CA3144416A1 - Optimized bacteria engineered to treat disorders involving the catabolism of leucine, isoleucine, and/or valine - Google Patents

Optimized bacteria engineered to treat disorders involving the catabolism of leucine, isoleucine, and/or valine Download PDF

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Publication number
CA3144416A1
CA3144416A1 CA3144416A CA3144416A CA3144416A1 CA 3144416 A1 CA3144416 A1 CA 3144416A1 CA 3144416 A CA3144416 A CA 3144416A CA 3144416 A CA3144416 A CA 3144416A CA 3144416 A1 CA3144416 A1 CA 3144416A1
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Prior art keywords
branched chain
amino acid
gene
chain amino
sequence
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Pending
Application number
CA3144416A
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English (en)
French (fr)
Inventor
Ning Li
Jian-rong GAO
Philippa Jane Reeder MORRISON
Christoper George Bergeron
Patrick M. BOYLE
Laura K. STONE
Dylan Alexander CARLIN
Alex C. Tucker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ginkgo Bioworks Inc
Synlogic Operating Co Inc
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Ginkgo Bioworks Inc
Synlogic Operating Co Inc
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Application filed by Ginkgo Bioworks Inc, Synlogic Operating Co Inc filed Critical Ginkgo Bioworks Inc
Publication of CA3144416A1 publication Critical patent/CA3144416A1/en
Pending legal-status Critical Current

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    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
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    • A61K35/74—Bacteria
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    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
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    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
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    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
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    • C12P7/00—Preparation of oxygen-containing organic compounds
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    • C12Y101/01105—Retinol dehydrogenase (1.1.1.105)
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    • C12Y104/01009—Leucine dehydrogenase (1.4.1.9)
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CA3144416A 2019-06-21 2020-06-19 Optimized bacteria engineered to treat disorders involving the catabolism of leucine, isoleucine, and/or valine Pending CA3144416A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962865129P 2019-06-21 2019-06-21
US201962864875P 2019-06-21 2019-06-21
US62/864,875 2019-06-21
US62/865,129 2019-06-21
PCT/US2020/038675 WO2020257610A1 (en) 2019-06-21 2020-06-19 Optimized bacteria engineered to treat disorders involving the catabolism of leucine, isoleucine, and/or valine

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CA3144416A1 true CA3144416A1 (en) 2020-12-24

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CA3144416A Pending CA3144416A1 (en) 2019-06-21 2020-06-19 Optimized bacteria engineered to treat disorders involving the catabolism of leucine, isoleucine, and/or valine

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US (2) US20220348933A1 (enExample)
EP (2) EP3986432A4 (enExample)
JP (1) JP2022537214A (enExample)
KR (1) KR20220042350A (enExample)
CN (1) CN114450403A (enExample)
AU (1) AU2020297586A1 (enExample)
CA (1) CA3144416A1 (enExample)
IL (1) IL289123A (enExample)
WO (2) WO2020257610A1 (enExample)

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WO2024064918A2 (en) * 2022-09-23 2024-03-28 Novome Biotechnologies, Inc. Recombinant fusion polypeptides for secreting soluble, heterologous cargo
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