JP2023008341A - antiviral material - Google Patents

Abstract

To provide an antiviral material that has a high inactivation effect against the new coronavirus (SARS-CoV-2) and can be applicable to various products for new coronavirus countermeasures.SOLUTION: An antiviral material has a substrate and a metal thin film formed on the substrate, and the metal thin film is formed by metal deposition means using pure copper or an alloy containing copper and zinc. By forming a thin film of these metals on the substrate by means of metal deposition means, it is possible to obtain an inactivation effect against the new coronavirus that is even higher than the inactivation effect of these metals themselves.SELECTED DRAWING: Figure 3

Description

TECHNICAL FIELD The present invention relates to an antiviral material having a high inactivation effect against the novel coronavirus (SARS-CoV-2).

Acute respiratory disease (COVID-19), caused by infection with a novel coronavirus (SARS-CoV-2), emerged in 2019 and is still prevalent worldwide. The new coronavirus is transmitted between humans through droplet infection caused by droplets generated by coughing and sneezing, or contact infection through objects that come into contact with hands, such as doorknobs.

It is recommended to wear a mask that covers the nose and mouth to suppress the spread of droplets generated by coughing and sneezing, and to prevent the new coronavirus from entering the human body through the mouth. It is also recommended to take measures such as installing a partition panel or the like between people facing each other or adjacent to each other in places where eating, drinking, customer service, or meetings are held.

However, if the virus is simply captured by the mask, the virus remains in the mask itself. If the mask body is touched when the mask is removed, the remaining virus may adhere to the hands and enter the human body through the mouth, or may adhere to doorknobs and the like to spread the virus again.

The same is true for the partition panel, and if the virus attached to the panel surface is not removed with alcohol or the like, there is a risk that the virus remaining on the partition panel will spread again.

Conventionally, although it is for influenza virus countermeasures, a mask using an anti-influenza virus agent that inactivates influenza viruses in the nonwoven fabric of the mask body has also been proposed (for example, Patent Document 1). According to such a mask, the influenza virus trapped in the mask body is inactivated by the anti-influenza virus agent, so re-spreading of the influenza virus can be suppressed.

JP-A-08-333271

By the way, the influenza virus and the new coronavirus have a common structural feature in that they have an envelope. However, it cannot be said that a substance that has an inactivating effect on influenza viruses necessarily has an inactivating effect on the novel coronavirus. Similarly, substances that have an inactivating effect against other coronaviruses (SARS-CoV and MERS-CoV) cannot necessarily be said to have an inactivating effect against the novel coronavirus.

An object of the present invention is to provide an antiviral material that has a high inactivation effect against the novel coronavirus (SARS-CoV-2) and that can be applied to various products for countermeasures against the novel coronavirus. and

The inventor of the present application has extensively studied substances that have an inactivating effect against the new coronavirus, and has found that pure copper and some alloys containing copper and zinc have a high inactivating effect against the new coronavirus. got In addition, by forming a thin film of these metals on a base material using a metal film-forming means, it is possible to obtain an antiviral material that has an inactivation effect that is higher than the inactivation effect of these metals themselves and that has a different tendency. I also got the knowledge that

The antiviral material of the present invention is
a substrate;
and a metal thin film formed on the base material,
The metal thin film is formed by a metal deposition means using pure copper or an alloy containing copper and zinc,
It is an antiviral material.

According to the present invention, there is provided an antiviral material that has a high inactivation effect against the novel coronavirus (SARS-CoV-2) and that can be applied to various products for countermeasures against the novel coronavirus. can be done.

FIG. 1 is a graph showing the inactivation of novel coronavirus (SARS-CoV-2) by copper and copper alloy thin film slabs after 10 or 20 minutes. FIG. 2a is an enlarged photograph of the spunbond nonwoven fabric before metal vapor deposition, and FIG. 2b is an enlarged photograph of the spunbond nonwoven fabric after metal vapor deposition. FIG. 3 is a graph showing the inactivation of novel coronavirus (SARS-CoV-2) by nonwoven fabric deposited with copper and copper alloy after 0 and 3 minutes. Figure 4 shows the infection titer of the new coronavirus (SARS-CoV-2) after 0, 0.5, 1 and 2 minutes after contact with a non-woven fabric deposited with a copper alloy (JIS C2100). It is a graph showing. Figure 5 shows the effect on the inactivation of the new coronavirus (SARS-CoV-2) after 0 and 3 minutes when pure copper is vapor-deposited by changing the basis weight (weight per unit area of the non-woven fabric) of the non-woven fabric. is a graph showing Figure 6 shows the novel coronavirus (SARS-CoV-2) after 0 and 3 minutes when a copper alloy (JIS C2600) is vapor-deposited by changing the basis weight (weight per unit area of the non-woven fabric) of the non-woven fabric. 10 is a graph showing the effect on inactivation. FIG. 7 is a graph showing the inactivation of the novel coronavirus (SARS-CoV-2) by a polycarbonate plate vapor-deposited with a copper alloy (JIS C2100, C2200) after 0, 1 and 3 minutes. FIG. 8 is a front view of a mask according to Example 4 of the present invention. 9 is a cross-sectional view taken along the line A--A of FIG. 8. FIG. 10 is a cross-sectional view of the vicinity of area B in FIG. 9. FIG.

An antiviral material according to one embodiment of the present invention is
a substrate;
and a metal thin film formed on the base material,
The metal thin film is formed by a metal film forming means using pure copper or an alloy containing copper and zinc (first configuration).

According to the above configuration, by using pure copper or an alloy containing copper and zinc to form a metal thin film on the base material by a metal film forming means, the plate-like body of pure copper or an alloy containing copper and zinc It is possible to enhance the inactivation effect against the new coronavirus.
Therefore, it is possible to provide an antiviral material that has a high inactivation effect against the novel coronavirus and can be applied to various products for countermeasures against the novel coronavirus.

In the above first configuration,
Of the pure copper used in the metal film forming means, or an alloy containing copper and zinc,
The pure copper has a Cu content of 99.90 mass% or more,
The alloy has a Cu content of 68.5 mass% or more and 96.0 mass% or less, a Pb content of 0.05 mass% or less, an Fe content of 0.05 mass% or less, and the balance being Zn and unavoidable impurities,
The inactivation effect (Mv) after 3 minutes calculated by the following formula from the infection titer of the new coronavirus (SARS-CoV-2) measured by the plaque method may be 3.0 or more (Second configuration).
Inactivation effect (Mv) = log (Ct/C0) - log (Nt/N0)
Ct: Infectious titer after control t hours C0: Infectious titer after control 0 hours Nt: Infectious titer after test article t hours NO: Infectious titer after test article 0 hours

According to the above configuration, pure copper or an alloy containing copper and zinc in a predetermined ratio is used to form a metal thin film on the base material by a metal film-forming means, resulting in a high inactivation effect against the new coronavirus. and can be used as an antiviral material that can be applied to various products for measures against the new coronavirus.
Specifically, with pure copper or an alloy plate containing copper and zinc, the inactivation effect (Mv) against the new coronavirus may not reach 3.0 even after 10 minutes. , An antiviral material in which a thin film of these metals is formed on a substrate by a metal film-forming method has an inactivation effect (Mv) of 3.0 or more after 3 minutes, and is extremely strong against the new coronavirus. An inactivation effect (Mv) can be exhibited.

In the above first configuration,
The alloy has a Cu content of 94.0 mass% or more and 96.0 mass% or less, a Pb content of 0.05 mass% or less, an Fe content of 0.05 mass% or less, and the balance being Zn and unavoidable impurities (third configuration).

According to the above configuration, a metal thin film is formed on the base material by a metal film forming means using an alloy of copper and zinc having a Cu content of 94.0 mass% or more and 96.0 mass%. It is possible to exhibit a high inactivation effect against
Specifically, in a copper-zinc alloy plate having a Cu content of 94.0 mass% or more and 96.0 mass%, the inactivation effect (Mv) against the new coronavirus is shown even after 10 minutes. While it is less than 3.0 (2.77), the inactivation effect (Mv) is 5.0 after 3 minutes when a metal thin film is formed on the substrate using the same alloy by the metal film forming means. The above (5.98) is reached, and a very strong inactivation effect (Mv) can be exhibited against the new coronavirus.

In the above first configuration,
The inactivation effect (Mv) for the new coronavirus (SARS-CoV-2) after 3 minutes is the same metal plate as the metal used in the metal film formation means, and the new coronavirus is inactivated after 10 minutes. It may be higher than the effect (Mv) (fourth configuration).

According to the above configuration, by using pure copper or an alloy containing copper and zinc to form a metal thin film on the base material by a metal film forming means, it is possible to exhibit a high inactivation effect against the new coronavirus. can.
Specifically, in a plate-shaped body of pure copper or an alloy containing Cu and Zn in a predetermined ratio, the inactivation effect (Mv) against the new coronavirus is less than 3.0 even after 10 minutes, The antiviral material, in which a metal thin film is formed on the base material using the same metal by metal film-forming means, has an inactivation effect (Mv) of 3.0 or more after 3 minutes, and is extremely effective against the new coronavirus. A strong inactivation effect (Mv) can be exhibited.

In the above first configuration,
The Cu content is in the range of 94.0 mass% or more and 96.0 mass% or less, the Pb content is 0.05 mass% or less, the Fe content is 0.05 mass% or less, and the balance is Zn and inevitable impurities. The antiviral material formed using the obtained alloy, and the inactivation effect (Mv) on the new coronavirus (SARS-CoV-2) after 3 minutes is
The Cu content is in the range of 89.0 mass% or more and 91.0 mass% or less, the Pb content is 0.05 mass% or less, the Fe content is 0.05 mass% or less, and the balance is Zn and inevitable impurities. It may be higher than the inactivation effect (Mv) after 3 minutes on the new coronavirus (SARS-CoV-2) of the antiviral material formed using the obtained alloy (fifth configuration ).

According to the above configuration, a metal thin film is formed on the base material by a metal film forming means using an alloy of copper and zinc having a Cu content of 94.0 mass% or more and 96.0 mass%. It is possible to exhibit a high inactivation effect against
Specifically, in the alloy plate containing copper and zinc, the inactivation effect (Mv) against the new coronavirus after 10 minutes is The alloy of copper and zinc with a Cu content of 89.0 mass% or more and 91.0 mass% is higher than the alloy of and zinc,
In the antiviral material in which a thin film of these metals was formed on the base material by the metal film-forming means, the tendency of the inactivation effect (Mv) against the new coronavirus after 3 minutes changed, and the Cu content was 94. A copper-zinc alloy with a Cu content of 0 mass% or more and 96.0 mass% is higher than a copper-zinc alloy with a Cu content of 89.0 mass% or more and 91.0 mass%.

In any one of the first to fifth configurations,
The base material is a nonwoven fabric,
The lighter the weight per unit area of the nonwoven fabric, the higher the inactivation effect (Mv) for the novel coronavirus (SARS-CoV-2) after 3 minutes (sixth configuration).

According to the above configuration, when the base material is a nonwoven fabric, by selecting a material with a lighter weight per unit area, it is possible to exhibit a higher inactivation effect against the new coronavirus.

In any one of the first to fifth configurations,
The base material is a plate-shaped body formed of a synthetic resin material,
The light transmittance of the metal thin film may be 50% or less (seventh configuration).

According to the above configuration, the base material is a plate-shaped body formed of a synthetic resin material, and the light transmittance of the metal thin film formed by the metal film forming means using pure copper or an alloy containing copper and zinc is 50% or less. By doing so, it is possible to produce an antiviral material that exhibits a high inactivation effect against the new coronavirus and allows light to pass through.

A mask may be configured using an antiviral material in which the base material in any one of the first to sixth configurations is a nonwoven fabric (eighth configuration).

According to the above configuration, it is possible to provide a mask that has a high inactivation effect against the new coronavirus (SARS-CoV-2) and can suppress the re-spreading of the new coronavirus.

A partition may be configured using the antiviral material having any one of the first to seventh configurations (ninth configuration).

According to the above configuration, it is possible to provide a partition that has a high inactivation effect against the new coronavirus (SARS-CoV-2) and can suppress the re-spreading of the new coronavirus.

[Embodiment]
The antiviral material according to the present invention is constructed by forming a metal thin film on a base material by a metal film forming means using pure copper or an alloy containing copper and zinc.

The base material may be any material to which a metal thin film can be attached, and examples thereof include nonwoven fabrics, synthetic resin panels, and films. In addition, even if the material is difficult to adhere a metal thin film to, it is possible to allow the metal thin film to adhere by painting or pretreatment. Products using antiviral materials include masks, partition panels, face shields, air filters, foot wipe mats, and other products that require antiviral properties against the new coronavirus. As the base material, for example, a nonwoven fabric can be selected as a base material for a mask, and a translucent synthetic resin plate or film can be used as a base material for a partition panel or a face shield. can.

Non-woven fabrics are defined in JIS-L0222 as "fiber sheets, webs or batts, in which the fibers are oriented in one direction or randomly, and the fibers are bound by entanglement, fusion, and/or adhesion. However, excluding paper, woven fabrics, knitted fabrics, tufts and fulled felts”. Although the manufacturing method of the nonwoven fabric is not limited, nonwoven fabrics suitable for masks include spunbond nonwoven fabrics and meltblown nonwoven fabrics. Paper, woven fabrics, knitted fabrics, tufts, and flattened felts are not included in nonwoven fabrics, but can be used as the base material of the antiviral material of the present invention.

The synthetic resin material is not particularly limited, and any material to which a metal thin film can be attached may be used. For example, polycarbonate or acrylic can be used as the material for the partition panel.

A known metal film-forming means can be used to form the metal thin film on the substrate. The metal film-forming means may be either a physical film-forming method (Physical Vapor Deposition) or a chemical film-forming method (Chemical Vapor Depositions). A method such as sputtering can be selected. Vacuum deposition is a means of heating a metal to evaporate or sublimate it in a vacuum to form a metal thin film on a substrate. Metal can be heated by resistance heating or high frequency induction heating. Sputtering is a means of forming a metal thin film on a substrate by ionizing argon gas in a chamber and making it collide with a metal deposition material (target). In this embodiment, the metal thin film is formed by a resistance heating type vacuum vapor deposition means. In order to improve the adhesion of the metal thin film, an undercoat may be applied to the substrate surface, or argon gas may be introduced into the atmosphere for forming the thin film.

The amount of the metal thin film attached can be controlled by the film thickness, but since the light transmittance decreases as the amount of the metal thin film attached increases, the amount of the metal thin film attached should be controlled by the light transmittance. can also In this embodiment, a transparent synthetic resin plate is placed together with a base material in a vacuum vapor deposition apparatus, and the light transmittance (visible light transmittance) of the synthetic resin plate is measured after the vapor deposition process to determine the adhesion amount of the metal thin film. managing. In this embodiment, "TLV-304-BP" manufactured by Asahi Spectrosco Co., Ltd. was used as a visible light transmittance measuring device, and the visible light transmittance was measured at a measurement wavelength of 550 nm.

[Antiviral evaluation]
In order to evaluate the antiviral property of the antiviral material according to the embodiment, the antiviral material using nonwoven fabric and polycarbonate as the base material was used to evaluate the inactivation effect against the novel coronavirus. In addition, in order to compare the antiviral properties of the metal material itself and the antiviral properties of the metal thin film, we also evaluated the inactivation effect of copper and copper alloy thin film flat plates (copper and copper alloy plates). rice field.

[material]
Test virus: Novel coronavirus (SARS-CoV-2; 2019-nCoV JPN/TY/WK-521 strain)
・VeroE6 cells were infected with the novel coronavirus, and the cells confirmed to have a cytopathic effect were collected and cryopreserved in a freezer at -80°C.
- After repeated freezing and thawing twice, the mixture was centrifuged, and the supernatant was concentrated and purified by microfiltration and ultrafiltration.
- This was used as a test virus solution, and stored frozen in a -80°C freezer until testing.

[Calculation of inactivation effect]
The inactivation effect was calculated as follows.
Inactivation effect (Mv) = log (Ct/C0) - log (Nt/N0)
=logCt/Nt
Ct: Infectious titer after control t hours C0: Infectious titer after control 0 hours Nt: Infectious titer after test article t hours NO: Infectious titer after test article 0 hours logCt: Infectious titer after control t hours Numeric logNt: A common logarithmic value Mv≧3.0 of the infectivity titer after t hours of test article is considered to be sufficiently effective (ISO 18184).

[Calculation of reduction rate (%)]
The reduction rate was calculated from the logarithmic reduction value (=Mv) as follows.
Reduction rate (%) = (1-1/10 ^ (logarithmic reduction value)) x 100

[Comparative example]
[Antiviral property test by thin film plate of copper and copper alloy]
In order to compare with the antiviral material, an antiviral test was conducted on pure copper and alloy thin plates containing copper and zinc (plates made of pure copper and copper alloys).

Table 1 shows the kind names and chemical compositions of copper and copper alloys (wrought copper products (JIS products)).
C1020 is pure copper and has a Cu content of 99.96 mass % or more, with the remainder being inevitable impurities. In general, copper having a Cu content of 99.90 mass % to 99.95 mass % or more is called pure copper.
C2100, C2200, C2600, C2680, and C2810 are alloys containing predetermined proportions of copper and zinc, respectively.
C2100 has a Cu content of 94.0 mass% or more and 96.0 mass% or less, a Pb content of 0.05 mass% or less, an Fe content of 0.05 mass% or less, and the balance being Zn and It is regarded as an unavoidable impurity.
Similarly, C2200, C2600, C2680, and C2810 each contain copper and zinc in the proportions shown in Table 1.

[Test method]
A 2.5 cm square thin film flat plate (copper or copper alloy plate) was used as a test sample, and a glass plate was used as a control.
・50 μl of the novel coronavirus was inoculated into the test sample and covered with a 2 cm square film.
- Protein (Bovine serum albumin) was added to the new coronavirus to be inoculated to make the protein concentration 3 mg/ml, which is the same as saliva.
- Each was allowed to stand under room temperature conditions for 10 minutes or 20 minutes.
- After the action time, the virus fluid was recovered with 5 ml of EDTA-containing DMEM medium.
- VeroE6 cells were infected with the recovered solution, and the virus infectivity titer was measured by the plaque method.
- After culturing for 3 days, the cells were observed, and the virus infectivity titer and virus inactivation effect were calculated.

The test results of this test are shown below.
Table 2 is a table showing the infectivity titer, inactivation effect (Mv), and reduction rate after 10 minutes or 20 minutes of novel coronavirus by copper and copper alloy thin film plates.
FIG. 1 is a graph showing inactivation of novel coronavirus by copper and copper alloy thin film plates after 10 or 20 minutes.

As shown in Table 2 and FIG. 1, it was found that the inactivation effect of C2200 (about 90% Cu and about 10% Zn) is relatively high in copper and copper alloy plates. For C2200, it was confirmed that the virus amount decreased to below the detection limit after 10 minutes.
The inactivation effect (Mv) of C2200 after 10 minutes was 6.31, reaching Mv≧3.0, which is considered to be sufficiently effective against the novel coronavirus.
For pure copper (C1020) and alloys of copper and zinc (C2100, C2600, C2680, and C2810) other than C2200, none of the inactivation effects (Mv) after 10 minutes reached Mv≧3.0.

For the inactivation effect (Mv) after 20 minutes, C1020, C2100, and C2600, in addition to C2200, reached Mv≧3.0.
However, unlike C2200, C1020, C2100 and C2600 did not reduce the viral load below the detection limit even after 20 minutes.

From the above, it was found that the inactivation effect of C2200 (about 90% Cu, about 10% Zn) is relatively high in the novel coronavirus inactivation test using thin flat plates (plates) of copper and copper alloys. It was also found that pure copper (C1020) and alloys of copper and zinc (C2100, C2600) also have an inactivating effect on the novel coronavirus. It was also found that C2801 (Cu about 60%, Zn about 40%) has the highest inactivating effect against influenza virus, but is inferior to other alloys in its inactivating effect against the novel coronavirus.

[Example 1]
[Antiviral property test of non-woven fabric deposited with copper and copper alloy]
An antiviral test was conducted on a nonwoven fabric to which a thin film of a metal containing copper or copper and zinc was attached. A spunbond nonwoven fabric was used as the nonwoven fabric, and the basis weight (weight per unit area) of the nonwoven fabric was 30 g/m ² . The metal film forming means was vacuum deposition using a resistance heating method. The adhesion amount (visible light transmittance) of the metal thin film was set to 11%. FIG. 2a is an enlarged photograph of the spunbond nonwoven fabric before metal vapor deposition, and FIG. 2b is an enlarged photograph of the spunbond nonwoven fabric after metal vapor deposition. Note that the larger the visible light transmittance, the thinner the metal thin film, and the smaller the visible light transmittance, the thicker the metal thin film.

[Test method]
・The following tests were performed with reference to ISO 18184 (JIS L 1922) "Antiviral test method for textile products".
- 0.2 mL of virus liquid was dropped onto a 40 mm square test sample and allowed to stand at room temperature for 3 minutes (C2100 was also tested for 0.5 minutes, 1 minute, and 2 minutes).
- Protein (Bovine serum albumin) was added to the new coronavirus to be inoculated to make the protein concentration 3 mg/ml, which is the same as saliva.
・After the action time, the test product and 3 to 4 glass beads were added to 5 ml of DMEM medium containing EDTA, and the virus solution was recovered by stirring with a vortex.
- VeroE6 cells were infected with the recovered solution, and the virus infectivity titer was measured by the plaque method.
- After culturing for 3 days, the cells were observed, and the virus infectivity titer and virus inactivation effect were calculated.

The test results of this test are shown below.
Table 3 is a table showing the infectivity titer, inactivation effect (Mv), and reduction rate of the new coronavirus after 0 and 3 minutes by nonwoven fabrics on which copper and copper alloys are vapor-deposited.
FIG. 3 is a graph showing the inactivation of the novel coronavirus after 0 and 3 minutes by the non-woven fabric deposited with copper and copper alloy.

As shown in Table 3 and FIG. 3, the inactivation effect (Mv) after 3 minutes of the non-woven fabric vapor-deposited with pure copper and copper alloy, and the inactivation after 10 minutes with the same metal thin film plate (plate) When comparing the effect (Mv), it was found that the non-woven fabric vapor-deposited with pure copper and copper alloy had a higher deactivation effect (Mv), except for some copper alloys (C2200).
In particular, Cu (C1020, about 99.9% Cu), C2100 (about 95% Cu, about 5% Zn), C2200 (about 90% Cu, about 10% Zn), and C2600 (about 70% Cu, about Zn 30%), the inactivation effect is very high. The inactivation effect (Mv) of the nonwoven fabric to which these metal thin films are attached is 4.0 to 5.0 or more after only 3 minutes, and the Mv is considered to be sufficiently effective against the new coronavirus. ≧3.0 is reached.
For C2680 and C2801, the inactivation effect (Mv) after 3 minutes did not reach Mv≧3.0, but an effect close to the inactivation effect (Mv) after 10 minutes by the plate-like body of the same alloy was obtained. (see Table 2).

For Cu (C1020, Cu about 99.9%), C2100 (Cu about 95%, Zn about 5%), and C2600 (Cu about 70%, Zn about 30%), in thin film plates (platelets), While the inactivation effect (Mv) against the new coronavirus is less than 3.0 even after 10 minutes (see Table 2), an antivirus in which a metal thin film is formed on the substrate using the same metal by metal film-forming means The inactivating effect (Mv) of the material reached 3.0 or more after 3 minutes, demonstrating a very strong inactivating effect (Mv) against the new coronavirus.

For C2200 (Cu about 90%, Zn about 10%), the inactivation effect (Mv) for the new coronavirus after 10 minutes is 3.0 or more (6.31) in the thin film plate (plate). On the other hand (see Table 2), the antiviral material in which a metal thin film was formed on the substrate using C2200 by the metal film-forming means had an inactivation effect (Mv) of 3.0 or more (5. 10), and exhibits a very strong inactivation effect (Mv) against the new coronavirus even in the state of a metal thin film.

For C2100 (Cu about 95%, Zn about 5%), in the state of thin film plate (plate), the inactivation effect (Mv) after 10 minutes is less than 3.0 (2.77), after 20 minutes While the inactivation effect (Mv) of C2100 is 5.32 (see Table 2), the inactivation effect (Mv) is 5.0 after 3 minutes when the metal thin film is formed on the nonwoven fabric using C2100. The above (5.98) is reached, which is higher than the inactivation effect (Mv) of the metal plate itself, and exhibits a very strong inactivation effect (Mv) against the new coronavirus.

Comparing C2100 (Cu about 95%, Zn about 5%) and C2200 (Cu about 90%, Zn about 10%), in the state of thin film plate (plate), the inactivation effect (Mv) after 10 minutes C2200 exerts the highest effect at 6.31 while C2100 does not reach Mv≧3.0 at 2.77 (see Table 2). That is, in the state of a thin film flat plate (plate-like body), the inactivation effect (Mv) tends to satisfy C2100<C2200. However, the non-woven fabrics vapor-deposited with C2100 and C2200 have inactivation effects (Mv) after 3 minutes of C2100 (Mv=5.98) and C2200 (Mv=5.10), respectively. In other words, when C2100 and C2200 are vapor-deposited, the tendency of the inactivation effect (Mv) on the new coronavirus changes to C2100>C2200, and it was found that C2100 exhibits the highest inactivation effect.

Here, a shorter time antiviral test with C2100 (~95% Cu, ~5% Zn) vapor-deposited nonwoven fabric is described.
Table 4 shows the infectivity value, inactivation effect (Mv), and reduction rate of the novel coronavirus after 0 minutes, 0.5 minutes, 1 minute, and 2 minutes after non-woven fabric deposited with a copper alloy (JIS C2100). is a table showing
FIG. 4 is a graph showing the infection titer of the new coronavirus after 0, 0.5, 1 and 2 minutes after contact with a non-woven fabric deposited with a copper alloy (JIS C2100).

As shown in Table 4 and FIG. 4, when a metal thin film was formed on the nonwoven fabric using C2100, the inactivation effect (Mv) against the new coronavirus was 2.76 after 0.5 minutes and The viral load decreased by 99.9979%, the inactivation effect (Mv) was 4.69, reaching Mv≧3.0, and after only 2 minutes, the viral load reached the limit of detection and the inactivation effect (Mv ) is 5.98.
As described above, it was found that the antiviral material in which a metal thin film is formed on a nonwoven fabric using C2100 can exhibit an extremely strong inactivation effect (Mv) against the new coronavirus.

[Example 2]
[Antiviral test with different nonwoven fabric thickness (basis weight)]
An antiviral material was formed by changing the thickness (basis weight/weight per unit area) of the nonwoven fabric used as the base material, and attaching a thin film of pure copper or an alloy containing copper and zinc to form an antiviral material, and an antiviral test was performed. A spunbond nonwoven fabric was used as the nonwoven fabric, and the basis weight (weight per unit area) of the nonwoven fabric was 20 (g/m ² ), 30 (g/m ² ), and 40 (g/m ² ). The thickness of the nonwoven fabric increases as the basis weight of the nonwoven fabric increases. The metal film forming means was vacuum deposition using a resistance heating method. The adhesion amount (visible light transmittance) of the metal thin film was set to 11%.

[Test method]
[Nonwoven fabric]
・The following tests were performed with reference to ISO 18184 (JIS L 1922) "Antiviral test method for textile products".
- 0.2 mL of virus solution was dropped onto a 40 mm square test sample, and left at room temperature for 3 minutes.
- Protein (Bovine serum albumin) was added to the new coronavirus to be inoculated to make the protein concentration 3 mg/ml, which is the same as saliva.
・After the action time, the test product and 3 to 4 glass beads were added to 5 ml of DMEM medium containing EDTA, and the virus solution was recovered by stirring with a vortex.
- VeroE6 cells were infected with the recovered solution, and the virus infectivity titer was measured by the plaque method.
- After culturing for 3 days, the cells were observed, and the virus infectivity titer and virus inactivation effect were calculated.

The test results of this test are shown below.
Table 5 shows the infectivity value and inactivation effect (Mv) of the new coronavirus after 0 minutes and 3 minutes when copper (JIS C1020) and copper alloy (JIS C2600) are vapor-deposited by changing the basis weight of the nonwoven fabric. and reduction rate.
FIG. 5 is a graph showing the effect on the inactivation of the new coronavirus after 0 and 3 minutes when pure copper (JIS C1020) is vapor-deposited on a non-woven fabric with different basis weight.
FIG. 6 is a graph showing the effect on the inactivation of the novel coronavirus after 0 and 3 minutes when a copper alloy (JIS C2600) is vapor-deposited by changing the basis weight of the non-woven fabric.

As shown in Table 5 and FIG. 5, the inactivation effect (Mv ) is 3.0 to 5.0 or more after only 3 minutes, regardless of the basis weight of the nonwoven fabric, and has reached Mv ≥ 3.0, which is considered to be sufficiently effective against the new coronavirus. .

For Cu (C1020, about 99.9% Cu), the infectivity of the nonwoven fabric with a basis weight of 20 reaches the detection limit in just 3 minutes. The infectivity titers of the nonwoven fabrics with basis weights of 30 and 40 did not reach the detection limit after 3 minutes.

Regarding C2600 (Cu about 70%, Zn about 30%), none of the nonwoven fabrics of any basis weight reached the detection limit after 3 minutes. Infectivity decreased in the order of basis weight 20, 30, and 40, and inactivation effect (Mv) also increased.

Regarding the relationship between the basis weight of the nonwoven fabric and the deactivation effect (Mv), in the case of Cu (C1020, Cu about 99.9%), in the case of C2600 (Cu about 70%, Zn about 30%), after 3 minutes The inactivation effect (Mv) is 20>30>40.
In other words, when the base material is a nonwoven fabric, a higher inactivation effect against the novel coronavirus can be exhibited by selecting a material with a lighter weight per unit area.

[Example 3]
[Antiviral property test using a synthetic resin plate on which a copper alloy is vapor-deposited]
An antiviral test was conducted on a synthetic resin plate to which a thin film of metal containing copper and zinc was attached. The material of the synthetic resin plate was polycarbonate. The metal film forming means was vacuum deposition using a resistance heating method. The adhesion amount (visible light transmittance) of the metal thin film was set to 50%. When the visible light transmittance is 50%, the back side can be seen through the synthetic resin plate.

[Test method]
[Polycarbonate]
- The test was conducted as follows according to ISO21702.
・A 5 cm square copper alloy vapor-deposited polycarbonate was used as the test piece.
- The test sample was inoculated with 150 μl of the new coronavirus and covered with a 4 cm square film.
- Each was allowed to stand at room temperature for 1 minute or 3 minutes.
- After the action time, the virus fluid was recovered with 5 ml of EDTA-containing DMEM medium.
- VeroE6 cells were infected with the recovered solution, and the virus infectivity titer was measured by the plaque method.
- After culturing for 3 days, the cells were observed, and the virus infectivity titer and virus inactivation effect were calculated.

The test results of this test are shown below.
Table 6 shows the infectivity value, inactivation effect (Mv), and reduction rate of the new coronavirus after 0, 1, and 3 minutes by a polycarbonate plate deposited with a copper alloy (JIS C2100, C2200). It is a table showing
FIG. 7 is a graph showing the inactivation of the novel coronavirus by a polycarbonate plate deposited with a copper alloy (JIS C2100, C2200) after 0, 1 and 3 minutes.

As shown in Table 6 and FIG. 7, the deactivation effect (Mv) after 3 minutes of polycarbonate plates vapor-deposited with copper alloys (C2100, C2200) and 10 A comparison of the deactivation efficiencies (Mv) after minutes (see Table 2) revealed that for C2100, the vapor-deposited polycarbonate plates had higher deactivation efficiencies (Mv).

For C2100 (Cu about 95%, Zn about 5%), the virus load decreased by 99.9932% after just 1 minute, and the inactivation effect (Mv) reached 4.0 or more (4.17), Mv > 3.0, which is considered sufficiently effective against the virus. After 3 minutes, the amount of virus was confirmed to decrease below the detection limit, and the inactivation effect (Mv) was 5.0 or more (5.21).

For C2200 (Cu about 90%, Zn about 10%), after 3 minutes, the virus amount was confirmed to decrease below the detection limit, and the inactivation effect (Mv) was 5.0 or more (5.21). It reached Mv ≥ 3.0, which is considered to be sufficiently effective against the new coronavirus.

In this way, according to the inactivation test of the new coronavirus using a polycarbonate plate on which a copper alloy (C2100, C2200) is vapor-deposited, even if the amount of deposited metal thin film is small (visible light transmittance of 50%), Regardless, the result was that a sufficient inactivation effect was obtained against the new coronavirus in just 3 minutes.

[Example 4]
[Mask using antiviral material]
The antiviral material of the present invention described above has a very high inactivation effect against the novel coronavirus. An example of a mask constructed using the antiviral material of the present invention will be described below.

First, the overall configuration of the mask 100 will be described. FIG. 8 is a front view of a mask according to Example 4 of the present invention. 9 is a cross-sectional view taken along the line A--A of FIG. 8. FIG. 10 is a cross-sectional view of the vicinity of area B in FIG. 9. FIG. As shown in FIG. 8, the mask 100 includes a mask body 10, a shape-retaining member 30, and ear hooks 50. As shown in FIG. The mask 100 of this embodiment is a so-called pleated mask. The mask body 10 is a member that covers a predetermined range of the user's face (for example, a range including the nose and mouth) by spreading pleats (folds) 25 for use.

The mask body 10 is constructed by laminating three layers of nonwoven fabrics, a surface layer 21, an intermediate layer 22, and a back layer 23 (see FIG. 10). The surface layer 21, the intermediate layer 22, and the back layer 23 are formed with a plurality of pleats 25 extending in the left-right direction in a laminated state. Top, bottom, left and right sides of the surface layer 21 , the intermediate layer 22 , and the back layer 23 are fixed by welding portions 27 .

When the user wears the mask 100 on the face, the surface layer 21 of the mask 100 is placed on the side opposite to the face, and the back layer 23 of the mask 100 is placed on the face side. The antiviral material according to the present invention is used for the surface layer 21 .

The antiviral material uses a non-woven fabric as the base material, selects pure copper that has a high inactivation effect against the new coronavirus, or an alloy containing copper and zinc, and applies a metal thin film to the base material by metal film-forming means. It can be configured by forming.

The intermediate layer 22 is a layer that traps viruses, bacteria, etc. inside the surface layer 21 . A meltblown nonwoven fabric can be used as the intermediate layer 22 . The back layer 23 is a nonwoven fabric layer that is placed on the user's face while the mask 100 is worn by the user. Since the back layer 23 comes into contact with the user's face, it is preferable to use a highly flexible nonwoven fabric.

The thickness and the like of the non-woven fabric constituting the surface layer 21, the intermediate layer 22, and the back layer 23 are not particularly limited, but the barrier properties of the mask body 10 should be such that PFE, BFE, and VFE are each 99% or more. It is preferable to select the nonwoven fabrics that constitute the surface layer 21, the intermediate layer 22, and the back layer 23. PFE is the collection efficiency of particles of about 0.1 μm size, BFE is the collection efficiency of particles containing bacteria of about 0.3 μm size, and VFE is the collection efficiency of particles of about 0.1 μm to 5.0 μm size, including viruses. It shows the collection efficiency of the particles.

The shape retaining member 30 is a member that retains the shape of the mask body 10 . In this embodiment, a first shape-retaining member 31 and a second shape-retaining member 32 are provided as the shape-retaining member 30 .

The first shape-retaining material 31 is arranged near the upper side of the mask body 10 and held between the folded nonwoven fabrics (surface layer 21, intermediate layer 22, and back layer 23) (see FIG. 10). . The first shape retaining member 31 is a member also called a nose fitter.

The second shape-retaining member 32 is arranged near the center in the vertical direction of the mask body 10 and held between the surface layer 21 and the intermediate layer 22 (see FIGS. 3 and 4). The second shape-retaining member 32 is a member for keeping the shape of the mask body 10 curved so that the central portion of the mask body 10 is less likely to come into contact with the face when the mask body 10 is placed on the face of the user. is.

The antiviral material according to the present invention can be used as the shape-retaining material 30 (31, 32). In this case, resin such as polypropylene, metal such as aluminum, or a combination of resin and metal is used as the base material. Pure copper, which has a high inactivation effect against the new coronavirus, or an alloy containing copper and zinc is selected and used, and an antiviral material is used by forming a metal thin film on the substrate by metal film-forming means. A shape-retaining material 30 (31, 32) can be configured.

The ear hook portion 50 is a member that is hung on the ear (auricle) to fix the mask body 10 to the wearer's face when the user wears the mask 100 on the face. The ends of the ear hooks 50 are attached to the sides of the mask body 10 by welds 28 .

The antiviral material according to the present invention can be used for the ear hook portion 50 . In this case, for example, the substrate can be a stretchable woven fabric. For example, it is possible to use a fabric structure in which the warp and the weft are woven by tubular weaving and the front and back structures are connected with rubber threads. By adopting a fabric structure using high-count yarns for the warp yarns, the ear hooking part 50 is soft and pleasant to the touch, so that the mask 100 can be made so that the ears are less likely to hurt even if the mask is worn for a long time. In addition, the base material of the antiviral material may be a woven fabric, or the fibers constituting the woven fabric may be used as the base material of the antiviral material.

According to the mask described above, it is possible to provide a mask that has a high inactivation effect against the new coronavirus (SARS-CoV-2) and can suppress the re-spreading of the new coronavirus.

[Example 5]
[Partition using antiviral material]
An example of a partition constructed using the antiviral material of the present invention will be described.

Partitions are installed between people who face each other or are adjacent to each other in a place where eating, drinking, customer service, or meetings are held. Partitions can take various forms, such as a freestanding type, a hanging type, a panel-like hard type, and a sheet-like flexible type.

When applying the antiviral material according to the present invention to a partition, a translucent synthetic resin plate or film can be used as the base material. Note that the partition does not necessarily have to be transparent, and a translucent or opaque partition can be used as necessary.

The metal thin film attached to the base material may be attached to both sides of the base material, or may be attached to only one side. The amount of metal thin film attached is determined so as to satisfy both the required light transmittance and the inactivation effect against the novel coronavirus. The light transmittance may be the 50% used in Example 3, or if necessary, the light transmittance may be increased by reducing the amount of metal thin film attached, or by increasing the amount of metal thin film attached. The light transmittance may be lowered by

A metal thin film may be formed in a gradation so that the light transmittance is changed depending on the part of the partition. In this case, the light transmittance may be set high for a portion that needs to be visually recognized through the partition, and the light transmittance may be set low for the other portions. In this case, it is possible to achieve both visibility and an inactivation effect against the novel coronavirus.

Acrylic is generally used as a material for the partition panel, but it is preferable to use polycarbonate as the base material for the antiviral material because acrylic does not easily adhere to metal thin films. Argon gas may be used to roughen the surface of the substrate (make it uneven) so that the metal thin film can easily adhere to it.

According to the partition described above, it is possible to provide a partition that has a high inactivation effect against the new coronavirus (SARS-CoV-2) and can suppress the re-spreading of the new coronavirus.

[Modification]
The antiviral material according to the present invention is not limited to the embodiment described above. The pure copper and the alloy of copper and zinc used for the metal film formation were JIS standard products, but are not limited to this, and any pure copper or alloy of copper and zinc specified in the present invention can be used. be able to.

Although the embodiments of the present invention have been described above, the above-described embodiments are merely examples for carrying out the present invention. Therefore, the present invention is not limited to the above-described embodiment, and can be implemented by appropriately modifying the above-described embodiment without departing from the scope of the invention.

Claims (9)

a substrate;
and a metal thin film formed on the base material,
The metal thin film is formed by a metal deposition means using pure copper or an alloy containing copper and zinc,
Antiviral material. Of the pure copper used in the metal film forming means, or an alloy containing copper and zinc,
The pure copper has a Cu content of 99.90 mass% or more,
The alloy has a Cu content of 68.5 mass% or more and 96.0 mass% or less, a Pb content of 0.05 mass% or less, an Fe content of 0.05 mass% or less, and the balance being Zn and unavoidable impurities,
The inactivation effect (Mv) after 3 minutes calculated by the following formula from the infection titer of the new coronavirus (SARS-CoV-2) measured by the plaque method is 3.0 or more.
The antiviral material according to claim 1.
Inactivation effect (Mv) = log (Ct/C0) - log (Nt/N0)
Ct: Infectious titer after control t hours C0: Infectious titer after control 0 hours Nt: Infectious titer after test article t hours NO: Infectious titer after test article 0 hours The alloy has a Cu content of 94.0 mass% or more and 96.0 mass% or less, a Pb content of 0.05 mass% or less, an Fe content of 0.05 mass% or less, and the balance being Zn and unavoidable impurities,
The antiviral material according to claim 1. The inactivation effect (Mv) for the new coronavirus (SARS-CoV-2) after 3 minutes is the same metal plate as the metal used in the metal film formation means, and the new coronavirus is inactivated after 10 minutes. higher than efficacy (Mv),
The antiviral material according to claim 1. The Cu content is in the range of 94.0 mass% or more and 96.0 mass% or less, the Pb content is 0.05 mass% or less, the Fe content is 0.05 mass% or less, and the balance is Zn and inevitable impurities. The antiviral material formed using the obtained alloy, and the inactivation effect (Mv) on the new coronavirus (SARS-CoV-2) after 3 minutes is
The Cu content is in the range of 89.0 mass% or more and 91.0 mass% or less, the Pb content is 0.05 mass% or less, the Fe content is 0.05 mass% or less, and the balance is Zn and inevitable impurities. higher than the inactivation effect (Mv) after 3 minutes on the new coronavirus (SARS-CoV-2) of the antiviral material formed using the alloy obtained,
The antiviral material according to claim 1. The base material is a nonwoven fabric,
The lighter the weight per unit area of the nonwoven fabric, the higher the inactivation effect (Mv) after 3 minutes for the new coronavirus (SARS-CoV-2).
The antiviral material according to any one of claims 1 to 5. The base material is a plate-shaped body formed of a synthetic resin material,
The light transmittance of the metal thin film is set to 50% or less,
The antiviral material according to any one of claims 1 to 5. 7. A mask according to any one of claims 1 to 6, which is constructed using an antiviral material in which the base material is a non-woven fabric. A partition constructed using the antiviral material according to any one of claims 1 to 7.

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