JP2022501340A - メトホルミンの作用を増強する化合物 - Google Patents
メトホルミンの作用を増強する化合物 Download PDFInfo
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- JP2022501340A JP2022501340A JP2021514515A JP2021514515A JP2022501340A JP 2022501340 A JP2022501340 A JP 2022501340A JP 2021514515 A JP2021514515 A JP 2021514515A JP 2021514515 A JP2021514515 A JP 2021514515A JP 2022501340 A JP2022501340 A JP 2022501340A
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- compound
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- glycoside
- ome
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Abstract
Description
国際ガイドラインによれば、ビグアニドの1つであるメトホルミンは、その効力、低血糖症のリスクが非常に低いこと、及び低コストであることを主な理由として、2型糖尿病の治療に推奨される第一選択の経口治療薬である(PMID:18941734)。加えて、心血管疾患及び癌発生率の低減を含む他の有益な効果が存在する可能性が高い(PMID:15849206)。
本発明は、概して、(i)代謝疾患又は心血管疾患の予防又は治療に好適な作用剤と、(ii)本明細書に記載の一般式(I)を有する化合物と、を含む薬物に関する。
(i)メトホルミン、又はこれらの塩と、
(ii)一般式(I)
を有する化合物、又はその塩と、
を含む薬物に関し、
化合物(ii)において、R1、R2、R3、R4、R5、R6、R7、及びR8は、それぞれ独立して、H;OH;OMe;O−グリコシド;ハロゲン;アルデヒド;カルボン酸;第一級アミン、第二級アミン、又は第三級アミン;第一級アミド又は第二級アミド;シアノ;ニトロ;スルホネート;スルフェート;場合により置換された及び/若しくは場合により分枝状のC1〜C20アルキル;場合により置換された及び/若しくは場合により分枝状のC2〜C20アルケニル;場合により置換された及び/若しくは場合により分枝状のC4〜C20ポリアルケニル;場合により置換された及び/若しくは場合により分枝状のC2〜C20アルキニル;又は、場合により置換された及び/若しくは場合により分枝状のC4〜C20ポリアルキニルである。
一実施形態では、薬物の化合物(i)及び化合物(ii)は、単一製剤において組み合わされる。一実施形態では、薬物の化合物(i)及び化合物(ii)は、化合物(i)とは異なる少なくとも1つの他の抗糖尿病剤と、単一製剤において組み合わされる。
本明細書に記載される本発明の薬物を薬学的に許容可能な形態で含む医薬組成物も提供される。
投与を必要とする対象への本発明の薬物又は医薬組成物の投与を含む、代謝疾患又は心血管疾患を予防又は治療する方法であって、薬物又は医薬組成物は、(i)代謝疾患又は心血管疾患の予防又は治療に好適な作用剤、及び/又は(ii)本明細書に記載の一般式(I)を有する化合物、を含む、方法も提供される。
1)アルケニル基、アルキニル基、アルコキシ基、シクロアルキル基、シクロアルケニル基、シクロアルコキシ基、シクロアルケニルオキシ基、アシル基、アシルアミノ基、アシルオキシ基、アミノ基、置換アミノ基、アミノカルボニル基、アルコキシカルボニルアミノ基、アジド基、シアノ基、ハロゲン基、ヒドロキシ基、ケト基、チオカルボニル基、カルボキシ基、カルボキシアルキル基、アリールチオ基、ヘテロアリールチオ基、ヘテロシクリルチオ基、チオール基、アルキルチオ基、アリール基、アリールオキシ基、ヘテロアリール基、アミノスルホニル基、アミノカルボニルアミノ基、ヘテロアリールオキシ基、ヘテロシクリル基、ヘテロシクロオキシ基、ヒドロキシアミノ基、アルコキシアミノ基、ニトロ基、−S(O)−アルキル基、−S(O)−シクロアルキル基、−S(O)−ヘテロシクリル基、−S(O)−アリール基、−S(O)−ヘテロアリール基、−S(O)2−アルキル基、−S(O)2−シクロアルキル基、−S(O)2−ヘテロシクリル基、−S(O)2−アリール基及び−S(O)2−ヘテロアリール基からなる群から選択される1個、2個、3個、4個又は5個の置換基(いくつかの実施形態では、1個、2個又は3個の置換基)を有する、上記定義によるアルキル鎖。定義によって特に制約されない限り、すべての置換基は、場合により、アルキル基、アルケニル基、アルキニル基、カルボキシ基、カルボキシアルキル基、アミノカルボニル基、ヒドロキシ基、アルコキシ基、ハロゲン基、CF3基、アミノ基、置換アミノ基、シアノ基、シクロアルキル基、ヘテロシクリル基、アリール基、ヘテロアリール基、及び−S(O)nR<a>基[式中、R<a>はアルキル基、アリール基又はヘテロアリール基であり、nは0、1、又は2である]から選択される1個、2個、又は3個の置換基によって更に置換され得る;又は
2)酸素、硫黄、及びNR<a>[式中、R<a>は、水素、アルキル基、シクロアルキル基、アルケニル基、シクロアルケニル基、アルキニル基、アリール基、ヘテロアリール基、及びヘテロシクリル基から選択される]から独立して選択される1〜10個の原子(例えば、1個、2個、3個、4個又は5個の原子)が介在する、上記定義によるアルキル鎖。すべての置換基は、場合により、アルキル基、アルケニル基、アルキニル基、カルボキシ基、カルボキシアルキル基、アミノカルボニル基、ヒドロキシ基、アルコキシ基、ハロゲン基、CF3基、アミノ基、置換アミノ基、シアノ基、シクロアルキル基、ヘテロシクリル基、アリール基、ヘテロアリール基、及び−S(O)nR<a>[式中、R<a>はアルキル基、アリール基又はヘテロアリール基であり、nは0、1、又は2である]によって更に置換され得る;又は
3)1個、2個、3個、4個、又は5個の上記定義による置換基を有し、かつ上記定義による1〜10個の原子(例えば、1個、2個、3個、4個又は5個の原子)が介在する、上記定義によるアルキル基。
ルシアントリジンは、細菌に発現させたAMPKα2β1γ1複合体のAMPによる活性化に対して相加効果をもたらす。
ルシアントリジン及びメトホルミンは、初代培養肝細胞における脂質生成の阻害に対して相加効果を有する。
Claims (19)
- (i)メトホルミンと、
(ii)一般式(I)
を有する化合物と、
を含む、薬物であって、
化合物(ii)において、R1、R2、R3、R4、R5、R6、R7、及びR8は、それぞれ独立して、H;OH;OMe;O−グリコシド;ハロゲン;アルデヒド;カルボン酸;第一級アミン、第二級アミン、又は第三級アミン;第一級アミド又は第二級アミド;シアノ;ニトロ;スルホネート;スルフェート;場合により置換された及び/若しくは場合により分枝状のC1〜C20アルキル;場合により置換された及び/若しくは場合により分枝状のC2〜C20アルケニル;場合により置換された及び/若しくは場合により分枝状のC4〜C20ポリアルケニル;場合により置換された及び/若しくは場合により分枝状のC2〜C20アルキニル;又は、場合により置換された及び/若しくは場合により分枝状のC4〜C20ポリアルキニルである、薬物。 - 化合物(ii)において、R1、R2、R3、R4、R7、及びR8は、それぞれ独立して、H;OH;OMe;O−グリコシド;ハロゲン;アルデヒド;カルボン酸;第一級アミン、第二級アミン、又は三級アミン;第一級アミド又は第二級アミド;シアノ;ニトロ;スルホネート;スルフェート;場合により置換された及び/若しくは場合により分枝状のC1〜C20アルキル;場合により置換された及び/若しくは場合により分枝状のC2〜C20アルケニル;場合により置換された及び/若しくは場合により分枝状のC4〜C20ポリアルケニル;場合により置換された及び/若しくは場合により分枝状のC2〜C20アルキニル;又は、場合により置換された及び/若しくは場合により分枝状のC4〜C20ポリアルキニルであり;R5は、H;OMe;O−グリコシド;ハロゲン;アルデヒド;カルボン酸;第一級アミン、第二級アミン、又は第三級アミン;第一級アミド又は第二級アミド;シアノ;ニトロ;スルホネート;スルフェート;場合により置換された及び/若しくは場合により分枝状のC1〜C20アルキル;場合により置換された及び/若しくは場合により分枝状のC2〜C20アルケニル;場合により置換された及び/若しくは場合により分枝状のC4〜C20ポリアルケニル;場合により置換された及び/若しくは場合により分枝状のC2〜C20アルキニル;又は、場合により置換された及び/若しくは場合により分枝状のC4〜C20ポリアルキニルであり;R6は、H;OH;O−グリコシド;ハロゲン;アルデヒド;カルボン酸;第一級アミン、第二級アミン、又は第三級アミン;第一級アミド又は第二級アミド;シアノ;ニトロ;スルホネート;スルフェート;場合により置換された及び/若しくは場合により分枝状のC1〜C20アルキル;場合により置換された及び/若しくは場合により分枝状のC2〜C20アルケニル;場合により置換された及び/若しくは場合により分枝状のC4〜C20ポリアルケニル;場合により置換された及び/若しくは場合により分枝状のC2〜C20アルキニル;又は、場合により置換された及び/若しくは場合により分枝状のC4〜C20ポリアルキニルである、請求項1に記載の薬物。
- 化合物(ii)において、R1、R2、R3、R4、R7、及びR8は、それぞれ独立して、H;OH;OMe;O−グリコシド;ハロゲン;アルデヒド;カルボン酸;第一級アミン、第二級アミン、又は第三級アミン;第一級アミド又は第二級アミド;シアノ;ニトロ;スルホネート;スルフェートであり;R5は、H;OMe;O−グリコシド;ハロゲン;アルデヒド;カルボン酸;第一級アミン、第二級アミン、又は第三級アミン;第一級アミド又は第二級アミド;シアノ;ニトロ;スルホネート;スルフェートであり;R6は、H;OH;O−グリコシド;ハロゲン;アルデヒド;カルボン酸;第一級アミン、第二級アミン、又は第三級アミン;第一級アミド又は第二級アミド;シアノ;ニトロ;スルホネート;スルフェートである、請求項1又は2に記載の薬物。
- 化合物(ii)において、R1、R3、及びR8は、それぞれ独立して、H;OH;OMe;O−グリコシド;ハロゲン;アルデヒド;カルボン酸であり;R2は、OH;OMe;O−グリコシド;ハロゲン;アルデヒド;カルボン酸であり;R4は、H;OH;O−グリコシド;ハロゲン;アルデヒド;カルボン酸であり;R5は、H;OMe;O−グリコシド;ハロゲン;アルデヒド;カルボン酸であり;R6は、H;OH;O−グリコシド;ハロゲン;アルデヒド;カルボン酸であり;かつ、R7は、H;OH;O−グリコシド;ハロゲン;アルデヒド;カルボン酸である、請求項1〜3のいずれか一項に記載の薬物。
- 化合物(ii)において、R1、R3、及びR8は、それぞれ独立して、H;OH;OMeであり;R2は、OH;OMeであり;R4は、H;OHであり;R5は、H;OMeであり;R6は、H;OHであり;かつ、R7は、H;OHである、請求項1〜4のいずれか一項に記載の薬物。
- 化合物(ii)において、R1、R3、R6、及びR8は、それぞれ独立して、Hであり;R2は、OH;OMeであり;R4は、OHであり;R5は、H;OMeであり;かつ、R7は、H;OHである、請求項1〜5のいずれか一項に記載の薬物。
- メトホルミン又はその塩と、一般式(I)の化合物又はその塩とが、単一製剤において組み合わされている、請求項1〜7のいずれか一項に記載の薬物。
- メトホルミン又はその塩と、一般式(I)の化合物又はその塩とが、複数の組成物に別々に配合され、組み合わせて使用される、請求項1〜7のいずれか一項に記載の薬物。
- 薬学的に許容可能な形態の、請求項1〜9のいずれか一項に記載の薬物を含む医薬組成物。
- 代謝疾患又は心血管疾患の予防又は治療に使用するための、請求項10に記載の医薬組成物。
- 前記代謝疾患が糖尿病である、請求項11に記載の使用のための医薬組成物。
- 前記糖尿病の予防又は治療が、脂質生成の阻害を増加させることによるものである、請求項12に記載の使用のための医薬組成物。
- 前記糖尿病の予防又は治療が、肝細胞における脂質生成の阻害を増加させることと、AMP活性化タンパク質キナーゼ(AMPK)の活性化によってインスリン感受性を改善することと、によるものである、請求項13に記載の使用のための医薬組成物。
- メトホルミンが、対象の薬理学的用量未満で使用される、請求項9〜14のいずれか一項に記載の使用のための医薬組成物。
- 前記薬理学的用量未満が、前記対象の標準的な薬理学的用量の約50%以下である、請求項15に記載の使用のための医薬組成物。
- メトホルミンの前記薬理学的用量未満が、メトホルミン使用に関連する副作用の発生率を低減し、前記副作用が、乳酸アシドーシス、及び/又は胃腸管副作用、特に下痢、悪心、及び嘔吐である、請求項14及び15に記載の使用のための医薬組成物。
- 請求項1〜9のいずれか一項に記載の薬物又は請求項10〜17のいずれか一項に記載の医薬組成物を、投与を必要としている対象に投与することを含む、代謝疾患又は心血管疾患を予防又は治療する方法。
- 前記疾患が、糖尿病である、請求項18に記載の方法。
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