JP2022541013A - 肝臓ｘ受容体アゴニストでマイボーム腺機能不全を治療するための方法 - Google Patents

肝臓ｘ受容体アゴニストでマイボーム腺機能不全を治療するための方法 Download PDF

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JP2022541013A
JP2022541013A JP2022502212A JP2022502212A JP2022541013A JP 2022541013 A JP2022541013 A JP 2022541013A JP 2022502212 A JP2022502212 A JP 2022502212A JP 2022502212 A JP2022502212 A JP 2022502212A JP 2022541013 A JP2022541013 A JP 2022541013A
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trifluoromethyl
phenyl
lxr
agonist
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JP2022541013A5 (https=
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エム． アダムス，クリストファー
ファン，チャン
テイゼイラ，サンドラ
チボドー，ブレット
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ノバルティス アーゲー
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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JP2022502212A 2019-07-15 2020-07-13 肝臓ｘ受容体アゴニストでマイボーム腺機能不全を治療するための方法 Pending JP2022541013A (ja)

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US201962874433P 2019-07-15 2019-07-15
US62/874,433 2019-07-15
US201962939138P 2019-11-22 2019-11-22
US62/939,138 2019-11-22
PCT/IB2020/056584 WO2021009664A1 (en) 2019-07-15 2020-07-13 Methods for treating meibomian gland dysfunction with liver x receptor agonists

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JP2022541013A true JP2022541013A (ja) 2022-09-21
JP2022541013A5 JP2022541013A5 (https=) 2023-07-20

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US (1) US20220257596A1 (https=)
EP (1) EP3999055A1 (https=)
JP (1) JP2022541013A (https=)
CN (1) CN114126618A (https=)
WO (1) WO2021009664A1 (https=)

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JP2024518128A (ja) * 2021-05-20 2024-04-24 ノバルティス アーゲー ３－（（３－（４－（２－（イソブチルスルホニル）フェノキシ）－３－（トリフルオロメチル）フェニル）－１，２，４－オキサジアゾール－５－イル）メチル）－５，５－ジメチル－１－（２－モルホリノエチル）イミダゾリジン－２，４－ジオンの製剤
CN115607547A (zh) * 2021-07-14 2023-01-17 厦门大学 一种睑板腺功能障碍动物模型的造模药物、构建方法与应用
CN119732940A (zh) * 2024-12-27 2025-04-01 重庆医科大学 肝x受体激动剂在改善和/或治疗抑郁样行为中的应用

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JP2021534212A (ja) * 2018-08-24 2021-12-09 ゼニオプロ ゲーエムベーハー 病的状態の治療における使用のための芳香族分子

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EP3999055A1 (en) 2022-05-25

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