JP2022513351A - 高インシュリン血症性低血糖症の治療のためのアベキシド - Google Patents

高インシュリン血症性低血糖症の治療のためのアベキシド Download PDF

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JP2022513351A
JP2022513351A JP2021545283A JP2021545283A JP2022513351A JP 2022513351 A JP2022513351 A JP 2022513351A JP 2021545283 A JP2021545283 A JP 2021545283A JP 2021545283 A JP2021545283 A JP 2021545283A JP 2022513351 A JP2022513351 A JP 2022513351A
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subject
avextide
hypoglycemia
administered
administration
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JP2021545283A
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Japanese (ja)
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JP2022513351A5 (https=
Inventor
コリーン・エム・クレイグ
リサ・ポーター
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Eiger Biopharmaceuticals Inc
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Eiger Biopharmaceuticals Inc
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Application filed by Eiger Biopharmaceuticals Inc filed Critical Eiger Biopharmaceuticals Inc
Publication of JP2022513351A publication Critical patent/JP2022513351A/ja
Publication of JP2022513351A5 publication Critical patent/JP2022513351A5/ja
Priority to JP2024168092A priority Critical patent/JP2025000798A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2021545283A 2018-10-15 2019-10-15 高インシュリン血症性低血糖症の治療のためのアベキシド Pending JP2022513351A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024168092A JP2025000798A (ja) 2018-10-15 2024-09-27 高インシュリン血症性低血糖症の治療のためのアベキシド

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862745915P 2018-10-15 2018-10-15
US62/745,915 2018-10-15
US201862746229P 2018-10-16 2018-10-16
US62/746,229 2018-10-16
US201962823493P 2019-03-25 2019-03-25
US62/823,493 2019-03-25
PCT/US2019/056278 WO2020081534A1 (en) 2018-10-15 2019-10-15 Avexitide for the treatment of hyperinsulinemic hypoglycemia

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024168092A Division JP2025000798A (ja) 2018-10-15 2024-09-27 高インシュリン血症性低血糖症の治療のためのアベキシド

Publications (2)

Publication Number Publication Date
JP2022513351A true JP2022513351A (ja) 2022-02-07
JP2022513351A5 JP2022513351A5 (https=) 2022-10-21

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ID=70283142

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021545283A Pending JP2022513351A (ja) 2018-10-15 2019-10-15 高インシュリン血症性低血糖症の治療のためのアベキシド
JP2024168092A Pending JP2025000798A (ja) 2018-10-15 2024-09-27 高インシュリン血症性低血糖症の治療のためのアベキシド

Family Applications After (1)

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JP2024168092A Pending JP2025000798A (ja) 2018-10-15 2024-09-27 高インシュリン血症性低血糖症の治療のためのアベキシド

Country Status (10)

Country Link
US (1) US20210338780A1 (https=)
EP (2) EP4233842A3 (https=)
JP (2) JP2022513351A (https=)
CN (1) CN112867730A (https=)
AU (2) AU2019359807B2 (https=)
BR (1) BR112021006968A2 (https=)
CA (1) CA3115527A1 (https=)
CL (1) CL2021000892A1 (https=)
IL (2) IL314504A (https=)
WO (1) WO2020081534A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022271753A1 (en) 2021-06-21 2022-12-29 Eiger Biopharmaceuticals, Inc. Treatment of congenital hyperinsulinism with avexitide
CN121219002A (zh) * 2023-04-21 2025-12-26 小利兰斯坦福大学董事会 Glp-1r拮抗作用改善胃肠外科手术后的营养

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018094404A1 (en) * 2016-11-21 2018-05-24 Eiger Biopharmaceuticals, Inc. Buffered formulations of exendin (9-39)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8076288B2 (en) * 2004-02-11 2011-12-13 Amylin Pharmaceuticals, Inc. Hybrid polypeptides having glucose lowering activity
WO2013120022A2 (en) * 2012-02-08 2013-08-15 Seneb Biosciences, Inc. Treatment of hypoglycemia
US20160185837A1 (en) * 2013-08-16 2016-06-30 Medimmune Limited Gip and glp-1 receptor dual-agonists for the treatment of diabetes
LT3297653T (lt) * 2015-05-22 2022-01-10 The Board Of Trustees Of The Leland Stanford Junior University Postbariatrinės hipoglikemijos gydymas glp-1 antagonistais
US10653753B2 (en) * 2016-03-04 2020-05-19 Eiger Biopharmaceuticals, Inc. Treatment of hyperinsulinemic hypoglycemia with exendin-4 derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018094404A1 (en) * 2016-11-21 2018-05-24 Eiger Biopharmaceuticals, Inc. Buffered formulations of exendin (9-39)

Also Published As

Publication number Publication date
WO2020081534A1 (en) 2020-04-23
BR112021006968A2 (pt) 2021-07-27
IL282059A (en) 2021-05-31
AU2019359807A1 (en) 2021-05-13
US20210338780A1 (en) 2021-11-04
EP3867266A1 (en) 2021-08-25
AU2025208421A1 (en) 2025-08-14
CL2021000892A1 (es) 2021-11-12
CA3115527A1 (en) 2020-04-23
JP2025000798A (ja) 2025-01-07
IL314504A (en) 2024-09-01
EP3867266A4 (en) 2022-07-13
AU2019359807B2 (en) 2025-04-24
EP4233842A2 (en) 2023-08-30
EP4233842A3 (en) 2023-10-25
CN112867730A (zh) 2021-05-28

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