JP2022520428A - Ruvcドメインを有する酵素 - Google Patents

Ruvcドメインを有する酵素 Download PDF

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JP2022520428A
JP2022520428A JP2021547336A JP2021547336A JP2022520428A JP 2022520428 A JP2022520428 A JP 2022520428A JP 2021547336 A JP2021547336 A JP 2021547336A JP 2021547336 A JP2021547336 A JP 2021547336A JP 2022520428 A JP2022520428 A JP 2022520428A
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seq
sequence
endonuclease
nuclease system
engineered
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JPWO2020168291A5 (es
Inventor
トーマス,ブライアン
ブラウン,クリストファー
カンター,ローズ
デヴォート,オードラ
バターフィールド,クリスティーナ
アレクサンダー,リサ
エス.エー. ゴルツマン,ダニエラ
リュー,ジェイソン
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メタゲノミ アイピー テクノロジーズ,エルエルシー
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Publication of JP2022520428A publication Critical patent/JP2022520428A/ja
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    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90Stable introduction of foreign DNA into chromosome
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    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90Stable introduction of foreign DNA into chromosome
    • C12N15/902Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/21Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/20Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/50Physical structure
    • C12N2310/53Physical structure partially self-complementary or closed
    • C12N2310/531Stem-loop; Hairpin

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
JP2021547336A 2019-02-14 2020-02-14 Ruvcドメインを有する酵素 Ceased JP2022520428A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023146414A JP7502537B2 (ja) 2019-02-14 2023-09-08 Ruvcドメインを有する酵素

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201962805899P 2019-02-14 2019-02-14
US201962805868P 2019-02-14 2019-02-14
US201962805878P 2019-02-14 2019-02-14
US62/805,868 2019-02-14
US62/805,899 2019-02-14
US62/805,878 2019-02-14
US201962874414P 2019-07-15 2019-07-15
US62/874,414 2019-07-15
PCT/US2020/018432 WO2020168291A1 (en) 2019-02-14 2020-02-14 Enzymes with ruvc domains

Related Child Applications (1)

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JP2023146414A Division JP7502537B2 (ja) 2019-02-14 2023-09-08 Ruvcドメインを有する酵素

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JP2022520428A true JP2022520428A (ja) 2022-03-30
JPWO2020168291A5 JPWO2020168291A5 (es) 2023-02-21

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JP2021547336A Ceased JP2022520428A (ja) 2019-02-14 2020-02-14 Ruvcドメインを有する酵素
JP2023146414A Active JP7502537B2 (ja) 2019-02-14 2023-09-08 Ruvcドメインを有する酵素

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US (1) US20240117330A1 (es)
EP (1) EP3924482A4 (es)
JP (2) JP2022520428A (es)
KR (2) KR20240007322A (es)
CN (2) CN113728098A (es)
AU (2) AU2020223370B2 (es)
CA (1) CA3130135A1 (es)
MX (2) MX2021009886A (es)
WO (1) WO2020168291A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7502537B2 (ja) 2019-02-14 2024-06-18 メタゲノミ,インク. Ruvcドメインを有する酵素

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* Cited by examiner, † Cited by third party
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US10913941B2 (en) 2019-02-14 2021-02-09 Metagenomi Ip Technologies, Llc Enzymes with RuvC domains
GB2594339B (en) * 2020-02-14 2023-02-08 Metagenomi Inc Enzymes with RUVC domains
EP4114932A4 (en) 2020-03-06 2024-03-13 Metagenomi, Inc. CLASS II, TYPE V CRISPR SYSTEMS
MX2022012110A (es) * 2020-03-31 2022-10-18 Metagenomi Inc Sistemas crispr clase ii tipo ii.
WO2022056301A1 (en) * 2020-09-11 2022-03-17 Metagenomi Ip Technologies, Llc Base editing enzymes
WO2022098681A2 (en) * 2020-11-03 2022-05-12 Caspr Biotech Corporation Novel class 2 crispr-cas rna-guided endonucleases
KR20230134543A (ko) * 2021-01-22 2023-09-21 메타지노미, 인크. 신규한 조작된 뉴클레아제 및 키메라 뉴클레아제
WO2022159742A1 (en) * 2021-01-22 2022-07-28 Metagenomi, Inc Novel engineered and chimeric nucleases
WO2022232638A2 (en) * 2021-04-30 2022-11-03 Metagenomi, Inc. Enzymes with ruvc domains
WO2023122663A2 (en) * 2021-12-23 2023-06-29 Mammoth Biosciences, Inc. Effector proteins and methods of use
WO2023194359A1 (en) * 2022-04-04 2023-10-12 Alia Therapeutics Srl Compositions and methods for treatment of usher syndrome type 2a
WO2023245141A2 (en) * 2022-06-15 2023-12-21 Beam Therapeutics Inc. Compositions and methods for reducing complement activation
WO2024056880A2 (en) * 2022-09-16 2024-03-21 Alia Therapeutics Srl Enqp type ii cas proteins and applications thereof

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SG10201912327SA (en) * 2012-12-12 2020-02-27 Broad Inst Inc Engineering and Optimization of Improved Systems, Methods and Enzyme Compositions for Sequence Manipulation
US10392607B2 (en) * 2015-06-03 2019-08-27 The Regents Of The University Of California Cas9 variants and methods of use thereof
WO2016205759A1 (en) * 2015-06-18 2016-12-22 The Broad Institute Inc. Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
WO2018035250A1 (en) * 2016-08-17 2018-02-22 The Broad Institute, Inc. Methods for identifying class 2 crispr-cas systems
CN112020554A (zh) * 2018-02-23 2020-12-01 先锋国际良种公司 新颖cas9直系同源物
CA3130135A1 (en) 2019-02-14 2020-08-20 Metagenomi Ip Technologies, Llc Enzymes with ruvc domains

Non-Patent Citations (1)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7502537B2 (ja) 2019-02-14 2024-06-18 メタゲノミ,インク. Ruvcドメインを有する酵素

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Publication number Publication date
AU2023206079A1 (en) 2023-08-10
MX2021009886A (es) 2021-10-13
US20240117330A1 (en) 2024-04-11
AU2020223370B2 (en) 2023-04-20
CN113728098A (zh) 2021-11-30
EP3924482A4 (en) 2023-04-05
WO2020168291A1 (en) 2020-08-20
KR102623312B1 (ko) 2024-01-09
KR20240007322A (ko) 2024-01-16
AU2020223370A1 (en) 2021-10-07
JP2023179468A (ja) 2023-12-19
MX2023006575A (es) 2023-06-16
CN116515797A (zh) 2023-08-01
EP3924482A1 (en) 2021-12-22
KR20210139254A (ko) 2021-11-22
JP7502537B2 (ja) 2024-06-18
CA3130135A1 (en) 2020-08-20

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