JP2023067791A - Composition for oral administration - Google Patents

Abstract

To provide a composition for oral administration in which an unpleasant odor from 4-vinylguaiacol is suppressed.SOLUTION: Provided is a composition for oral administration, comprising a component (A) 4-vinylguaiacol and a component (B) menthol, wherein the mass ratio of the component (B) to the component (A) [(B)/(A)] is 20 to 50,000.SELECTED DRAWING: None

Description

The present invention relates to oral compositions.

Ferulic acid is known to have a high antioxidant effect, and is expected to be an effective component in the treatment and prevention of diseases associated with the onset of oxidative stress, such as cancer, diabetes, and cardiovascular disease. Since ferulic acid exists in the cell walls of plants, it is routinely ingested from foods such as fruits, vegetables, and grains. However, it is known that ferulic acid is converted to 4-vinyl guaiacol by microorganisms or heating, and 4-vinyl guaiacol becomes an off-flavor called "smoke odor" or "chemical odor" of sake, for example. Therefore, it is recognized as a substance whose generation should be prevented.

Since the unpleasant odor of food and drink tends to hinder continuous intake, various techniques for suppressing the unpleasant odor have been studied. For example, by adding 3-menthoxy-1,2-propanediol, N-[(ethoxycarbonyl)methyl]-p-menthane-3-carboxamide or 1,8-cineol, proteins derived from animals and plants, decomposition products thereof, or A method for suppressing unpleasant odors derived from peptides (Patent Document 1), a method for suppressing unpleasant deteriorated odors derived from citral by adding aromatic components such as ethylpyruvate and methyljasmonate (Patent Document 2), A method of adding methyl parmate, nerol, phenethyl alcohol, 1,8-cineole or the like to suppress the unpleasant odor of wort or malt extract (Patent Document 3) has been reported.

WO2019/39490 JP 2019-94507 A JP 2020-178664 A

An object of the present invention is to provide an oral composition in which the unpleasant odor of 4-vinylguaiacol is suppressed.

In view of the above problems, the present inventors have made intensive studies and found that menthol is effective in suppressing the unpleasant odor of 4-vinylguaiacol, and that menthol is contained at a constant ratio with respect to 4-vinylguaiacol. found that the unpleasant odor of 4-vinylguaiacol can be suppressed.

That is, the present invention provides the following [1] to [5].
[1] The following components (A) and (B)
(A) 4-vinylguaiacol, and (B) menthol,
A composition for oral use, wherein the mass ratio of component (A) to component (B) [(B)/(A)] is from 20 to 50,000.
[2] The oral composition according to [1] above, which is a solid oral composition.
[3] The oral composition according to [2], wherein the content of component (B) is 0.01% by mass or more and less than 25% by mass.
[4] The oral composition according to [2] or [3], wherein the content of component (A) is 0.00001% by mass or more.
[5] An unpleasant odor inhibitor of 4-vinylguaiacol containing menthol as an active ingredient.

According to the present invention, it is possible to provide an oral composition in which the unpleasant odor of 4-vinylguaiacol is suppressed.

[Oral composition]
The oral composition of the present invention contains 4-vinylguaiacol as component (A). Component (A) may be a chemically synthesized product (eg, a reagent) or a product derived from a natural product.
Products derived from natural products include, for example, plants, and may be extracts. The plant is not particularly limited as long as it contains the component (A), but examples include coffee beans, rice bran, and barley bran. 1 type or 2 types or more can be used for a plant. The extraction method and extraction conditions for the plant extract are not particularly limited, and known methods can be employed. Moreover, the plant extract may be either a concentrate or a dry product.

When using a product derived from a natural product as the component (A), since coffee beans are rich in ferulic acid and 4-vinylguaiacol is likely to be produced by roasting, it is preferable to contain a roasted coffee bean extract. .
The degree of roasting of the roasted coffee beans is not particularly limited and can be selected as appropriate. For example, when using lightly roasted coffee beans, the L value is preferably 30 or more, more preferably 32 or more, still more preferably 34 or more, and from the viewpoint of flavor, preferably less than 60, more preferably 55 or less, 45 or less is more preferable. When dark roasted coffee beans are used, the L value is preferably 10 or more, more preferably 15 or more, and preferably 25 or less, more preferably 20 or less from the viewpoint of flavor. As used herein, the "L value" is the lightness of roasted coffee beans measured with a color difference meter, with black being L value 0 and white being L value 100. The bean species and production area of the coffee beans are not particularly limited, and can be appropriately selected. One or a mixture of two or more types of coffee beans of different bean species and production areas can also be used.

The oral composition of the present invention contains menthol as component (B). Component (B) has several diastereomers and enantiomers, any of which can be used, but preferably contains L-menthol, and contains 90% or more of L-menthol. is more preferable. Component (B) can contain one or more.

Moreover, the component (B) may be a chemically synthesized product or a product derived from a natural product. As a product derived from natural products, for example, L-menthol isolated from natural essential oils can be used. Examples of essential oils containing L-menthol include peppermint essential oil, Japanese mint essential oil, and essential oils obtained from Mentha genus plants of the Labiatae family. Specifically, apple mint, water mint, Corsican mint, spearmint, mint, pennyroyal, horse mint, Mentha Keruwina and the like can be mentioned. In addition, the synthetic product is prepared by a known method (for example, "Development of asymmetric synthesis technology using BINAP-metal complex catalyst", Hidenori Unbayashi, Takasago Koryo Jiho, No. 127, p. 4-11 (1997)) can be obtained by

The composition for oral use of the present invention has a mass ratio [(B)/(A)] of component (A) to component (B) of 20 to 50,000. From the viewpoint of suppressing unpleasant odors, it is preferably 40 or more, more preferably 55 or more, more preferably 70 or more, still more preferably 90 or more, still more preferably 150 or more, still more preferably 300 or more, still more preferably 400 or more, and 450 or more. is even more preferred. In addition, from the viewpoint of suppressing the bitterness of the component (B), that is, menthol, the mass ratio [(B)/(A)] is preferably 45000 or less, more preferably 20000 or less, further preferably 12000 or less, and 7000 or less. is more preferably 6000 or less, more preferably 5500 or less, even more preferably 5200 or less, even more preferably 1000 or less, and even more preferably 600 or less. The composition for oral use of the present invention preferably has a mass ratio [(B)/(A)] of 40 to 45,000, more preferably 55 to 20,000, still more preferably 70 to 20,000, More preferably 90 to 12000, more preferably 90 to 7000, still more preferably 150 to 6000, still more preferably 300 to 5500, still more preferably 400 to 5200, still more preferably 450 ~600.

As used herein, the term "oral composition" refers to a composition that poses little danger to human health and is exclusively orally ingested in normal social life. It is not limited to categories such as Therefore, the oral composition of the present invention can be used as a general food, health food (functional food and drink), food with health claims (food for specified health use, food with nutrient function claims, food with function claims), pharmaceutical department It means a wide range of foods and drinks that constitute quasi-products, pharmaceuticals, etc. Therefore, the composition for oral use of the present invention may be liquid or solid at room temperature (20° C.±15° C.), and may take any suitable form.
Preferred embodiments of the oral composition of the present invention include, for example, a solid oral composition and a liquid oral composition. Each composition will be described below in line with preferred embodiments.

[Solid oral composition]
The shape of the solid composition for oral use of the present invention is not particularly limited as long as it is solid at room temperature (20°C ± 15°C). Various things are mentioned. The solid content of the solid composition for oral use of the present invention is usually 80% by mass or more, preferably 90% by mass or more, more preferably 93% by mass or more, and still more preferably 95% by mass or more, Even more preferably, it is 97% by mass or more. The upper limit of the solid content is not particularly limited, and may be 100% by mass. As used herein, the term “solid content” refers to the mass of the residue obtained by drying 1 g of a sample in an electric constant temperature dryer at 105° C. for 3 hours and removing volatile substances.

The specific configuration of component (A) contained in the solid composition for oral use of the present invention is as described above. , green coffee beans are preferred, and chemically synthesized products (eg, reagents), roasted coffee bean extracts, and green coffee bean extracts are more preferred.

The content of component (A) in the solid composition for oral use of the present invention is preferably 0.00001% by mass or more, more preferably 0.00005% by mass or more, from the viewpoint that the effects of the present invention are easily received. 0.0001% by mass or more is more preferable, 0.0003% by mass or more is still more preferable, 0.0004% by mass or more is still more preferable, and from the viewpoint of suppressing the unpleasant odor of component (A), 0.02% by mass The following is preferable, 0.015% by mass or less is more preferable, 0.01% by mass or less is still more preferable, and 0.006% by mass or less is even more preferable. The content of component (A) in the solid composition for oral use of the present invention is preferably 0.00001 to 0.02% by mass, more preferably 0.00005 to 0.02% by mass, More preferably 0.0001 to 0.015% by mass, still more preferably 0.0003 to 0.01% by mass, and even more preferably 0.0004 to 0.006% by mass. Here, the "(A) content of 4-vinylguaiacol" in the present specification is measured by an analytical method suitable for the situation of the sample to be measured among commonly known analytical methods, such as the GC/MS method. can be done. Concretely, the method described in the examples below can be mentioned. In addition, when measuring, the sample should be freeze-dried to match the detection range of the instrument, and contaminants in the sample should be removed to match the resolution of the instrument. may be applied.

The specific configuration of the component (B) contained in the solid composition for oral use of the present invention is as described above, but the component (B) preferably contains L-menthol. 90% or more is more preferable.

The content of the component (B) in the solid composition for oral use of the present invention is preferably 0.01% by mass or more, more preferably 0.02% by mass or more, from the viewpoint of suppressing the unpleasant odor of the component (A). 0.04 mass % or more is more preferable, 0.08 mass % or more is still more preferable, 0.2 mass % or more is still more preferable, and 0.3 mass % or more is still more preferable. Also, from the viewpoint of suppressing the bitterness of component (B), it is preferably less than 25% by mass, more preferably 15% by mass or less, even more preferably 7% by mass or less, further preferably 1.5% by mass or less, and 1% by mass. The following are even more preferred. The content of component (B) in the solid composition for oral use of the present invention is preferably 0.01% by mass or more and less than 25% by mass, more preferably 0.02% by mass or more and less than 25% by mass, More preferably 0.04 to 15% by mass, still more preferably 0.08 to 7% by mass, still more preferably 0.2 to 1.5% by mass, still more preferably 0.3 to 1 % by mass. Here, the "(B) content of menthol" as used herein can be measured by an analysis method suitable for the situation of the measurement sample among commonly known analysis methods, for example, a GC/MS method. Concretely, the method described in the examples below can be mentioned. In order to match the detection range of the instrument, the sample should be freeze-dried, or contaminants should be removed from the sample to match the resolution of the instrument. may be applied.

The solid composition for oral use of the present invention has a mass ratio of component (A) to component (B) [(B)/(A)] of 20 to 50,000. is the same as the explanation in .

The solid oral composition of the present invention can contain an acceptable carrier as necessary in order to obtain a solid form. For example, excipients (e.g., waxy corn starch, sweet potato starch, starch such as potato starch; xylitol, sorbitol, maltitol, lactitol, reduced palatinose, trehalose, sugar alcohols such as palatinose; lactose; oligosaccharides; crystalline cellulose; light anhydrous silicic acid; calcium hydrogen phosphate, etc.), binders (e.g., gelatin, pregelatinized starch, polyvinylpyrrolidone, polyvinyl alcohol, pullulan, hydrogenated oil, etc.), disintegrants (e.g., carmellose, carmellose calcium, croscarmellose sodium, crospovidone), lubricants (e.g. calcium stearate, magnesium stearate, sucrose fatty acid ester, sodium stearyl fumarate, talc, silicon dioxide, etc.), flavoring agents (e.g., stevia, etc.), fillers, surfactants , dispersants, buffers, antioxidants, preservatives, quality stabilizers, diluents and the like. The solid composition for oral use of the present invention preferably contains lactose as an excipient from the viewpoint of suppressing the unpleasant odor of component (A). From the same point of view, it is preferable to contain at least one selected from calcium stearate and silicon dioxide as a lubricant.
Further, the solid composition for oral use of the present invention may contain acidulants, sweeteners, amino acids, proteins, vitamins, minerals, flavorings, fruit juices, plant extracts, esters, pigments, milk components, cocoa to enhance palatability. One or more additives such as powders, seasonings, vegetable oils and fats can be contained. The content of the carrier and additive can be appropriately set within a range that does not impair the purpose of the present invention.

The solid composition for oral use of the present invention can be provided as food, pharmaceuticals, and quasi-drugs. Among them, solid food is preferable, and powdered food is more preferable, because the effect of the present invention can be easily obtained.
When the solid composition for oral use of the present invention is food, examples thereof include jelly, gummies, candy, snacks, biscuits, chocolate, rice crackers, processed foods such as sausages, and general foods, but are limited to these. However, it may be a health food or a food with health claims.
In addition, when the solid composition for oral use of the present invention is a drug or quasi-drug, its dosage form includes, for example, granules, powders, tablets, pills, chewables, lozenges and the like. Moreover, when it is made into a tablet, it can be made into a split tablet with a score line.
Additionally, the solid oral composition of the present invention can be an instant beverage composition. As used herein, the term "instant beverage composition" refers to a composition diluted with a liquid according to a prescribed usage and orally ingested as a reconstituted beverage. The liquid is not particularly limited as long as it can be reconstituted into a beverage, and examples thereof include water, carbonated water, milk, and soy milk, and the temperature of the liquid does not matter. The dilution ratio may be according to the prescribed usage, but is usually 30 to 800 times by weight, preferably 80 to 600 times by weight. In addition, the content of the components (A) and (B), the mass ratio [(B)/(A)], and the pH of the reconstituted beverage prepared from the instant beverage according to a predetermined usage will be described later. It can have the same configuration as the RTD beverage composition.

The solid composition for oral use of the present invention can be produced according to a conventional method, and an appropriate method can be adopted. For example, component (A) and component (B), optionally a carrier and / or an additive, the mass ratio of component (A) to component (B) [(B) / (A)] is within the above range It can be produced by mixing so that The mixing order of component (A) and component (B) is not particularly limited, and one may be added to the other, or both may be added simultaneously. As a mixing method, an appropriate method such as stirring or shaking can be adopted, and a mixing device may be used. The mixing method of the mixing device may be a container rotation type or a container fixed type. As the container rotating type, for example, a horizontal cylindrical type, a V type, a double cone type, a cubic type, etc. can be adopted. As the fixed container type, for example, a ribbon type, a screw type, a conical screw type, a paddle type, a fluidized bed type, a Phillips blender, or the like can be employed.

Compression molding can also be used to shape the mixture. For example, in the case of tablet form, the mixture may be directly compressed and molded (direct powder compression method), or granulated using dry granulation method, wet granulation method, etc. and then compressed and molded (granule compression method). law). When directly compressing and molding to produce a tablet, a rotary tableting machine, a single-shot tableting machine, or the like can be used as a tableting machine. In addition, when making tablets after granulation by granulation method, extrusion granulation method using cylindrical granulator, spherical granulator, pelleter, etc.; crushing granulation method using speed mill, power mill, etc.; Granules are produced by a dynamic granulation method, agitation granulation method, fluidized bed granulation method, or the like, dried and granulated, and then the resulting granules are compressed with the tableting machine to form tablets. method can be adopted.

Moreover, the solid composition for oral use of the present invention can be filled in a package. Examples of packages include bottles, cans, bottles, box-type containers, stick-type packages, and pillow-type packages. A commercially available filling machine may be used to fill the package with the solid composition for oral use of the present invention.

[Liquid oral composition]
The form of the liquid composition for oral use of the present invention is not particularly limited as long as it has fluidity at normal temperature (20°C ± 15°C), and examples thereof include liquid, concentrated liquid, gel, and jelly. can.

The specific configuration of the component (A) contained in the liquid composition for oral use of the present invention is as described above, but the source of the component (A) is a chemically synthesized product (e.g., reagent), roasted coffee beans, is preferred, and chemically synthesized products (eg, reagents) and roasted coffee bean extracts are more preferred.

The content of the component (A) in the liquid composition for oral use of the present invention is preferably 0.000001% by mass or more, more preferably 0.00001% by mass or more, from the viewpoint that the effects of the present invention are easily received. 0.000016% by mass or more is more preferable, and from the viewpoint of suppressing the unpleasant odor of component (A), 0.0001% by mass or less is preferable, 0.00006% by mass or less is more preferable, and 0.00003% by mass or less is preferable. More preferred. The content of component (A) in the liquid composition for oral use of the present invention is preferably 0.000001 to 0.0001% by mass, more preferably 0.00001 to 0.00006% by mass, More preferably, it is 0.000016 to 0.00003% by mass.

The specific configuration of the component (B) contained in the solid composition for oral use of the present invention is as described above, but the component (B) preferably contains L-menthol. 90% or more is more preferable.

The content of the component (B) in the liquid composition for oral use of the present invention is preferably 0.0001% by mass or more, more preferably 0.0007% by mass or more, from the viewpoint of suppressing the unpleasant odor of the component (A). 0.005% by mass or more is more preferable, and from the viewpoint of suppressing the bitterness of the component (B), it is preferably 0.1% by mass or less, more preferably 0.05% by mass or less, and further preferably 0.02% by mass or less. preferable. The content of component (B) in the liquid composition for oral use of the present invention is preferably 0.0001 to 0.1% by mass, more preferably 0.0007 to 0.05% by mass, More preferably, it is 0.005 to 0.02% by mass.

The liquid composition for oral use of the present invention has a mass ratio [(B)/(A)] of component (A) to component (B) of 20 to 50,000. is the same as the explanation in .

The liquid composition for oral use of the present invention may optionally contain sweeteners, acidulants, amino acids, proteins, vitamins, minerals, flavorings, fruit juices, plant extracts, esters, pigments, emulsifiers, milk components, cocoa powder, seasonings, and plant extracts. One or two or more additives such as oils and fats, antioxidants, preservatives, pH adjusters, gelling agents, and carriers can be contained. The content of the additive can be appropriately set within a range that does not impair the object of the present invention.

Examples of product forms of the liquid composition for oral use of the present invention include RTD (ready-to-drink) type beverage compositions; dairy products such as yogurt, processed milk and fermented milk; salad oil, tempura oil, margarine, mayonnaise, fats and fats such as shortening, whipped cream and dressings; seasonings such as sauces and sauces; and health, beauty and nutritional supplements such as drinks. Here, the term "RTD type beverage composition" as used herein refers to a beverage that can be drunk as it is without dilution.

Among them, an RTD type beverage composition is preferable as a liquid composition for oral use. Examples of the form of the RTD beverage composition include liquid, concentrated liquid, gel, and jelly. When the form is a concentrated liquid, gel, or jelly, the solid content concentration is not particularly limited as long as the beverage composition can be sucked through a mouthpiece or straw provided in the container.

The pH (20° C.) of the RTD beverage composition is preferably 3 or higher, more preferably 3.5 or higher, still more preferably 4 or higher, and preferably 7 or lower, from the viewpoint of flavor. , more preferably 6.5 or less, and still more preferably 6 or less. In addition, pH shall be measured with a pH meter after adjusting the temperature to 20°C.

RTD beverage compositions may be non-alcoholic or alcoholic beverages. Here, the term "non-alcoholic beverage" as used herein refers to a beverage with an alcohol concentration of less than 1 v/v%, and includes beverages that do not contain any alcohol and beverages with an alcohol concentration of 0.00 v/v%. subsumed. As used herein, the term "alcohol" means ethanol unless otherwise specified.
Examples of non-alcoholic beverages include coffee drinks, tea drinks, carbonated drinks, fruit juice drinks, vegetable drinks, milk drinks, sports drinks, isotonic drinks, enhanced water, bottled water, near water, nutritional drinks, beauty drinks, and the like. can be mentioned. Examples of alcoholic beverages include beer, wine, sake, plum wine, low-malt beer, whiskey, brandy, shochu, rum, gin, and liqueurs.

The RTD beverage composition may be packaged. The container is not particularly limited as long as it is a normal packaging container, and examples include a molded container (so-called PET bottle) containing polyethylene terephthalate as a main component, a metal can, a paper container combined with a metal foil or a plastic film, a bottle, and the like. mentioned.

When the RTD type beverage composition is a packaged beverage composition, it may be heat sterilized. The heat sterilization method is not particularly limited as long as it conforms to the conditions stipulated in applicable laws and regulations (the Food Sanitation Law in Japan).

The liquid composition for oral use of the present invention can be produced according to a conventional method, and an appropriate method can be adopted. For example, component (A) and component (B) and, if necessary, additives are added so that the mass ratio [(B)/(A)] of component (A) and component (B) is within the above range. It can be manufactured by mixing. The mixing order of component (A), component (B) and other components is not particularly limited, and they can be added in any order.

[Unpleasant odor inhibitor for 4-vinylguaiacol]
The unpleasant odor inhibitor of the present invention contains (B) menthol as an active ingredient, and is exclusively used for suppressing the unpleasant odor of (A) 4-vinylguaiacol, which is felt excessively.
In the unpleasant odor inhibitor of the present invention, the component (B) may coexist with the component (A). In that case, the mass ratio of the component (A) to the component (B) [(B)/(A)] is preferably controlled within the above range.

Moreover, the unpleasant odor inhibitor of the present invention can be applied not only to component (A) but also to oral products containing component (A).
The oral product is not particularly limited as long as it can be orally ingested, and may be liquid or solid. For example, foods and beverages, pharmaceuticals, quasi-drugs, etc. containing the component (A) can be mentioned. Among them, food and drink are preferred.
Examples of food and drink products include RTD beverages or instant beverages containing component (A), and food products containing component (A). In addition, food and drink can be manufactured according to a conventional method according to the kind of food and drink.
The dosage form of the pharmaceuticals and quasi-drugs is not particularly limited, and examples thereof include formulations for oral administration, and known dosage forms such as liquids and syrups can be employed. In addition, known additives can be blended in formulation. In addition, pharmaceuticals and quasi-drugs can be manufactured according to a conventional method.
The content and mass ratio [(B)/(A)] of component (A) and component (B) in the oral product are as described above.

When the composition for oral use of the present invention contains a specific amount or more of furfuryl mercaptan in the composition for oral use, the problem of the unpleasant odor of component (A) 4-vinylguaiacol, which is the problem of the present invention, arises. It is possible that there is no such case. Specifically, this is the case where the composition for oral use contains 0.00006% by mass or more of furfuryl mercaptan. Therefore, the content of furfuryl mercaptan in the oral composition of the present invention is preferably less than 0.00006% by mass, more preferably less than 0.00003% by mass, and even more preferably 0.00001% by mass. less than, and most preferably substantially no. The effects of the present invention are exhibited particularly effectively for such oral compositions. Here, the term "substantially free" as used herein is a concept that includes not only the complete absence of furfuryl mercaptan in the oral composition, but also the concentration below the detection limit. The content of furfuryl mercaptan can be measured by an analysis method suitable for the situation of the measurement sample among commonly known measurement methods, for example, it can be measured by the GC/MS method.

When the composition for oral use of the present invention contains a specific amount or more of xylitol in the composition for oral use, the problem of the unpleasant odor of component (A) 4-vinylguaiacol, which is the problem of the present invention, does not occur. is possible. Specifically, it is the case where the composition for oral use contains 35% by mass or more of xylitol. Therefore, the content of xylitol in the oral composition of the present invention is preferably less than 35% by mass, more preferably less than 15% by mass, even more preferably less than 5% by mass, and even more preferably It does not contain substantially. The effects of the present invention are exhibited particularly effectively for such oral compositions.

The oral composition of the present invention preferably has a caffeine content of 0.01% by mass or less. It is known that the amount of caffeine increases as the degree of roasting of coffee beans increases, and is contained in a large amount in coffee beverages made from roasted coffee beans. The content of caffeine in the oral composition of the present invention is preferably 0.01% by mass or less, more preferably 0.005% by mass or less, from the viewpoint of easily receiving the effects of the present invention, It is more preferably 0.0001% by mass or less, and even more preferably substantially free. The effects of the present invention are particularly effective in low-caffeine oral compositions, since a high caffeine content can mask the unpleasant odor of 4-vinylguaiacol. Here, the term "substantially free" as used herein is a concept that includes not only the complete absence of caffeine in the oral composition, but also the concentration below the detection limit. The caffeine content can be measured by an analysis method suitable for the situation of the measurement sample among commonly known measurement methods, for example, it can be analyzed by liquid chromatography. In order to match the detection range of the instrument, the sample should be freeze-dried, or contaminants should be removed from the sample to match the resolution of the instrument. may be applied.

In relation to the above-described embodiments, the present invention further discloses the following embodiments.
<1a> The following components (A) and (B)
(A) 4-vinylguaiacol, and (B) menthol,
A solid composition for oral use, wherein the mass ratio of component (A) to component (B) [(B)/(A)] is from 20 to 50,000.

<2a> The solid oral composition according to <1a>, wherein the mass ratio [(B)/(A)] of the component (A) and the component (B) in the solid oral composition is preferably 40 to 45000. composition.
<3a> The solid oral composition according to <1a>, wherein the mass ratio [(B)/(A)] between the component (A) and the component (B) in the solid oral composition is preferably 55 to 20000. composition.
<4a> The solid oral composition according to <1a>, wherein the mass ratio [(B)/(A)] of the component (A) to the component (B) in the solid oral composition is preferably 70 to 20000. composition.
<5a> The solid oral composition according to <1a>, wherein the mass ratio [(B)/(A)] between the component (A) and the component (B) in the solid oral composition is preferably 90 to 12000. composition.
<6a> The solid oral composition according to <1a>, wherein the mass ratio [(B)/(A)] between the component (A) and the component (B) in the solid oral composition is preferably 90 to 7000. composition.
<7a> The solid oral composition according to <1a>, wherein the mass ratio [(B)/(A)] of the component (A) to the component (B) in the solid oral composition is preferably 150 to 6000. composition.
<8a> The solid oral composition according to <1a>, wherein the mass ratio [(B)/(A)] between the component (A) and the component (B) in the solid oral composition is preferably 300 to 5500. composition.
<9a> The solid oral composition according to <1a>, wherein the mass ratio [(B)/(A)] of the component (A) and the component (B) in the solid oral composition is preferably 400 to 5200. composition.
<10a> The solid oral composition according to <1a>, wherein the mass ratio [(B)/(A)] between the component (A) and the component (B) in the solid oral composition is preferably 450 to 600. composition.

<11a> The solid oral composition according to any one of <1a> to <10a>, wherein the content of component (B) in the solid oral composition is 0.01% by mass or more and less than 25% by mass. thing.
<12a> The solid composition according to any one of <1a> to <10a>, wherein the content of component (B) in the solid composition for oral use is preferably 0.02% by mass or more and less than 25% by mass. Oral composition.
<13a> The solid composition for oral use according to any one of <1a> to <10a>, wherein the content of component (B) in the solid oral composition is preferably 0.04 to 15% by mass. thing.
<14a> The solid composition for oral use according to any one of <1a> to <10a>, wherein the content of component (B) in the solid oral composition is preferably 0.08 to 7% by mass. thing.
<15a> The solid oral composition according to any one of <1a> to <10a>, wherein the content of component (B) in the solid oral composition is preferably 0.2 to 1.5% by mass. composition.
<16a> The solid composition for oral use according to any one of <1a> to <10a>, wherein the content of component (B) in the solid oral composition is preferably 0.3 to 1% by mass. thing.

<17a> The solid oral composition according to any one of <1a> to <16a>, wherein the content of component (A) in the solid oral composition is preferably 0.00001% by mass or more. .
<18a> The solid oral composition according to any one of <1a> to <16a>, wherein the content of component (A) in the solid oral composition is preferably 0.00005% by mass or more. .
<19a> The solid oral composition according to any one of <1a> to <16a>, wherein the content of component (A) in the solid oral composition is preferably 0.00005 to 0.02% by mass. composition.
<20a> The solid oral composition according to any one of <1a> to <16a>, wherein the content of component (A) in the solid oral composition is preferably 0.0001 to 0.015% by mass. composition.
<21a> The solid oral composition according to any one of <1a> to <16a>, wherein the content of component (A) in the solid oral composition is preferably 0.0003 to 0.01% by mass. composition.
<22a> The solid oral composition according to any one of <1a> to <16a>, wherein the content of component (A) in the solid oral composition is preferably 0.0004 to 0.006% by mass. composition.

<23a> The solid composition for oral use according to any one of <1a> to <22a>, which preferably contains an excipient.
<24a> The solid oral composition according to <22a>, which preferably contains lactose as the excipient.

<25a> The solid oral composition according to any one of <1a> to <24a>, wherein the content of furfuryl mercaptan in the solid oral composition is preferably less than 0.00006% by mass.
<26a> The solid oral composition according to any one of <1a> to <24a>, wherein the content of furfuryl mercaptan in the solid oral composition is preferably less than 0.00003% by mass.
<27a> The solid oral composition according to any one of <1a> to <24a>, wherein the content of furfuryl mercaptan in the solid oral composition is preferably less than 0.00001% by mass.
<28a> The solid oral solid composition according to any one of <1a> to <24a>, which preferably does not substantially contain furfuryl mercaptan (concentration below detection limit). Composition.

<29a> The solid composition for oral use according to any one of <1a> to <28a>, wherein the content of xylitol in the solid composition for oral use is preferably less than 35% by mass.
<30a> The solid composition for oral use according to any one of <1a> to <28a>, wherein the content of xylitol in the solid composition for oral use is preferably less than 15% by mass.
<31a> The solid composition for oral use according to any one of <1a> to <28a>, wherein the content of xylitol in the solid composition for oral use is preferably less than 5% by mass.
<32a> The solid composition for oral use according to any one of <1a> to <28a>, which preferably does not substantially contain xylitol (concentration below detection limit). .

<33a> The solid composition for oral use according to any one of <1a> to <32a>, wherein the content of caffeine in the solid oral composition is preferably 0.01% by mass or less.
<34a> The solid oral composition according to any one of <1a> to <32a>, wherein the content of caffeine in the solid oral composition is preferably 0.005% by mass or less.
<35a> The solid composition for oral use according to any one of <1a> to <32a>, wherein the content of caffeine in the solid oral composition is preferably 0.0001% by mass or less.
<36a> The solid composition for oral use according to any one of <1a> to <32a>, which preferably does not substantially contain caffeine (the concentration is below the detection limit). .
<37a> Any of the above <1a> to <36a>, wherein the 4-vinylguaiacol source is one or more selected from chemically synthesized products (e.g., reagents), roasted coffee bean extracts, and green coffee bean extracts. 1. Solid oral composition according to 1 above.

<1b> The following components (A) and (B)
(A) 4-vinylguaiacol, and (B) menthol,
A liquid composition for oral use, wherein the mass ratio of component (A) to component (B) [(B)/(A)] is from 20 to 50,000.

<2b> The liquid oral composition according to <1b>, wherein the mass ratio [(B)/(A)] between the component (A) and the component (B) in the liquid oral composition is preferably 40 to 45000. composition.
<3b> The liquid oral composition according to <1b>, wherein the mass ratio [(B)/(A)] of the component (A) to the component (B) in the liquid oral composition is preferably 55 to 20000. composition.
<4b> The liquid oral composition according to <1b>, wherein the mass ratio [(B)/(A)] of the component (A) to the component (B) in the liquid oral composition is preferably 70 to 20000. composition.
<5b> The liquid oral composition according to <1b>, wherein the mass ratio [(B)/(A)] between the component (A) and the component (B) in the liquid oral composition is preferably 90 to 12000. composition.
<6b> The liquid oral composition according to <1b>, wherein the mass ratio [(B)/(A)] of the component (A) to the component (B) in the liquid oral composition is preferably 90 to 7000. composition.
<7b> The liquid oral composition according to <1b>, wherein the mass ratio [(B)/(A)] between the component (A) and the component (B) in the liquid oral composition is preferably 150 to 6000. composition.
<8b> The liquid oral composition according to <1b>, wherein the mass ratio [(B)/(A)] between the component (A) and the component (B) in the liquid oral composition is preferably 300 to 5500. composition.
<9b> The liquid oral composition according to <1b>, wherein the mass ratio [(B)/(A)] between the component (A) and the component (B) in the liquid oral composition is preferably 400 to 5200. composition.
<10b> The liquid oral composition according to <1b>, wherein the mass ratio [(B)/(A)] of the component (A) to the component (B) in the liquid oral composition is preferably 450 to 600. composition.

<11b> The liquid oral composition according to any one of <1b> to <10b>, wherein the content of component (B) in the liquid oral composition is preferably 0.0001 to 0.1% by mass. composition.
<12b> The liquid oral composition according to any one of <1b> to <10b>, wherein the content of component (B) in the liquid oral composition is preferably 0.0007 to 0.05% by mass. composition.
<13b> The liquid oral composition according to any one of <1b> to <10b>, wherein the content of component (B) in the liquid oral composition is preferably 0.005 to 0.02% by mass. composition.

<14b> The liquid composition for oral use according to any one of <1b> to <13b>, wherein the content of component (A) in the liquid composition for oral use is preferably 0.000001% by mass or more. .
<15b> The liquid oral composition according to any one of <1b> to <13b>, wherein the content of component (A) in the liquid oral composition is preferably 0.000001 to 0.0001% by mass. composition.
<16b> The liquid oral composition according to any one of <1b> to <13b>, wherein the content of component (A) in the liquid oral composition is preferably 0.00001 to 0.00006% by mass. composition.
<17b> The liquid oral composition according to any one of <1b> to <13b>, wherein the content of component (A) in the liquid oral composition is preferably 0.000016 to 0.00003% by mass. composition.

<18b> The liquid composition for oral use according to any one of <1b> to <17b>, which is preferably an RTD type beverage composition.
<19b> The liquid composition for oral use according to any one of <1b> to <17b>, which is preferably a non-alcoholic RTD beverage composition.
<20b> The liquid composition for oral use according to any one of <1b> to <17b>, which is preferably a packaged beverage composition.

<21b> The liquid composition for oral use according to any one of <1b> to <19b>, wherein the content of furfuryl mercaptan in the liquid composition for oral use is preferably less than 0.00006% by mass.
<22b> The liquid composition for oral use according to any one of <1b> to <19b>, wherein the content of furfuryl mercaptan in the liquid composition for oral use is preferably less than 0.00003% by mass.
<23b> The liquid composition for oral use according to any one of <1b> to <19b>, wherein the content of furfuryl mercaptan in the liquid composition for oral use is preferably less than 0.00001% by mass.
<24b> The liquid oral composition according to any one of <1b> to <19b>, which preferably does not substantially contain furfuryl mercaptan (concentration below the detection limit) in the liquid oral composition. Composition.

<25b> The liquid composition for oral use according to any one of <1b> to <24b>, wherein the content of xylitol in the liquid composition for oral use is preferably less than 35% by mass.
<26b> The liquid composition for oral use according to any one of <1b> to <24b>, wherein the content of xylitol in the liquid composition for oral use is preferably less than 15% by mass.
<27b> The liquid composition for oral use according to any one of <1b> to <24b>, wherein the content of xylitol in the liquid composition for oral use is preferably less than 5% by mass.
<28b> The liquid composition for oral use according to any one of <1b> to <24b>, which preferably does not substantially contain xylitol (concentration below detection limit). .

<29b> The liquid composition for oral use according to any one of <1b> to <28b>, wherein the content of caffeine in the liquid composition for oral use is preferably 0.01% by mass or less.
<30b> The liquid composition for oral use according to any one of <1b> to <28b>, wherein the content of caffeine in the liquid composition for oral use is preferably 0.005% by mass or less.
<31b> The liquid composition for oral use according to any one of <1b> to <28b>, wherein the content of caffeine in the liquid composition for oral use is preferably 0.0001% by mass or less.
<32b> The liquid composition for oral use according to any one of <1b> to <28b>, which preferably does not substantially contain caffeine (the concentration is below the detection limit) in the liquid composition for oral use. .
<33b> Any of the above <1a> to <32b>, wherein the 4-vinylguaiacol source is one or more selected from chemically synthesized products (e.g., reagents), roasted coffee bean extracts, and green coffee bean extracts. 1. The liquid oral composition according to 1 above.

<1c> An unpleasant odor inhibitor of 4-vinylguaiacol containing menthol as an active ingredient.

<2c> The unpleasant odor inhibitor according to <1c> above, wherein (B) menthol is allowed to coexist with (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 40 to 45000. .
<3c> The unpleasant odor inhibitor according to <1c> above, wherein (B) menthol is allowed to coexist with (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 55 to 20000. .
<4c> The unpleasant odor inhibitor according to <1c> above, wherein (B) menthol is allowed to coexist with (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 70 to 20000. .
<5c> The unpleasant odor inhibitor according to <1c> above, wherein (B) menthol is allowed to coexist with (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 90 to 12000. .
<6c> The unpleasant odor inhibitor according to <1c> above, wherein (B) menthol is allowed to coexist with (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 90 to 7000. .
<7c> The unpleasant odor inhibitor according to <1c> above, wherein (B) menthol is allowed to coexist with (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 150 to 6000. .
<8c> The unpleasant odor suppressant according to <1c> above, wherein (B) menthol is allowed to coexist with (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 300 to 5500. .
<9c> The unpleasant odor inhibitor according to <1c> above, wherein (B) menthol is allowed to coexist with (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 400 to 5200. .
<10c> The unpleasant odor inhibitor according to <1c> above, wherein (B) menthol is allowed to coexist with (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 450 to 600. .

<1d> A method for suppressing an unpleasant odor of 4-vinyl guaiacol, wherein (A) 4-vinyl guaiacol is coexisted with (B) menthol at a mass ratio of preferably 20 to 6000 [(B)/(A)].
<2d> A method for suppressing an unpleasant odor of 4-vinyl guaiacol, wherein (A) 4-vinyl guaiacol is coexisted with (B) menthol, preferably at a mass ratio [(B)/(A)] of 40 to 45,000.
<3d> A method for suppressing an unpleasant odor of 4-vinyl guaiacol, wherein (B) menthol is allowed to coexist with (A) 4-vinyl guaiacol, preferably at a mass ratio [(B)/(A)] of 55 to 20,000.
<4d> A method for suppressing an unpleasant odor of 4-vinyl guaiacol, wherein (B) menthol is allowed to coexist with (A) 4-vinyl guaiacol, preferably at a mass ratio [(B)/(A)] of 70 to 20,000.
<5d> A method for suppressing an unpleasant odor of 4-vinylguaiacol, comprising coexisting (B) menthol with respect to (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 90 to 12000.
<6d> A method for suppressing an unpleasant odor of 4-vinyl guaiacol, wherein (B) menthol is allowed to coexist with (A) 4-vinyl guaiacol, preferably at a mass ratio [(B)/(A)] of 90 to 7000.
<7d> A method for suppressing an unpleasant odor of 4-vinyl guaiacol, wherein (B) menthol is allowed to coexist with (A) 4-vinyl guaiacol, preferably at a mass ratio [(B)/(A)] of 150 to 6000.
<8d> A method for suppressing an unpleasant odor of 4-vinylguaiacol, wherein (A) 4-vinylguaiacol is coexisted with (B) menthol, preferably at a mass ratio of 300 to 5500 [(B)/(A)].
<9d> A method for suppressing an unpleasant odor of 4-vinyl guaiacol, wherein (B) menthol is allowed to coexist with (A) 4-vinyl guaiacol, preferably at a mass ratio [(B)/(A)] of 400 to 5200.
<10d> A method for suppressing an unpleasant odor of 4-vinyl guaiacol, wherein (A) 4-vinyl guaiacol is coexisted with (B) menthol at a mass ratio of preferably 1450 to 600 [(B)/(A)].

<1e> An oral composition comprising (A) an oral composition containing 4-vinylguaiacol and (B) menthol, preferably at a mass ratio [(B)/(A)] of 150 to 6000. A method for suppressing an unpleasant odor of 4-vinylguaiacol in the medium.

<2e> The unpleasant odor suppressing method according to <1e> above, wherein (B) menthol is contained with respect to (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 40 to 45000. .
<3e> The unpleasant odor suppressing method according to <1e> above, wherein (B) menthol is contained with respect to (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 55 to 20000. .
<4e> The unpleasant odor suppressing method according to <1e> above, wherein (B) menthol is contained with respect to (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 70 to 20000. .
<5e> The unpleasant odor suppressing method according to <1e> above, wherein (B) menthol is contained with respect to (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 90 to 12000. .
<6e> The unpleasant odor suppressing method according to <1e> above, wherein (B) menthol is added to (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 90 to 7000. .
<7e> The unpleasant odor suppressing method according to <1e> above, wherein (B) menthol is contained with respect to (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 150 to 6000. .
<8e> The unpleasant odor suppressing method according to <1e> above, wherein (B) menthol is added to (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 300 to 5500. .
<9e> The unpleasant odor suppressing method according to <1e> above, wherein (B) menthol is added to (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 400 to 5200. .
<10e> The unpleasant odor suppressing method according to <1e> above, wherein (B) menthol is added to (A) 4-vinylguaiacol, preferably at a mass ratio [(B)/(A)] of 450 to 600. .
<11e> Any of the above <1e> to <10e>, wherein the 4-vinylguaiacol source is one or more selected from chemically synthesized products (e.g., reagents), roasted coffee bean extracts, and green coffee bean extracts. 1. The method for suppressing an unpleasant odor according to 1.

(1) Analysis of 4-vinyl guaiacol A sample was sampled in a vial, the aroma component in the headspace was adsorbed by SPME fibers, and subjected to GC/MS measurement.

Analysis conditions are as follows.
HS-GC/MS conditions/measurement equipment; HP6890 (manufactured by Agilent)
・ Column: BC-WAX inner diameter 0.25 mm × length 50 m, particle diameter 0.25 μm (GL Sciences Co., Ltd.)
・Temperature program: 60°C (5 min) → 230°C, temperature rise at 5°C/min ・Head pressure: 14.8 psi
・Inlet temperature: 210°C
・Detector temperature; 200°C
・Split ratio; 30:1
・Carrier gas; helium
・Scan mode; ionization voltage 70 eV

(2) Analysis of menthol Add 150 mL of water and 8 mL of heptane to 2.0 g of the sample, distill with a distillation apparatus for quantitative determination of essential oils, separate the heptane layer and use it as a measurement sample, and measure it under the following analysis conditions. do.

・Model: 6890N/5975B interXL (manufactured by Agilent)
・Column: DB-WAX (manufactured by Agilent)
・Temperature: sample injection port 220°C, column 80°C (held for 1 minute) → 5°C/minute temperature increase → 150°C → 15°C/minute temperature increase → 200°C
・Injection method: split 30:1
・Injection volume: 1 μL
・Gas flow rate: Helium 1 mL/min ・Ion source temperature: 230°C
・Ionization method: EI
・ Set mass number: m / z 136 naphthalene-d8 (internal standard substance)

Production example 1
Production of Unground Green Coffee Bean Preparation An unground green coffee bean preparation was obtained by the method described in Example 1 of JP-A-2018-70591. The resulting unground green coffee bean preparation had a 4-vinylguaiacol content of 0.0053% by weight.

Production example 2
Manufacture of deep-roasted coffee bean preparation L29 roasted coffee beans (produced in Vietnam) were pulverized and filled into 6 cylindrical extraction towers (inner diameter 160 mm × height 660 mm) with a filling amount of 4.2 kg per tower. filled to Then, hot water at 150° C. was sent from the bottom to the top of the first-stage extraction tower. Next, the coffee extract discharged from the upper part of the first-stage extraction tower was sent from the lower part of the second-stage extraction tower to the upper part. This operation was repeated for the third and subsequent extraction towers, and the coffee extract discharged from the upper part of the sixth extraction tower was quickly cooled and collected. All extractions were performed at a flow rate of 20 mL/min under a pressure of 0.3 MPa. The obtained extract was heated and concentrated under reduced pressure at 30 torr and 50° C. using a rotary evaporator (Type N-1100V, manufactured by Tokyo Rika Kikai Co., Ltd.) to obtain a concentrated composition of Brix10. Subsequently, 100 g of activated carbon (Shirasagi WH2C LSS, manufactured by Nippon Envirochemicals) was added to a cylindrical column (inner diameter 72 mm x height 100 mm) and sterilized at 80 ° C. for 10 minutes. The liquid was fed at 25° C. and a flow rate of 64.0 mL/min, and 2.4 kg of the activated carbon-treated liquid was obtained as the final amount of collected liquid from the column outlet. The resulting treated liquid was dried using a spray dryer to obtain a deep roasted coffee bean preparation. The resulting dark roasted coffee bean preparation had a 4-vinylguaiacol content of 0.000453% by mass.

Sensory Evaluation A sensory test was performed by two expert panels on the “unpleasant odor of 4-vinylguaiacol” and the “bitter taste of menthol” of the test solid oral composition according to the following procedure.

(1) Unpleasant odor of 4-vinyl guaiacol (4-VG) 4-VG reagent (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) and lactose (manufactured by Shizen Kenko Co., Ltd.) were uniformly mixed in the proportions shown in Table 1. A "standard powder composition 1" was prepared by adjusting the intensity of the "unpleasant odor" to seven levels, and two expert panels agreed to give the scores shown in Table 1 for the unpleasant odor of each composition. Next, each expert panel ingested the compositions shown in Table 1, starting with the one with the lowest 4-VG concentration, and memorized the intensity of the “unpleasant odor”. Each expert panel then ingested each test solid oral composition, rated the degree of "unpleasant odor", and determined the closest "unpleasant odor" out of the "standard powder composition 1". Then, based on the scores determined by each expert panel, the final score was determined through consultation. Note that the smaller the score, the stronger the “unpleasant odor” felt.

(2) Menthol bitterness L-menthol reagent (mint brain SUUU, manufactured by TENKU, 99% or more) and lactose (manufactured by Shizen Kenko Co., Ltd.) are uniformly mixed in the proportions shown in Table 2, and the strength of "bitterness" is determined. was adjusted to 5 levels to prepare "standard powder composition 2". Next, each expert panel ingested the compositions shown in Table 2, starting with the one with the lowest menthol concentration, and memorized the intensity of "bitterness." Each expert panel then ingested each test solid oral composition, rated the degree of "bitterness", and determined which of the "standard powder composition 2" most closely resembled "bitterness." Then, based on the scores determined by each expert panel, the final score was determined through consultation. Note that the smaller the score, the stronger the “bitterness” felt.

Examples 1 to 5 and Comparative Examples 1 and 2
A 4-vinylguaiacol (4-VG) reagent, a menthol reagent, and lactose were uniformly mixed in the proportions shown in Table 3 to obtain a powdery solid composition for oral use. The obtained solid composition for oral use was analyzed and sensory evaluated. Table 3 shows the results.

Examples 6 to 9 and Comparative Examples 3 and 4
A powdery solid composition for oral use was obtained in the same manner as in Example 1, except that the proportions shown in Table 4 were changed. The obtained solid composition for oral use was analyzed and sensory evaluated. Table 4 shows the results.

Examples 10-15 and Comparative Examples 5-7
A powdery solid composition for oral use was obtained in the same manner as in Example 1, except that the proportions shown in Table 5 were changed. The obtained solid composition for oral use was analyzed and sensory evaluated. Table 5 shows the results.

Examples 16-19
A powdery solid oral composition was obtained in the same manner as in Example 1 except that the coffee bean preparations obtained in Production Examples 1 and 2 were used as the 4-VG source and the proportions were changed as shown in Table 6. . The obtained solid composition for oral use was analyzed and sensory evaluated. Table 6 shows the results.

Examples 20-21 and Comparative Example 8
A 4-vinylguaiacol (4-VG) reagent, a menthol reagent, and water were uniformly mixed in the proportions shown in Table 7 to obtain a liquid composition for oral use. Analysis and sensory evaluation were performed on the resulting liquid composition for oral use. Table 7 shows the results.

Examples 22-23
A powdery solid oral composition was prepared in the same manner as in Example 1, except that a green coffee bean preparation (Lunafenon C-200, Kao Corporation) was used as the 4-VG source and the proportions were changed as shown in Table 8. got stuff The obtained solid composition for oral use was analyzed and sensory evaluated. Table 8 shows the results.

Example 24
Green coffee bean preparation (Lunafenon C-200, Kao Corporation) 26.6 parts by mass as a 4-VG source, menthol 0.34 parts by mass, calcium stearate 1.9 parts by mass, and silicon dioxide 0.9 Finally, lactose was added so that the total amount was 100 parts by mass, and mixed uniformly. Then, using a single-shot tableting machine (manufactured by RIKEN), tableting was performed with a ring-shaped punch having a hole diameter of 14 mm at a mass of 1 g/tablet to obtain circular tablets. Analysis and sensory evaluation were performed on the obtained tablets. Table 9 shows the results.

Tables 3 to 9 show that the unpleasant odor of 4-vinylguaiacol can be reduced by adding menthol to 4-vinylguaiacol at a constant ratio.

Claims (4)

the following components (A) and (B)
(A) 4-vinylguaiacol, and (B) menthol,
A composition for oral use, wherein the mass ratio of component (A) to component (B) [(B)/(A)] is from 20 to 50,000. 2. The oral composition according to claim 1, which is a solid oral composition. The oral composition according to claim 2, wherein the content of component (B) is 0.01% by mass or more and less than 25% by mass. The oral composition according to claim 2 or 3, wherein the content of component (A) is 0.00001% by mass or more.