JP2022506958A - Ｍｉｒ－１０ｂ活性を調節するためのマイクロｒｎａ化合物及び方法 - Google Patents

Ｍｉｒ－１０ｂ活性を調節するためのマイクロｒｎａ化合物及び方法 Download PDF

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JP2022506958A
JP2022506958A JP2021525119A JP2021525119A JP2022506958A JP 2022506958 A JP2022506958 A JP 2022506958A JP 2021525119 A JP2021525119 A JP 2021525119A JP 2021525119 A JP2021525119 A JP 2021525119A JP 2022506958 A JP2022506958 A JP 2022506958A
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nucleoside
certain embodiments
compound
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glioma
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JP2022506958A5 (OSRAM
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チャールズ アール． アラーソン
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レグルス セラピューティクス インコーポレイテッド
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    • A—HUMAN NECESSITIES
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/335—Modified T or U

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  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2021525119A 2018-11-13 2019-11-12 Ｍｉｒ－１０ｂ活性を調節するためのマイクロｒｎａ化合物及び方法 Pending JP2022506958A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862760546P 2018-11-13 2018-11-13
US62/760,546 2018-11-13
PCT/US2019/060841 WO2020102142A1 (en) 2018-11-13 2019-11-12 Microrna compounds and methods for modulating mir-10b activity

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JP2022506958A true JP2022506958A (ja) 2022-01-17
JP2022506958A5 JP2022506958A5 (OSRAM) 2022-10-03

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JP2021525119A Pending JP2022506958A (ja) 2018-11-13 2019-11-12 Ｍｉｒ－１０ｂ活性を調節するためのマイクロｒｎａ化合物及び方法

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US (1) US20220096517A1 (OSRAM)
EP (1) EP3880310A1 (OSRAM)
JP (1) JP2022506958A (OSRAM)
KR (1) KR20210091732A (OSRAM)
CN (1) CN112996568A (OSRAM)
AU (1) AU2019381681A1 (OSRAM)
CA (1) CA3117981A1 (OSRAM)
MA (1) MA54226A (OSRAM)
TW (1) TW202031268A (OSRAM)
WO (1) WO2020102142A1 (OSRAM)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11236337B2 (en) 2016-11-01 2022-02-01 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
US11584932B2 (en) 2016-11-01 2023-02-21 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
WO2021262919A2 (en) 2020-06-26 2021-12-30 The Research Foundation For The State University Of New York 5-halouracil-modified micrornas and their use in the treatment of cancer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010022166A2 (en) * 2008-08-19 2010-02-25 Maine Institute For Human Genetics And Health Micro rna (mirna) and neurofibromatosis type 1 : a role in diagnosis and therapy
WO2011048125A1 (en) * 2009-10-20 2011-04-28 Santaris Pharma A/S Oral delivery of therapeutically effective lna oligonucleotides
JP2014527807A (ja) * 2011-09-07 2014-10-23 株式会社スリー・ディー・マトリックス 骨肉腫のためのマイクロｒｎａに基づく方法およびアッセイ
WO2018106566A1 (en) * 2016-12-05 2018-06-14 Regulus Therapeutics Inc. Modified oligonucleotides for treatment of polycystic kidney disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008042973A2 (en) 2006-10-03 2008-04-10 Alnylam Pharmaceuticals, Inc. Lipid containing formulations
NZ596608A (en) * 2009-06-12 2014-01-31 Santaris Pharma As New potent anti apob antisense compounds
EP2841579B1 (en) * 2012-04-25 2018-10-10 Regulus Therapeutics Inc. Microrna compounds and methods for modulating mir-21 activity

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010022166A2 (en) * 2008-08-19 2010-02-25 Maine Institute For Human Genetics And Health Micro rna (mirna) and neurofibromatosis type 1 : a role in diagnosis and therapy
WO2011048125A1 (en) * 2009-10-20 2011-04-28 Santaris Pharma A/S Oral delivery of therapeutically effective lna oligonucleotides
JP2014527807A (ja) * 2011-09-07 2014-10-23 株式会社スリー・ディー・マトリックス 骨肉腫のためのマイクロｒｎａに基づく方法およびアッセイ
WO2018106566A1 (en) * 2016-12-05 2018-06-14 Regulus Therapeutics Inc. Modified oligonucleotides for treatment of polycystic kidney disease

Also Published As

Publication number Publication date
KR20210091732A (ko) 2021-07-22
MA54226A (fr) 2021-09-22
EP3880310A1 (en) 2021-09-22
CA3117981A1 (en) 2020-05-22
AU2019381681A1 (en) 2021-05-27
TW202031268A (zh) 2020-09-01
WO2020102142A1 (en) 2020-05-22
US20220096517A1 (en) 2022-03-31
CN112996568A (zh) 2021-06-18

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