JP2023036056A - Centipede bite damage inhibitor and method for inhibiting centipede bite damage - Google Patents

Abstract

To provide a centipede bite damage inhibitor that can inhibit bite damage by centipedes.SOLUTION: A centipede bite damage inhibitor contains at least one selected from the group consisting of a monoterpene compound and an alkyl lactate ester having 5 or more carbon atoms as an active ingredient.SELECTED DRAWING: None

Description

TECHNICAL FIELD The present invention relates to a centipede bite inhibitor and a method for inhibiting centipede bite.

Centipedes are an example of crawling pests, live in grassy areas, between stone walls, in soil, etc., and feed on small insects, spiders, earthworms, and the like. In recent years, centipedes have been appearing more often near residential areas, and sometimes enter houses in search of food. Then, the centipede that has invaded the house hides in the furniture or shoes, and when it comes into contact with a person, it may bite and cause a bite.
Conventionally, as a method for exterminating centipedes, for example, a method using an aerosol agent using pyrethroid is known (for example, Patent Documents 1 and 2).

JP 2016-155774 A JP 2018-162242 A

However, although conventional aerosol agents using pyrethroids, such as those described in Patent Documents 1 and 2, can exterminate centipedes, they cannot necessarily suppress the biting behavior of centipedes. Therefore, an aerosol agent using a pyrethroid has the risk of being bitten by a centipede before the centipede is knocked down.

Accordingly, an object of the present invention is to provide a centipede bite inhibitor capable of suppressing the bite of a centipede.

The present inventors have found that a specific compound has the effect of suppressing the bite of centipedes, and by using such a compound as an active ingredient, it is possible to suppress the bite of centipedes, and have completed the present invention.

That is, the present invention relates to a centipede bite inhibitor containing, as an active ingredient, at least one selected from the group consisting of monoterpene compounds and lactic acid alkyl esters having 5 or more carbon atoms.
The present invention also relates to a method for inhibiting centipede bites by applying the centipede bite inhibitor to the centipede body surface.

According to the centipede bite inhibitor of the present invention, since the centipede bite inhibitor contains a specific compound, centipede bite can be suppressed. That is, according to the present invention, the risk of being bitten by a centipede can be suppressed, and the centipede can be safely repelled or exterminated.

Specific embodiments of the present invention will be described in detail below, but the present invention is not limited to the following embodiments. The present invention can be implemented with appropriate modifications as long as the purpose is achieved.

<Centipede bite inhibitor>
The centipede bite inhibitor of the present invention (hereinafter also simply referred to as a bite inhibitor) contains at least one selected from the group consisting of monoterpene compounds and lactic acid alkyl esters having 5 or more carbon atoms as an active ingredient. contains.

In the present specification, centipede bite (hereinafter also simply referred to as bite) refers to damage caused by the bite of a centipede. In addition, suppression of bites means suppressing the occurrence of bites or reducing the risk of occurrence of bites by suppressing the bites of centipedes.

Centipede as used herein is a general term for centipedes. Specific examples of centipedes include Tobis centipede, Sessia centipede, Blue centipede, Red centipede, Issun centipede, and the like.

(active ingredient)
The centipede bite inhibitor of the present invention contains, as an active ingredient, at least one selected from the group consisting of monoterpene compounds and lactic acid alkyl esters having 5 or more carbon atoms.

As a result of intensive studies, the present inventors have newly found that the above-mentioned active ingredients, that is, monoterpene compounds and lactate alkyl esters having 5 or more carbon atoms, have the effect of suppressing centipede bites. Since centipede bites can be suppressed by suppressing centipede bites, the risk of being bitten when encountering centipedes can be suppressed, and the centipedes can be safely repelled or exterminated. It is not clear why these active ingredients can suppress the bite of centipedes. It is thought that it is because it becomes impossible to take action. In other words, it is presumed that the above-mentioned active ingredient does not stop the behavior of centipedes, but that the centipedes become hyperactive and prevent the biting behavior of the centipedes, thereby obtaining the effect of suppressing the biting behavior. .

(Monoterpene compound)
A terpene-based compound refers to a compound having isoprene as a constituent unit. Among them, a monoterpene-based compound is a compound having 10 carbon atoms and having a structure composed of two isoprene units. The monoterpene-based compound may be a cyclic monoterpene-based compound having a ring structure, or a chain monoterpene-based compound. In addition, the number of rings in the cyclic monoterpene compound may be one (monocyclic) or two or more (multicyclic). The ring in the cyclic monoterpene compound may be composed only of carbon atoms, or may be composed of carbon atoms and atoms other than carbon atoms.

Specific examples of monoterpene compounds include monoterpene ketones, monoterpene alcohols, monoterpene hydrocarbons, monoterpene ethers, monoterpene aldehydes, monoterpene phenols, and the like. Among them, the monoterpene-based compound is preferably at least one selected from the group consisting of monoterpene ketones, monoterpene alcohols, monoterpene hydrocarbons, monoterpene ethers and monoterpene aldehydes.

Examples of monoterpene ketones include menthone, carvone, piperitone, carbomenthone, piperitenone, isomenthone, pulegone, thujone, camphor and the like, with menthone, carvone and thujone being more preferred.
Examples of monoterpene alcohols include terpinen-4-ol, citronellol, nerol, linalool, geraniol, menthol, borneol, hinokitiol, carveol, pinocampheol, terpineol, isopulegol, p-menthane-3,8-diol, and the like. and more preferred are terpinen-4-ol, nerol and linalool.
Examples of monoterpene hydrocarbons include limonene, α-pinene, β-pinene, terpinolene, terpinene, phellandrene, sabinene, carene, himcarene, camphene, and myrcene, with limonene, α-pinene, and β-pinene being more preferred. preferable.
Examples of monoterpene ethers include 1,8-cineole, rose oxide, linalool oxide and the like, with 1,8-cineol being more preferred.
Examples of monoterpene aldehydes include cyclic monoterpene aldehydes such as perillaldehyde and myrtenal, and chain monoterpene aldehydes such as citral and citronellal. The monoterpene aldehyde is more preferably a chain monoterpene aldehyde, and more preferably citral or citronellal.
Examples of monoterpene phenols include thymol, carvacrol, eugenol and the like.

(Lactic acid alkyl ester having 5 or more carbon atoms)
A lactic acid alkyl ester having 5 or more carbon atoms means a compound having 5 or more carbon atoms among lactic acid alkyl esters. In the lactic acid alkyl ester having 5 or more carbon atoms, the alkyl group is preferably a chain or cyclic alkyl group having 2 to 8 carbon atoms, more preferably a chain alkyl group having 2 to 6 carbon atoms, and a chain alkyl group having 2 to 4 carbon atoms. Alkyl groups are more preferred. Ethyl lactate and butyl lactate are particularly preferred as the alkyl lactate having 5 or more carbon atoms.

These active ingredients may be used individually by 1 type, and may use multiple types together.

The centipede bite inhibitor of the present invention may consist of only the above active ingredients, or may further contain other ingredients. In the centipede bite suppressant of the present invention, the content of the active ingredient is preferably 0.005 w/w% or more, more preferably 0.01 w/w% or more, from the viewpoint of sufficiently suppressing bites, and 0.01 w/w% or more. 1 w/w% or more is more preferable, and 0.5 w/w% or more is particularly preferable. The upper limit of the content of the active ingredient is not particularly limited, and may be adjusted appropriately in consideration of the feeling of use such as odor and irritation. w % or less is more preferable, and 15 w/w % or less is even more preferable.

When the dosage form of the centipede bite inhibitor of the present invention is an aerosol agent, the content of the active ingredient with respect to the total amount of the stock solution and the propellant can be expressed in w/v%, and the bite can be sufficiently suppressed. 0.005 w/v% or more is preferable, 0.01 w/v% or more is more preferable, 0.1 w/v% or more is still more preferable, and 0.5 w/v% or more is particularly preferable. The upper limit of the content of the active ingredient is not particularly limited, and may be adjusted appropriately in consideration of the feeling of use such as odor and irritation. v% or less is more preferable, and 15 w/v% or less is even more preferable.

(other ingredients)
The centipede bite inhibitor of the present invention may contain various solvents as other components. Examples of solvents include, but are not limited to, alcohols (methanol, ethanol, isopropyl alcohol, butanol, hexanol, benzyl alcohol, ethylene glycol, etc.), ethers (diethyl ether, ethylene glycol dimethyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether , propylene glycol monomethyl ether, tetrahydrofuran, dioxane, etc.), esters (ethyl acetate, butyl acetate, isopropyl myristate, etc.), ketones (acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone, etc.), aromatic or aliphatic hydrocarbons (xylene, toluene, alkylnaphthalene, phenylxylylethane, kerosene, light oil, hexane, cyclohexane, etc.), halogenated hydrocarbons (chlorobenzene, dichloromethane, dichloroethane, trichloroethane, etc.), nitriles (acetonitrile, isobutyronitrile, etc.) , sulfoxides (dimethyl sulfoxide, etc.), heterocyclic solvents (sulfolane, γ-butyrolactone, N-methyl-2-pyrrolidone, N-ethyl-2-pyrrolidone, N-octyl-2-pyrrolidone, 1,3-dimethyl- 2-imidazolidinone), acid amides (N,N-dimethylformamide, N,N-dimethylacetamide, etc.), alkylidene carbonates (propylene carbonate, etc.) and water. As water, tap water, ion-exchanged water, distilled water, filtered water, sterilized water, underground water, and the like are used.

Although detailed later, the dosage form of the centipede bite inhibitor of the present invention is not particularly limited. Here, for example, when the dosage form is an aerosol, the solvent is preferably a saturated hydrocarbon. Examples of saturated hydrocarbons include paraffinic hydrocarbons and naphthenic hydrocarbons, among which paraffinic hydrocarbons composed of normal paraffin and isoparaffin are preferred. Typical normal paraffins mainly have 12 to 14 carbon atoms. N-14, normal paraffin MA and the like, and isoparaffin includes, for example, IP Clean LX and IP Solvent manufactured by Idemitsu Kosan Co., Ltd. Further, as a solvent, it is preferable to use one or more selected from esters, especially fatty acid esters, and among ethers, glycol ethers, heterocyclic solvents, and alcohols in combination.

In addition, the bite inhibitor of the present invention may optionally contain various surfactants such as nonionic surfactants, anionic surfactants, cationic surfactants and amphoteric surfactants, and antioxidants. It may contain various additives such as agents, emulsifiers, antifoaming agents, preservatives, thickeners, fragrances, excipients and the like.

In addition, the bite inhibitor of the present invention may further contain an insecticidal component effective against centipedes, a synergistic agent thereof, and the like. When the bite inhibitor further contains an insecticidal component, it can inhibit centipede bites and kill insects.
By containing the insecticidal component, when the centipede is exterminated by the insecticidal component, the bite of the centipede can be suppressed until the centipede is knocked down, so the centipede can be safely exterminated.

The insecticidal component is not particularly limited, but includes allethrin, resmethrin, flamethrin, prallethrin, terarethrin, phthalthrin, phenothrin, permethrin, cyphenothrin, cypermethrin, transfluthrin, metofluthrin, profluthrin, imiprothrin, empentrin, monfluorothrin, etofenprox, pyrethroid compounds such as silafluofen and bifenthrin; carbamate compounds such as propoxur and carbaryl; organophosphorus compounds such as fenitrothion and DDVP; oxadiazole compounds such as methoxadiazone; phenylpyrazole compounds such as fipronil; insect juvenile hormone-like compounds such as methoprene and hydroprene; anti-juvenile hormone-like compounds such as plecosene; The insecticidal component is preferably a pyrethroid compound, more preferably phthalthrin, permethrin, transfluthrin, monfluorothrin, or bifenthrin, because of its quick-acting properties.

An insecticidal component and a synergist such as synepyrine or piperonyl butoxide may be used in combination. The insecticidal component may be used singly or in combination of two or more depending on the purpose.

When the bite suppressant contains an insecticidal component, the content thereof is preferably 0.01 w/w% or more, more preferably 0.05 w/w% or more, more preferably 0.1 w/w/ w % or more is more preferable. The content of the insecticidal component is preferably 10 w/w% or less, more preferably 7.5 w/w% or less, even more preferably 5 w/w% or less.

When the bite suppressant contains an insecticidal component and the dosage form of the bite suppressant is an aerosol, the content of the insecticidal component can also be expressed as w/v%, and the total amount of the stock solution and propellant 0.01 w/v% or more is preferable, 0.05 w/v% or more is more preferable, and 0.1 w/v% or more is still more preferable. The content of the insecticidal component is preferably 10 w/v% or less, more preferably 7.5 w/v% or less, even more preferably 5 w/v% or less.

(Production method)
The method for producing the centipede bite inhibitor of the present invention is not particularly limited, but examples include a method of mixing an active ingredient and, if necessary, other ingredients at room temperature or under heating.

(dosage form)
The dosage form of the centipede bite inhibitor of the present invention is not particularly limited.
Specific dosage forms include oils, emulsions, wettable powders, flowables (suspensions in water, emulsions in water, etc.), microcapsules, powders, granules, tablets, gels, liquids, sprays, Examples include aerosol agents, natural evaporation agents, heat evaporation agents, fan preparations, and the like. Among these, spray preparations such as aerosols and sprays are preferable because they are easy to attach the bite inhibitor to the body surface of the centipede, and it is easy to obtain the effect of suppressing the bite, even from a distance from the centipede. Aerosol formulations are more preferred because they are easier to handle.
Carriers, additives and the like necessary for formulation may be further used depending on the desired dosage form.

Aerosol formulations generally consist of a liquid concentrate and a propellant for propelling the liquid concentrate. A wide range of known propellants can be used, including liquefied petroleum gas (LPG), dimethyl ether, CFC alternatives (such as HFO and HFC), carbon dioxide gas, nitrogen gas, and the like. Among these, it is preferable to use LPG and dimethyl ether. In addition, the ratio of the propellant content is 30 to 95v with respect to the total amount of the undiluted solution and the propellant, since it is easy to attach the anti-bite agent to the body surface of the centipede and to obtain the effect of suppressing the bite. /v% is preferred, and 50 to 95v/v% is more preferred.

The content ratio of the active ingredient in the stock solution of the aerosol agent is preferably 0.01 w/v% or more, more preferably 0.05 w/v% or more, further preferably 0.1 w/v% or more, and 0.5 w/v% or more. V % or more is particularly preferred, and 1 w/v % or more is most preferred. The upper limit of the content of the active ingredient is not particularly limited, and may be adjusted appropriately in consideration of the feeling of use such as odor and irritation. 30 w/v% or less is more preferable.
When the bite inhibitor contains an insecticidal component, the content of the insecticidal component in the undiluted solution of the aerosol agent is preferably 0.05 w/v % or more, more preferably 0.1 w/v % or more, and 0.05 w/v % or more. 5 w/v % or more is more preferable. The content of the insecticidal component is preferably 25 w/v% or less, more preferably 15 w/v% or less, even more preferably 10 w/v% or less.

<Methods for Suppressing Centipede Bites>
A method for inhibiting centipede bites using the agent for inhibiting centipede bites of the present invention (hereinafter also referred to as a method for inhibiting centipede bites) will be described. The method for suppressing bite by centipedes is not particularly limited as long as it can suppress bite by centipedes. For example, a method of applying an effective amount of the centipede bite inhibitor of the present invention to the body surface of centipedes is preferable. That is, the present invention relates to a method for inhibiting centipede bites by treating the centipede body surface with the centipede bite inhibitor of the present invention.

As a method of treating the body surface of the centipede with the bite inhibitor, for example, there is a method of adhering the bite inhibitor to the body surface of the centipede. Methods for attaching the bite inhibitor to the body surface of the centipede include spraying, dripping, spraying, and applying the bite inhibitor to the centipede, and immersing the centipede in the bite inhibitor. be done. From the viewpoint of suppressing bites more simply and effectively, a method of attaching the bite suppressing agent to the body surface of the centipede by spraying or spraying is preferable.

By suppressing the bite of a centipede by such a bite suppression method, the risk of being bitten by a centipede can be suppressed, and the centipede can be safely repelled or exterminated.

<How to Kill Centipedes>
Next, the centipede insecticidal method using the centipede bite inhibitor of the present invention (hereinafter also simply referred to as the insecticidal method) will be described. Such an insecticidal method is a method for killing centipedes using an insecticidal component, and includes applying an effective amount of a centipede bite inhibitor to the body surface of centipedes to suppress centipede bites. That is, the present invention relates to a method for killing centipedes, which comprises treating the centipede body surface with the centipede bite inhibitor of the present invention to suppress the centipede bites.

Preferred embodiments of the method for treating the body surface of centipedes with a centipede bite inhibitor are the same as the preferred embodiments of the treatment method in the bite inhibition method described above.

Specific aspects of the insecticidal method include, for example, the following (i) to (iii). From the viewpoint of convenience, method (i) is preferable.
(i) A method comprising applying an effective amount of a bite inhibitor containing an insecticidal component to the body surface of a centipede.
(ii) A method comprising applying an insecticidal composition containing an insecticidal component to a centipede and concurrently treating the body surface of the centipede with an effective amount of a bite inhibitor.
(iii) After treating the body surface of the centipede with an effective amount of the bite inhibitor, an insecticide composition containing an insecticidal component is applied to the centipede while the bite inhibitory effect of the bite inhibitor is maintained. method involving

The insecticidal component and other components contained in the insecticide composition are not particularly limited as long as they do not impair the effects of the present invention, and known components can be used as appropriate. As the insecticidal component, for example, the above insecticidal component that can be contained in the bite inhibitor can be preferably used. In addition, the formulation and application method of the insecticide composition are not particularly limited, and in the above (ii) and (iii), the formulation and application method of the insecticide composition and the formulation and treatment method of the bite inhibitor. may be different from each other.

Such an insecticidal method includes applying an effective amount of a centipede bite inhibitor to the body surface of the centipede to suppress the centipede bite, so that the centipede is not bitten until the centipede is knocked down by the insecticidal component. can be suppressed. This provides a safer method of killing centipedes.

EXAMPLES The present invention will be described in more detail below with reference to Examples, but the present invention is not limited to these.

[Test Example 1]
Using each of the specimens shown in Table 1, it was tested whether or not each specimen inhibited the centipede bite.
(Test method)
(1) One centipede (Tobis centipede) was placed in a plastic cup with a diameter of 10 cm and a height of 10 cm.
(2) Next, about 0.2 mL of the specimen was dropped near the head of the centipede.
(3) Immediately after dropping, one adult German cockroach was placed in the same plastic cup. After that, it was observed for about 1 minute, and it was confirmed whether the centipede would bite the German cockroach when the centipede and the German cockroach came into contact for the first time, and evaluation was made according to the following criteria. If the observation time is about 1 minute, it can be said that the centipede and the German cockroach usually come into contact with each other at least once during that time.
◯: The centipede did not bite the German cockroach at the first contact.
x: The centipede bit the German cockroach at the first contact.
(4) For each specimen, the plastic cup and test insects (centipedes and German cockroaches) were replaced with new ones each time, and (1) to (3) were repeated three times. However, in Reference Example 1-1, only (1) and (3) were performed three times in total without using a specimen.
Table 1 shows the results of Test Example 1.

Biting by centipedes was confirmed in Reference Example 1-1 in which no specimen was used, whereas biting by centipedes was not confirmed in Examples 1-1 to 1-14. Therefore, it was confirmed that the specimens used in Examples 1-1 to 1-14 can suppress centipede bites.
On the other hand, in Comparative Examples 1-1 to 1-7, centipede bite was confirmed as in Reference Example 1-1. That is, the specimens used in Comparative Examples 1-1 to 1-7 could not suppress the centipede bite. In the table, phytol and geranyllinalool are compounds having 20 carbon atoms (diterpene compounds) having a structure consisting of four isoprene units, and nerolidol and β-caryophyllene are compounds having 15 carbon atoms having a structure consisting of three isoprene units. It is a compound (sesquiterpene compound). Methyl lactate is a 4-carbon lactate alkyl ester. From the above, it was found that selectively using at least one component selected from the group consisting of monoterpene compounds and lactic acid alkyl esters having 5 or more carbon atoms can suppress centipede bites.

[Test Example 2]
The aerosol formulations of Examples 2-1 and 2-2 were prepared as specimens so as to have the formulations shown in Table 2, and each was filled in an aerosol bottle (capacity 100 mL). Using these, it was tested whether each sample inhibits centipede bite. In the table, "DME" represents dimethyl ether contained as an aerosol propellant. The content of the active ingredient (mentone) in the aerosol formulations of Examples 2-1 and 2-2 was 0.67 w/v% of the total amount of the stock solution and the propellant. The specific gravity of the undiluted solution in the aerosol preparation of Example 2-1 is 0.753, and the specific gravity of the undiluted solution in the aerosol preparation of Example 2-2 is 0.791.

(Test method)
(1) One centipede (Tobis centipede) was placed in a plastic cup with a diameter of 10 cm and a height of 10 cm.
(2) Next, the specimen was injected for 1 second onto the centipede (injection amount: about 2 g).
(3) It was confirmed whether the centipede bites the German cockroach by the same procedure as in Test Example 1 (3), and the same criteria as in Test Example 1 (3) were used for evaluation.
(4) For each specimen, the plastic cup and test insects (centipedes and German cockroaches) were replaced with new ones each time, and (1) to (3) were repeated three times.
Table 3 shows the results of Test Example 2.

According to the results in Table 3, it was confirmed that the aerosol formulations of Examples 2-1 and 2-2 could also suppress centipede bites. The aerosol agent of Example 2-2 is a bite inhibitor further containing permethrin, which is an insecticidal component. According to the aerosol formulation of Example 2-2, centipede bites can be suppressed until the centipede is knocked down by the insecticidal component.

[Test Example 3]
The aerosol preparations of Comparative Example 3-1 and Example 3-1 were prepared as specimens so as to have the formulations shown in Table 4, and each was filled in an aerosol bottle (capacity: 100 mL). Using these, it was tested whether each sample inhibits centipede bite. The content of the active ingredient (mentone) in the aerosol formulation of Example 3-1 was 0.5 w/v% of the total amount of the stock solution and the propellant. The specific gravity of the stock solution in the aerosol formulation of Example 3-1 is 0.752.

(Test method)
(1) One centipede (Tobis centipede) was placed in a plastic cup with a diameter of 10 cm and a height of 10 cm.
(2) Next, the specimen was injected for 0.5 second onto the centipede (injection amount: about 1 g).
(3) It was confirmed whether the centipede bites the German cockroach by the same procedure as in Test Example 1 (3), and the same criteria as in Test Example 1 (3) were used for evaluation.
(4) For each specimen, the plastic cup and test insects (centipedes and German cockroaches) were replaced with new ones each time, and (1) to (3) were repeated three times.
Table 5 shows the results of Test Example 3.

Both the aerosol formulations of Comparative Example 3-1 and Example 3-1 contain the insecticidal component permethrin. Therefore, centipedes were knocked down after each test using the aerosol formulations of Comparative Example 3-1 and Example 3-1. That is, according to the results in Table 5, the aerosol formulation of Example 3-1 containing the active ingredient can also suppress centipede bites until the centipede is knocked down by the insecticidal ingredient. On the other hand, in the aerosol formulation of Comparative Example 3-1 containing no active ingredient, although the centipede was knocked down by the insecticidal ingredient, the bite of the centipede could not be suppressed until the centipede was knocked down.

Claims (2)

A centipede bite inhibitor containing, as an active ingredient, at least one selected from the group consisting of monoterpene compounds and lactic acid alkyl esters having 5 or more carbon atoms. A method for inhibiting centipede bites by treating the centipede body surface with the centipede bite inhibitor according to claim 1 .