JP2022510218A5 - - Google Patents

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Publication number
JP2022510218A5
JP2022510218A5 JP2021530200A JP2021530200A JP2022510218A5 JP 2022510218 A5 JP2022510218 A5 JP 2022510218A5 JP 2021530200 A JP2021530200 A JP 2021530200A JP 2021530200 A JP2021530200 A JP 2021530200A JP 2022510218 A5 JP2022510218 A5 JP 2022510218A5
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JP
Japan
Prior art keywords
seq
nos
sequence numbers
sequence
immunoglobulin
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Pending
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JP2021530200A
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English (en)
Japanese (ja)
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JP2022510218A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/063854 external-priority patent/WO2020113164A1/en
Publication of JP2022510218A publication Critical patent/JP2022510218A/ja
Publication of JP2022510218A5 publication Critical patent/JP2022510218A5/ja
Priority to JP2024133895A priority Critical patent/JP2024174865A/ja
Priority to JP2026042273A priority patent/JP2026116944A/ja
Pending legal-status Critical Current

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JP2021530200A 2018-11-30 2019-11-29 ヘテロ二量体四価特異性抗体およびこれらの使用 Pending JP2022510218A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2024133895A JP2024174865A (ja) 2018-11-30 2024-08-09 ヘテロ二量体四価特異性抗体およびこれらの使用
JP2026042273A JP2026116944A (ja) 2018-11-30 2026-03-16 ヘテロ二量体四価特異性抗体およびこれらの使用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862774111P 2018-11-30 2018-11-30
US62/774,111 2018-11-30
US201962794523P 2019-01-18 2019-01-18
US62/794,523 2019-01-18
PCT/US2019/063854 WO2020113164A1 (en) 2018-11-30 2019-11-29 Heterodimeric tetravalency and specificity antibody compositions and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024133895A Division JP2024174865A (ja) 2018-11-30 2024-08-09 ヘテロ二量体四価特異性抗体およびこれらの使用

Publications (2)

Publication Number Publication Date
JP2022510218A JP2022510218A (ja) 2022-01-26
JP2022510218A5 true JP2022510218A5 (enExample) 2022-12-05

Family

ID=70853677

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2021530200A Pending JP2022510218A (ja) 2018-11-30 2019-11-29 ヘテロ二量体四価特異性抗体およびこれらの使用
JP2024133895A Pending JP2024174865A (ja) 2018-11-30 2024-08-09 ヘテロ二量体四価特異性抗体およびこれらの使用
JP2026042273A Pending JP2026116944A (ja) 2018-11-30 2026-03-16 ヘテロ二量体四価特異性抗体およびこれらの使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2024133895A Pending JP2024174865A (ja) 2018-11-30 2024-08-09 ヘテロ二量体四価特異性抗体およびこれらの使用
JP2026042273A Pending JP2026116944A (ja) 2018-11-30 2026-03-16 ヘテロ二量体四価特異性抗体およびこれらの使用

Country Status (6)

Country Link
US (1) US20220098329A1 (enExample)
EP (1) EP3902834A4 (enExample)
JP (3) JP2022510218A (enExample)
AU (1) AU2019387482A1 (enExample)
CA (1) CA3121168A1 (enExample)
WO (1) WO2020113164A1 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111201030B (zh) 2017-07-25 2024-11-01 真和制药有限公司 通过阻断tim-3和其配体的相互作用治疗癌症
KR20210124308A (ko) 2019-01-30 2021-10-14 트루바인딩 아이엔씨. 항-gal3 항체 및 이의 용도
JP7137696B2 (ja) 2019-05-14 2022-09-14 プロヴェンション・バイオ・インコーポレイテッド 1型糖尿病を予防するための方法および組成物
AU2020392243A1 (en) 2019-11-28 2022-06-16 Regenxbio Inc. Microdystrophin gene therapy constructs and uses thereof
MX2022014786A (es) 2020-05-26 2023-01-16 Truebinding Inc Metodos para tratar enfermedades inflamatorias mediante el bloqueo de galectina-3.
KR20230092863A (ko) 2020-06-11 2023-06-26 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
WO2022018262A1 (en) 2020-07-24 2022-01-27 Cellectis S.A. T-cells expressing immune cell engagers in allogenic settings
EP4192489A4 (en) 2020-08-05 2024-12-11 Synthekine, Inc. IL2RB-BINDING MOLECULES AND METHODS OF USE
JP7743500B2 (ja) 2020-08-05 2025-09-24 シンセカイン インコーポレイテッド Il10受容体結合性分子および使用方法
US12540188B2 (en) 2020-08-05 2026-02-03 Synthekine, Inc. IL10Rα/IL2Rγ synthetic cytokines
US11124568B1 (en) * 2020-08-19 2021-09-21 Vitruviae LLC CD3/CD25 antibodies for neuro-immune diseases
EP4210832A1 (en) * 2020-09-14 2023-07-19 Vor Biopharma, Inc. Chimeric antigen receptors for treatment of cancer
AU2021381768A1 (en) * 2020-11-18 2023-06-22 Memorial Sloan Kettering Cancer Center Anti-gpa33 multi-specific antibodies and uses thereof
AU2022205313A1 (en) * 2021-01-06 2023-07-20 Tonix Pharma Limited Methods of inducing immune tolerance with modified anti-cd154 antibodies
WO2022150791A2 (en) * 2021-01-11 2022-07-14 Synthekine, Inc. Compositions and methods related to il2 receptor binding
AU2022218137A1 (en) 2021-02-03 2023-08-24 Mozart Therapeutics, Inc. Binding agents and methods of using the same
EP4341300A1 (en) 2021-05-21 2024-03-27 Cellectis S.A. Enhancing efficacy of t-cell-mediated immunotherapy by modulating cancer-associated fibroblasts in solid tumors
MX2023013851A (es) 2021-05-24 2023-12-08 Provention Bio Inc Metodos para el tratamiento de diabetes tipo 1.
CN117940459A (zh) * 2021-08-25 2024-04-26 西雅图免疫公司 靶向egfr和her3的双特异性四价抗体
WO2023055376A1 (en) * 2021-09-30 2023-04-06 Virtuoso Binco, Inc. Multispecific antibodies for targeting cd47 and icam1 and methods of use thereof
EP4419567A4 (en) * 2021-10-20 2025-09-17 Memorial Sloan Kettering Cancer Center MULTI-SPECIFIC ANTI-TSHR ANTIBODIES AND THEIR USES
JP2024540374A (ja) 2021-11-05 2024-10-31 アメリカン ダイアグノスティックス アンド セラピー, エルエルシー (エーディーエックスアールエックス) がん胎児性抗原に対するモノクローナル抗体、及びそれらの使用
JP7767613B2 (ja) 2021-11-15 2025-11-11 システィミューン,インコーポレイテッド 二重特異性抗体-カンプトテシン薬物複合体及びその製薬的使用
EP4467569A4 (en) * 2022-01-21 2026-02-11 Harbour Biomed Shanghai Co Ltd ANTI-B7-H7 ANTIBODIES OR ANTIGEN-BINDING FRAGMENT OF THESE, ITS PREPARATION PROCESS AND ITS USE
IL315960A (en) 2022-03-30 2024-11-01 Pinetree Therapeutics Inc Bispecific antibodies comprising an nrp1 binding domain and methods of use thereof
CN114685609B (zh) * 2022-04-11 2023-04-14 东北农业大学 一种超短自组装抗菌肽fwr及其制备方法与应用
US20250002588A1 (en) 2023-04-07 2025-01-02 Diagonal Therapeutics Inc. Bispecific agonistic antibodies to activin a receptor like type 1 (alk1)
EP4720125A1 (en) 2023-05-30 2026-04-08 Paragon Therapeutics, Inc. Alpha4beta7 integrin antibody compositions and methods of use
EP4762093A1 (en) 2023-08-14 2026-06-24 Paragon Therapeutics, Inc. Alpha 4 beta 7 integrin binding proteins and methods of use
CN118146376B (zh) * 2024-05-09 2024-07-05 成都微芯新域生物技术有限公司 Hla-g抗体及其制备方法和用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7147851B1 (en) * 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
US7070995B2 (en) * 2001-04-11 2006-07-04 City Of Hope CE7-specific redirected immune cells
US7125843B2 (en) * 2001-10-19 2006-10-24 Neose Technologies, Inc. Glycoconjugates including more than one peptide
WO2009129538A2 (en) * 2008-04-18 2009-10-22 Xencor, Inc. Human equivalent monoclonal antibodies engineered from nonhuman variable regions
NZ603581A (en) * 2010-06-19 2015-05-29 Sloan Kettering Inst Cancer Anti-gd2 antibodies
CN103429620B (zh) * 2010-11-05 2018-03-06 酵活有限公司 在Fc结构域中具有突变的稳定异源二聚的抗体设计
WO2012162067A2 (en) * 2011-05-21 2012-11-29 Macrogenics, Inc. Cd3-binding molecules capable of binding to human and non-human cd3
KR101850591B1 (ko) * 2012-10-05 2018-04-19 제넨테크, 인크. 염증성 장 질환의 진단 및 치료 방법
SG11201506451UA (en) * 2013-03-06 2015-09-29 Merrimack Pharmaceuticals Inc Anti-c-met tandem fc bispecific antibodies
MX2015013163A (es) * 2013-03-15 2016-04-04 Zyngenia Inc Complejos multiespecificos multivalente y monovalentes y sus usos.
CN105530959B (zh) * 2013-03-15 2021-09-17 纪念斯隆-凯特琳癌症中心 多聚化技术
CA2904805A1 (en) * 2013-04-29 2014-11-06 F. Hoffmann-La Roche Ag Fc-receptor binding modified asymmetric antibodies and methods of use
ES2959480T3 (es) * 2014-02-07 2024-02-26 Univ Mcmaster Acoplador de células T - antígeno trifuncional y métodos y usos del mismo
MX386342B (es) * 2014-07-25 2025-03-18 Memorial Sloan Kettering Cancer Center Móleculas de unión a her2 y cd3 biespecíficas.
BR112017024770A2 (pt) * 2015-05-21 2018-07-31 Alligator Bioscience Ab polipeptídeos inovadores
EP3526257A2 (en) * 2016-10-14 2019-08-21 Dana-Farber Cancer Institute, Inc. Modular tetravalent bispecific antibody platform
EP3574012A1 (en) * 2017-01-27 2019-12-04 Memorial Sloan Kettering Cancer Center Bispecific her2 and cd3 binding molecules
KR20190140943A (ko) * 2017-04-24 2019-12-20 메모리얼 슬로안 케터링 캔서 센터 항-cd33 항체 제제

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