JP2022533358A - 終末糖化産物受容体ｒｎａのモジュレーター及び調節 - Google Patents

終末糖化産物受容体ｒｎａのモジュレーター及び調節 Download PDF

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JP2022533358A
JP2022533358A JP2021568406A JP2021568406A JP2022533358A JP 2022533358 A JP2022533358 A JP 2022533358A JP 2021568406 A JP2021568406 A JP 2021568406A JP 2021568406 A JP2021568406 A JP 2021568406A JP 2022533358 A JP2022533358 A JP 2022533358A
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rage
aons
aon
exon
mrna
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JP2022533358A5 (https=
JPWO2020227758A5 (https=
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ウィルトン，スティーブン
クリストファー トーマス，マーリン
ロサド，カルロス
ジェーン ピッカリング，レリーン
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モナシュ ユニバーシティ
マードック ユニバーシティ
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Publication of JP2022533358A5 publication Critical patent/JP2022533358A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3233—Morpholino-type ring
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/3513—Protein; Peptide
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/33—Alteration of splicing

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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2021568406A 2019-05-14 2020-05-07 終末糖化産物受容体ｒｎａのモジュレーター及び調節 Pending JP2022533358A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025061149A JP2025106369A (ja) 2019-05-14 2025-04-02 終末糖化産物受容体ｒｎａのモジュレーター及び調節

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
AU2019901641A AU2019901641A0 (en) 2019-05-14 Modulators and Modulation of the Receptor for Advanced Glycation End-Products RNA
AU2019901641 2019-05-14
AU2019902095 2019-06-17
AU2019902095A AU2019902095A0 (en) 2019-06-17 Modulators and Modulation of the Receptor for Advanced Glycation End-Products RNA
AU2019902772 2019-08-02
AU2019902772A AU2019902772A0 (en) 2019-08-02 Modulators and Modulation of the Receptor for Advanced Glycation End-Products RNA
AU2019903900 2019-10-16
AU2019903900A AU2019903900A0 (en) 2019-10-16 Modulators and Modulation of the Receptor for Advanced Glycation End-Products RNA
PCT/AU2020/050449 WO2020227758A1 (en) 2019-05-14 2020-05-07 Modulators and modulation of the receptor for advanced glycation end-products rna

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JP2025061149A Division JP2025106369A (ja) 2019-05-14 2025-04-02 終末糖化産物受容体ｒｎａのモジュレーター及び調節

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JP2022533358A true JP2022533358A (ja) 2022-07-22
JP2022533358A5 JP2022533358A5 (https=) 2023-08-15
JPWO2020227758A5 JPWO2020227758A5 (https=) 2023-08-15

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JP2021568406A Pending JP2022533358A (ja) 2019-05-14 2020-05-07 終末糖化産物受容体ｒｎａのモジュレーター及び調節
JP2025061149A Pending JP2025106369A (ja) 2019-05-14 2025-04-02 終末糖化産物受容体ｒｎａのモジュレーター及び調節

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US (3) US11441148B2 (https=)
EP (1) EP3969590A4 (https=)
JP (2) JP2022533358A (https=)
KR (1) KR20220009971A (https=)
CN (1) CN114127288A (https=)
AU (2) AU2020276337B2 (https=)
BR (1) BR112021022714A2 (https=)
CA (1) CA3140209A1 (https=)
IL (1) IL288040A (https=)
MX (1) MX2021013858A (https=)
SG (1) SG11202112144RA (https=)
WO (1) WO2020227758A1 (https=)

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Publication number Priority date Publication date Assignee Title
JP2022533358A (ja) 2019-05-14 2022-07-22 モナシュ ユニバーシティ 終末糖化産物受容体ｒｎａのモジュレーター及び調節
WO2024229505A1 (en) * 2023-05-05 2024-11-14 RAGE Biotech Pty Ltd Administration of oligonucleotides
AU2023447004A1 (en) * 2023-05-05 2025-10-16 RAGE Biotech Pty Ltd Methods of monitoring splicing
KR20260027924A (ko) * 2023-05-19 2026-03-03 레이지 바이오텍 피티와이 리미티드 연기 노출의 영향 최소화 방법
KR20260027923A (ko) * 2023-05-19 2026-03-03 레이지 바이오텍 피티와이 리미티드 폐 섬유증 치료 방법
AU2024352066A1 (en) * 2023-09-27 2026-04-09 Changchun Genescience Pharmaceutical Co., Ltd. New sirna, composition comprising same, and use
WO2025076595A1 (en) * 2023-10-12 2025-04-17 RAGE Biotech Pty Ltd Rnai agents targeting rage
WO2025222258A1 (en) * 2024-04-24 2025-10-30 RAGE Biotech Pty Ltd Methods of treating or preventing obstructive pulmonary disease
WO2025236048A1 (en) * 2024-05-17 2025-11-20 RAGE Biotech Pty Ltd Methods of treating the effects of smoke

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WO2020227758A8 (en) 2021-11-18
KR20220009971A (ko) 2022-01-25
US20240141360A1 (en) 2024-05-02
US20210388363A1 (en) 2021-12-16
US11441148B2 (en) 2022-09-13
AU2025223886A1 (en) 2025-09-18
WO2020227758A1 (en) 2020-11-19
US20230015481A1 (en) 2023-01-19
EP3969590A1 (en) 2022-03-23
CA3140209A1 (en) 2020-11-19
AU2020276337B2 (en) 2025-05-29
SG11202112144RA (en) 2021-11-29
US12565656B2 (en) 2026-03-03
JP2025106369A (ja) 2025-07-15
AU2020276337A1 (en) 2021-12-02
MX2021013858A (es) 2022-03-22
US11674143B2 (en) 2023-06-13
IL288040A (en) 2022-01-01
CN114127288A (zh) 2022-03-01
EP3969590A4 (en) 2024-05-15
BR112021022714A2 (pt) 2022-01-18

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