JP2022535178A - 標的特異的エクソソームおよび増殖因子生成物を開発するための方法および組成物 - Google Patents

標的特異的エクソソームおよび増殖因子生成物を開発するための方法および組成物 Download PDF

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JP2022535178A
JP2022535178A JP2021544344A JP2021544344A JP2022535178A JP 2022535178 A JP2022535178 A JP 2022535178A JP 2021544344 A JP2021544344 A JP 2021544344A JP 2021544344 A JP2021544344 A JP 2021544344A JP 2022535178 A JP2022535178 A JP 2022535178A
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disease
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mesenchymal stem
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JPWO2020160342A5 (https=
JP2022535178A5 (https=
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ペティネ，ケネス，アレン
モーズリー，ティモシー，アレキサンダー
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ダイレクト バイオロジクス エルエルシー
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
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    • C12N5/0666—Mesenchymal stem cells from hair follicles
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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JP2021544344A 2019-01-30 2020-01-30 標的特異的エクソソームおよび増殖因子生成物を開発するための方法および組成物 Pending JP2022535178A (ja)

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JP2024202674A JP2025037913A (ja) 2019-01-30 2024-11-20 標的特異的エクソソームおよび増殖因子生成物を開発するための方法および組成物

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US201962798908P 2019-01-30 2019-01-30
PCT/US2020/015982 WO2020160342A1 (en) 2019-01-30 2020-01-30 Methods and compositions for developing target specific exosome and growth factor products

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JP2024202674A Division JP2025037913A (ja) 2019-01-30 2024-11-20 標的特異的エクソソームおよび増殖因子生成物を開発するための方法および組成物

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JP2022535178A true JP2022535178A (ja) 2022-08-05
JPWO2020160342A5 JPWO2020160342A5 (https=) 2023-02-07
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JP2024202674A Pending JP2025037913A (ja) 2019-01-30 2024-11-20 標的特異的エクソソームおよび増殖因子生成物を開発するための方法および組成物

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US (1) US20220136053A1 (https=)
EP (1) EP3917489A4 (https=)
JP (2) JP2022535178A (https=)
KR (1) KR20210121183A (https=)
AU (1) AU2020214832A1 (https=)
BR (1) BR112021014994A2 (https=)
CA (1) CA3128050A1 (https=)
IL (1) IL285228A (https=)
JO (1) JOP20210202A1 (https=)
MX (1) MX2021009254A (https=)
SG (1) SG11202108129SA (https=)
WO (1) WO2020160342A1 (https=)
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JP2021526556A (ja) 2018-05-30 2021-10-07 ダイレクト バイオロジクス エルエルシー 成長因子および細胞外小胞を凍結または粉状にした、間葉系幹細胞（ｍｓｃ）の調製物を含む助剤、ならびにその使用方法
BR112021015549A2 (pt) 2019-02-07 2021-10-26 Direct Biologics Llc Método para tratar osteoartrite com uma combinação de exossomos de células tronco mesenquimais, células tronco mesenquimais sinoviais e andaimes
CA3146433A1 (en) 2019-07-18 2021-01-21 Direct Biologics Llc Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use
US12590310B2 (en) 2020-04-22 2026-03-31 Direct Biologics, Llc Methods and compositions for treating inflammatory conditions associated with infectious disease
JP2023180556A (ja) * 2022-06-09 2023-12-21 日本メナード化粧品株式会社 薄毛の遺伝的素因の判定方法
WO2024233684A2 (en) * 2023-05-08 2024-11-14 Vitti Labs Methods of treating ovarian conditions and diseases
US12502407B2 (en) 2024-04-25 2025-12-23 Direct Biologics, Llc Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles
CN118516305B (zh) * 2024-07-22 2024-11-26 深圳大学 力学信号调控下的外泌体制备方法、外泌体及其在骨、软骨再生修复领域的应用
CN120899659A (zh) * 2025-08-06 2025-11-07 河北医科大学第三医院 一种过表达cap基因和lgr5基因的外泌体在制备治疗软骨炎症药物中的应用

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US20170189449A1 (en) * 2008-02-22 2017-07-06 Agency For Science, Technology And Research (A*Star) Mesenchymal stem cell particles
WO2018162696A1 (en) * 2017-03-10 2018-09-13 Institut Pasteur Common genetic variations at the tcra-tcrd locus control thymic function in humans
WO2019231562A1 (en) * 2018-05-30 2019-12-05 Direct Biologics Llc A growth factor and extracellular vesicle frozen or powdered additive comprising a mesenchymal stem cell (msc) preparation and methods of use
JP2022516607A (ja) * 2018-12-26 2022-03-01 ダイレクト バイオロジクス エルエルシー 皮膚および毛髪障害を治療するための方法および組成物

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WO2012061537A2 (en) * 2010-11-02 2012-05-10 The Trustees Of Columbia University In The City Of New York Methods for treating hair loss disorders
WO2018162696A1 (en) * 2017-03-10 2018-09-13 Institut Pasteur Common genetic variations at the tcra-tcrd locus control thymic function in humans
WO2019231562A1 (en) * 2018-05-30 2019-12-05 Direct Biologics Llc A growth factor and extracellular vesicle frozen or powdered additive comprising a mesenchymal stem cell (msc) preparation and methods of use
JP2022516607A (ja) * 2018-12-26 2022-03-01 ダイレクト バイオロジクス エルエルシー 皮膚および毛髪障害を治療するための方法および組成物

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KR20210121183A (ko) 2021-10-07
SG11202108129SA (en) 2021-08-30
BR112021014994A2 (pt) 2021-10-05
EP3917489A1 (en) 2021-12-08
CA3128050A1 (en) 2020-08-06
US20220136053A1 (en) 2022-05-05
JP2025037913A (ja) 2025-03-18
MX2021009254A (es) 2021-09-28
IL285228A (en) 2021-09-30
ZA202105483B (en) 2022-07-27
JOP20210202A1 (ar) 2023-01-30
WO2020160342A1 (en) 2020-08-06
AU2020214832A1 (en) 2021-08-19
EP3917489A4 (en) 2022-11-09

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