JP2022537214A - メープルシロップ尿症(msud)の処置のおける使用のための酵素の生合成 - Google Patents
メープルシロップ尿症(msud)の処置のおける使用のための酵素の生合成 Download PDFInfo
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- C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962865129P | 2019-06-21 | 2019-06-21 | |
| US201962864875P | 2019-06-21 | 2019-06-21 | |
| US62/864,875 | 2019-06-21 | ||
| US62/865,129 | 2019-06-21 | ||
| PCT/US2020/038813 WO2020257707A1 (en) | 2019-06-21 | 2020-06-19 | Biosynthesis of enzymes for use in treatment of maple syrup urine disease (msud) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022537214A true JP2022537214A (ja) | 2022-08-24 |
| JPWO2020257707A5 JPWO2020257707A5 (enExample) | 2023-06-27 |
Family
ID=74037433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021576258A Pending JP2022537214A (ja) | 2019-06-21 | 2020-06-19 | メープルシロップ尿症(msud)の処置のおける使用のための酵素の生合成 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20220348933A1 (enExample) |
| EP (2) | EP3986432A4 (enExample) |
| JP (1) | JP2022537214A (enExample) |
| KR (1) | KR20220042350A (enExample) |
| CN (1) | CN114450403A (enExample) |
| AU (1) | AU2020297586A1 (enExample) |
| CA (1) | CA3144416A1 (enExample) |
| IL (1) | IL289123A (enExample) |
| WO (2) | WO2020257610A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11208649B2 (en) | 2015-12-07 | 2021-12-28 | Zymergen Inc. | HTP genomic engineering platform |
| US9988624B2 (en) | 2015-12-07 | 2018-06-05 | Zymergen Inc. | Microbial strain improvement by a HTP genomic engineering platform |
| US20220031771A1 (en) * | 2020-07-31 | 2022-02-03 | Iowa State University Research Foundation, Inc. | Microencapsulated and chromosome integrated compositions for l-dopa microbiome therapy |
| CN113484435B (zh) * | 2021-07-05 | 2023-04-07 | 中国人民解放军空军军医大学 | 检测血浆支链氨基酸和支链a酮酸水平的物质的应用及产品 |
| WO2024064918A2 (en) * | 2022-09-23 | 2024-03-28 | Novome Biotechnologies, Inc. | Recombinant fusion polypeptides for secreting soluble, heterologous cargo |
| WO2025046062A1 (en) | 2023-08-31 | 2025-03-06 | Snipr Biome Aps | A novel type of crispr/cas system |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104774813A (zh) * | 2015-04-20 | 2015-07-15 | 南京工业大学 | 一种亮氨酸脱氢酶及其制备方法和应用 |
| US20150225750A1 (en) * | 2012-08-17 | 2015-08-13 | Easel Biotechnologies, Llc | Two-Stage Production of Higher Alcohols |
| US20170232043A1 (en) * | 2015-06-10 | 2017-08-17 | Synlogic, Inc. | Bacteria engineered to treat disorders involving the catabolism of a branched chain amino acid |
| CN109321538A (zh) * | 2018-09-07 | 2019-02-12 | 江南大学 | 一种基于数据库基因挖掘方法获得的亮氨酸脱氢酶 |
| CN109679978A (zh) * | 2018-12-12 | 2019-04-26 | 浙江工业大学 | 一种用于制备l-2-氨基丁酸的重组共表达体系及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6119738B2 (ja) * | 2012-03-30 | 2017-04-26 | 味の素株式会社 | 改変ロイシン脱水素酵素 |
| US10059969B1 (en) * | 2014-10-03 | 2018-08-28 | Abbvie Inc. | Process for the preparation of (S)-2-amino-non-8-enoic acid |
| US10610546B2 (en) * | 2015-05-13 | 2020-04-07 | Synlogic Operating Company Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| WO2017123676A1 (en) * | 2016-01-11 | 2017-07-20 | Synlogic, Inc. | Recombinant bacteria engineered to treat diseases and disorders associated with amino acid metabolism and methods of use thereof |
| CN108103038B (zh) * | 2017-12-15 | 2021-03-02 | 江南大学 | 一种合成l-苯甘氨酸的单细胞工厂及其构建与应用 |
| CN108559735B (zh) * | 2018-05-10 | 2020-07-07 | 江南大学 | 一种亮氨酸脱氢酶突变体的构建及其应用 |
| WO2021146394A1 (en) * | 2020-01-14 | 2021-07-22 | Synlogic Operating Company, Inc. | Optimized bacteria engineered to treat disorders involving the catabolism of leucine, isoleucine, and/or valine |
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2020
- 2020-06-19 CN CN202080058809.3A patent/CN114450403A/zh active Pending
- 2020-06-19 EP EP20825572.9A patent/EP3986432A4/en not_active Withdrawn
- 2020-06-19 EP EP20827890.3A patent/EP3987037A4/en not_active Withdrawn
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150225750A1 (en) * | 2012-08-17 | 2015-08-13 | Easel Biotechnologies, Llc | Two-Stage Production of Higher Alcohols |
| CN104774813A (zh) * | 2015-04-20 | 2015-07-15 | 南京工业大学 | 一种亮氨酸脱氢酶及其制备方法和应用 |
| US20170232043A1 (en) * | 2015-06-10 | 2017-08-17 | Synlogic, Inc. | Bacteria engineered to treat disorders involving the catabolism of a branched chain amino acid |
| CN109321538A (zh) * | 2018-09-07 | 2019-02-12 | 江南大学 | 一种基于数据库基因挖掘方法获得的亮氨酸脱氢酶 |
| CN109679978A (zh) * | 2018-12-12 | 2019-04-26 | 浙江工业大学 | 一种用于制备l-2-氨基丁酸的重组共表达体系及其应用 |
Non-Patent Citations (1)
| Title |
|---|
| ACCESSION NO. A0A1T4PGG9, JPN6024021960, ISSN: 0005474547 * |
Also Published As
| Publication number | Publication date |
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| WO2020257610A8 (en) | 2021-01-28 |
| AU2020297586A1 (en) | 2022-02-10 |
| CA3144416A1 (en) | 2020-12-24 |
| US20220362311A1 (en) | 2022-11-17 |
| EP3987037A4 (en) | 2024-01-03 |
| KR20220042350A (ko) | 2022-04-05 |
| CN114450403A (zh) | 2022-05-06 |
| EP3987037A1 (en) | 2022-04-27 |
| EP3986432A4 (en) | 2023-08-30 |
| WO2020257610A1 (en) | 2020-12-24 |
| IL289123A (en) | 2022-02-01 |
| WO2020257707A1 (en) | 2020-12-24 |
| US20220348933A1 (en) | 2022-11-03 |
| EP3986432A1 (en) | 2022-04-27 |
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