JP2022526669A5 - - Google Patents
Info
- Publication number
- JP2022526669A5 JP2022526669A5 JP2021560108A JP2021560108A JP2022526669A5 JP 2022526669 A5 JP2022526669 A5 JP 2022526669A5 JP 2021560108 A JP2021560108 A JP 2021560108A JP 2021560108 A JP2021560108 A JP 2021560108A JP 2022526669 A5 JP2022526669 A5 JP 2022526669A5
- Authority
- JP
- Japan
- Prior art keywords
- cas
- crispr
- editing system
- base editing
- based base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962833454P | 2019-04-12 | 2019-04-12 | |
| US62/833,454 | 2019-04-12 | ||
| PCT/US2020/027867 WO2020210776A1 (en) | 2019-04-12 | 2020-04-12 | Crispr/cas-based base editing composition for restoring dystrophin function |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022526669A JP2022526669A (ja) | 2022-05-25 |
| JP2022526669A5 true JP2022526669A5 (enExample) | 2023-04-24 |
| JP7881154B2 JP7881154B2 (ja) | 2026-06-29 |
Family
ID=72750921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021560108A Active JP7881154B2 (ja) | 2019-04-12 | 2020-04-12 | ジストロフィン機能を修復するためのＣＲＩＳＰＲ／Ｃａｓをベースにした塩基編集組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20220177879A1 (enExample) |
| EP (1) | EP3952884A4 (enExample) |
| JP (1) | JP7881154B2 (enExample) |
| WO (1) | WO2020210776A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2841572B1 (en) | 2012-04-27 | 2019-06-19 | Duke University | Genetic correction of mutated genes |
| US9828582B2 (en) | 2013-03-19 | 2017-11-28 | Duke University | Compositions and methods for the induction and tuning of gene expression |
| US10676726B2 (en) | 2015-02-09 | 2020-06-09 | Duke University | Compositions and methods for epigenome editing |
| KR20240132120A (ko) | 2015-08-25 | 2024-09-02 | 듀크 유니버시티 | Rna-가이드된 엔도뉴클레아제를 이용하는 게놈 조작에서 특이성을 개선하는 조성물 및 방법 |
| WO2017066497A2 (en) | 2015-10-13 | 2017-04-20 | Duke University | Genome engineering with type i crispr systems in eukaryotic cells |
| US12214054B2 (en) | 2015-11-30 | 2025-02-04 | Duke University | Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use |
| EP3443081A4 (en) | 2016-04-13 | 2019-10-30 | Duke University | CRISPR / CAS9-BASED REPRESSORS FOR IN VIVO SHUT-OFF OF GEN-TARGETS AND METHOD OF USE |
| JP7490211B2 (ja) | 2016-07-19 | 2024-05-27 | デューク ユニバーシティ | Ｃｐｆ１に基づくゲノム編集の治療適用 |
| US12509492B2 (en) | 2018-01-19 | 2025-12-30 | Duke University | Genome engineering with CRISPR-Cas systems in eukaryotes |
| TWI887234B (zh) | 2019-04-14 | 2025-06-21 | 美國公爵大學 | 治療杜興氏（ｄｕｃｈｅｎｎｅ）肌肉失養症之大型突變熱點之ａａｖ載體介導之刪除 |
| WO2021113390A1 (en) * | 2019-12-02 | 2021-06-10 | Shape Therapeutics Inc. | Compositions for treatment of diseases |
| WO2022204476A1 (en) * | 2021-03-26 | 2022-09-29 | The Board Of Regents Of The University Of Texas System | Nucleotide editing to reframe dmd transcripts by base editing and prime editing |
| CA3260237A1 (en) | 2022-06-24 | 2023-12-28 | Tune Therapeutics, Inc. | Compositions, systems and methods for reducing low-density lipoprotein by targeted gene repression |
| CN119912582B (zh) * | 2024-06-17 | 2025-11-04 | 中国农业大学 | 单碱基编辑器及其所用脱氨酶与应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014197748A2 (en) * | 2013-06-05 | 2014-12-11 | Duke University | Rna-guided gene editing and gene regulation |
| KR20240132120A (ko) * | 2015-08-25 | 2024-09-02 | 듀크 유니버시티 | Rna-가이드된 엔도뉴클레아제를 이용하는 게놈 조작에서 특이성을 개선하는 조성물 및 방법 |
| WO2017070632A2 (en) * | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
| US12214054B2 (en) * | 2015-11-30 | 2025-02-04 | Duke University | Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use |
| WO2018017751A1 (en) * | 2016-07-19 | 2018-01-25 | Supereye, Inc. | Systems and methods for predictive visual rendering |
| JP7490211B2 (ja) * | 2016-07-19 | 2024-05-27 | デューク ユニバーシティ | Ｃｐｆ１に基づくゲノム編集の治療適用 |
| AU2017364106A1 (en) * | 2016-11-28 | 2019-06-20 | The Board Of Regents Of The University Of Texas System | Prevention of muscular dystrophy by CRISPR/Cpfl-mediated gene editing |
| JOP20190166A1 (ar) * | 2017-01-05 | 2019-07-02 | Univ Texas | استراتيجية مثلى من أجل تعديلات تخطي إكسون باستخدام crispr/cas9 مع متواليات توجيه ثلاثي |
| CN110892069B (zh) * | 2017-03-30 | 2024-02-09 | 国立大学法人京都大学 | 基于基因组编辑的外显子跳跃诱导方法 |
| AU2018251801B2 (en) * | 2017-04-12 | 2024-11-07 | Massachusetts Institute Of Technology | Novel type VI CRISPR orthologs and systems |
| KR102894715B1 (ko) * | 2018-08-03 | 2025-12-03 | 빔 테라퓨틱스, 인크. | 핵산 표적 서열을 변형시키기 위한 다중-이펙터 핵염기 편집기 및 이를 이용하는 방법 |
-
2020
- 2020-04-12 JP JP2021560108A patent/JP7881154B2/ja active Active
- 2020-04-12 WO PCT/US2020/027867 patent/WO2020210776A1/en not_active Ceased
- 2020-04-12 EP EP20786814.2A patent/EP3952884A4/en active Pending
- 2020-04-12 US US17/603,243 patent/US20220177879A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA3128755C (en) | Compositions and methods for treating hemoglobinopathies | |
| US12612612B2 (en) | Methods for exon skipping and gene knockout using base editors | |
| US20230348876A1 (en) | Base editing enzymes | |
| US10982200B2 (en) | Enzymes with RuvC domains | |
| US11667917B2 (en) | Composition for genome editing using CRISPR/CPF1 system and use thereof | |
| Zhang et al. | Genetic variation at the matrix metalloproteinase-9 locus on chromosome 20q12. 2–13.1 | |
| JP2025181841A5 (enExample) | ||
| Lee et al. | Role of nucleotide sequences of loxP spacer region in Cre-mediated recombination | |
| CN110892069B (zh) | 基于基因组编辑的外显子跳跃诱导方法 | |
| ES2781323T3 (es) | Montaje de ADN mediado por nucleasas | |
| EP3178935B1 (en) | Genome editing using campylobacter jejuni crispr/cas system-derived rgen | |
| Han et al. | Alu recombination-mediated structural deletions in the chimpanzee genome | |
| JP2024073596A5 (enExample) | ||
| JP2022546608A5 (enExample) | ||
| US20230074594A1 (en) | Genome editing using crispr in corynebacterium | |
| JP2019536425A5 (enExample) | ||
| Sertori et al. | Genome editing in zebrafish: a practical overview | |
| CA3128878A1 (en) | Compositions and methods for treating alpha-1 antitrypsin deficiency | |
| JP2018537963A5 (enExample) | ||
| AU2016244033A1 (en) | CRISPR/CAS-related methods and compositions for treating Duchenne Muscular Dystrophy and Becker Muscular Dystrophy | |
| KR20250075667A (ko) | 신규한 아데닌 탈아미노효소 변이체 및 이를 사용한 염기 교정 방법 | |
| WO2023086953A1 (en) | Compositions and methods for the treatment of hereditary angioedema (hae) | |
| US20230348877A1 (en) | Base editing enzymes | |
| US20220220460A1 (en) | Enzymes with ruvc domains | |
| JP2021522825A5 (enExample) |