JP2022515249A - 癌の治療におけるドセタキセルの長期使用 - Google Patents

癌の治療におけるドセタキセルの長期使用 Download PDF

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Publication number
JP2022515249A
JP2022515249A JP2021536409A JP2021536409A JP2022515249A JP 2022515249 A JP2022515249 A JP 2022515249A JP 2021536409 A JP2021536409 A JP 2021536409A JP 2021536409 A JP2021536409 A JP 2021536409A JP 2022515249 A JP2022515249 A JP 2022515249A
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Prior art keywords
docetaxel
cancer
plasma concentration
treatment
side effects
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JP2021536409A
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English (en)
Japanese (ja)
Inventor
ヘンドリック ベイネン、ジェイコブ
ヘンリクス マティアス シェレンス、ヨハネス
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モドラ ファーマシューティカルズ ビー．ブイ．
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Publication of JP2022515249A publication Critical patent/JP2022515249A/ja
Priority to JP2023075517A priority Critical patent/JP2023102787A/ja
Priority to JP2025049089A priority patent/JP2025094189A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021536409A 2018-12-21 2019-12-18 癌の治療におけるドセタキセルの長期使用 Pending JP2022515249A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023075517A JP2023102787A (ja) 2018-12-21 2023-05-01 癌の治療におけるドセタキセルの長期使用
JP2025049089A JP2025094189A (ja) 2018-12-21 2025-03-24 癌の治療におけるドセタキセルの長期使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18215472 2018-12-21
EP18215472.4 2018-12-21
PCT/EP2019/086124 WO2020127606A1 (en) 2018-12-21 2019-12-18 Cancer treatment using docetaxel by controlling peak plasma levels

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023075517A Division JP2023102787A (ja) 2018-12-21 2023-05-01 癌の治療におけるドセタキセルの長期使用

Publications (1)

Publication Number Publication Date
JP2022515249A true JP2022515249A (ja) 2022-02-17

Family

ID=64901394

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2021536409A Pending JP2022515249A (ja) 2018-12-21 2019-12-18 癌の治療におけるドセタキセルの長期使用
JP2023075517A Pending JP2023102787A (ja) 2018-12-21 2023-05-01 癌の治療におけるドセタキセルの長期使用
JP2025049089A Pending JP2025094189A (ja) 2018-12-21 2025-03-24 癌の治療におけるドセタキセルの長期使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023075517A Pending JP2023102787A (ja) 2018-12-21 2023-05-01 癌の治療におけるドセタキセルの長期使用
JP2025049089A Pending JP2025094189A (ja) 2018-12-21 2025-03-24 癌の治療におけるドセタキセルの長期使用

Country Status (14)

Country Link
US (3) US20220079910A1 (https=)
EP (2) EP3897610B1 (https=)
JP (3) JP2022515249A (https=)
KR (1) KR20220002860A (https=)
CN (1) CN113543781A (https=)
AU (2) AU2019410060A1 (https=)
BR (1) BR112021012255A2 (https=)
CA (1) CA3124316C (https=)
CL (1) CL2021001638A1 (https=)
ES (1) ES3026709T3 (https=)
IL (1) IL284213A (https=)
MX (2) MX2021007478A (https=)
PE (1) PE20220250A1 (https=)
WO (1) WO2020127606A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023102787A (ja) * 2018-12-21 2023-07-25 モドラ ファーマシューティカルズ ビー．ブイ． 癌の治療におけるドセタキセルの長期使用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020127607A1 (en) * 2018-12-21 2020-06-25 Modra Pharmaceuticals B.V. Combination treatment for solid tumors using docetaxel and a cyp3a inhibitor
GB202201935D0 (en) 2022-02-14 2022-03-30 Modra Pharmaceuticals B V Methods and compositions for treating cancer in taxane-resistant patients

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010536837A (ja) * 2007-08-24 2010-12-02 スティヒティング ヘット ネーデルランド カンケル インスティテュート 組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR054215A1 (es) 2006-01-20 2007-06-13 Eriochem Sa Una formulacion farmaceutica de un taxano, una composicion solida de un taxano liofilizado a partir de una solucion de acido acetico, un procedimiento para la preparacion de dicha composicion solida de un taxano, una composicion solubilizante de un taxano liofilizado, y un conjunto de elementos (kit
US9089544B2 (en) * 2007-08-24 2015-07-28 Slotervaart Participaties Bv Composition
MX2010002179A (es) * 2007-08-24 2010-04-27 Stichting Het Nl Kanker I Composicion para el tratamiento de enfermedades neoplasicas.
JP2012500788A (ja) 2008-08-22 2012-01-12 スティヒティング ヘット ネーデルランド カンケル インスティテュート 組成物
WO2020127607A1 (en) * 2018-12-21 2020-06-25 Modra Pharmaceuticals B.V. Combination treatment for solid tumors using docetaxel and a cyp3a inhibitor
PE20220250A1 (es) * 2018-12-21 2022-02-16 Modra Pharmaceuticals B V Uso de docetaxel en el tratamiento de cancer mediante control de niveles maximos en plasma

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010536837A (ja) * 2007-08-24 2010-12-02 スティヒティング ヘット ネーデルランド カンケル インスティテュート 組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EUROPEAN JOURNAL OF CANCER, vol. 86, JPN6022026010, 2017, pages 217 - 225, ISSN: 0004961328 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023102787A (ja) * 2018-12-21 2023-07-25 モドラ ファーマシューティカルズ ビー．ブイ． 癌の治療におけるドセタキセルの長期使用

Also Published As

Publication number Publication date
EP4670718A2 (en) 2025-12-31
CA3124316A1 (en) 2020-06-25
BR112021012255A2 (pt) 2021-09-28
CL2021001638A1 (es) 2022-04-22
IL284213A (en) 2021-08-31
JP2023102787A (ja) 2023-07-25
AU2019410060A1 (en) 2021-08-05
MX2025008270A (es) 2025-08-01
EP4670718A3 (en) 2026-03-04
US20220323399A1 (en) 2022-10-13
US20220079910A1 (en) 2022-03-17
EP3897610C0 (en) 2025-04-16
AU2023204682A1 (en) 2023-08-10
CA3124316C (en) 2023-07-04
EP3897610B1 (en) 2025-04-16
KR20220002860A (ko) 2022-01-07
EP3897610A1 (en) 2021-10-27
CN113543781A (zh) 2021-10-22
JP2025094189A (ja) 2025-06-24
ES3026709T3 (en) 2025-06-12
PE20220250A1 (es) 2022-02-16
US20250312305A1 (en) 2025-10-09
MX2021007478A (es) 2021-10-13
WO2020127606A1 (en) 2020-06-25
US11571408B2 (en) 2023-02-07

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