JP2022506958A - Ｍｉｒ－１０ｂ活性を調節するためのマイクロｒｎａ化合物及び方法 - Google Patents

Ｍｉｒ－１０ｂ活性を調節するためのマイクロｒｎａ化合物及び方法 Download PDF

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JP2022506958A
JP2022506958A JP2021525119A JP2021525119A JP2022506958A JP 2022506958 A JP2022506958 A JP 2022506958A JP 2021525119 A JP2021525119 A JP 2021525119A JP 2021525119 A JP2021525119 A JP 2021525119A JP 2022506958 A JP2022506958 A JP 2022506958A
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nucleoside
certain embodiments
compound
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glioma
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JPWO2020102142A5 (https=
JP2022506958A5 (https=
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チャールズ アール． アラーソン
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レグルス セラピューティクス インコーポレイテッド
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    • A—HUMAN NECESSITIES
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    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/335—Modified T or U

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  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2021525119A 2018-11-13 2019-11-12 Ｍｉｒ－１０ｂ活性を調節するためのマイクロｒｎａ化合物及び方法 Pending JP2022506958A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862760546P 2018-11-13 2018-11-13
US62/760,546 2018-11-13
PCT/US2019/060841 WO2020102142A1 (en) 2018-11-13 2019-11-12 Microrna compounds and methods for modulating mir-10b activity

Publications (3)

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JP2022506958A true JP2022506958A (ja) 2022-01-17
JPWO2020102142A5 JPWO2020102142A5 (https=) 2022-10-03
JP2022506958A5 JP2022506958A5 (https=) 2022-10-03

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JP2021525119A Pending JP2022506958A (ja) 2018-11-13 2019-11-12 Ｍｉｒ－１０ｂ活性を調節するためのマイクロｒｎａ化合物及び方法

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US (1) US20220096517A1 (https=)
EP (1) EP3880310A1 (https=)
JP (1) JP2022506958A (https=)
KR (1) KR20210091732A (https=)
CN (1) CN112996568A (https=)
AU (1) AU2019381681A1 (https=)
CA (1) CA3117981A1 (https=)
MA (1) MA54226A (https=)
TW (1) TW202031268A (https=)
WO (1) WO2020102142A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11236337B2 (en) 2016-11-01 2022-02-01 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
US11584932B2 (en) 2016-11-01 2023-02-21 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
WO2021262919A2 (en) 2020-06-26 2021-12-30 The Research Foundation For The State University Of New York 5-halouracil-modified micrornas and their use in the treatment of cancer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010022166A2 (en) * 2008-08-19 2010-02-25 Maine Institute For Human Genetics And Health Micro rna (mirna) and neurofibromatosis type 1 : a role in diagnosis and therapy
WO2011048125A1 (en) * 2009-10-20 2011-04-28 Santaris Pharma A/S Oral delivery of therapeutically effective lna oligonucleotides
JP2014527807A (ja) * 2011-09-07 2014-10-23 株式会社スリー・ディー・マトリックス 骨肉腫のためのマイクロｒｎａに基づく方法およびアッセイ
WO2018106566A1 (en) * 2016-12-05 2018-06-14 Regulus Therapeutics Inc. Modified oligonucleotides for treatment of polycystic kidney disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3192788A1 (en) 2006-10-03 2017-07-19 Arbutus Biopharma Corporation Lipid containing formulations
ES2555057T3 (es) * 2009-06-12 2015-12-28 Roche Innovation Center Copenhagen A/S Nuevos potentes compuestos antisentido anti-ApoB
PE20142404A1 (es) * 2012-04-25 2015-02-02 Regulus Therapeutics Inc Compuestos de microarn y metodos de modulacion de la actividad de mir-21

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010022166A2 (en) * 2008-08-19 2010-02-25 Maine Institute For Human Genetics And Health Micro rna (mirna) and neurofibromatosis type 1 : a role in diagnosis and therapy
WO2011048125A1 (en) * 2009-10-20 2011-04-28 Santaris Pharma A/S Oral delivery of therapeutically effective lna oligonucleotides
JP2014527807A (ja) * 2011-09-07 2014-10-23 株式会社スリー・ディー・マトリックス 骨肉腫のためのマイクロｒｎａに基づく方法およびアッセイ
WO2018106566A1 (en) * 2016-12-05 2018-06-14 Regulus Therapeutics Inc. Modified oligonucleotides for treatment of polycystic kidney disease

Also Published As

Publication number Publication date
CN112996568A (zh) 2021-06-18
TW202031268A (zh) 2020-09-01
WO2020102142A1 (en) 2020-05-22
EP3880310A1 (en) 2021-09-22
MA54226A (fr) 2021-09-22
AU2019381681A1 (en) 2021-05-27
KR20210091732A (ko) 2021-07-22
CA3117981A1 (en) 2020-05-22
US20220096517A1 (en) 2022-03-31

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