JP2022553824A5 - - Google Patents
Info
- Publication number
- JP2022553824A5 JP2022553824A5 JP2022525803A JP2022525803A JP2022553824A5 JP 2022553824 A5 JP2022553824 A5 JP 2022553824A5 JP 2022525803 A JP2022525803 A JP 2022525803A JP 2022525803 A JP2022525803 A JP 2022525803A JP 2022553824 A5 JP2022553824 A5 JP 2022553824A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid vector
- vector according
- transcription factor
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962930520P | 2019-11-04 | 2019-11-04 | |
| US62/930,520 | 2019-11-04 | ||
| US202063024959P | 2020-05-14 | 2020-05-14 | |
| US63/024,959 | 2020-05-14 | ||
| PCT/US2020/058795 WO2021091950A1 (en) | 2019-11-04 | 2020-11-04 | Vestibular supporting cell promoters and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022553824A JP2022553824A (ja) | 2022-12-26 |
| JP2022553824A5 true JP2022553824A5 (https=) | 2023-11-10 |
Family
ID=75848663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022525803A Pending JP2022553824A (ja) | 2019-11-04 | 2020-11-04 | 前庭支持細胞プロモーター及びその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20220331449A1 (https=) |
| EP (1) | EP4076467A4 (https=) |
| JP (1) | JP2022553824A (https=) |
| CN (2) | CN119391775A (https=) |
| TW (1) | TWI902721B (https=) |
| WO (1) | WO2021091950A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220054640A1 (en) * | 2018-12-11 | 2022-02-24 | Decibel Therapeutics, Inc. | Compositions and methods for the delivery of therapeutic agents across the round window membrane |
| CN118043468A (zh) * | 2021-06-11 | 2024-05-14 | 分贝治疗公司 | 用于内耳中的细胞类型特异性基因表达的组合物和方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002082904A2 (en) * | 2001-04-13 | 2002-10-24 | The Trustees Of The University Of Pennsylvania | Method of treating or retarding the development of blindness |
| US20070161031A1 (en) * | 2005-12-16 | 2007-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Functional arrays for high throughput characterization of gene expression regulatory elements |
| WO2008076556A2 (en) * | 2006-11-15 | 2008-06-26 | Massachusetts Eye & Ear Infirmary | Generation of inner ear cells |
| WO2009108274A2 (en) * | 2008-02-26 | 2009-09-03 | The University Of North Carolina At Chapel Hill | Methods and compositions for adeno-associated virus (aav) with hi loop mutations |
| WO2012149038A1 (en) * | 2011-04-25 | 2012-11-01 | Advanced Bioscience Laboratories, Inc. | Truncated hiv envelope proteins (env), methods and compositions related thereto |
| MX367100B (es) * | 2012-02-17 | 2019-08-05 | The Children´S Hospital Of Philadelphia | Composiciones del vector aav y metodos para su transferencia genetica a celulas, organos y tejidos. |
| US20140024663A1 (en) * | 2012-07-17 | 2014-01-23 | Georgia Health Sciences University Research Institute, Inc. | Atb(0,+) amino acid transporter as a drug target for treatment of estrogen receptor-positive breast cancer |
| US20150209406A1 (en) * | 2012-09-07 | 2015-07-30 | Massachusetts Eye And Ear Infirmary | Methods and compositions for regenerating hair cells and/or supporting cells |
| US20160298080A1 (en) * | 2013-12-03 | 2016-10-13 | The Johns Hopkins University | Method for highly efficient conversion of human stem cells to lineage-specific neurons |
| SG10201913266UA (en) * | 2015-12-11 | 2020-02-27 | Massachusetts Eye & Ear Infirmary | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
| EP3407901B1 (en) * | 2016-01-29 | 2021-07-21 | Massachusetts Eye & Ear Infirmary | Expansion and differentiation of inner ear supporting cells and methods of use thereof |
| US11191847B2 (en) * | 2016-04-15 | 2021-12-07 | The Trustees Of The University Of Pennsylvania | Gene therapy for treating hemophilia B |
| WO2018145111A1 (en) * | 2017-02-06 | 2018-08-09 | Children's Medical Center Corporation | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
| US20190345516A1 (en) * | 2018-03-12 | 2019-11-14 | Musc Foundation For Research Development | Methods for treating eye disease |
-
2020
- 2020-11-04 TW TW109138358A patent/TWI902721B/zh active
- 2020-11-04 CN CN202411518110.7A patent/CN119391775A/zh active Pending
- 2020-11-04 EP EP20885698.9A patent/EP4076467A4/en active Pending
- 2020-11-04 CN CN202080091035.4A patent/CN115052634B/zh active Active
- 2020-11-04 WO PCT/US2020/058795 patent/WO2021091950A1/en not_active Ceased
- 2020-11-04 JP JP2022525803A patent/JP2022553824A/ja active Pending
-
2022
- 2022-05-03 US US17/735,221 patent/US20220331449A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Gou et al. | miR-210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia | |
| Xiao et al. | miR-605 joins p53 network to form a p53: miR-605: Mdm2 positive feedback loop in response to stress | |
| JP2022553824A5 (https=) | ||
| CN101603042B (zh) | 可用于乙型肝炎病毒感染治疗的rna干扰靶点 | |
| JP2023500672A5 (https=) | ||
| US20230136245A1 (en) | Gene therapy for neurodegenerative disorders using polynucleotide silencing and replacement | |
| Jie et al. | Generation of MiRNA sponge constructs targeting multiple MiRNAs | |
| CN102356156A (zh) | 用于治疗神经退行性疾病或与细胞周期未预期激活相关疾病的包含编码cdk4/cdk6抑制子的诱导型基因的载体 | |
| KR20110110058A (ko) | miRNA의 발현 억제를 이용한 성체줄기세포의 노화 억제 방법 | |
| JP2023500670A5 (https=) | ||
| JP2024517250A5 (https=) | ||
| RU2023130395A (ru) | Промоторы вестибулярных поддерживающих клеток и их применение | |
| CN110129318A (zh) | 长链非编码rna pralr及其表达质粒和用途 | |
| CN110760583A (zh) | 一种长链非编码rna bc088259及其应用 | |
| Kesireddy et al. | Multipurpose modular lentiviral vectors for RNA interference and transgene expression | |
| US20070036740A1 (en) | Modulation of hair growth | |
| CN109136377B (zh) | 成人t细胞白血病的治疗药物及诊断试剂盒 | |
| CN102639560A (zh) | 靶向Sipa1l1的siRNA用于降低脂肪生成的用途 | |
| US20220186228A1 (en) | Synthetic microrna mimics | |
| RU2816137C1 (ru) | Двухцепочечная РНК, способная снижать экспрессию мутантного аллеля с.607GA гена GNAO1 человека | |
| Takizawa et al. | Basic and clinical studies on functional RNA molecules for advanced medical technologies | |
| Geller et al. | Functional promoter testing using a modified lentiviral transfer vector | |
| CN102203128A (zh) | Plac8活性抑制剂用于调控脂肪生成的用途 | |
| CN120603946A (zh) | circRNA表达构建体 | |
| Harper et al. | Construction of Small-Hairpin RNA Expression Vectors |