JP2022516409A - 機械学習を用いた患者のための薬剤有効性のランク付けの判定 - Google Patents
機械学習を用いた患者のための薬剤有効性のランク付けの判定 Download PDFInfo
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Abstract
Description
Claims (20)
- 薬剤特性を判定する方法であって、
複数の薬剤についての薬剤投与に関する抽出された情報を分析することと、
各薬剤について、前記薬剤に対応する複数の属性についての1つ又は複数の薬剤特性を判定することであって、前記属性は、前記薬剤がターゲットとする変異又は遺伝子、及び前記変異又は前記遺伝子を含む生物学的経路を含む、判定することと、
判定された前記薬剤特性に基づいた薬剤有効性スコアに従って前記複数の薬剤をランク付けすることと
を含む方法。 - 前記薬剤特性は、エフィカシー、毒性及びポテンシーから成る群のうちの1つ又は複数から選択される、請求項1に記載の方法。
- 前記抽出された情報は、前臨床、臨床及び後臨床情報を含み、前記抽出された情報は、薬剤特性を含む、請求項1に記載の方法。
- 前記抽出された情報で機械学習モジュールを訓練することと、
訓練された前記機械学習モジュールに基づいて前記複数の薬剤の各薬剤についての1つ又は複数の薬剤特性を予測することと、
患者特有のがんの治療のために前記薬剤をランク付けすることであって、各薬剤は、前記患者のがんと関連した特定の遺伝子、遺伝子変異、又は生物学的経路をターゲットとし、前記予測される薬剤特性に基づいている、ランク付けすることと
を含む、請求項3に記載の方法。 - 複数の薬剤について、共通の構造特徴及び対応する薬剤特性を特定することと、
前記薬剤のどれが毒性と関連付けられるかを特定することと、
前記共通の構造特徴及び前記薬剤特性を特定する情報で訓練された機械学習モジュールを用いて、毒性と関連した前記複数の薬剤の他の薬剤を予測することと
を含む、請求項1に記載の方法。 - 前記複数の薬剤は、共通のターゲットに基づいてグループに分類され、各グループ内の前記薬剤をランク付けする、請求項1に記載の方法。
- 前記属性は、患者についての遺伝子、遺伝子変異、又は生物学的経路を含む、患者特有の情報を含み、
前記患者の遺伝子、遺伝子変異、又は生物学的経路をターゲットとする複数の薬剤を特定することと、
前記薬剤有効性スコアに基づいて前記患者のための特定された前記薬剤をランク付けすることと
をさらに含む、請求項1に記載の方法。 - コンテンツ・リポジトリ内の文書を分類するためのコンピュータ・システムであって、前記システムは、
複数の薬剤についての薬剤投与に関する抽出された情報を分析することと、
各薬剤について、前記薬剤に対応する複数の属性についての1つ又は複数の薬剤特性を判定することであって、前記属性は、前記薬剤をターゲットにする変異又は遺伝子、及び前記変異又は前記遺伝子を含む生物学的経路を含む、判定することと、
判定された前記薬剤特性に基づいた薬剤有効性スコアに従って前記複数の薬剤をランク付けすることと
を行うように構成された少なくとも1つのプロセッサを含む、システム。 - 前記薬剤特性は、エフィカシー、毒性及びポテンシーから成る群のうちの1つ又は複数から選択される、請求項8に記載のシステム。
- 前記抽出された情報は、前臨床、臨床及び後臨床情報を含み、前記抽出された情報は、薬剤特性を含む、請求項8に記載のシステム。
- 前記プロセッサは、
前記抽出された情報で機械学習モジュールを訓練することと、
訓練された前記機械学習モジュールに基づいて前記複数の薬剤の各薬剤についての1つ又は複数の薬剤特性を予測することと、
患者特有のがんの治療のために前記薬剤をランク付けすることであって、各薬剤は、前記患者のがんと関連した特定の遺伝子、遺伝子変異、又は生物学的経路をターゲットとし、前記予測される薬剤特性に基づいている、ランク付けすることと
を行うようにさらに構成される、請求項10に記載のシステム。 - 前記プロセッサは、
複数の薬剤について、共通の構造特徴及び対応する薬剤特性を特定することと、
前記薬剤のどれが毒性と関連付けられるかを特定することと、
前記共通の構造特徴及び前記薬剤特性を特定する情報で訓練された機械学習モジュールを用いて、毒性と関連した前記複数の薬剤の他の薬剤を予測することと
を行うようにさらに構成される、請求項8に記載のシステム。 - 前記複数の薬剤は、共通のターゲットに基づいてグループに分類され、各グループ内に前記薬剤をランク付けする、請求項8に記載のシステム。
- 前記属性は、患者についての遺伝子、遺伝子変異、又は生物学的経路を含む、患者特有の情報を含み、前記プロセッサは、
前記患者の遺伝子、遺伝子変異、又は生物学的経路をターゲットとする複数の薬剤を特定することと、
前記薬剤有効性スコアに基づいて前記患者のための特定された前記薬剤をランク付けすることと
を行うようにさらに構成される、請求項8に記載のシステム。 - コンテンツ・リポジトリ内の文書を分類するためのコンピュータ・プログラム製品であって、前記コンピュータ・プログラム製品は、プログラム命令がそこに具体化されたコンピュータ可読ストレージ媒体を含み、前記プログラム命令は、コンピュータにより実行可能であり、前記コンピュータに、
複数の薬剤についての薬剤投与に関する抽出された情報を分析することと、
各薬剤について、前記薬剤に対応する複数の属性についての1つ又は複数の薬剤特性を判定することであって、前記属性は、前記薬剤をターゲットにする変異又は遺伝子、及び前記変異又は前記遺伝子を含む生物学的経路を含む、判定することと、
判定された前記薬剤特性に基づいた薬剤有効性スコアに従って前記複数の薬剤をランク付けすることと
を行わせる、コンピュータ・プログラム製品。 - 前記薬剤特性は、エフィカシー、毒性及びポテンシーから成る群の1つ又は複数から選択される、請求項15に記載のコンピュータ・プログラム製品。
- 前記抽出された情報は、前臨床、臨床及び後臨床情報を含み、前記抽出された情報は、薬剤特性を含む、請求項15に記載のコンピュータ・プログラム製品。
- 前記プログラム命令は、
前記抽出された情報で機械学習モジュールを訓練することと、
訓練された前記機械学習モジュールに基づいて前記複数の薬剤の各薬剤についての1つ又は複数の薬剤特性を予測することと、
患者特有のがんの治療のために前記薬剤をランク付けすることであって、各薬剤は、前記患者のがんと関連した特定の遺伝子、遺伝子変異、又は生物学的経路をターゲットとし、前記予測される薬剤特性に基づいている、ランク付けすることと
を行うようにさらに実行可能である、請求項15に記載のコンピュータ・プログラム製品。 - 前記プログラム命令は、
複数の薬剤について、共通の構造特徴及び対応する薬剤特性を特定することと、
前記薬剤のどれが毒性と関連付けられるかを特定することと、
前記共通の構造特徴及び前記薬剤特性を特定する情報で訓練された機械学習モジュールを用いて、毒性と関連した前記複数の薬剤の他の薬剤を予測することと
を行うようにさらに実行可能である、請求項15に記載のコンピュータ・プログラム製品。 - 前記属性は、患者についての遺伝子、遺伝子変異、又は生物学的経路を含む、患者特有の情報を含み、前記プログラム命令は、
前記患者の遺伝子、遺伝子変異、又は生物学的経路をターゲットとする複数の薬剤を特定することと、
前記薬剤有効性スコアに基づいて前記患者のための特定された前記薬剤をランク付けすることと
を行うようにさらに実行可能である、請求項15に記載のコンピュータ・プログラム製品。
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