JP2022515720A - Ｉｌ－１７に特異的な二環式ペプチドリガンド - Google Patents

Ｉｌ－１７に特異的な二環式ペプチドリガンド Download PDF

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Publication number
JP2022515720A
JP2022515720A JP2021534203A JP2021534203A JP2022515720A JP 2022515720 A JP2022515720 A JP 2022515720A JP 2021534203 A JP2021534203 A JP 2021534203A JP 2021534203 A JP2021534203 A JP 2021534203A JP 2022515720 A JP2022515720 A JP 2022515720A
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JP
Japan
Prior art keywords
seq
referred
peptide ligand
sar
peptide
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Pending
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JP2021534203A
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English (en)
Japanese (ja)
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JP2022515720A5 (https=
JPWO2020120978A5 (https=
Inventor
シェン リューホン
ラニ ラシッド
マッド ジェマ
トイフェル ダニエル
ウォーカー エドワード
Original Assignee
バイスクルアールディー・リミテッド
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Publication date
Application filed by バイスクルアールディー・リミテッド filed Critical バイスクルアールディー・リミテッド
Publication of JP2022515720A publication Critical patent/JP2022515720A/ja
Publication of JP2022515720A5 publication Critical patent/JP2022515720A5/ja
Publication of JPWO2020120978A5 publication Critical patent/JPWO2020120978A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2021534203A 2018-12-13 2019-12-13 Ｉｌ－１７に特異的な二環式ペプチドリガンド Pending JP2022515720A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1820316.6A GB201820316D0 (en) 2018-12-13 2018-12-13 Bicyclic peptide ligands specific for IL-17
GB1820316.6 2018-12-13
PCT/GB2019/053534 WO2020120978A1 (en) 2018-12-13 2019-12-13 Bicyclic peptide ligands specific for il-17

Publications (3)

Publication Number Publication Date
JP2022515720A true JP2022515720A (ja) 2022-02-22
JP2022515720A5 JP2022515720A5 (https=) 2022-12-19
JPWO2020120978A5 JPWO2020120978A5 (https=) 2022-12-19

Family

ID=65146974

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021534203A Pending JP2022515720A (ja) 2018-12-13 2019-12-13 Ｉｌ－１７に特異的な二環式ペプチドリガンド

Country Status (6)

Country Link
US (1) US20220024983A1 (https=)
EP (1) EP3894007A1 (https=)
JP (1) JP2022515720A (https=)
CN (1) CN113474046A (https=)
GB (1) GB201820316D0 (https=)
WO (1) WO2020120978A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112021010453A2 (pt) 2018-12-19 2021-08-24 Leo Pharma A/S Composto, e, composição farmacêutica
WO2021123767A1 (en) * 2019-12-16 2021-06-24 Bicycletx Limited Bicyclic peptide ligands specific for il-17
GB201918558D0 (en) * 2019-12-16 2020-01-29 Bicycle Tx Ltd Bicyclic peptide ligands specific for IL-17
GB201918559D0 (en) * 2019-12-16 2020-01-29 Bicycle Tx Ltd Bicyclic peptide ligands specific for IL-17
GB201918557D0 (en) * 2019-12-16 2020-01-29 Bicycle Tx Ltd Bicyclic peptide ligands specific for IL-17
KR20230019507A (ko) 2020-04-30 2023-02-08 얀센 파마슈티카 엔.브이. Il-17의 조절제로서의 이미다조피리다진

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3192802A1 (en) * 2016-01-18 2017-07-19 Bicycle Therapeutics Limited Stabilized peptide derivatives
JP2018502825A (ja) * 2014-10-29 2018-02-01 バイサイクル・セラピューティクス・リミテッド Ｍｔ１−ｍｍｐに特異的な二環性ペプチドリガンド
JP2021528431A (ja) * 2018-06-22 2021-10-21 バイスクルテクス・リミテッド Ｉｌ−１７に結合するためのペプチドリガンド

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
DK1844337T3 (da) 2005-01-24 2013-09-30 Pepscan Systems Bv Bindingsforbindelser, immunogene forbindelser og peptidmimetika
CN101326195B9 (zh) 2005-12-13 2022-11-11 伊莱利利公司 抗il-17抗体
AU2009211253B2 (en) 2008-02-05 2014-11-06 Bicyclerd Limited Methods and compositions
WO2010062858A1 (en) 2008-11-26 2010-06-03 Allergan, Inc. Il-17 antibody inhibitor for treating dry eye
EP2569335B1 (en) 2010-05-14 2018-08-22 Orega Biotech Methods of treating and/or preventing cell proliferation disorders with il-17 antagonists
US20130195868A1 (en) 2010-06-24 2013-08-01 Eleven Biotherapeutics, Inc. Treating surface of the eye disorders
EP3181146A1 (en) * 2015-12-16 2017-06-21 Ruprecht-Karls-Universität Heidelberg Cyclic ntcp-targeting peptides and their uses as entry inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018502825A (ja) * 2014-10-29 2018-02-01 バイサイクル・セラピューティクス・リミテッド Ｍｔ１−ｍｍｐに特異的な二環性ペプチドリガンド
EP3192802A1 (en) * 2016-01-18 2017-07-19 Bicycle Therapeutics Limited Stabilized peptide derivatives
JP2021528431A (ja) * 2018-06-22 2021-10-21 バイスクルテクス・リミテッド Ｉｌ−１７に結合するためのペプチドリガンド

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEN, S ET AL.: "Peptide Ligands Stabilized by Small Molecules", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 53, JPN5022003111, 2014, DE, pages 1602 - 1606, ISSN: 0005175120 *
HEINIS, C ET AL.: "Phage-encoded combinatorial chemical libraries based on bicyclic peptides", NATURE CHEMICAL BIOLOGY, vol. 5, no. 7, JPN5022003110, 2009, pages 502 - 507, ISSN: 0005175119 *
KALE, SS ET AL.: "Cyclization of peptides with two chemical bridges affords large scaffold diversities", NATURE CHEMISTRY, vol. 10, no. 7, JPN6023042562, July 2018 (2018-07-01), pages 715 - 723, ISSN: 0005327360 *

Also Published As

Publication number Publication date
CN113474046A (zh) 2021-10-01
GB201820316D0 (en) 2019-01-30
US20220024983A1 (en) 2022-01-27
WO2020120978A1 (en) 2020-06-18
EP3894007A1 (en) 2021-10-20

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