JP2022504096A - 炎症関連胃腸障害の処置のためのプロバイオティクスの組み合わせ - Google Patents
炎症関連胃腸障害の処置のためのプロバイオティクスの組み合わせ Download PDFInfo
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Abstract
【選択図】 なし
Description
アッセイの前日、Nestle Culture Collectionから選択された3種の細菌株、NCC 3001、2818及び2705を、10mLのMRS+システインで培養し、嫌気性条件下、37℃で16時間増殖させた。
3名の健康なドナーから単離したPBMCをPBSで1回洗浄した。500gで5分間遠心分離した後、細胞ペレットを、2mLのRPMI+10%のウシ胎児血清(FCS)に再懸濁した。細胞を計数し、調製物を、2×106個/mLとなるよう調整した。
PBMCを12ウェルの培養プレート(500μL)に播種し、次いで細菌調製物を添加した(500μL)。共培養物を、10%のCO2下、37℃で24時間インキュベートした。
Caco-2及びHT-29-MTX細胞を、12ウェル培養プレートにおいて、ポリスチレンフィルタインサート上で3:1の比で共培養した。分化(14日間)の際、共培養物を細菌調製物(5×106個)とともに24時間プレインキュベートした後、TNFα(0.6ng/mL)及びIFNγ(2.5ng/mL)により基底外側を刺激し、バリアの完全性を変化させた(対照)。経上皮電気抵抗(TEER)を16時間後に測定して、炎症によりバリア透過性に誘導される変化を、TNFα/IFNγで処理した対照と比較して、TEERの増加パーセントとして示し定量した。
Claims (23)
- 胃腸の炎症の低減に使用するための、又は炎症関連胃腸障害の処置若しくは予防に使用するための、プロバイオティクスの組み合わせであって、ビフィドバクテリウム・ロンガムCNCM I-2618及びビフィドバクテリウム・ラクティスCNCM I-3446を含む、組み合わせ。
- ビフィドバクテリウム・ロンガムATCC BAA-999を更に含む、請求項1に記載の組み合わせ。
- 前記炎症関連胃腸障害が、炎症性サイトカイン及び/又は抗炎症性サイトカインによって調節され、好ましくは前記炎症関連胃腸障害が、IL-10及び/又はIL-12によって調節され、又は、前記炎症関連胃腸障害が、制御性T細胞若しくはTh17/Tregの分化によって調節され、又は、前記炎症関連胃腸障害が、クオラムセンシングシグナル伝達阻害剤によって調節される、請求項1又は2に記載の組み合わせ。
- 前記炎症関連胃腸障害が、ビフィズス菌及び乳酸桿菌などの有益細菌の不均衡によって調節され、又は、前記炎症関連胃腸障害が、ディフェンシン若しくはムチンによって調節され、又は、前記炎症関連胃腸障害が、酸化ストレス若しくはCRPなどの炎症マーカーによって調節される、請求項1~3のいずれか一項に記載の組み合わせ。
- 炎症性サイトカインの産生若しくは発現を減少若しくは抑制するための、好ましくはIL-10である抗炎症サイトカインの産生若しくは発現を増加させるための、及び/又は、好ましくはIL-12である炎症性サイトカインの産生若しくは発現を減少若しくは抑制するための、より好ましくはIL-10及びIL-12の濃度比を調節するための、消化管内のビフィズス菌及び乳酸桿菌などの有益な細菌群を増加させるための、ディフェンシン若しくはムチンの産生又は発現を促進するための、酸化ストレス若しくはCRPなどの炎症マーカーを低減するための、酪酸などの短鎖脂肪酸を含むがこれらに限定されない微生物叢代謝機能を促進するための、組織治癒を支援若しくは促進するための、又は消化管バリアを強化若しくは改善するための、腸バリアの修復及び/若しくは機能を改善するための、腸バリアの透過性を改善若しくは強化するための、制御性T細胞の活性化若しくはTh17/Tregの分化を調節するための、好ましくは、制御性T細胞の活性化若しくはTh17/Tregの分化を促進するための、又は、クオラムセンシングシグナル伝達阻害剤を促進するための、請求項1又は2に記載の組み合わせ。
- 前記炎症関連胃腸障害が炎症性腸疾患であり、特に、大腸炎、潰瘍性大腸炎、慢性腸疾患、クローン病、及び回腸嚢炎からなる群から選択されるものである、又は前記炎症関連胃腸障害が食品反応性の下痢症疾患である、請求項1~5のいずれか一項に記載の組み合わせ。
- 前記炎症関連胃腸障害が、潰瘍性大腸炎、クローン病又は食品反応性の下痢症である、請求項1~6のいずれか一項に記載の組み合わせ。
- 請求項1~7のいずれか一項に記載の使用のためのプロバイオティクスの組成物であって、当該組成物が、抗炎症性サイトカインの濃度又は発現を増加させるものであり、より好ましくは、前記抗炎症性サイトカインがIL-10である、組成物。
- 対象が、哺乳動物、好ましくはヒト又は伴侶動物であり、好ましくは、対象が、乳児、小児、青年、又は成人のヒト、イヌ、子イヌ、ネコ、又は子ネコである、請求項1~7のいずれか一項に記載の組み合わせ。
- 前記プロバイオティクスの組み合わせにおける各プロバイオティクスが、1日当たり108~1012cfuに相当する量で対象に投与される、請求項1~7及び9のいずれか一項に記載の組み合わせ。
- 組成物の形態で投与される、請求項1~7、9及び10のいずれか一項に記載の組み合わせ。
- 前記組成物が、医薬製剤、獣医用製剤、栄養剤、経管栄養剤、サプリメント、機能性食品、飲料製品、及びペットケア製品からなる群から選択される、請求項11に記載の組み合わせ。
- プロバイオティクスの組み合わせを含む組成物であって、前記プロバイオティクスの組み合わせが、ビフィドバクテリウム・ロンガムCNCM I-2618及びビフィドバクテリウム・ラクティスCNCM I-3446を含む、組成物。
- 前記プロバイオティクスの組み合わせが、ビフィドバクテリウム・ロンガムATCC BAA-999を更に含む、請求項13に記載の組成物。
- 各プロバイオティクスを、1日当たり108~1012cfuに相当する量で前記プロバイオティクスの組み合わせに含む、請求項13又は14に記載の組成物。
- 医薬製剤、獣医用製剤、栄養剤、経管栄養剤、サプリメント、機能性食品、飲料製品、及びペットケア製品からなる群から選択される、請求項13、14又は15に記載の組成物。
- 胃腸の炎症の低減に使用するための、又は炎症関連胃腸障害の処置若しくは予防に使用するための、組成物の製造に使用するためのプロバイオティクスの組み合わせであって、ビフィドバクテリウム・ロンガムCNCM I-2618及びビフィドバクテリウム・ラクティスCNCM I-3446を含む、組み合わせ。
- ビフィドバクテリウム・ロンガムATCC BAA-999を更に含む、請求項17に記載の組み合わせ。
- 対象における、胃腸の炎症を低減するための、腸バリアを強化するための、又は炎症性腸疾患を治療若しくは予防するための方法であって、前記対象にプロバイオティクスの組み合わせを投与する工程、を含み、前記プロバイオティクスの組み合わせが、ビフィドバクテリウム・ロンガムCNCM I-2618及びビフィドバクテリウム・ラクティスCNCM I-3446である、方法。
- 前記プロバイオティクスの組み合わせが、ビフィドバクテリウム・ロンガムATCC BAA-999を更に含む、請求項19に記載の方法。
- 炎症により誘導される腸バリアの機能不全の予防に使用するための、腸バリアの透過性の低減に使用するための、バリアの修復の改善に使用するための、腸バリアの機能の改善に使用するための、及び/又は腸バリアの強化/保護に使用するための、プロバイオティクスの組み合わせであって、ビフィドバクテリウム・ロンガムCNCM I-2618及びビフィドバクテリウム・ラクティスCNCM I-3446を含む、組み合わせ。
- 前記使用が、腸バリアの修復及び/又は腸バリアの機能の改善のためのものである、請求項21に記載の組み合わせ。
- ビフィドバクテリウム・ロンガムATCC BAA-999を更に含む、請求項21又は22に記載の組み合わせ。
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WO2007093619A1 (en) * | 2006-02-15 | 2007-08-23 | Nestec S.A. | Use of bifidobacterium longum for the prevention and treatment of inflammation |
WO2007140621A1 (en) * | 2006-06-09 | 2007-12-13 | Nutravital Inc. | Probiotic compositions and uses thereof |
EP2127661A1 (en) * | 2008-05-27 | 2009-12-02 | Nestec S.A. | Probiotics to improve gut microbiotica |
US20120164109A1 (en) * | 2009-08-18 | 2012-06-28 | Nestec S.A. | nutritional composition comprising bifidobacterium longum strains and reducing food allergy symptoms, especially in infants and children |
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JP7296454B2 (ja) | 2023-06-22 |
BR112021005316A2 (pt) | 2021-06-15 |
AU2019353693A1 (en) | 2021-04-01 |
EP3860631A1 (en) | 2021-08-11 |
CA3114973A1 (en) | 2020-04-09 |
MX2021003224A (es) | 2021-05-27 |
US20210330719A1 (en) | 2021-10-28 |
CN112955163A (zh) | 2021-06-11 |
WO2020070087A1 (en) | 2020-04-09 |
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