JP2023004122A - High-sensitivity particle concentration measurement device - Google Patents

Abstract

To improve fat measurement accuracy in a low concentration range.SOLUTION: A high-sensitivity particle concentration measurement device designed to be used under irradiation light to a subject is provided, the device comprising a received light intensity detection unit having a photosensitivity in a range of 500 pW to 400 nW, inclusive, and being configured to detect intensity of received light emanating from the subject, and a control unit configured to derive particle concentration within the subject from the received light intensity.SELECTED DRAWING: Figure 1

Description

The embodiments described in this specification relate to a high-sensitivity particle concentration measurement device that improves measurement sensitivity in a low concentration region and reduces measurement errors due to measurement sites.

Conventional noninvasive lipid measurement in blood calculates lipid concentration from changes in scattering intensity of lipid particles. (See Patent Document 1, for example).

Japanese Patent Application Laid-Open No. 2017-144079

However, in the conventional technique, the received light intensity due to scattering draws an S-shaped curve, and in securing linearity at low values, sufficient resolution may not be obtained, and the correlation may deteriorate. In addition, since the conventional technique targets the vein for measurement, skill is required to determine the measurement site.

An object of the present invention is to improve the accuracy of lipid measurement in the low-concentration range and to reduce the labor required to detect the optimum measurement site.

The present invention is a high-sensitivity particle concentration measuring device used under irradiation light to a subject, which has a light sensitivity of 500 pW or more and 400 nW or less, and a received light intensity detection unit that detects the received light intensity emitted from the subject. and a controller for calculating the particle concentration in the subject from the received light intensity.

The present invention is a high-sensitivity particle concentration measuring device that is used under irradiation light to a subject, has a light sensitivity of 500 pW or more and 400 nW or less, and has a received light intensity detection unit that detects the received light intensity emitted from the subject. is a high-sensitivity particle concentration measurement program that causes the computer to execute a process of calculating the particle concentration in the subject from the received light intensity.

The present invention is a high-sensitivity particle concentration measuring device that is used under irradiation light to a subject, has a light sensitivity of 500 pW or more and 400 nW or less, and has a received light intensity detection unit that detects the received light intensity emitted from the subject. is a high-sensitivity particle concentration measurement method in which the computer calculates the particle concentration in the subject from the received light intensity.

The present invention is a highly sensitive particle connected to a user device that is used under irradiation light to a subject, has a light sensitivity of 500 pW or more and 400 nW or less, and has a light receiving intensity detection unit that detects the light receiving intensity emitted from the subject. A high-sensitivity particle concentration measurement program that causes a computer of a concentration measurement device to execute a process of calculating the concentration of particles in a subject from the received light intensity transmitted from a user device.

The present invention is a highly sensitive particle connected to a user device that is used under irradiation light to a subject, has a light sensitivity of 500 pW or more and 400 nW or less, and has a light receiving intensity detection unit that detects the light receiving intensity emitted from the subject. This is a high-sensitivity particle concentration measurement method in which the computer of the concentration measurement device calculates the particle concentration in the subject from the received light intensity transmitted from the user device.

Schematic diagram of a high-sensitivity particle concentration measuring device. The figure which shows the position of the test object at the time of measurement, and a highly sensitive particle concentration measuring device. The block diagram of the control system of a highly sensitive particle concentration measuring device. Measurement results using a photodiode. Measurement result of fat loading test. The figure which shows the correlation of light reception intensity and lipid concentration. The figure which shows the correlation with an intensity|strength and triglyceride concentration. The figure which shows the correlation with an intensity|strength and triglyceride concentration. The figure which shows the correlation with an intensity|strength and triglyceride concentration. 4 is a flow chart of high-sensitivity particle concentration measurement operation; Schematic diagram of a high-sensitivity particle concentration measurement system. The block diagram of the control system of a highly sensitive particle concentration measuring device. 4 is a flow chart of high-sensitivity particle concentration measurement operation;

Embodiments will be described below with reference to the drawings. In the embodiments, lipids in blood are taken as an example of particles to be measured. However, the object to be measured is not limited to blood lipids, and the particle concentration of any component in the living body can be measured.

FIG. 1 is a diagram schematically showing a configuration example of a high-sensitivity particle concentration measuring device 100 according to an embodiment. As shown in FIG. 1, the high-sensitivity particle concentration measuring device 100 has a light blocking plate 11, a received light intensity detection section 12, an irradiation section 13, and a control section .

FIG. 2 is a diagram showing the positions of the subject and the high-sensitivity particle concentration measuring device during measurement. The light shielding plate 11 of the embodiment is a plate made of black plastic. Blocks light B. The shape of the light shielding plate 11 of the embodiment is elliptical. The shape, size, and material of the light shielding plate 11 are not limited to those described above, and may have a function of shielding a predetermined range around the received light intensity detecting section 12 from light.

By shielding the irradiation light B from the irradiation-light shielding boundary position to the light receiving point, the light that has passed a certain distance within the skin layer can be selected and measured. Thereby, the SN ratio can be increased. It should be noted that there is a possibility that measurement can be performed even with weak light and in a close proximity state by devising such as giving periodicity to the light.

Furthermore, the reason why it is desirable that the irradiation light be planar is that the incident angle with respect to the subject should not be perpendicular, and any light source having diffusivity can be substituted.

The received light intensity detection unit 12 of the embodiment receives light emitted from inside the subject C to the outside of the subject C. As shown in FIG. The received light intensity detector 12 of the embodiment is a photodiode. The received light intensity detection unit 12 is not limited to a photodiode, and may be a CCD or CMOS. The received light intensity detector 12 may be configured to receive light with a wavelength other than visible light. The received light intensity detector 12 is provided substantially at the center of the light shielding plate 11 . However, the received light intensity detection section 12 is not limited to the central portion, and it is sufficient if a light-shielded area is formed around the received light intensity detection section 12 . The received light intensity detector 12 is controlled by the controller 14 . The received light intensity detector 12 transmits the detected light intensity to the controller 14 .

The light receiving sensitivity of the received light intensity detection unit 12 of the embodiment is 500 pW or more and 400 nW or less, preferably 500 pW or more and 200 nW or less, more preferably 500 pW or more and 80 nW or less, and still more preferably 500 pW or more and 40 nW or less. The light-receiving sensitivity of the light-receiving intensity detector 12 may be set by a fixed circuit that adjusts the resistance applied to the photodiode.

The irradiation unit 13 of the embodiment irradiates the irradiation light B. As shown in FIG. The irradiation unit 13 of the embodiment does not come into contact with the subject and is arranged with a predetermined distance from the subject. As a result, the light from the irradiation unit 13 is diffused, and the irradiation light to the subject becomes planar. The irradiation unit 13 of the embodiment is arranged at a predetermined distance from the received light intensity detection unit 12 and arranged in a circular shape with the received light intensity detection unit 22 as the center. good. Note that the arrangement of the irradiation units 13 is not limited to this, and it is sufficient that irradiation can be performed over a wide range. The irradiation unit 13 is, for example, a fluorescent lamp, an LED, a laser, an incandescent lamp, an HID, a halogen lamp, or the like. The illuminance of the irradiation unit 13 is controlled by the control unit 14 . It is also possible to increase the irradiation intensity, target veins, and search for vein position information. Also, the irradiation area may be about the surface area of the LED, but a wider range is preferable. Although the irradiation unit 13 of the embodiment does not come into contact with the subject, it may be brought into contact with the subject as long as it can irradiate in a plane with an LED or the like.

In the embodiment, the irradiation unit 13 is provided in the apparatus, but indoor light (fluorescent lamp, LED, laser, incandescent lamp, HID, halogen lamp, etc.) outside the apparatus may be used.

Next, the configuration of the control system of the highly sensitive particle concentration measuring device 100 will be described. FIG. 3 is a block diagram of the highly sensitive particle concentration measuring device 100 of the embodiment. Via system bus 142, CPU (Central Processing Unit) 141, ROM (Read Only Memory) 143, RAM (Random Access Memory) 144, HDD (Hard Disk Drive) 145, external I/F (Interface) 146, received light intensity The detection unit 12 and the irradiation unit 13 are connected. The CPU 141 , ROM 143 and RAM 144 constitute the control section 14 .

The ROM 143 preliminarily stores programs to be executed by the CPU 141 and threshold values.

The RAM 144 has various memory areas such as an area for developing programs executed by the CPU 141 and a work area for data processing by the programs.

The HDD 145 stores the data of the calibration curve created by a plurality of people to correlate the lipid concentration with the received light intensity or the amount of change in the received light intensity. The HDD 145 may be any device that stores data in a non-volatile manner, such as an SSD (Solid State Drive) or the like.

The external I/F 146 is an interface for communicating with an external device such as a client terminal (PC). The external I/F 146 may be an interface that performs data communication with an external device. It may be an interface.

In the high-sensitivity particle concentration measurement device 100 having the configuration described above, the high-sensitivity particle concentration measurement device 100 executes a particle concentration measurement job based on a preset program.

As shown in FIG. 2, in the embodiment, the received light intensity is measured without bringing the irradiation unit 13 into contact with the subject C. As shown in FIG. This reduces the measurement error due to the measurement site. The irradiation unit 13 planarly irradiates the irradiation light B toward the surface of the subject. Although the irradiation unit 13 of the embodiment does not come into contact with the subject, it may be brought into contact with the subject as long as it can irradiate in a plane with an LED or the like.

In the conventional method, the light source was brought into close contact with the living body in order to allow the light to enter the living body efficiently. In addition, when diffusion approximation, which is the conventional measurement principle, is used, it is desirable that the light source is a point light source or a light source that can be regarded as a point light source.

However, in the conventional measurement principle based on the diffusion approximation, since the actual living body is not a homogeneous system, there was a difference in the measured value depending on the measurement site.

In the embodiment, the irradiation unit 13 is provided, but it is also possible to use illumination light provided in the room where the high-sensitivity particle concentration measuring device 100 is installed, or a wide range of irradiation by natural light (sunlight, moonlight, etc.). good. In this case, the irradiation section 13 becomes unnecessary.

The irradiating unit 13 was considered to have the effect of averaging complex tissues by irradiating light over a wide area, and verification was performed using indoor lighting. At the same time, the light receiving sensitivity range of the light receiving intensity detecting section 12 (photodiode) was set as shown in Table 1 in order to verify the improvement of the low-value density.

In the embodiment, a fluorescent lamp for indoor lighting is used as the irradiation unit 13 . In the case of a fluorescent lamp for indoor lighting, the irradiation light is applied to the subject over a wide area in a planar manner. In the case of a fluorescent lamp, since the frequency of the household power source is 50 Hz, the signal with periodicity is considered to be the light transmitted through the subject from the fluorescent lamp as the light source.

FIG. 4 shows the results of measurement using a photodiode adjusted to each light sensitivity range shown in Table 1 as the light intensity detector 12 . As a result, the periodicity of the fluorescent lamp could not be confirmed with the photodiode with low light sensitivity.

However, as the light receiving sensitivity of the light receiving intensity detecting section 12 was increased, the periodicity of the fluorescent lamps could be confirmed. Since periodicity has begun to be confirmed under the condition D in Table 1, it is considered desirable that the upper limit of the received light intensity of the received light intensity detection unit 12 can be measured at 400 nW or less. From the results shown in FIG. 4, the upper limit of the received light intensity of the received light intensity detection unit 12 is preferably 200 nW, more preferably 80 nW or less, and even more preferably 40 nW or less.

On the other hand, the lower limit of the light receiving sensitivity of the light receiving intensity detection unit 12 may be any sensitivity that can detect the light receiving intensity, for example, 500 pW or more.

The control unit 14 calculates the lipid concentration from the received light intensity detected by the received light intensity detection unit 12 .

Lipid concentration refers to changes in the average particle size and number of lipid particles such as chylomicrons and VLDL in the blood. Changes in lipid particle concentration increase the scattering coefficient of blood, a phenomenon that affects the intensity of received light. refers to something that has a causal relationship with

As shown in FIG. 6, the method of calculating the lipid concentration is to measure the correlation between the received light intensity and the lipid concentration in advance by a plurality of people, and linearly or curve-approximate the distribution of the received light intensity and the lipid concentration to generate a calibration curve (for example, , y=−0.0441x+48.34 in the figure) is stored in the HDD 145, and the control unit 14 calculates the lipid concentration corresponding to the received light intensity from the statistical data.

Although the statistical data is stored in the HDD 145 in the embodiment, it may be stored in the RAM 144 as well.

In order to examine whether the low value measurement of lipid fluctuation is improved or not, a fat loading test was performed and measured. The results are shown in FIG. 5, and changes in wave height were observed as the triglyceride concentration increased over time.

Next, the wave height of the received light intensity was defined as the intensity (Intensity), and the correlation with the triglyceride concentration was confirmed. As a result, as shown in FIG. 7, the correlation coefficient between the received light intensity and the triglyceride concentration showed a good correlation of 0.823.

FIG. 7 shows the measurement of the forearm, and FIG. 8 shows the result of similarly measuring the wrist. As shown in Fig. 8, the correlation coefficient between the received light intensity and the triglyceride concentration is 0.7 or more, which is a good correlation. rice field.

Similarly, even when the triglyceride concentration was low, as shown in FIG. 9, the correlation coefficient between the received light intensity and the triglyceride concentration was 0.7 or more, indicating a good correlation.

In other words, in non-invasive lipid measurement, by setting the received light intensity to 500 pW or more and 400 nW or less in order to measure accurately, even a person with a low lipid level can be measured, and the complexity of positioning is greatly improved.

In the high-sensitivity particle concentration measuring device 100 having the configuration as described above, the high-sensitivity particle concentration measuring device 100 executes high-sensitivity particle concentration measuring processing based on a preset program.

FIG. 10 is a flow chart of processing for high-sensitivity particle concentration measurement.

The irradiating unit irradiates the subject with light over a wide area at a predetermined irradiation position (STEP 101), and the light receiving sensitivity is 500 pW or more and 400 nW or less, preferably 500 pW or more and 200 nW or less, more preferably 500 pW or more and 80 nW or less, and even more preferably. is set to 500 pW or more and 40 nW or less detects the received light intensity emitted from the subject (STEP 102), and the controller calculates the particle concentration in the subject from the received light intensity (STEP 103). In addition, indoor illumination light or natural light may be used as the irradiation light.

Further, a light shielding part for shielding the surface of the subject from light may be further provided around the received light intensity detection part, and the particle concentration may be the lipid concentration. It should be noted that the specific contents of processing and the range of photosensitivity have been described above, so descriptions thereof will be omitted.

In the embodiment, the received light intensity detection unit and the control unit are configured as an integrated device, but the present invention is not limited to this. A sensor (CMOS, etc.) may be used, and the control unit may be installed in a server device or the like connected to the user device via a network. Furthermore, the data transmission from the measurement unit to the calculation unit may be wireless or wired, and may be selected according to the communication environment.

FIG. 11 shows a system configuration diagram of the embodiment. The system has a sensitive particle concentration measuring device 200 , a user device 300 and an access point 400 .

The user device 300 has an irradiation unit 313 that irradiates the subject with light over a wide area, and a received light intensity detection unit 32 that detects the received light intensity emitted from the subject. The light sensitivity of the received light intensity detection unit 32 of the user device 300 is set to 500 pW to 400 nW, preferably 500 pW to 200 nW, more preferably 500 pW to 80 nW, further preferably 500 pW to 40 nW. The user device 300 may further include a light blocking section 31 around the received light intensity detecting section 32 for blocking light to the surface of the subject.

The high-sensitivity particle concentration measuring device 200 of the embodiment is communicably connected to the user device 300 via the access point 400 or the like. The high-sensitivity particle concentration measurement device 200 has a control unit 24 that calculates the particle concentration from the received light intensity transmitted from the user device 300 . Illumination light or natural light may be used as the irradiation light. The particle concentration may be lipid concentration or turbidity notation. It should be noted that since the specific contents of the processing have been described above, the description thereof will be omitted.

The high-sensitivity particle concentration measuring device 200 of the embodiment is, for example, a server device. The configuration of the control system of the high-sensitivity particle concentration measuring device 200 of the embodiment will be described. FIG. 12 is a block diagram of a highly sensitive particle concentration measuring device 200 of the embodiment. A CPU 202 , a ROM (Read Only Memory) 203 , a RAM (Random Access Memory) 204 , an external I/F (Interface) 205 and a storage unit 23 are connected via a system bus 208 . The CPU 202 , ROM 203 and RAM 204 constitute a control unit 24 .

The ROM 203 stores programs to be executed by the CPU 202 and threshold values in advance.

In the RAM 204, various memory areas such as an area for loading programs executed by the CPU 202 and a work area for data processing by the program are dynamically formed.

The storage unit 23 stores statistical data obtained by using a calibration curve created by a plurality of people for the correlation between the lipid concentration and the received light intensity or the amount of change in the received light intensity. The storage unit 23 may be any device that stores data in a non-volatile manner, and is internal storage such as an SSD (Solid State Drive) or HDD (Hard Disc Drive).

Although the statistical data is stored in the storage unit 23 in the embodiment, it may be stored in the RAM 204 .

The controller 24 calculates the particle concentration from the received light intensity.

An external I/F 205 is an interface for communicating with an external device. The external I/F 205 may be any interface that performs data communication with an external device. For example, the external I/F 205 may be a device (such as a USB memory) that is locally connected to an external device, or a network interface for communicating via a network. Furthermore, the data communication method may be Wi-Fi (registered trademark) communication or USB communication.

In the high-sensitivity particle concentration measurement device 200 having the configuration as described above, the high-sensitivity particle concentration measurement device 200 executes high-sensitivity particle concentration measurement processing based on a preset program.

FIG. 13 is a flow chart of the operation of high-sensitivity particle concentration measurement. The irradiating unit of the user device 300 irradiates the subject with a wide range of planar light at a predetermined irradiation position (STEP 201), and sets the light sensitivity to 500 pW or more and 400 nW or less, preferably 500 pW or more and 200 nW or less, more preferably 500 pW or more and 80 nW. Thereafter, the received light intensity detection unit of the user device 300, which is more preferably set to 500 pW or more and 40 nW or less, detects the received light intensity emitted from the subject (STEP 202), and the highly sensitive particle concentration measuring device 200 control unit receives the light. A particle concentration in the subject is calculated from the intensity (STEP 203). In addition, indoor illumination light or natural light may be used as the irradiation light.

Further, a light shielding unit for shielding the surface of the subject from light may be further provided around the received light intensity detection unit of the user device 300, and the particle concentration may be the lipid concentration. It should be noted that since the specific contents of the processing have been described above, the description thereof will be omitted.

Although the embodiment has been described above, this embodiment is presented as an example and is not intended to limit the scope of the invention. This novel embodiment can be embodied in various other forms, and various omissions, replacements, and modifications can be made without departing from the scope of the invention. This embodiment and its modifications are included in the scope and gist of the invention, and are included in the scope of the invention described in the claims and its equivalents.

100: Highly sensitive particle concentration measuring device 11: Light shielding plate 12: Received light intensity detection unit 13: Irradiation unit 14: Control unit

Claims (12)

A high-sensitivity particle concentration measuring device used under irradiation light to a subject,
a light receiving intensity detection unit that has a light receiving sensitivity of 500 pW or more and 400 nW or less and detects the light receiving intensity emitted from the subject;
a control unit that calculates the particle concentration in the subject from the received light intensity;
A high-sensitivity particle concentration measuring device with 2. The high-sensitivity particle concentration measuring device according to claim 1, wherein the light receiving sensitivity of said light receiving intensity detecting section is 500 pW or more and 200 nW or less. 2. The high-sensitivity particle concentration measuring device according to claim 1, wherein the light receiving sensitivity of said light receiving intensity detecting section is 500 pW or more and 80 nW or less. 2. The high-sensitivity particle concentration measuring device according to claim 1, wherein the light receiving sensitivity of said light receiving intensity detecting section is 500 pW or more and 40 nW or less. 5. The high-sensitivity particle concentration measuring device according to claim 1, further comprising an irradiation unit for irradiating said predetermined irradiation light. 6. The high-sensitivity particle concentration measuring device according to claim 1, further comprising a light shielding part for shielding light to the surface of the object around said received light intensity detecting part. 7. The highly sensitive particle concentration measuring device according to any one of claims 1 to 6, wherein the particle concentration is lipid concentration. A computer of a high-sensitivity particle concentration measuring device having a light receiving intensity detection unit that is used under irradiation light to a subject, has a light receiving sensitivity of 500 pW or more and 400 nW or less, and detects the light receiving intensity emitted from the subject. ,
A high-sensitivity particle concentration measurement program for executing a process of calculating the particle concentration in the subject from the received light intensity. A computer of a high-sensitivity particle concentration measuring device that is used under irradiation light to a subject, has a light sensitivity of 500 pW or more and 400 nW or less, and has a received light intensity detection unit that detects the received light intensity emitted from the subject. ,
A high-sensitivity particle concentration measurement method for calculating the particle concentration in the subject from the received light intensity. A high-sensitivity particle concentration measurement device that is used under irradiation light to a subject, has a light sensitivity of 500 pW or more and 400 nW or less, and has a light reception intensity detection unit that detects the light reception intensity emitted from the subject, and is connected to a user device. and
A high-sensitivity particle concentration measurement device having a controller that calculates the particle concentration in the subject from the received light intensity transmitted from the user device. A high-sensitivity particle concentration measurement device that is used under irradiation light to a subject, has a light sensitivity of 500 pW or more and 400 nW or less, and has a light reception intensity detection unit that detects the light reception intensity emitted from the subject, and is connected to a user device. on the computer of
A high-sensitivity particle concentration measurement program for executing a process of calculating the particle concentration in the subject from the received light intensity transmitted from the user device. A high-sensitivity particle concentration measurement device that is used under irradiation light to a subject, has a light sensitivity of 500 pW or more and 400 nW or less, and has a light reception intensity detection unit that detects the light reception intensity emitted from the subject, and is connected to a user device. the computer of
A high-sensitivity particle concentration measurement method for calculating a particle concentration in the subject from the received light intensity transmitted from the user device.

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