|
US4036945A
(en)
|
1976-05-03 |
1977-07-19 |
The Massachusetts General Hospital |
Composition and method for determining the size and location of myocardial infarcts
|
|
US4331647A
(en)
|
1980-03-03 |
1982-05-25 |
Goldenberg Milton David |
Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
ATE300615T1
(de)
|
1990-08-29 |
2005-08-15 |
Genpharm Int |
Transgene mäuse fähig zur produktion heterologer antikörper
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5239078A
(en)
|
1990-11-21 |
1993-08-24 |
Glycomed Incorporated |
Matrix metalloprotease inhibitors
|
|
US5189178A
(en)
|
1990-11-21 |
1993-02-23 |
Galardy Richard E |
Matrix metalloprotease inhibitors
|
|
EP1210428B1
(en)
|
1999-08-23 |
2015-03-18 |
Dana-Farber Cancer Institute, Inc. |
Pd-1, a receptor for b7-4, and uses therefor
|
|
JP4808363B2
(ja)
|
2000-09-05 |
2011-11-02 |
バイオカイン セラピューティックス リミテッド |
新規ポリペプチド及びこれを含む抗hiv剤
|
|
AR036993A1
(es)
|
2001-04-02 |
2004-10-20 |
Wyeth Corp |
Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas
|
|
ES2350687T3
(es)
|
2002-07-03 |
2011-01-26 |
Ono Pharmaceutical Co., Ltd. |
Composiciones de inmunopotenciación.
|
|
WO2004020462A1
(ja)
|
2002-08-27 |
2004-03-11 |
Fujii, Nobutaka |
Cxcr4拮抗薬およびその用途
|
|
CN1753912B
(zh)
|
2002-12-23 |
2011-11-02 |
惠氏公司 |
抗pd-1抗体及其用途
|
|
CN103555733A
(zh)
|
2005-01-05 |
2014-02-05 |
F-星生物技术研究与开发有限公司 |
分子中互补决定区以外的区域中工程改造了的具有结合特性的合成免疫球蛋白结构域
|
|
RU2494107C2
(ru)
|
2005-05-09 |
2013-09-27 |
Оно Фармасьютикал Ко., Лтд. |
Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами
|
|
AT503902B1
(de)
|
2006-07-05 |
2008-06-15 |
F Star Biotech Forsch & Entw |
Verfahren zur manipulation von immunglobulinen
|
|
CA2673719C
(en)
|
2006-12-21 |
2018-07-24 |
Biokine Therapeutics Ltd. |
T-140 peptide analogs having cxcr4 super-agonist activity for bone marrow recovery
|
|
HRP20131167T1
(hr)
|
2007-06-18 |
2014-01-03 |
Merck Sharp & Dohme B.V. |
Antitijela za humani receptor programirane smrti pd-1
|
|
WO2009114335A2
(en)
|
2008-03-12 |
2009-09-17 |
Merck & Co., Inc. |
Pd-1 binding proteins
|
|
WO2010098788A2
(en)
|
2008-08-25 |
2010-09-02 |
Amplimmune, Inc. |
Pd-i antagonists and methods for treating infectious disease
|
|
CN102203132A
(zh)
|
2008-08-25 |
2011-09-28 |
安普利穆尼股份有限公司 |
Pd-1拮抗剂的组合物和使用方法
|
|
KR101814408B1
(ko)
|
2008-09-26 |
2018-01-04 |
다나-파버 캔서 인스티튜트 인크. |
인간 항-pd-1, pd-l1, 및 pd-l2 항체 및 그의 용도
|
|
CA2744449C
(en)
|
2008-11-28 |
2019-01-29 |
Emory University |
Methods for the treatment of infections and tumors
|
|
WO2010089411A2
(en)
|
2009-02-09 |
2010-08-12 |
Universite De La Mediterranee |
Pd-1 antibodies and pd-l1 antibodies and uses thereof
|
|
CN103932972A
(zh)
|
2009-03-30 |
2014-07-23 |
天蓝制药公司 |
聚合物-药剂缀合物、颗粒、组合物和相关使用方法
|
|
US20110160159A1
(en)
|
2009-09-15 |
2011-06-30 |
John Ryan |
Treatment of cancer
|
|
CA3083324A1
(en)
|
2010-03-05 |
2011-09-09 |
The Johns Hopkins University |
Compositions and methods for targeted immunomodulatory antibodies and fusion proteins
|
|
JP2013532153A
(ja)
|
2010-06-18 |
2013-08-15 |
ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド |
慢性免疫病に対する免疫治療のためのtim−3およびpd−1に対する二重特異性抗体
|
|
JP6238459B2
(ja)
|
2011-08-01 |
2017-11-29 |
ジェネンテック, インコーポレイテッド |
Pd−1軸結合アンタゴニストとmek阻害剤を使用する癌の治療方法
|
|
US9439942B2
(en)
|
2012-04-24 |
2016-09-13 |
Biokine Therapeutics Ltd. |
Peptides and use thereof in the treatment of large cell lung cancer
|
|
AU2013202947B2
(en)
*
|
2012-06-13 |
2016-06-02 |
Ipsen Biopharm Ltd. |
Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
|
|
ES2812208T3
(es)
|
2013-03-14 |
2021-03-16 |
Bristol Myers Squibb Co |
Combinación de un agonista de DR5 y un antagonista de anti-PD-1 y métodos de uso
|
|
EP3307778A1
(en)
|
2015-06-12 |
2018-04-18 |
Bristol-Myers Squibb Company |
Treatment of cancer by combined blockade of the pd-1 and cxcr4 signaling pathways
|
|
IL274572B2
(en)
|
2015-07-16 |
2024-01-01 |
Biolinerx Ltd |
Compositions and methods for treating cancer
|
|
MX385425B
(es)
*
|
2015-08-21 |
2025-03-18 |
Ipsen Biopharm Ltd |
Irinotecán liposomal y oxaliplatino, 5-fluoroacilo y leucovorina para usarse en el tratamiento de cáncer pancreático metastásico.
|
|
EP3535026A1
(en)
|
2016-11-02 |
2019-09-11 |
Ipsen Biopharm Limited |
Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin)
|
|
AU2018292618A1
(en)
|
2017-06-27 |
2019-12-19 |
Novartis Ag |
Dosage regimens for anti-TIM-3 antibodies and uses thereof
|
|
WO2020079692A1
(en)
|
2018-10-17 |
2020-04-23 |
Biolinerx Ltd. |
Treatment of metastatic pancreatic adenocarcinoma
|
|
WO2020148745A1
(en)
|
2019-01-17 |
2020-07-23 |
Biolinerx Ltd. |
Specific combination therapy for treatment of pancreatic cancer
|
|
WO2020148744A1
(en)
|
2019-01-17 |
2020-07-23 |
Biolinerx Ltd. |
Combination therapy for treatment of pancreatic cancer
|
|
WO2021009761A1
(en)
|
2019-07-18 |
2021-01-21 |
Biolinerx Ltd. |
Combination therapy for the treatment of cancer
|
|
US11599666B2
(en)
|
2020-05-27 |
2023-03-07 |
Sap Se |
Smart document migration and entity detection
|
|
JP2024501709A
(ja)
|
2020-12-30 |
2024-01-15 |
バイオラインアールエックス・リミテッド |
Bl-8040の組成物
|