amount of glycyrrhizic acid or a salt thereof is not particularly limited, but in the oil-in-water emulsion composition of the present invention, it is preferably 0.01 to 0.5% by mass, and 0.05 to 0.05% by mass, based on the total amount of the formulation. 2% by mass is more preferred.

<3> Component (C): Carboxyvinyl polymer Carboxyvinyl polymer is a water-soluble vinyl polymer having a carboxyl group, which structurally contains acrylic acid as a main chain and cross-linking agents such as allyl sucrose and pentaerythritol. is
Specifically, Carbopol 940, Carbopol 941, Carbopol 980, Carbopol 981 (Lubrizol Advanced Materials), Syntaren L (3V SIGMA), AQPEC HV-501E (Sumitomo Seika), Hibis Wako Commercially available products such as Hibisu Wako 103, Hibisu Wako 104, Hibisu Wako 105 (Fuji Film Wako Pure Chemical Industries, Ltd.) can be used.

The amount of the carboxyvinyl polymer is not particularly limited, but in the oil-in-water emulsion composition of the present invention, the free form containing no salt portion is 0.05 to 0.7% by mass based on the total amount of the formulation. is preferred, and 0.1 to 0.5% by mass is more preferred. This is because if the amount is too small, the stability may be impaired, and if the amount is too large, the usability may be impaired due to excessive hardness, or the feeling of use may be impaired because the feeling of sliminess cannot be suppressed. In addition, it is preferable to increase the viscosity using a pH adjuster during the manufacturing process.

<4> Component (D): Xanthan Gum Xanthan gum is one of polysaccharides and is produced by fermenting starch such as corn with bacteria (Xanthomonas campestris). The molecular weight is about 2 million or 13 million to 50 million. It consists of repeating units of 2 molecules of glucose, 2 molecules of mannose, and glucuronic acid. Xanthan gum also includes potassium, sodium and calcium salts. Since it becomes viscous when mixed with water, it is used in a wide range of applications as a thickening agent and thickening stabilizer.
Specifically, commercially available products such as Keltrol T (CP Kelco) and Nomcoat Z (Nisshin OilliO Group) can be used.

The amount of xanthan gum is not particularly limited. more preferred. This is because if the amount is too small, the effect of suppressing or stabilizing the feeling of sliminess may not be obtained, and if the amount is too large, the feeling of use may be impaired. In addition, in the oil-in-water emulsion composition of the present invention, xanthan gum is preferably contained in a range in which the ratio of carboxyvinyl polymer to xanthan gum is 1:10 to 10:1. This is because of the balance between stability and usability.

<5> Component (E): Ceramide and its derivatives Ceramide and its derivatives include sphingophospholipids such as sphingomyelin, ceramide phosphoethanolamine, ceramide phosphoglycerol, ceramide phosphoglycerol phosphate, and ceramide phosphoinositol; glycosylceramide, galactosyl glycosphingolipids such as ceramide sulfate, lactosylsulfatide, and ganglioside;

Ceramide and its derivatives are used in plants such as rice bran, bran, millet, millet, soybeans, and corn; the skin, brain, nerve tissue, etc. of animals such as pigs, cattle, horses, and sheep; It may be obtained by any method, such as those obtained by extraction and purification from, etc., by conventional methods, or those obtained by synthesis.

The ceramide and its derivatives of the present invention can be exemplified by cosmetic labels such as ceramide EOP, ceramide NS, ceramide NG, ceramide NP, ceramide AS, ceramide AP, ceramide EOS and cerebroside.
Specific commercial products include Ceramide TIC-001 (Ceramide NG (formerly known as Ceramide 2), Takasago International Corporation), Ceramide III (Ceramide NP (formerly known as Ceramide 3), Evonik), Ceramide VI (Ceramide AP (formerly known as Ceramide 6II) ), Evonik), Bioceramide CH (cerebroside (horse phingolipid), Industrias Associadas), and the like can be used.

The amount of ceramide and its derivatives is not particularly limited. % by mass is more preferred.

<6> Component (F): Hydrogenated Phospholipid Phospholipids include phosphatidylcholine (lecithin), phosphatidylglycerol, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidic acid, and lyso forms thereof, which are naturally occurring. phosphatidylcholine (lecithin) is preferably used. In the present invention, hydrogenated phospholipids are used.
A hydrogenated phospholipid having a phosphatidylcholine (PC) content of 30 to 95% by mass, preferably 50 to 80% by mass, is used.
Specifically, commercially available products such as NIKKOL Resinol S-10M (Nikko Chemicals), Basis LS-60HR (Nisshin OilliO Group), SLP-PC70HS (Tsuji Oil Co.) can be used.

The amount of the hydrogenated phospholipid is not particularly limited, but in the oil-in-water emulsion composition of the present invention, it is preferably 0.001 to 0.3% by mass relative to the total amount of the formulation, and 0.01 to 0.1 % by mass is more preferred.

<7> Component (G): Hydrocarbon oil that is liquid at 25°C The hydrocarbon oil that is liquid at 25°C is not particularly limited as long as it is commonly used in cosmetics. Examples of the number of carbon atoms include those in the range of 24 to 60, and may be saturated, unsaturated, linear or branched.
Specifically, squalane, polybutene, hydrogenated polyisobutene, α-olefin oligomer, liquid paraffin, and the like can be exemplified. , Purified Polybutene HV-100F (SB) (Nippon Natural Products Co., Ltd.), Nisseki Polybutene HV-35/HV-100/300F/1900F (JX Nikko Nisseki Energy Co., Ltd.), Nomcoat HP30/HP100 (Nisshin Oilio Group, Inc.) and the like can be used.

The amount of hydrocarbon oil that is liquid at 25 ° C. is not particularly limited, but in the oil-in-water emulsion composition of the present invention, it is preferably 0.1 to 2.5% by mass relative to the total amount of the formulation, and 0.5 ~2.5% by mass is more preferred.

<8> Component (H): Water This embodiment is an oil-in-water emulsion composition containing water. Water is used as a dispersion medium, and its type is not particularly limited. Examples thereof include purified water, distilled water, ion-exchanged water, tap water, hot spring water, and deep sea water.

Other raw materials to be blended in the formulation may be selected arbitrarily, but when preparing an emulsified composition from components (E), (F), and (G), it is useful to coexist with a polyhydric alcohol, Glycerin is particularly effective.
Of course, polyhydric alcohols other than glycerin can also be blended.
Examples include ethylene glycol, diethylene glycol, triethylene glycol, higher polyethylene glycols, propylene glycol, dipropylene glycol, higher polypropylene glycols, butylenes such as 1,3-butylene glycol and 1,4-butylene glycol. Glycols, diols such as 1,2-pentanediol, 1,3-propanediol and 1,2-hexanediol, diglycerin, higher polyglycerols, sugar alcohols such as sorbitol, mannitol, xylitol and maltitol , ethylene oxide (hereinafter abbreviated as EO) and propylene oxide (hereinafter abbreviated as PO) adducts of glycerins, EO and PO adducts of sugar alcohols, monosaccharides such as galactose, glucose and fructose and their EO and PO Polysaccharides such as adducts, trehalose, maltose and lactose (excluding glycosaminoglycans) and polyhydric alcohols such as their EO and PO adducts.

Along with the raw materials described above, oils, surfactants, water-soluble components, drugs, etc., which are usually used in cosmetics and external medicines, are blended as necessary.
Examples of raw materials to be blended include natural animal and vegetable oils such as olive oil, mink oil, castor oil, palm oil, beef tallow, evening primrose oil, coconut oil, castor oil, cocoa oil, macadamia nut oil; waxes such as jojoba oil, beeswax, Lanolin, carnauba wax, candelilla wax, etc.; higher alcohols such as lauryl alcohol, stearyl alcohol, cetyl alcohol, oleyl alcohol; higher fatty acids such as lauric acid, palmitic acid, stearic acid, oleic acid, behenic acid, lanolin fatty acid, etc.; Ester oils such as butyl stearate, hexyl laurate, diisopropyl adipate, diisopropyl sebacate, octyldodecyl myristate, isopropyl myristate, isopropyl palmitate isopropyl myristate, cetyl isooctanoate, neopentyl glycol dicaprate, cyclohexanedicarboxylic acid. Bisethoxydiglycol, etc.; oil-soluble active ingredients such as vitamin E, carrot oil; surfactants anionic surfactants (alkyl carboxylates, alkyl sulfonates, alkyl sulfates, alkyl phosphates), cationic interfaces Active agents (alkylamine salts, alkyl quaternary ammonium salts), amphoteric surfactants: carboxylic acid type amphoteric surfactants (amino type, betaine type), sulfate type amphoteric surfactants, sulfonic acid type amphoteric surfactants, nonionic surfactants (ether nonionic surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants), Other surfactants (derivatives of protein hydrolysates, polymer surfactants, surfactants containing titanium and silicon, fluorocarbon surfactants); drugs such as plant extracts, conchiolin hydrolysates, vitamins C, allantoin, elastin, arbutin, collagen, triclosan, trichlorocarban, methylparaben, butylparaben; powders such as talc, sericite, mica, kaolin, silica, calcium carbonate, methylsiloxane network polymer, acrylic resin spheres, nylon fibers , zinc oxide, iron oxide, zirconium oxide, ultramarine, and Prussian blue.

The oil-in-water emulsion composition of the present invention is characterized by containing ceramide and its derivatives, hydrogenated phospholipid, and hydrocarbon oil that is liquid at 25°C. As the oil-in-water emulsion composition of the present invention, ceramide and its derivatives are dissolved in a hydrocarbon oil that is liquid at 25°C, and this is made into an emulsion with hydrogenated phospholipids in the presence of a polyhydric alcohol. is preferably in an emulsified form in which is dispersed in other pharmaceutical ingredients.
Specifically, a mixture of ceramide and its derivatives, hydrogenated soybean phospholipid, and polyhydric alcohol was heated to 70 to 85°C to form a homogeneous solution, which was heated to 70 to 85°C. It is mixed and stirred with a liquid hydrocarbon oil at ℃ to form an emulsion, and then subjected to a high mechanical force treatment such as a microfluidizer, extruder, disper, high pressure homomixer, etc., to make finer emulsified particles. preferable. Refinement of emulsified particles is also effective for stabilizing the emulsion, and when using a microfluidizer, it is preferable to pass through the microfluidizer 1 to 3 times. Immediately after preparation of the composition, the average particle size of the emulsified particles is preferably 800 nm or less, more preferably 300 nm or less. By setting the emulsified particles to such a size, an excellent stabilizing effect of the formulation system can be obtained. The obtained emulsion can be used as a production intermediate and dispersed in other formulation components to form the oil-in-water emulsion composition of the present invention. Such a method is preferred. The production intermediate emulsion is preferably 5.0 to 20.0% by mass, more preferably 8.0 to 15.0% by mass, based on the entire oil-in-water emulsion composition of the present invention.

In the present invention, the "average particle size of emulsified particles" means a 50% size (cumulative median size, median size) determined by a laser diffraction/scattering method based on Mie scattering theory. Specifically, the particle size distribution of the emulsified particles is prepared on a volume basis using a laser diffraction particle size distribution analyzer, and the median value thereof is taken as the average particle diameter. As a measurement sample, a dispersion of the emulsified composition in water can be used. As the laser diffraction particle size distribution analyzer, for example, a laser diffraction particle size distribution analyzer “SALD2000” manufactured by Shimadzu Corporation can be used.

The present invention will be described in more detail below with specific test examples, but the present invention is not limited to these.

According to the formulation shown in Table 1 below, an oil-in-water emulsion composition was prepared as follows. The unit of numerical values in the table is % by mass unless otherwise specified.

The preparation method is as follows.
After mixing the component B, the mixture was heated to 80° C., stirred and emulsified, and treated once with a microfluidizer at 124 MPa to obtain fine emulsified particles, which were used as a production intermediate.
The C component excluding the A component and the pH adjuster was dissolved and stirred, and the pH adjuster was added thereto. After mixing, the mixture was heated to 75° C., the production intermediate was added and dispersed while stirring, and this was cooled to obtain an oil-in-water emulsion composition.
However, in Example 10, the production intermediate was emulsified only by stirring, and was not treated with a microfluidizer.
In Comparative Example 1, only mixing and stirring of all components was performed.

The notes in the table are as follows.
Note 1) Product name Hibis Wako 105 (Fujifilm Wako Pure Chemical Industries, Ltd.)
Note 2) Product name Keltrol T (CP Kelco)
Note 3) Product name: Ceramide VI (Evonik)
Note 4) Product name: Ceramide TIC-001 (Takasago International Corporation)
Note 5) Product name Bioceramide CH (Industrias Associadas)
Note 6) Product name: NIKKOL Resinol S-10M (Nikko Chemicals)
Note 7) Product name: NOMUCORT HP30VE (Nisshin OilliO Group)

The "average emulsion particle size" in Table 1 was measured by dispersing the emulsion composition in water using a laser diffraction particle size distribution analyzer "SALD2000" manufactured by Shimadzu Corporation.

"Formulation stability" in Table 1 was determined as follows.
The formulation was filled into a transparent glass bottle and stored under conditions of 40°C and 75% RH for 6 months. The emulsified state of this was confirmed visually.
◯: No state change such as separation or aggregation was observed.
Δ: State changes such as separation and aggregation are slightly observed.
x: State changes such as separation and aggregation are clearly observed.

"Usability" in Table 1 was determined as follows.
10 in-house specialist panelists used each test product and answered whether or not they felt a slimy feel during use.
Number of people who feel a slimy feeling Evaluation
0 to 1 ◎
2 to 4 ○
5～ △

The "moisture transpiration inhibition rate" in Fig. 1 was tested according to the following procedure (n = 3).
1. A saturated magnesium chloride solution was placed in a desiccator in advance and allowed to stand until the humidity became 33% or less.
2. 15 mL of purified water was placed in a 30 mL vial, and a silicon packing having a hole with an inner diameter of 10 mm was put on the mouth of the vial.
3. 25 mg of the test product was uniformly applied to a 16 mm diameter membrane filter (ADVANTEC: CELLULOSE ACETATE, 3.0 μm pore size). A blank was used when the test product was not applied.
4. The membrane filter was covered on silicon packing and fixed with a hole cap with an inner diameter of 12 mm.
5. The vial was weighed precisely and placed in a desiccator.
After 6.48 hours, the vials were accurately weighed.

In addition, the moisture transpiration suppression rate was calculated from the following formula.
Moisture transpiration suppression rate (%) = (B - A) / B x 100
(A: water loss after 48 hours of test product, B: water loss after 48 hours of blank)
As shown in Table 2, Examples 1 to 10 had a higher moisture transpiration suppressing effect than Comparative Example 1.

All of Examples 1 to 5 were able to provide an oil-in-water emulsified composition having excellent formulation stability, less slimy feeling, excellent feeling of use, and excellent water transpiration suppression effect. In addition, all of Examples 6 to 10 are stable preparations, have a less slimy feel during use, and can provide an oil-in-water emulsified composition having an effect of suppressing water evaporation.

Claims (6)

An oil-in-water emulsion composition characterized by containing the following components.
(A) 1 or 2 or more selected from sulfated polysaccharides 0.01 to 0.5% by mass
(B) one or more selected from glycyrrhizic acid or salts thereof
0.01 to 0.5% by mass
(C) carboxyvinyl polymer 0.05 to 0.7 mass%
(D) xanthan gum 0.1 to 1.0% by mass
(E) ceramide and its derivatives 0.1 to 1.0 mass%
(F) Hydrogenated phospholipid 0.001 to 0.3% by mass
(G) 0.1 to 2.5% by mass of hydrocarbon oil that is liquid at 25°C
(H) water 2. The oil-in-water emulsion composition according to claim 1, wherein the component (A) contains one or more selected from sodium chondroitin sulfate, heparin analogues, and fucoidan derived from brown algae. . 3. The oil-in-water emulsion composition according to claim 2, wherein the component (E) contains one or more selected from ceramide NS, ceramide NP, ceramide AP, and equine sphingolipids. The oil-in-water emulsion composition according to claim 3, wherein the phosphatidylcholine content of component (F) is 30 to 95 mass%. 5. The oil-in-water emulsion composition according to claim 1, wherein the average emulsion particle size is 800 nm or less. It is characterized by emulsifying the system containing the components (E) to (G) and the polyhydric alcohol and dispersing this in the system containing the components (A) to (D) and the component (H). , The method for producing an oil-in-water emulsion composition according to claim 5.

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