|
US4217344A
(en)
|
1976-06-23 |
1980-08-12 |
L'oreal |
Compositions containing aqueous dispersions of lipid spheres
|
|
US4235871A
(en)
|
1978-02-24 |
1980-11-25 |
Papahadjopoulos Demetrios P |
Method of encapsulating biologically active materials in lipid vesicles
|
|
US4186183A
(en)
|
1978-03-29 |
1980-01-29 |
The United States Of America As Represented By The Secretary Of The Army |
Liposome carriers in chemotherapy of leishmaniasis
|
|
US4261975A
(en)
|
1979-09-19 |
1981-04-14 |
Merck & Co., Inc. |
Viral liposome particle
|
|
US4485054A
(en)
|
1982-10-04 |
1984-11-27 |
Lipoderm Pharmaceuticals Limited |
Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
|
|
US4501728A
(en)
|
1983-01-06 |
1985-02-26 |
Technology Unlimited, Inc. |
Masking of liposomes from RES recognition
|
|
US5049386A
(en)
|
1985-01-07 |
1991-09-17 |
Syntex (U.S.A.) Inc. |
N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4897355A
(en)
|
1985-01-07 |
1990-01-30 |
Syntex (U.S.A.) Inc. |
N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4946787A
(en)
|
1985-01-07 |
1990-08-07 |
Syntex (U.S.A.) Inc. |
N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4797368A
(en)
|
1985-03-15 |
1989-01-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
Adeno-associated virus as eukaryotic expression vector
|
|
US4774085A
(en)
|
1985-07-09 |
1988-09-27 |
501 Board of Regents, Univ. of Texas |
Pharmaceutical administration systems containing a mixture of immunomodulators
|
|
US5422251A
(en)
|
1986-11-26 |
1995-06-06 |
Princeton University |
Triple-stranded nucleic acids
|
|
US4837028A
(en)
|
1986-12-24 |
1989-06-06 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5176996A
(en)
|
1988-12-20 |
1993-01-05 |
Baylor College Of Medicine |
Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
|
|
US5264618A
(en)
|
1990-04-19 |
1993-11-23 |
Vical, Inc. |
Cationic lipids for intracellular delivery of biologically active molecules
|
|
WO1991017424A1
(en)
|
1990-05-03 |
1991-11-14 |
Vical, Inc. |
Intracellular delivery of biologically active substances by means of self-assembling lipid complexes
|
|
US5173414A
(en)
|
1990-10-30 |
1992-12-22 |
Applied Immune Sciences, Inc. |
Production of recombinant adeno-associated virus vectors
|
|
US5420032A
(en)
|
1991-12-23 |
1995-05-30 |
Universitge Laval |
Homing endonuclease which originates from chlamydomonas eugametos and recognizes and cleaves a 15, 17 or 19 degenerate double stranded nucleotide sequence
|
|
US5792632A
(en)
|
1992-05-05 |
1998-08-11 |
Institut Pasteur |
Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
|
|
US5587308A
(en)
|
1992-06-02 |
1996-12-24 |
The United States Of America As Represented By The Department Of Health & Human Services |
Modified adeno-associated virus vector capable of expression from a novel promoter
|
|
WO1994026877A1
(en)
|
1993-05-17 |
1994-11-24 |
The Regents Of The University Of California |
Ribozyme gene therapy for hiv infection and aids
|
|
DE69534629D1
(de)
|
1994-01-18 |
2005-12-29 |
Scripps Research Inst |
Derivate von zinkfingerproteinen und methoden
|
|
US6140466A
(en)
|
1994-01-18 |
2000-10-31 |
The Scripps Research Institute |
Zinc finger protein derivatives and methods therefor
|
|
JP4285766B2
(ja)
|
1994-03-23 |
2009-06-24 |
オハイオ ユニバーシティ |
緻密にした核酸および細胞へのデリバリ
|
|
US5585245A
(en)
|
1994-04-22 |
1996-12-17 |
California Institute Of Technology |
Ubiquitin-based split protein sensor
|
|
GB9824544D0
(en)
|
1998-11-09 |
1999-01-06 |
Medical Res Council |
Screening system
|
|
USRE39229E1
(en)
|
1994-08-20 |
2006-08-08 |
Gendaq Limited |
Binding proteins for recognition of DNA
|
|
US5789538A
(en)
|
1995-02-03 |
1998-08-04 |
Massachusetts Institute Of Technology |
Zinc finger proteins with high affinity new DNA binding specificities
|
|
US5928638A
(en)
|
1996-06-17 |
1999-07-27 |
Systemix, Inc. |
Methods for gene transfer
|
|
US5925523A
(en)
|
1996-08-23 |
1999-07-20 |
President & Fellows Of Harvard College |
Intraction trap assay, reagents and uses thereof
|
|
US6342345B1
(en)
|
1997-04-02 |
2002-01-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Detection of molecular interactions by reporter subunit complementation
|
|
GB9710809D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
GB9710807D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
ES2341926T3
(es)
|
1998-03-02 |
2010-06-29 |
Massachusetts Institute Of Technology |
Poliproteinas con dedos de cinc que tienen enlazadores mejorados.
|
|
WO1999061066A2
(en)
|
1998-05-27 |
1999-12-02 |
Avigen, Inc. |
Convection-enhanced delivery of aav vectors
|
|
US6140081A
(en)
|
1998-10-16 |
2000-10-31 |
The Scripps Research Institute |
Zinc finger binding domains for GNN
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US7013219B2
(en)
|
1999-01-12 |
2006-03-14 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
|
US6599692B1
(en)
|
1999-09-14 |
2003-07-29 |
Sangamo Bioscience, Inc. |
Functional genomics using zinc finger proteins
|
|
AU776576B2
(en)
|
1999-12-06 |
2004-09-16 |
Sangamo Biosciences, Inc. |
Methods of using randomized libraries of zinc finger proteins for the identification of gene function
|
|
ATE355368T1
(de)
|
2000-01-24 |
2006-03-15 |
Gendaq Ltd |
Nucleinsäure bindende polypeptide gekennzeichnet durch flexible linker verbundene nucleinsäuredomäne
|
|
US6689558B2
(en)
|
2000-02-08 |
2004-02-10 |
Sangamo Biosciences, Inc. |
Cells for drug discovery
|
|
US20020061512A1
(en)
|
2000-02-18 |
2002-05-23 |
Kim Jin-Soo |
Zinc finger domains and methods of identifying same
|
|
AU2001263155A1
(en)
|
2000-05-16 |
2001-11-26 |
Massachusetts Institute Of Technology |
Methods and compositions for interaction trap assays
|
|
JP2002060786A
(ja)
|
2000-08-23 |
2002-02-26 |
Kao Corp |
硬質表面用殺菌防汚剤
|
|
AU2002228841C1
(en)
|
2000-12-07 |
2006-11-23 |
Sangamo Biosciences, Inc |
Regulation of angiogenesis with zinc finger proteins
|
|
GB0108491D0
(en)
|
2001-04-04 |
2001-05-23 |
Gendaq Ltd |
Engineering zinc fingers
|
|
US7182944B2
(en)
|
2001-04-25 |
2007-02-27 |
The United States Of America As Represented By The Department Of Health And Human Services |
Methods of increasing distribution of nucleic acids
|
|
JP2005500061A
(ja)
|
2001-08-20 |
2005-01-06 |
ザ スクリップス リサーチ インスティテュート |
Ｃｎｎについての亜鉛フィンガー結合ドメイン
|
|
CN100463962C
(zh)
|
2001-12-07 |
2009-02-25 |
图尔金株式会社 |
嵌合蛋白质的表型筛选
|
|
DK2573170T3
(en)
|
2001-12-17 |
2018-04-09 |
Univ Pennsylvania |
Sequences of adeno-associated virus (AAV) serotype 9, vectors containing them, and their use
|
|
US7074596B2
(en)
|
2002-03-25 |
2006-07-11 |
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College |
Synthesis and use of anti-reverse mRNA cap analogues
|
|
WO2005004794A2
(en)
|
2003-06-09 |
2005-01-20 |
Alnylam Pharmaceuticals Inc. |
Method of treating neurodegenerative disease
|
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
US8409861B2
(en)
|
2003-08-08 |
2013-04-02 |
Sangamo Biosciences, Inc. |
Targeted deletion of cellular DNA sequences
|
|
EP1683862B1
(en)
|
2003-09-25 |
2012-08-01 |
Chiba-Prefecture |
Microarray for assessing neuroblastoma prognosis and method of assessing neuroblastoma prognosis
|
|
CN1897977A
(zh)
|
2003-10-20 |
2007-01-17 |
Ns基因公司 |
帕金森氏病的体内基因治疗
|
|
MX2007003850A
(es)
|
2004-10-05 |
2007-11-21 |
Genzyme Corp |
Canula escalonada.
|
|
CA2607104A1
(en)
|
2005-05-05 |
2006-11-16 |
The Arizona Board Of Regents On Behalf Of The University Of Arizona |
Sequence enabled reassembly (seer) - a novel method for visualizing specific dna sequences
|
|
EP1928557B1
(en)
|
2005-08-23 |
2018-06-06 |
The Regents of The University of California |
Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery
|
|
ES2582091T3
(es)
|
2005-10-18 |
2016-09-09 |
Precision Biosciences |
Meganucleasas diseñadas racionalmente con especificidad de secuencia y afinidad de unión a ADN alteradas
|
|
DK2019683T4
(da)
|
2006-04-25 |
2022-08-29 |
Univ California |
Indgivelse af vækstfaktorer til behandling af CNS-lidelser
|
|
EP2027262B1
(en)
|
2006-05-25 |
2010-03-31 |
Sangamo Biosciences Inc. |
Variant foki cleavage half-domains
|
|
BRPI0716427A2
(pt)
|
2006-08-11 |
2014-03-11 |
Dow Agrosciences Llc |
Recombinação homóloga mediada por nuclease de apêndice de zinco
|
|
US7837668B2
(en)
|
2006-10-10 |
2010-11-23 |
Ceregene, Inc. |
Needle assembly for use in delivering precise dosages of proteinaceous pharmaceutical compositions and methods for use of same
|
|
CN104072561B
(zh)
|
2007-06-19 |
2017-12-22 |
路易斯安那州州立大学及农业机械学院管理委员会 |
信使rna帽的抗‑反向硫代磷酸类似物的合成和用途
|
|
EP2188384B1
(en)
|
2007-09-27 |
2015-07-15 |
Sangamo BioSciences, Inc. |
Rapid in vivo identification of biologically active nucleases
|
|
US9394531B2
(en)
|
2008-05-28 |
2016-07-19 |
Sangamo Biosciences, Inc. |
Compositions for linking DNA-binding domains and cleavage domains
|
|
WO2009151591A2
(en)
|
2008-06-10 |
2009-12-17 |
Sangamo Biosciences, Inc. |
Methods and compositions for generation of bax- and bak-deficient cell lines
|
|
SG191561A1
(en)
|
2008-08-22 |
2013-07-31 |
Sangamo Biosciences Inc |
Methods and compositions for targeted single-stranded cleavage and targeted integration
|
|
US20110023153A1
(en)
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in alzheimer's disease
|
|
US20110016539A1
(en)
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genome editing of neurotransmission-related genes in animals
|
|
KR20100080068A
(ko)
|
2008-12-31 |
2010-07-08 |
주식회사 툴젠 |
신규한 징크 핑거 뉴클레아제 및 이의 용도
|
|
EP2206723A1
(en)
|
2009-01-12 |
2010-07-14 |
Bonas, Ulla |
Modular DNA-binding domains
|
|
UA107571C2
(xx)
|
2009-04-03 |
2015-01-26 |
|
Фармацевтична композиція
|
|
CA2769262C
(en)
|
2009-07-28 |
2019-04-30 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating trinucleotide repeat disorders
|
|
CA2769670C
(en)
|
2009-07-31 |
2018-10-02 |
Ethris Gmbh |
Rna with a combination of unmodified and modified nucleotides for protein expression
|
|
US8586526B2
(en)
|
2010-05-17 |
2013-11-19 |
Sangamo Biosciences, Inc. |
DNA-binding proteins and uses thereof
|
|
US8956828B2
(en)
|
2009-11-10 |
2015-02-17 |
Sangamo Biosciences, Inc. |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
|
|
US20110135613A1
(en)
|
2009-12-03 |
2011-06-09 |
The J. David Gladstone Institutes |
Methods for treating apolipoprotein e4-associated disorders
|
|
ES2751916T3
(es)
|
2010-02-08 |
2020-04-02 |
Sangamo Therapeutics Inc |
Semidominios de escisión genomanipulados
|
|
HRP20200254T1
(hr)
|
2010-05-03 |
2020-05-29 |
Sangamo Therapeutics, Inc. |
Pripravci za povezivanje modula cink fingera
|
|
US9322023B2
(en)
|
2011-10-06 |
2016-04-26 |
Cornell University |
Constructs and methods for the assembly of biological pathways
|
|
HK1200871A1
(en)
|
2011-11-16 |
2015-08-14 |
Sangamo Therapeutics, Inc. |
Modified dna-binding proteins and uses thereof
|
|
WO2013130824A1
(en)
|
2012-02-29 |
2013-09-06 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating huntington's disease
|
|
BR112014020753B1
(pt)
|
2012-03-02 |
2021-10-05 |
Nissan Motor Co., Ltd |
Dispositivo de detecção de objeto tridimensional
|
|
EP2931899A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
CN105264091B
(zh)
|
2013-03-14 |
2020-02-28 |
Ionis制药公司 |
用于调节tau表达的组合物和方法
|
|
CN105683376A
(zh)
|
2013-05-15 |
2016-06-15 |
桑格摩生物科学股份有限公司 |
用于治疗遗传病状的方法和组合物
|
|
WO2014197748A2
(en)
|
2013-06-05 |
2014-12-11 |
Duke University |
Rna-guided gene editing and gene regulation
|
|
TW202246503A
(zh)
|
2013-07-19 |
2022-12-01 |
美商百健Ｍａ公司 |
用於調節τ蛋白表現之組合物
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
CA3131284C
(en)
|
2013-08-28 |
2023-09-19 |
David Paschon |
Compositions for linking dna-binding domains and cleavage domains
|
|
ES2739288T3
(es)
|
2013-09-13 |
2020-01-30 |
California Inst Of Techn |
Recuperación selectiva
|
|
WO2015089375A1
(en)
*
|
2013-12-13 |
2015-06-18 |
The General Hospital Corporation |
Soluble high molecular weight (hmw) tau species and applications thereof
|
|
CN106459894B
(zh)
|
2014-03-18 |
2020-02-18 |
桑格摩生物科学股份有限公司 |
用于调控锌指蛋白表达的方法和组合物
|
|
WO2015153760A2
(en)
|
2014-04-01 |
2015-10-08 |
Sangamo Biosciences, Inc. |
Methods and compositions for prevention or treatment of a nervous system disorder
|
|
WO2015171932A1
(en)
*
|
2014-05-08 |
2015-11-12 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating huntington's disease
|
|
WO2015188056A1
(en)
|
2014-06-05 |
2015-12-10 |
Sangamo Biosciences, Inc. |
Methods and compositions for nuclease design
|
|
US11077132B2
(en)
|
2015-02-04 |
2021-08-03 |
F. Hoffmann-La Roche Ag |
Tau antisense oligomers and uses thereof
|
|
US20170035860A1
(en)
|
2015-04-02 |
2017-02-09 |
Alexander C. Flynn |
Compositions and methods for treatment of neurogenerative diseases
|
|
WO2017011556A1
(en)
*
|
2015-07-13 |
2017-01-19 |
The General Hospital Corporation |
Rare phosphorylated high molecular weight (hmw) tau species that are involved in neuronal uptake and propagation and applications thereof
|
|
MY189674A
(en)
|
2015-10-28 |
2022-02-24 |
Sangamo Therapeutics Inc |
Liver-specific constructs, factor viii expression cassettes and methods of use thereof
|
|
KR20180101442A
(ko)
|
2016-02-02 |
2018-09-12 |
상가모 테라퓨틱스, 인코포레이티드 |
Dna-결합 도메인 및 절단 도메인을 연결시키기 위한 조성물
|
|
WO2017197141A2
(en)
|
2016-05-13 |
2017-11-16 |
Sangamo Therapeutics, Inc. |
Targeted treatment of androgenic alopecia
|
|
EP3995574A1
(en)
|
2016-08-24 |
2022-05-11 |
Sangamo Therapeutics, Inc. |
Regulation of gene expression using engineered nucleases
|
|
KR102455249B1
(ko)
|
2016-08-24 |
2022-10-17 |
상가모 테라퓨틱스, 인코포레이티드 |
가공된 표적 특이적 뉴클레아제
|
|
WO2018039471A2
(en)
|
2016-08-25 |
2018-03-01 |
Trustees Of Boston University |
Synthetic transcriptional and epigenetic regulators based on engineered, orthogonal zinc finger proteins
|
|
CA3035534A1
(en)
|
2016-09-07 |
2018-03-15 |
Sangamo Therapeutics, Inc. |
Modulation of liver genes
|
|
US11371023B2
(en)
|
2016-11-22 |
2022-06-28 |
Wisconsin Alumni Research Foundation |
Artificial transcription factors and uses thereof
|
|
IL266862B2
(en)
|
2016-12-01 |
2024-01-01 |
Sangamo Therapeutics Inc |
Tau modulators and methods and preparations for their administration
|
|
EP3861130A4
(en)
|
2018-10-02 |
2022-08-03 |
Sangamo Therapeutics, Inc. |
GENETIC MODULATORS
|
|
WO2020072677A1
(en)
|
2018-10-02 |
2020-04-09 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modulation of tau proteins
|
|
TW202134288A
(zh)
|
2020-01-22 |
2021-09-16 |
美商聖加莫治療股份有限公司 |
用於抑制tau蛋白表現之鋅指蛋白轉錄因子
|