JP2023087101A - Internal composition, and method for improving aftertaste of sweetness and method of inhibiting discoloration - Google Patents

Abstract

To provide a sweet, internal composition with an improved aftertaste of sweetness of a sweetener.SOLUTION: An internal composition contains crocetin and sweetener.SELECTED DRAWING: None

Description

TECHNICAL FIELD The present invention relates to an oral composition with improved sweetness quality, a method for improving aftertaste of sweetness, and a method for inhibiting discoloration.

With the recent trend toward health and low-calorie consumption, so-called “high-intensity sweeteners” have come to be used in place of sucrose, which causes obesity and tooth decay, in sweetened oral compositions. Many of the high-intensity sweeteners have a stronger sweetness than sucrose, and can impart sufficient sweetness with a small amount of use. can.

These high-intensity sweeteners generally have a strong aftertaste of sweetness and off-flavours, so there is a problem that they cannot provide delicious sweetness like sucrose. In order to solve this problem, for example, Patent Document 1 proposes a sweetening composition in which L-arabinose is blended with a non-sugar sweetener or sugar alcohol. According to this sweetening composition, it is said that the peculiar sweetness and aftertaste of the high-intensity sweetener are improved, and a more delicious sweetener can be provided.

However, this product uses L-arabinose, which is originally a sweetener, to adjust the balance of the sweetening characteristics of high-intensity sweeteners (strength of sweetness and length of time in which sweetness is felt), resulting in its unique characteristics. It is considered to improve the aftertaste of sweetness and off-flavours, and there is a problem that the blending ratio must be changed for each type of high-intensity sweetener, which is complicated.
In addition, there is no mention of improvement of off-flavours by ingredients other than sweeteners. Therefore, there is a demand for a method that can more simply improve the characteristic sweetness and unpleasant aftertaste of high-intensity sweeteners.

On the other hand, along with the recent trend toward health, oral compositions expected to have various effects such as improving physical condition have been provided. In particular, there are no legal regulations for oral compositions that contain nutrients such as vitamins and useful ingredients such as lactic acid bacteria and are expected to have functions and effects derived from these useful ingredients. Therefore, it is commonly sold on the market and has become familiar to people.

Crocetin is one of the useful ingredients that can be expected to have the above-mentioned various effects. Crocetin is
Rubiaceae Gardenia (Gardenia augusta MERRIL var. gr
andiflora HORT. , Gardenia jasminoides ELL
IS) fruit, dried stigma of saffron, etc.
prevention and recovery from asthenopia), etc. (see, for example, Patent Document 2). However, crocetin is usually tasteless. Therefore, when incorporated into an oral composition having a sweetness that is health-conscious and low-calorie, that is, an oral composition having a high-intensity sweetener, an oral composition that can be expected to exhibit the functions and effects derived from crocetin. However, it is common general technical knowledge that a complicated method is required to improve the characteristic sweetness and unpleasant aftertaste of high-intensity sweeteners. be. Therefore, there is a demand for the development of a delicious oral composition that is suitable for health-conscious people and has the functions and effects derived from crocetin, while improving the unique sweetness and unpleasant aftertaste of high-intensity sweeteners. there is

Japanese Patent Application Laid-Open No. 2004-73197 JP 2007-215465 A

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a composition for internal use having a sweetness in which the aftertaste of the sweetness of a sweetener is improved.

In order to achieve the above objects, the first gist of the present invention is an oral composition containing crocetin and a sweetener. The second gist is a method for improving the above, and the third gist is a method for suppressing discoloration of an oral composition containing crocetin, which uses a sweetener and crocetin in combination.

That is, the present inventors conducted various studies to find out whether it is possible to make an oral composition, which is expected to have various effects such as improving physical condition, more easily ingestible. As a result, it was found that it is useful to add sweetness to the composition for internal use to bring it closer to a so-called luxury product. In particular, when crocetin is used in combination with a sweetener, the sweetness quality of the sweetener is unexpectedly improved,
The inventors have found that it can be made into a delicious composition for internal use, and came up with the present invention.

Since the composition for internal use of the present invention contains crocetin and a sweetener, crocetin improves the quality of sweetness of the sweetener and eliminates the aftertaste of sweetness and off-taste. Since the flavor (richness, richness, etc.) is also improved, the composition for internal use can be made closer to a so-called luxury product, and can be easily ingested.
The oral composition of the present invention includes food and drink (beverages and foods), quasi-drugs and pharmaceuticals.

Next, a mode for carrying out the present invention will be described. However, the present invention is not limited to the following embodiments.

The oral composition of the present invention contains crocetin and a sweetener.
Crocetin is usually obtained by hydrolyzing crocin (a digentiobiose ester of crocetin), which is a carotenoid yellow pigment. The above crocin is a gardenia of the family Rubiaceae (Gardenia augusta MERRIL var.
ora HORT. , Gardenia jasminoides ELLIS) fruit,
It is contained in dried stigmas of saffron and the like, and gardenia fruit is preferably used as an industrial raw material.

Crocetin used in the present invention may be a commercially available crocetin preparation. Examples of such commercially available products include Crobit P (crocetin content: 75 wt%, manufactured by Riken Vitamin) and Crobit 2.5WD (crocetin content: 2.5 wt%, manufactured by Riken Vitamin).

The content of crocetin in the oral composition of the present invention is not particularly limited. However, from the viewpoint of exhibiting the effect of the present invention, the amount of crocetin is usually 0.001 to 50% by mass, preferably 0.0% by mass, based on the total internal composition, in terms of crocetin with a purity of 100% by mass.
1 to 10% by mass, more preferably 0.05 to 2% by mass. In addition, the daily dose of crocetin is preferably 0.05 to 50 mg, more preferably 0.1 to 10 mg, and still more preferably 0.5 to 5 mg in terms of crocetin having a purity of 100% by mass. is. That is, if the amount of crocetin is too low, there is a tendency that the crocetin-derived medicinal ingredients cannot be sufficiently blended, and the effects of the present invention may not be exhibited sufficiently.
On the other hand, if the amount of crocetin is too high, the above medicinal ingredients will be excessively blended.

Next, the sweetener used in the present invention means all materials that give off a sweet taste, and includes not only those used as "sweeteners" in ingredient labeling, but also all those that give a sweet taste. Sweeteners used as sweeteners can be roughly divided into two types: sugar sweeteners and non-sugar sweeteners, both of which are included in the sweetener of the present invention.

The sugar-based sweeteners can be broadly classified into sugar, sugar derived from starch, other sugars, and sugar alcohols. Examples of starch-derived sugars include glucose, maltose, fructose, starch syrup, isomerized sugar, and isomaltooligosaccharide. Examples of the other sugars include fructooligosaccharides, galactooligosaccharides, xylooligosaccharides, and milk oligosaccharides. Examples of the sugar alcohol include xylitol, sorbitol, erythritol, maltitol, reduced isomaltulose, mannitol, and reduced starch syrup. Flavor (rich,
Richness, etc.) is highly improved, and moreover, it has properties that are difficult to be utilized by oral bacteria, and it is difficult to cause tooth decay. Sugar alcohols are preferably used as the sweetener of the present invention, and among them, xylitol. , sorbitol, erythritol, maltitol and reduced isomaltulose are preferably used. These can be used alone or in combination of two or more.

The above non-sugar sweeteners can be broadly classified into natural sweeteners and artificial sweeteners. Examples of the natural sweetener include stevia extract, licorice (glycyrrhizin), thaumatin and the like. Examples of artificial sweeteners include aspartame, neotame, sucralose, acesulfame potassium, saccharin, saccharin sodium, and the like. A non-sugar sweetener is preferable as the sweetener of the present invention from the viewpoint that it has a high degree of improvement in the aftertaste of sweetness and unpleasant taste, has a property that is difficult to be utilized by oral bacteria, and is less likely to cause tooth decay. Among them, stevia extract, aspartame, neotame, sucralose and acesulfame potassium are preferably used. These can be used alone or in combination of two or more. In addition, from the viewpoint that it is possible to improve both the flavor (richness, richness, etc.) and the aftertaste of sweetness and miscellaneous taste, and that it has a property that it is difficult to be used by oral bacteria and that it is difficult to cause tooth decay. A mixture of a sugar alcohol and a non-sugar sweetener is preferably used as the sweetener used in the present invention.

The content of the sweetener in the oral composition of the present invention is not particularly limited. However, from the viewpoint of exhibiting the effect of the present invention, it is usually contained in an amount of 0.001% by mass or more, preferably 0.005 to 95% by mass, and more preferably 0
. 01 to 90% by mass. That is, if the amount of sweetener is too small, there is a tendency that the effect of the present invention cannot be sufficiently exhibited.

Among them, when the sweetener is a sugar alcohol, the content of the sweetener is preferably 1% by mass or more, more preferably 5 to 95% by mass, based on the total composition for internal use.
It is more preferably 10 to 90% by mass.

In addition, when the sweetener is a non-sugar sweetener, the content of the sweetener is preferably 0.001% by mass or more, preferably 0.005 to 5% by mass, based on the total composition for internal use. more preferably 0.01 to 1% by mass.

In the present invention, the mass ratio of crocetin to sweetener (crocetin/sweetener) is 0.
0001 to 10, more preferably 0.0005 to 5, 0
. 001 to 1 is more preferred. This is because the effect of the present invention tends to be difficult to obtain if the amount is too small or too large.

Above all, when the sweetener is a sugar alcohol, the mass ratio of crocetin to the sweetener (
crocetin/sweetener) is preferably 0.0001-1, preferably 0.0005-0.
5 is more preferable, and 0.001 to 0.1 is even more preferable.

When the sweetener is a non-sugar sweetener, the mass ratio of crocetin to the sweetener (crocetin/sweetener) is preferably 0.001 to 10, more preferably 0.005 to 5. is more preferable, and 0.01 to 1 is even more preferable. Among them, when the sweetener is a natural sweetener, the mass ratio of crocetin to the sweetener (crocetin/sweetener) is 0.
. 001 to 1, more preferably 0.005 to 0.5, 0
. It is more preferably 01 to 0.1. As for the artificial sweetener, the mass ratio of crocetin to the sweetener (crocetin/sweetener) is preferably 0.001 to 10, more preferably 0.005 to 5, and more preferably 0.01 to 1 is more preferred.

Since the oral composition of the present invention contains crocetin, it improves asthenopia (prevention of asthenopia,
recovery), etc.

The oral composition of the present invention can contain other ingredients than crocetin and sweeteners. The oral composition of the present invention is further excellent in visual function improving effect [prevention or improvement of asthenopia, myopia, eye diseases (cataract, age-related macular degeneration, glaucoma, etc.)] and the like. , astaxanthin, bilberry extract, blueberry extract, black soybean polyphenol, DHA (docosahexaenoic acid), EPA (eicosapentaenoic acid), rafuma extract and honeysuckle extract. Among them, those containing at least one of lutein and bilberry extract are more preferable. These can be used alone or in combination of two or more.

The content of other components other than the above crocetin and sweetener is not particularly limited, but from the viewpoint that there is little possibility of inhibiting the effects of the present invention, the content is, relative to the entire oral composition, It is usually 0.0005 to 5% by mass, preferably 0.001 to 2% by mass, more preferably 0.005 to 1% by mass.

In addition, the composition for internal use of the present invention preferably contains fruit juice from the viewpoint of being more delicious. Above all, blueberries, grapes, apples, oranges, mandarin oranges, lemons,
Those containing juice derived from at least one selected from the group consisting of grapefruit, pineapple, peach, strawberry and raspberry are more preferred, and those containing juice derived from at least one of blueberries and grapes are even more preferred. . These can be used alone or in combination of two or more.

The content of the fruit juice is not particularly limited, but from the viewpoint that the effect of the present invention is unlikely to be impaired, the content is usually 1 to 99% by mass relative to the entire oral composition. , preferably 5 to 95% by mass, more preferably 10 to 90% by mass.
In the case of powdered fruit juice, it is usually 0.1 to 50% by mass, and 0.5 to 2
It is preferably 0% by mass, more preferably 1 to 10% by mass.

Furthermore, from the viewpoint of suppressing the discoloration of crocetin, the composition for internal use of the present invention preferably contains at least one of a fluidizing agent and a lubricant. Among them, calcium stearate,
At least one selected from the group consisting of magnesium stearate, hydrated silicon dioxide, light anhydrous silicic acid, heavy anhydrous silicic acid, aluminum silicate, talc, magnesium aluminometasilicate, glycerin fatty acid ester and sucrose fatty acid ester Those containing are more preferable, and calcium stearate and magnesium stearate are particularly preferable. These can be used alone or in combination of two or more.

In addition, the composition for internal use of the present invention may contain general pharmaceutical additives such as stabilizers, stabilizers, surfactants, solubilizers, buffers, bases, and adsorbents. , flavoring agents, binders, suspending agents, hardening agents, antioxidants, brightening agents, fragrances, coating agents, shells, wetting agents, wetting agents, fillers, antifoaming agents, cooling agents ) agent, chewing agent, anti-static agent, flavoring agent / fragrance, coloring agent,
Sugar coating agent, tonicity agent, softening agent, emulsifier, adhesive, adhesion enhancer, thickening agent, foaming agent, pH
Regulators, pH adjusters, excipients, dispersants, disintegrants, disintegration aids, fragrances, moisture-proof agents, preservatives,
A preservative, a solubilizer, a solubilizer, and a solvent can be contained as necessary. These can be used alone or in combination of two or more.

Specific examples of such formulation additives include corn starch, potato starch, wheat starch, sodium hydrogen carbonate, sodium chloride, crystalline cellulose, methyl cellulose, ethyl cellulose, hypromellose, hydroxypropyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, carboxymethyl cellulose. Calcium, carmellose calcium, hypromellose phthalate, cellulose acetate phthalate, pregelatinized starch, gum arabic, gelatin, sodium alginate, polyvinylpyrrolidone, polyvinyl alcohol, casein, sodium caseinate, carboxyvinyl polymer, hydrogenated vegetable oil, macrogol , silicone oil, agar, sodium bicarbonate, sodium alginate, shellac, glycerin, aromatic essential oils, water-soluble food coloring, yellow iron oxide, yellow iron sesquioxide, iron sesquioxide, brown iron oxide, black iron oxide, lake pigment ,
Benzoic acid, sodium benzoate, paraoxybenzoic acid, polysorbate 80, glycerin fatty acid ester, bleached beeswax, medium-chain fatty acid triglyceride, ascorbic acid, tocopherol, sodium thiosulfate, sodium edetate, citrus flavors such as orange and lemon, and grapes Fragrance, blueberry flavor, apple flavor, pineapple flavor, peach flavor, strawberry flavor, coffee flavor, chocolate flavor, yogurt flavor, milk flavor, lemon oil, peppermint oil, spearmint oil, spice oil, etc. and the like. These can be used alone or in combination of two or more. note that,
Pharmaceutical additives that can be used in the oral composition of the present invention are not limited to those listed above, and are not particularly limited as long as they are pharmaceutically applicable.

Then, the composition for internal use of the present invention can be obtained by mixing crocetin, a sweetener and, if necessary, other ingredients by a conventional method. That is, first, crocetin and a sweetener may be mixed and then other ingredients may be mixed with this mixture, or all ingredients including crocetin and a sweetener may be mixed at once.

It is generally used to make the oral composition of the present invention into tablets, granules, fine granules, powders, pills, dry syrups, etc., that is, when it is necessary to adjust the shape of the oral composition. Granulation methods such as spray granulation, stirring granulation, fluidized granulation, tumbling granulation, wet granulation such as tumbling fluidized granulation, and dry granulation such as compaction granulation can be used. In addition, the oral composition formed into tablets, granules, etc. can be divided into small portions and filled into individual packages. Tablets can be produced by mixing oral compositions, powders, fine granules, granules, pills, etc. with formulation additives, followed by compression molding. Coated formulations such as sugar-coated tablets, film-coated tablets and coated granules can be produced by conventional methods such as pan coating, fluidized coating, rolling coating, and combinations thereof.

The dosage form of the oral composition of the present invention is not particularly limited, and examples thereof include tablets, uncoated tablets, film-coated tablets, sugar-coated tablets, orally disintegrating tablets, chewable tablets, effervescent tablets,
Matrix tablets, pills, capsules, granules, powders, lozenges, jellies, gummies, gums, liquids, syrups and other food compositions, quasi-drugs or pharmaceuticals can be used. Granules and powders include powdered beverages, and liquid formulations include beverages such as soft drinks, nutritional drinks, fruit juice-containing beverages, tea beverages, coffee beverages, and milk beverages. Also, in addition to the above dosage forms,
It can also be general foods such as cookies, biscuits, snacks and chocolates. Orally disintegrating tablets, chewable tablets, lozenges, jellies, gummies, gums, liquids, and syrups, which have a shape that stays in the mouth for a long time, from the viewpoint of significantly exhibiting the effects of the present invention. Orally disintegrating tablets, chewable tablets, lozenges, jellies,
Gummies and gums are more preferred. That is, the longer the period of stay in the mouth, the more prominent the superiority of the oral composition of the present invention.

Crocetin usually exhibits a very strong yellow color. Therefore, an oral composition containing this usually has a yellow color derived from crocetin, although it depends on the content of crocetin. On the other hand, there is a tendency to observe more carefully the appearance of oral compositions that stay in the mouth for a long time. The internal use composition of the present invention is effective in suppressing yellow discoloration derived from crocetin for a long period of time and reducing changes in appearance. Therefore, the oral composition of the present invention is an orally disintegrating tablet, chewable tablet, troche tablet, jelly, gummy, gum, liquid and syrup, which are in a shape that stays in the mouth for a long time. is even more suitable for

In addition, the method for improving the aftertaste of sweetness of the oral composition containing the sweetener of the present invention is to use the sweetener and crocetin in combination. The quality of sweetness can be improved.

Furthermore, the method for suppressing discoloration of an oral composition containing crocetin of the present invention uses crocetin and a sweetener in combination, thereby suppressing the discoloration of crocetin over time.

Next, examples will be described together with comparative examples. However, the present invention is not limited to this. In addition, unless otherwise specified, the component compositions shown below are all based on mass (
parts by mass).

[Examples 1 to 19, Comparative Examples 1 to 9]
Oral compositions (Examples 1 to 19, Comparative Examples 1 to 9, all in powder form) were prepared according to the compositions shown in Tables 1 to 5 below. That is, each material was prepared and mixed at once to prepare a powdery composition for internal use. As for crocetin, Crobit P (crocetin content: 75 wt %, manufactured by Riken Vitamin Co., Ltd.), which is a crocetin preparation, was used.

The oral composition of each example and each comparative example was evaluated for sweetness and suppression of discoloration.
First, the sweetness was evaluated for Examples 1 to 8 and Comparative Examples 1 to 8, and then Examples 9 to
No. 19 and Comparative Example 9 were evaluated for suppression of discoloration. In addition, evaluation of sweetness and discoloration suppression was performed by the method shown below, respectively.

<Evaluation of sweetness>
Five panelists who had been trained in sensory tests evaluated the quality of sweetness of the compositions for internal use (aftereffects of sweetness and off-flavours). That is, each panelist scooped 1 scoop of the microspatula of the oral composition prepared according to the composition shown in Tables 1 to 3 and put it in the mouth, and the quality of sweetness (
sweetness and aftertaste) was scored based on the following criteria. Then, the sum of the points scored by the 5 panelists was applied to the following indices to evaluate each oral composition.
[Scoring criteria]
2 points (very good): No unpleasant sweetness or unpleasant taste remains.
1 point (good): A very small amount of unpleasant sweetness and miscellaneous taste remain, but they are not bothersome.
-1 point (poor): Unpleasant sweetness and unpleasant taste remain, but can be removed by rinsing the mouth with water.
-2 points (very bad): Unpleasant sweetness and unfavorable taste remain and cannot be removed by rinsing the mouth with water.
[Evaluation index]
◎ (very good): 6 points or more ○ (good): 3 points or more and less than 6 points × (bad): 0 points or more and less than 3 points XX (very bad): less than 0 points

As shown in Table 1, the oral compositions of Comparative Examples 1 to 3 containing only non-sugar sweeteners were
Evaluation of sweetness clearly indicated that unpleasant sweetness and off-taste remained, whereas
The compositions for internal use of Examples 1 to 3 did not leave any unpleasant sweet taste or unpleasant taste, or even if they remained, only a very small amount, which was not a problem. Further, as shown in Table 2, the oral compositions of Comparative Examples 4 and 5 containing only sugar alcohols were shown to leave an unpleasant sweet taste and unpleasant taste, whereas the oral compositions of Examples 4 and 5 The composition was shown to leave no unpleasant sweet or off-taste. Moreover, as shown in Table 3, similar effects were obtained when crystalline cellulose was contained as an excipient. These results show that the sweetness quality of the sweetener can be improved by adding crocetin to an oral composition containing at least one sweetener selected from the group consisting of non-sugar sweeteners, sugar alcohols and mixtures thereof. It is shown that it is possible to improve the pull-out after that.

<Evaluation of discoloration suppression>
About 0.5 g of the internal use composition prepared according to the composition shown in Tables 4 and 5 was placed in a glass bottle and sealed, and the color difference of the internal use composition immediately after preparation and after storage at 40 ° C. for one day (24 hours) was measured. bottom. The color difference was measured using a color difference meter (manufactured by Nippon Denshoku Industries Co., Ltd., product number: GC 5000) and calculated using the following formula 1. The results are also shown in Tables 4 and 5.
Formula 1: Color difference (ΔE*ab) = [(Δa ^* ) ² + (Δb ^* ) ² + (ΔL ^* ) ² ] ^1/2
Δa ^* : a value of the oral composition after storage−a value of the oral composition before storage Δb ^* : b value of the oral composition after storage−b value of the oral composition before storage ΔL ^* : after storage L value of oral composition - L value of oral composition before storage

Examples 9-1 containing both crocetin and sweetener as shown in Tables 4 and 5
In No. 9, the color difference before and after storage was small, and discoloration was effectively suppressed. Moreover, the effect of suppressing discoloration was dose-dependent.
On the other hand, Comparative Example 9, which contained only crocetin and did not contain a sweetener, showed a large color difference before and after storage.

[Formulation example]
Using materials shown in Tables 6 to 10 below, oral compositions of the present invention (formulation examples 1 to 27) were prepared. Formulation Examples 1-9 (see Table 6) are chewable, Formulation Examples 10-15 (Table 7) are tablets, Formulation Examples 16-19 (Table 8) are drinks, Formulation Examples 20- 23
(See Table 9) was in the form of jelly, and Formulation Examples 24 to 27 (see Table 10) were in the form of gummy. As materials for Formulation Examples 1 to 27, the crocetin used in Examples 1 to 19 is used, and the other materials are food ingredients or food additive standards. These oral compositions are excellent in improving visual function such as asthenopia and preventing myopia.

Sweetness was evaluated for Formulation Examples 1 to 27 shown in Tables 6 to 10 in the same manner as in Examples. As a result, all of Formulation Examples 1 to 27 containing crocetin and a sweetener did not leave any unpleasant sweetness or unfavorable taste. In addition, all of these are 1
No discoloration was observed even after the passage of days (24 hours). Therefore, it can be seen that the effect of incorporating crocetin in an oral composition containing a sweetener is ensured even when it is made into a formulation.

INDUSTRIAL APPLICABILITY The present invention can provide a delicious internal composition containing crocetin and a sweetener and suitable for health-conscious people.

Claims (8)

An internal composition comprising crocetin and a sweetener. The composition for internal use according to claim 1, wherein the mass ratio of crocetin to the sweetener is 0.0001-10. 3. The composition for internal use according to claim 1 or 2, wherein said sweetener is at least one selected from the group consisting of non-sugar sweeteners, sugar alcohols and mixtures thereof. 4. The composition for internal use according to claim 3, wherein said non-sugar sweetener is at least one selected from the group consisting of aspartame, neotame, sucralose, acesulfame potassium and stevia extract. 4. The composition for internal use according to claim 3, wherein the sugar alcohol is at least one selected from the group consisting of xylitol, sorbitol, erythritol, maltitol and reduced isomaltulose. 6. Any one of claims 1 to 5, wherein the oral composition is in the form of an orally disintegrating tablet, chewable tablet, granule, powder, troche, jelly, gummy, gum, liquid or syrup. The internal composition according to item 1. A method for improving the aftertaste of sweetness of an oral composition containing a sweetener, characterized by using a sweetener and crocetin in combination. A method for suppressing discoloration of an oral composition containing crocetin, characterized by using a sweetener and crocetin in combination.