JP2022180420A5 - - Google Patents
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- Publication number
- JP2022180420A5 JP2022180420A5 JP2022141656A JP2022141656A JP2022180420A5 JP 2022180420 A5 JP2022180420 A5 JP 2022180420A5 JP 2022141656 A JP2022141656 A JP 2022141656A JP 2022141656 A JP2022141656 A JP 2022141656A JP 2022180420 A5 JP2022180420 A5 JP 2022180420A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- hydrate
- antisense oligomer
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000692 anti-sense effect Effects 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 108091034117 Oligonucleotide Proteins 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 108010069091 Dystrophin Proteins 0.000 claims 3
- 201000006938 muscular dystrophy Diseases 0.000 claims 3
- 108700024394 Exon Proteins 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 231100000221 frame shift mutation induction Toxicity 0.000 claims 2
- 230000037433 frameshift Effects 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 108010058514 Phosphate-Binding Proteins Proteins 0.000 claims 1
- 102000006335 Phosphate-Binding Proteins Human genes 0.000 claims 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 125000000548 ribosyl group Chemical class C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020033483 | 2020-02-28 | ||
| JP2020033483 | 2020-02-28 | ||
| JP2022503739A JPWO2021172498A1 (https=) | 2020-02-28 | 2021-02-26 | |
| PCT/JP2021/007286 WO2021172498A1 (ja) | 2020-02-28 | 2021-02-26 | エクソン５１のスキッピングを誘導するアンチセンス核酸 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022503739A Division JPWO2021172498A1 (https=) | 2020-02-28 | 2021-02-26 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022180420A JP2022180420A (ja) | 2022-12-06 |
| JP2022180420A5 true JP2022180420A5 (https=) | 2023-03-14 |
| JP7292636B2 JP7292636B2 (ja) | 2023-06-19 |
Family
ID=77491251
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022503739A Pending JPWO2021172498A1 (https=) | 2020-02-28 | 2021-02-26 | |
| JP2022141656A Active JP7292636B2 (ja) | 2020-02-28 | 2022-09-06 | エクソン５１のスキッピングを誘導するアンチセンス核酸 |
| JP2025157620A Pending JP2026001070A (ja) | 2020-02-28 | 2025-09-24 | エクソン５１のスキッピングを誘導するアンチセンス核酸 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022503739A Pending JPWO2021172498A1 (https=) | 2020-02-28 | 2021-02-26 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025157620A Pending JP2026001070A (ja) | 2020-02-28 | 2025-09-24 | エクソン５１のスキッピングを誘導するアンチセンス核酸 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20230140736A1 (https=) |
| EP (1) | EP4112083A4 (https=) |
| JP (3) | JPWO2021172498A1 (https=) |
| KR (1) | KR20220145865A (https=) |
| CN (1) | CN115210376A (https=) |
| AU (1) | AU2021226089A1 (https=) |
| BR (1) | BR112022017066A2 (https=) |
| CA (1) | CA3173049A1 (https=) |
| CL (3) | CL2022002279A1 (https=) |
| CO (1) | CO2022013685A2 (https=) |
| EC (1) | ECSP22074446A (https=) |
| IL (1) | IL295967A (https=) |
| MX (1) | MX2022010545A (https=) |
| PE (1) | PE20230237A1 (https=) |
| TW (2) | TWI901457B (https=) |
| WO (1) | WO2021172498A1 (https=) |
| ZA (1) | ZA202209294B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7842395B2 (ja) * | 2019-12-19 | 2026-04-08 | 日本新薬株式会社 | エクソンスキッピングを可能にするアンチセンス核酸 |
| CA3244382A1 (en) | 2021-12-27 | 2025-02-26 | Nippon Shinyaku Co., Ltd. | PROCESS FOR THE PRODUCTION OF OLIGONUCLEIC ACID COMPOUNDS |
| WO2023168427A1 (en) | 2022-03-03 | 2023-09-07 | Yale University | Compositions and methods for delivering therapeutic polynucleotides for exon skipping |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4737323A (en) | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
| JP3398378B2 (ja) | 1989-12-20 | 2003-04-21 | アンチビラルス・インコーポレイテツド | リン含有キラルインターサブユニットリンケージを有する非電荷モルホリノ―基体ポリマー |
| JP2924179B2 (ja) | 1993-02-19 | 1999-07-26 | 日本新薬株式会社 | グリセロール誘導体，デバイス及び医薬組成物 |
| IL115849A0 (en) | 1994-11-03 | 1996-01-31 | Merz & Co Gmbh & Co | Tangential filtration preparation of liposomal drugs and liposome product thereof |
| EP1191097A1 (en) | 2000-09-21 | 2002-03-27 | Leids Universitair Medisch Centrum | Induction of exon skipping in eukaryotic cells |
| JP4777777B2 (ja) | 2002-11-25 | 2011-09-21 | 雅文 松尾 | ｍＲＮＡ前駆体のスプライシングを修飾するＥＮＡ核酸医薬 |
| CA2524255C (en) | 2003-03-21 | 2014-02-11 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure |
| ATE498685T1 (de) | 2004-06-28 | 2011-03-15 | Univ Western Australia | Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon |
| DK2735568T3 (da) | 2006-05-10 | 2017-11-13 | Sarepta Therapeutics Inc | Oligonukleotidanaloger med kationiske bindinger mellem underenheder |
| EP3443976A1 (en) | 2007-06-29 | 2019-02-20 | Sarepta Therapeutics, Inc. | Tissue specific peptide conjugates and methods |
| AU2008317566B2 (en) | 2007-10-26 | 2014-05-01 | Academisch Ziekenhuis Leiden | Means and methods for counteracting muscle disorders |
| MX2010004955A (es) | 2007-11-15 | 2010-06-30 | Avi Biopharma Inc | Metodo de sintesis de oligomeros de morfolina. |
| CN112574988A (zh) | 2008-10-24 | 2021-03-30 | 萨雷普塔治疗公司 | 用于dmd的多外显子跳跃组合物 |
| JP5786109B2 (ja) | 2008-10-27 | 2015-09-30 | プロセンサ テクノロジーズ ベー．フェー． | Ｄｕｃｈｅｎｎｅ型筋ジストロフィーｍＲＮＡ前駆体のエクソン４５の効率的なスキッピングのための方法及び手段 |
| TWI541024B (zh) * | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
| WO2012150960A1 (en) | 2011-05-05 | 2012-11-08 | Avi Biopharma, Inc. | Peptide oligonucleotide conjugates |
| CN117721110A (zh) * | 2011-12-28 | 2024-03-19 | 日本新药株式会社 | 反义核酸 |
| CN112251436A (zh) * | 2012-01-27 | 2021-01-22 | 比奥马林技术公司 | 治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸 |
| EP2870246B1 (en) * | 2012-07-03 | 2019-09-11 | BioMarin Technologies B.V. | Oligonucleotide for the treatment of muscular dystrophy patients |
| JP6519842B2 (ja) | 2013-10-04 | 2019-05-29 | 国立大学法人神戸大学 | 福山型筋ジストロフィー治療用アンチセンス核酸 |
| SMT201900169T1 (it) * | 2014-03-12 | 2019-05-10 | Nippon Shinyaku Co Ltd | Acido nucleico antisenso |
| RU2695430C2 (ru) * | 2014-06-17 | 2019-07-23 | Ниппон Синяку Ко., Лтд. | Антисмысловые нуклеиновые кислоты |
| EP3297649B1 (en) | 2015-05-19 | 2023-10-11 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| SI3331891T1 (sl) | 2015-08-05 | 2022-04-29 | Eisai R&D Management Co., Ltd. | Postopek priprave v bistvu diastereomerno čistega fosforodiamidatnega oligomera, fosforodiamidatni oligomer izdelan po takem postopku in farmacevtski sestavek, ki vsebuje tak fosforodiamidatni oligomer |
| SI3351633T1 (sl) * | 2015-09-15 | 2020-09-30 | Nippon Shinyaku Co., Ltd. | Protismiselna nukleinska kislina |
| JP7511326B2 (ja) | 2015-10-09 | 2024-07-05 | ウェイブ ライフ サイエンシズ リミテッド | オリゴヌクレオチド組成物およびその方法 |
| US20190330626A1 (en) * | 2016-07-15 | 2019-10-31 | Ionis Pharmaceuticals, Inc. | Compounds and methods for use in dystrophin transcript |
| IL297528A (en) | 2016-12-19 | 2022-12-01 | Sarepta Therapeutics Inc | Exon-skipping oligomer conjugates for muscular dystrophy |
| SMT202200366T1 (it) * | 2016-12-19 | 2022-11-18 | Sarepta Therapeutics Inc | Coniugati di oligomeri per salto di esone per distrofia muscolare |
| SI3554554T1 (sl) | 2016-12-19 | 2023-02-28 | Sarepta Therapeutics, Inc. | Oligomerni konjugati, ki preskakujejo ekson za mišično distrofijo |
| WO2019241385A2 (en) | 2018-06-13 | 2019-12-19 | Sarepta Therapeutics, Inc. | Exon skipping oligomers for muscular dystropy |
-
2021
- 2021-02-26 US US17/802,720 patent/US20230140736A1/en active Pending
- 2021-02-26 CA CA3173049A patent/CA3173049A1/en active Pending
- 2021-02-26 AU AU2021226089A patent/AU2021226089A1/en active Pending
- 2021-02-26 IL IL295967A patent/IL295967A/en unknown
- 2021-02-26 EP EP21760603.7A patent/EP4112083A4/en active Pending
- 2021-02-26 KR KR1020227032708A patent/KR20220145865A/ko active Pending
- 2021-02-26 MX MX2022010545A patent/MX2022010545A/es unknown
- 2021-02-26 PE PE2022001832A patent/PE20230237A1/es unknown
- 2021-02-26 WO PCT/JP2021/007286 patent/WO2021172498A1/ja not_active Ceased
- 2021-02-26 BR BR112022017066A patent/BR112022017066A2/pt unknown
- 2021-02-26 TW TW113145565A patent/TWI901457B/zh active
- 2021-02-26 JP JP2022503739A patent/JPWO2021172498A1/ja active Pending
- 2021-02-26 TW TW110107021A patent/TWI868323B/zh active
- 2021-02-26 CN CN202180017313.6A patent/CN115210376A/zh active Pending
-
2022
- 2022-08-18 ZA ZA2022/09294A patent/ZA202209294B/en unknown
- 2022-08-22 CL CL2022002279A patent/CL2022002279A1/es unknown
- 2022-08-25 US US17/895,186 patent/US11781140B2/en active Active
- 2022-09-06 JP JP2022141656A patent/JP7292636B2/ja active Active
- 2022-09-23 CO CONC2022/0013685A patent/CO2022013685A2/es unknown
- 2022-09-23 EC ECSENADI202274446A patent/ECSP22074446A/es unknown
-
2024
- 2024-05-16 CL CL2024001472A patent/CL2024001472A1/es unknown
- 2024-05-16 CL CL2024001471A patent/CL2024001471A1/es unknown
-
2025
- 2025-09-24 JP JP2025157620A patent/JP2026001070A/ja active Pending
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