JP2022517399A - Ｃｄ３８に特異的な二環式ペプチドリガンド - Google Patents

Ｃｄ３８に特異的な二環式ペプチドリガンド Download PDF

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Publication number
JP2022517399A
JP2022517399A JP2021541187A JP2021541187A JP2022517399A JP 2022517399 A JP2022517399 A JP 2022517399A JP 2021541187 A JP2021541187 A JP 2021541187A JP 2021541187 A JP2021541187 A JP 2021541187A JP 2022517399 A JP2022517399 A JP 2022517399A
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Japan
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seq
referred
sar
peptide ligand
amino acid
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JP2021541187A
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Japanese (ja)
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JP2022517399A5 (https=
JPWO2020148530A5 (https=
Inventor
バルダッサーレ レオナルド
ラニ ラシッド
パヴァン シルヴィア
ステイス キャサリン
トイフェル ダニエル
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バイスクルアールディー・リミテッド
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Publication of JP2022517399A publication Critical patent/JP2022517399A/ja
Publication of JP2022517399A5 publication Critical patent/JP2022517399A5/ja
Publication of JPWO2020148530A5 publication Critical patent/JPWO2020148530A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2021541187A 2019-01-15 2020-01-15 Ｃｄ３８に特異的な二環式ペプチドリガンド Pending JP2022517399A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1900530.5 2019-01-15
GBGB1900530.5A GB201900530D0 (en) 2019-01-15 2019-01-15 Bicyclic peptide ligands specific for CD38
PCT/GB2020/050074 WO2020148530A1 (en) 2019-01-15 2020-01-15 Bicyclic peptide ligands specific for cd38

Publications (3)

Publication Number Publication Date
JP2022517399A true JP2022517399A (ja) 2022-03-08
JP2022517399A5 JP2022517399A5 (https=) 2023-01-25
JPWO2020148530A5 JPWO2020148530A5 (https=) 2023-01-25

Family

ID=65528178

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021541187A Pending JP2022517399A (ja) 2019-01-15 2020-01-15 Ｃｄ３８に特異的な二環式ペプチドリガンド

Country Status (6)

Country Link
US (1) US20220133733A1 (https=)
EP (1) EP3911366A1 (https=)
JP (1) JP2022517399A (https=)
CN (1) CN113597317A (https=)
GB (1) GB201900530D0 (https=)
WO (1) WO2020148530A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6882978B2 (ja) 2014-10-29 2021-06-02 バイスクルアールディー・リミテッド Ｍｔ１−ｍｍｐに特異的な二環性ペプチドリガンド
JP7301757B2 (ja) 2017-06-26 2023-07-03 バイスクルアールディー・リミテッド 検出可能部分を持つ二環式ペプチドリガンドおよびその使用
CN111183147B (zh) 2017-08-04 2024-07-05 拜斯科技术开发有限公司 Cd137特异性的双环肽配体
JP2021514953A (ja) 2018-02-23 2021-06-17 バイスクルテクス・リミテッド 多量体二環式ペプチドリガンド
IL279489B2 (en) 2018-06-22 2025-10-01 Bicycletx Ltd Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
GB201820288D0 (en) 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
US12551567B2 (en) 2018-12-21 2026-02-17 Bicyclerd Limited Bicyclic peptide ligands specific for PD-L1
JP2022514618A (ja) 2018-12-21 2022-02-14 バイスクルテクス・リミテッド Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド
GB201900529D0 (en) 2019-01-15 2019-03-06 Bicycletx Ltd Bicyclic peptide ligands specific for CD38
TWI860386B (zh) 2019-07-30 2024-11-01 英商拜西可泰克斯有限公司 異質雙環肽複合物
IL300248A (en) 2020-08-03 2023-03-01 Bicycletx Ltd peptide-based linkers
GB202016331D0 (en) * 2020-10-15 2020-12-02 Bicyclerd Ltd Bicyclic peptide ligand drug conjugates
CN118388598A (zh) * 2024-04-22 2024-07-26 苏州大学附属第一医院 标记前体、探针及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006514104A (ja) * 2002-12-12 2006-04-27 テル アヴィヴ ユニヴァーシティ フューチャー テクノロジー ディヴェロップメント エル．ピー． グリコーゲンシンターゼキナーゼ−３阻害剤
JP2017519041A (ja) * 2014-05-21 2017-07-13 シクロポーターズ，インコーポレイテッド 細胞膜透過性ペプチド、並びにこの作製方法及び使用方法
US20180118786A1 (en) * 2015-04-28 2018-05-03 Ecole Polytechnique Federale De Lausanne (Epfl) NOVEL lNHIBITORS OF THE ENZYME ACTIVATED FACTOR XII (FXIIA)
WO2019002842A1 (en) * 2017-06-26 2019-01-03 Bicyclerd Limited BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE FRACTIONS AND USES THEREOF

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
DK2511297T3 (en) 2004-02-06 2015-06-15 Morphosys Ag Human anti-CD38 antibodies and their applications
DK1844337T3 (da) 2005-01-24 2013-09-30 Pepscan Systems Bv Bindingsforbindelser, immunogene forbindelser og peptidmimetika
EP2567976B1 (en) * 2005-03-23 2017-07-19 Genmab A/S Antibodies against CD38 for treatment of multiple myeloma
AU2009211253B2 (en) 2008-02-05 2014-11-06 Bicyclerd Limited Methods and compositions
JP6882978B2 (ja) 2014-10-29 2021-06-02 バイスクルアールディー・リミテッド Ｍｔ１−ｍｍｐに特異的な二環性ペプチドリガンド
GB201810320D0 (en) * 2018-06-22 2018-08-08 Bicycletx Ltd Peptide ligands for binding to CD38

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006514104A (ja) * 2002-12-12 2006-04-27 テル アヴィヴ ユニヴァーシティ フューチャー テクノロジー ディヴェロップメント エル．ピー． グリコーゲンシンターゼキナーゼ−３阻害剤
JP2017519041A (ja) * 2014-05-21 2017-07-13 シクロポーターズ，インコーポレイテッド 細胞膜透過性ペプチド、並びにこの作製方法及び使用方法
US20180118786A1 (en) * 2015-04-28 2018-05-03 Ecole Polytechnique Federale De Lausanne (Epfl) NOVEL lNHIBITORS OF THE ENZYME ACTIVATED FACTOR XII (FXIIA)
WO2019002842A1 (en) * 2017-06-26 2019-01-03 Bicyclerd Limited BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE FRACTIONS AND USES THEREOF

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LIUHONG CHEN, ET AL.: "The Bicycle platform: an efficient technology to generate high affinity, high selectivity molecules", BICYCLE THERAPEUTICS PUBLICATIONS [ONLINE], JPN6023022584, 2017, ISSN: 0005360628 *

Also Published As

Publication number Publication date
EP3911366A1 (en) 2021-11-24
GB201900530D0 (en) 2019-03-06
US20220133733A1 (en) 2022-05-05
CN113597317A (zh) 2021-11-02
WO2020148530A1 (en) 2020-07-23

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