JP2022180348A5 - - Google Patents
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- Publication number
- JP2022180348A5 JP2022180348A5 JP2022128528A JP2022128528A JP2022180348A5 JP 2022180348 A5 JP2022180348 A5 JP 2022180348A5 JP 2022128528 A JP2022128528 A JP 2022128528A JP 2022128528 A JP2022128528 A JP 2022128528A JP 2022180348 A5 JP2022180348 A5 JP 2022180348A5
- Authority
- JP
- Japan
- Prior art keywords
- small
- tag
- library
- encoded
- linked
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003384 small molecules Chemical class 0.000 claims 27
- 150000002605 large molecules Chemical class 0.000 claims 26
- 229920002521 macromolecule Polymers 0.000 claims 26
- 238000000034 method Methods 0.000 claims 17
- 238000003556 assay Methods 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 238000003776 cleavage reaction Methods 0.000 claims 4
- 230000007017 scission Effects 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 239000002184 metal Substances 0.000 claims 3
- 230000000269 nucleophilic effect Effects 0.000 claims 3
- 238000012216 screening Methods 0.000 claims 3
- 238000003786 synthesis reaction Methods 0.000 claims 3
- 239000011324 bead Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1618820.3 | 2016-11-08 | ||
| GB201618820 | 2016-11-08 | ||
| GB1709718.9 | 2017-06-19 | ||
| GBGB1709718.9A GB201709718D0 (en) | 2017-06-19 | 2017-06-19 | Tagless encoded chemical library |
| PCT/GB2017/053360 WO2018087539A1 (en) | 2016-11-08 | 2017-11-08 | Tagless encoded chemical library |
| JP2019523655A JP2020503846A (ja) | 2016-11-08 | 2017-11-08 | タグなしコード化化学ライブラリ |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523655A Division JP2020503846A (ja) | 2016-11-08 | 2017-11-08 | タグなしコード化化学ライブラリ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022180348A JP2022180348A (ja) | 2022-12-06 |
| JP2022180348A5 true JP2022180348A5 (enExample) | 2023-05-11 |
Family
ID=60702823
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523655A Pending JP2020503846A (ja) | 2016-11-08 | 2017-11-08 | タグなしコード化化学ライブラリ |
| JP2022128528A Pending JP2022180348A (ja) | 2016-11-08 | 2022-08-10 | タグなしコード化化学ライブラリ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523655A Pending JP2020503846A (ja) | 2016-11-08 | 2017-11-08 | タグなしコード化化学ライブラリ |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20190264199A1 (enExample) |
| EP (1) | EP3538653B1 (enExample) |
| JP (2) | JP2020503846A (enExample) |
| KR (1) | KR102355956B1 (enExample) |
| CN (1) | CN110249050B (enExample) |
| AU (1) | AU2017357638B2 (enExample) |
| CA (1) | CA3042974A1 (enExample) |
| IL (1) | IL266318B2 (enExample) |
| WO (1) | WO2018087539A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11084037B2 (en) * | 2017-09-25 | 2021-08-10 | Plexium, Inc. | Oligonucleotide encoded chemical libraries |
| CN110658163A (zh) * | 2018-06-29 | 2020-01-07 | 成都先导药物开发股份有限公司 | 一种合成dna编码化合物中的反应监测方法 |
| GB201817321D0 (en) * | 2018-10-24 | 2018-12-05 | Nanna Therapeutics Ltd | Microbeads for tagless encoded chemical library screening |
| WO2020096015A1 (ja) * | 2018-11-07 | 2020-05-14 | 国立大学法人 東京大学 | １種以上の被検物質と共存した細胞のゲノム関連情報を検出する方法 |
| WO2020206114A1 (en) * | 2019-04-02 | 2020-10-08 | The Trustees Of Columbia University In The City Of New York | Sequencing by synthesis with energy transfer dye pairs |
| EP3956467A1 (en) | 2019-04-16 | 2022-02-23 | F. Hoffmann-La Roche AG | Small molecule screening cellular assay using modified beads |
| CN112143783B (zh) * | 2019-06-27 | 2024-09-24 | 成都先导药物开发股份有限公司 | 一种可识别混合物对复杂生物体系的鉴别方法 |
| CN114829626A (zh) | 2019-10-10 | 2022-07-29 | 1859公司 | 用于微流体筛选的方法和系统 |
| CN114761577B (zh) * | 2020-01-10 | 2025-10-24 | 新克赛特株式会社 | 新型细胞表型筛选方法 |
| CN111304753B (zh) * | 2020-03-24 | 2020-12-01 | 深圳奇点药物科技有限公司 | Dna编码分子库的筛选方法和试剂盒 |
| US11628382B2 (en) | 2020-08-26 | 2023-04-18 | Duke University | Methods and apparatuses for purification of gel droplets supporting biological tissue |
| US20230357757A1 (en) * | 2020-10-23 | 2023-11-09 | Eth Zurich | Self-purified nucleic acid encoded libraries |
| CA3209941A1 (en) * | 2021-03-04 | 2022-09-09 | Corey M. DAMBACHER | Molecular barcodes and related methods and systems |
| WO2023174845A1 (en) * | 2022-03-13 | 2023-09-21 | Eleven Therapeutics Ltd | System and method for high throughput evaluation of chemical modifications of nucleic acid molecules |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0307428D0 (en) * | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
| AU2005216251B2 (en) * | 2004-02-23 | 2011-03-10 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
| EP2021113A2 (en) * | 2006-05-11 | 2009-02-11 | Raindance Technologies, Inc. | Microfluidic devices |
| WO2010094036A1 (en) * | 2009-02-13 | 2010-08-19 | X-Chem, Inc. | Methods of creating and screening dna-encoded libraries |
| WO2012019765A1 (en) * | 2010-08-10 | 2012-02-16 | European Molecular Biology Laboratory (Embl) | Methods and systems for tracking samples and sample combinations |
| PL3650458T3 (pl) * | 2015-02-24 | 2023-11-06 | City Of Hope | Platformy do analiz przesiewowych bibliotek kodowanych chemicznie i adresowanych przestrzennie |
| EP3268462B1 (en) * | 2015-03-11 | 2021-08-11 | The Broad Institute, Inc. | Genotype and phenotype coupling |
-
2017
- 2017-11-08 CN CN201780082633.3A patent/CN110249050B/zh active Active
- 2017-11-08 KR KR1020197016158A patent/KR102355956B1/ko not_active Expired - Fee Related
- 2017-11-08 AU AU2017357638A patent/AU2017357638B2/en not_active Ceased
- 2017-11-08 JP JP2019523655A patent/JP2020503846A/ja active Pending
- 2017-11-08 CA CA3042974A patent/CA3042974A1/en active Pending
- 2017-11-08 IL IL266318A patent/IL266318B2/en unknown
- 2017-11-08 WO PCT/GB2017/053360 patent/WO2018087539A1/en not_active Ceased
- 2017-11-08 US US16/348,054 patent/US20190264199A1/en not_active Abandoned
- 2017-11-08 EP EP17817014.8A patent/EP3538653B1/en active Active
-
2021
- 2021-11-29 US US17/536,889 patent/US20220073907A1/en not_active Abandoned
-
2022
- 2022-08-10 JP JP2022128528A patent/JP2022180348A/ja active Pending
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