JP2022171876A - Green juice for inhibiting increase of blood glucose level, green juice for antioxidation, green juice for controlling intestinal function, green juice for promoting collagen absorption, green juice for promoting calcium absorption, and green juice for inhibiting increase of blood cholesterol level - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide daily usable dry powders of Hordeum vulgare stems and leaves which have an inhibiting action of the increase of blood glucose level, an antioxidation action, a controlling action of intestinal function, a promoting action of collagen absorption, a promoting action of calcium absorption, and an inhibiting action the increase of blood cholesterol.

SOLUTION: A green juice for inhibiting increase of blood glucose level, green juice for antioxidation, green juice for controlling intestinal function, green juice for promoting collagen absorption, green juice for promoting calcium absorption, and green juice for inhibiting increase of blood cholesterol level of the invention contain an active ingredient at least one kind of dry powders selected from the group consisting of a specific kind of Hordeum vulgare.

SELECTED DRAWING: None

COPYRIGHT: (C)2023,JPO&INPIT

Description

TECHNICAL FIELD The present invention relates to a green juice for suppressing an increase in blood sugar level, an antioxidant green juice, a green juice for intestinal regulation, a green juice for promoting collagen absorption, a green juice for promoting calcium absorption, and a green juice for suppressing an increase in blood cholesterol level.

[1. Inhibition of blood sugar level elevation]
Obesity is known to cause various diseases, one of which is diabetes. In obesity, hypertrophy of adipocytes is observed, and not only adipocytes but also target cells of insulin such as muscle cells experience decreased insulin sensitivity at the cellular level. As a result, glucose tolerance deteriorates and eventually diabetes develops.

Treatment of diabetes includes administration of insulin. However, it requires regular insulin injections, which imposes a burden on the patient and requires high self-management ability.

An alternative to insulin injections is taking oral antidiabetic medications. Oral antidiabetic drugs include, for example, sulfonylureas that promote insulin secretion, insulin resistance improvers that act on tissues and cells to lower blood sugar levels, and α-glucosidase inhibitors that inhibit the breakdown of carbohydrates in the intestinal tract. There are drugs. However, these drugs cause side effects such as excessively lowering blood sugar levels and causing hypoglycemia.

Diabetes treatments such as those described above are effective in severely diabetic patients, even though the invasive methods may cause pain and side effects. However, it cannot be said to be effective at all for mild diabetic patients and those who are concerned about an increase in blood sugar level even if they do not develop diabetes.

Thus, there have been reports of ingredients and compositions useful for the prevention and early treatment of diabetes. For example, the present applicant proposed that ingestion of young barley grass powder has an effect of suppressing an increase in postprandial blood glucose level (Non-Patent Document 1). However, Non-Patent Document 1 merely describes that young barley powder has an effect of suppressing an increase in blood sugar level, and it was necessary to search for a barley variety to obtain a better effect.

[2. antioxidant effect]
Oxygen is essential for living organisms, but is known to damage living organisms when present as active oxygen. Examples of active oxygen include highly reactive reduced molecular species of oxygen such as superoxide radical (O ₂ ·), hydrogen peroxide (H ₂ O ₂ ), and OH radical (·OH); singlet oxygen ( ¹ O ₂ ), unsaturated fatty acid peroxy radical (LOO.), unsaturated fatty acid radical (L.), unsaturated fatty acid hydroperoxide (LOOH), unsaturated fatty acid alkoxy radical (LO.). Examples include lipid oxides.

Living organisms have various active oxygen scavenging mechanisms in their bodies. One of them is a mechanism in which superoxide dismutase (SOD) or the like acts to capture active oxygen in the body. However, under physical or chemical environmental conditions such as aging and extrinsic stress, in which the production of active oxygen increases, the mechanism for scavenging active oxygen may not function sufficiently. As a result, cleavage of proteins or DNA, peroxidation of lipids, and the like are caused, resulting in various disorders and diseases in living organisms.

Therefore, it is known to use a substance having an antioxidant effect to alleviate the effects of active oxygen in the body, such as suppressing the generation of active oxygen or eliminating it. For example, the present applicant has proposed a health food with enhanced SOD activity containing barley grass powder and honey (Patent Document 1). However, since this invention requires honey in addition to barley young leaves, there are problems such as restrictions on the ingredients to be blended and high manufacturing costs. It was necessary to search for barley cultivars with oxidizing properties.

[3. intestinal function]
In recent years, the number of people suffering from constipation has been increasing due to changes in eating habits, imbalanced diets, stress, and the like. Constipation is caused by the long retention of stool in the intestine. In addition, severe constipation causes an increase in harmful bacteria in the intestine and an increase in the absorption of harmful substances, which may lead to colon cancer. Therefore, the development of substances having constipation-improving effects and compositions having an intestinal-regulating effect obtained by blending such substances is underway.

For example, the present applicant has proposed a bowel movement improving agent containing, as an active ingredient, barley grass powder containing 30% by mass or more of water-insoluble components (Patent Document 2). However, Patent Document 2 merely describes that young barley grass powder has laxative-improving action, and it was necessary to search for barley varieties to obtain better effects.

[4. Collagen absorption promoting action]
Collagen is used as a food and drink material and a cosmetic material, and many studies have been made. Especially when ingesting collagen for cosmetic purposes, it is required to efficiently absorb the ingested collagen into the body.

For example, the present applicant proposed a composition for promoting collagen absorption containing barley grass (Patent Document 3). However, Patent Document 3 merely describes that young barley leaves have an effect of promoting collagen absorption, and it was necessary to search for barley varieties to obtain a better effect.

[5. Calcium absorption promoting action]
Calcium is a major mineral that forms bones and teeth, and is a divalent cation that plays an important role in living organisms. For example, in bones, calcium absorbed in the intestine and entering the blood is used for bone formation to form new bone. On the other hand, in bones, bone resorption, in which old bones are absorbed, is observed. In a healthy state, there is bone metabolism in which bone resorption and bone formation are balanced. However, when abnormalities in bone metabolism occur due to a decrease in calcium intake or the like, bone mass is reduced, resulting in bone-related diseases such as osteoporosis and bone fractures.

In addition, part of calcium in the body exists at a certain concentration in cells other than bones and teeth and in blood, and plays an important role in terms of nerve and muscle excitation, blood coagulation, and the like. Therefore, when calcium in the blood is insufficient, diseases based on abnormalities in nerves, muscles, blood, etc., and bone-related diseases due to accelerated bone resorption, etc. are observed.

By the way, calcium ingested from food is absorbed in the intestinal tract through two routes: active transport by the action of active vitamin D and passive transport depending on the concentration of soluble calcium, and is used for bone formation via blood. .

Active vitamin D3 formulations containing calcitriol, alfacalcidol, eldecalcitol, etc. as active ingredients are known to improve active transport by the action of active vitamin D. The use of such active vitamin D3 preparations promotes calcium absorption from the intestinal tract.

For example, the present applicant proposed a calcium absorption enhancer containing barley grass powder, lactose and sugar alcohol (Patent Document 4). However, the invention requires lactose and sugar alcohol in addition to young barley leaves, which causes problems such as restrictions on ingredients to be blended and high production costs. It was necessary to search for barley cultivars that have a high calcium absorption promoting effect.

[6. Blood Cholesterol Elevation Suppressive Action]
Cholesterol is an organic compound classified as a steroid, its molecular formula is C ₂₇ H ₄₆ O, and its CAS registry number is 57-88-5. Cholesterol itself is a biomolecule that contributes to the production of cell membranes, the synthesis of vitamin D, the production of adrenocortical hormones and bile acids, etc., and is considered to be a type of lipid that plays an important role in physiological phenomena in vivo. .

On the other hand, cholesterol forms a complex with lipoproteins, and is often regarded as a problem depending on the type of lipoprotein and its behavior in blood after forming the complex. That is, the complex of high-density lipoprotein and cholesterol (HDL cholesterol) plays a role in transporting excess cholesterol out of cells, and is generally called "good cholesterol." However, the complex of low-density lipoprotein and cholesterol (LDL cholesterol) is responsible for transporting cholesterol in the blood. This increases the risk of myocardial infarction, angina pectoris, and stroke. Therefore, LDL cholesterol is generally called "bad cholesterol".

Excess cholesterol is processed in the liver, and if there is too much cholesterol, it crystallizes when it is excreted from the liver, and may become calcified in the gallbladder or bile duct, resulting in cholelithiasis.

Therefore, when excess cholesterol in the blood increases, it itself or becomes LDL cholesterol, and exerts various adverse effects in the body. Therefore, drugs that inhibit HMG-CoA reductase, an enzyme that plays an important role in cholesterol biosynthesis, are used to lower blood cholesterol. Statins such as atorvastatin, rosuvastatin, and pitavastatin are known as HMG-CoA reductase inhibitors.

For example, the present applicant proposed an anti-cholesterol composition containing a material derived from wheat grass (Patent Document 5). However, Patent Document 5 merely describes that barley grass is effective in anti-cholesterol action, and it was necessary to search for barley varieties to obtain better effects.

On the other hand, popular barley cultivars change based on yield, disease and pest resistance standards, etc., so problems arise such as difficulty in obtaining seeds and difficulty in stable supply of stems and leaves of barley. Furthermore, a huge number of 30,000 or more varieties of barley are known (Non-Patent Document 2), and it has not been easy to search for a specific barley variety that can solve the above problems.

JP-A-2002-153239 JP 2010-47605 A JP 2011-115046 A JP-A-2002-142721 Japanese Patent Application Laid-Open No. 2001-314170

Tomoyasu Kamiya et al., Applied Pharmacology, 2013, Vol. 85, No. 1-2, pp. 1-6 Search results for the scientific name of barley "Hordeum vulgare" in the genetic resource database "Germplasm Resources Information Network" under the jurisdiction of the U.S. Department of Agriculture taxonomyid=19333>

[1. Inhibition of blood sugar level elevation]
The present invention provides a green juice for suppressing an increase in blood sugar level and an agent for suppressing an increase in blood sugar level, which contains a substance exhibiting a superior effect of suppressing an increase in blood sugar level compared to conventional substances having an effect of suppressing an increase in blood sugar level. is the problem to be solved by the invention.

[2. antioxidant effect]
An object of the present invention is to provide an antioxidative green juice containing a substance exhibiting a superior antioxidative action compared to conventional substances having an antioxidative action, and an antioxidant. Make it an issue.

[3. intestinal function]
It is an object of the present invention to provide a green juice for regulating bowel movements and an agent for regulating bowel movements, which contain a substance exhibiting a better laxation-improving action than conventional substances having a bowel movement-improving action. do.

[4. Collagen absorption promoting action]
An object of the present invention is to provide a green juice for promoting collagen absorption and a collagen absorption enhancer containing a substance exhibiting a superior collagen absorption promoting effect compared to conventional collagen absorption promoting substances.

[5. Calcium absorption promoting action]
The present invention provides a green juice for promoting calcium absorption and a calcium absorption enhancer containing a substance exhibiting a superior calcium absorption promoting effect compared to conventional substances having a calcium absorption promoting effect. Let it be a problem to be solved.

[6. Blood Cholesterol Elevation Suppressive Action]
The present invention provides a green juice for suppressing elevation of blood cholesterol containing a substance exhibiting a superior inhibitory effect on elevation of blood cholesterol compared with conventional substances having inhibitory activity on elevation of blood cholesterol, and an agent for suppressing elevation of blood cholesterol. The problem to be solved by the invention is to provide

[1. Inhibition of blood sugar level elevation]
In order to solve the above-mentioned problems, the applicant of the present invention has extensively studied various substances, and surprisingly, among barley, shunrai, fiber snow and silky snow (hereinafter also referred to as "specific variety 1") It was found that at least one dry powder of foliage of barley selected from the group consisting of ) has a superior effect of suppressing elevation of blood sugar level compared to dry powder of foliage of Ichibanboshi when orally administered. The present invention is an invention completed based on such findings.

[2. antioxidant effect]
In order to solve the above-mentioned problems, the applicant of the present application has extensively studied various substances, and surprisingly, fiber snow, silky snow, shunrai, ichibanboshi and harushizuku (hereinafter referred to as "specified variety 2") At least one dry powder of foliage of barley selected from the group consisting of (1) has an index showing antioxidant action such as SOD value and ORAC value compared to dry powder of foliage of Nishinohoshi, which is a kind of barley. I found it to be exceptionally good. The present invention is an invention completed based on such knowledge and success.

[3. intestinal function]
In order to solve the above-mentioned problems, the applicant of the present invention has extensively studied various substances, and surprisingly, a group consisting of shunrai, fiber snow and silky snow (hereinafter also referred to as "specified variety 3") The dry powder of at least one kind of barley stems and leaves selected from the above exhibits not only an effect of improving bowel movements but also an effect of improving the intestinal environment compared with the dry powder of stems and leaves of Ichibanboshi, which is a type of barley, and is excellent in regulating. It was found to exhibit an intestinal effect. The present invention is an invention completed based on such findings.

[4. Collagen absorption promoting action]
In order to solve the above-mentioned problems, the applicant of the present application has extensively studied various substances, and surprisingly, fiber snow, silky snow, shunrai, ichibanboshi and harushizuku (hereinafter referred to as "specified variety 4") At least one dry powder of barley foliage selected from the group consisting of) does not contain dry powder of foliage of barley or dry powder of foliage of Nishinohoshi, a type of barley. The inventors have found that, irrespective of the biological species from which the ingested collagen is derived, it exhibits a remarkably excellent collagen absorption promoting action. The present invention is an invention completed based on such findings.

[5. Calcium absorption promoting action]
In order to solve the above-mentioned problems, the applicant of the present application has extensively studied various substances, and surprisingly, Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow (hereinafter referred to as "Specific Variety 5") At least one barley foliage dry powder selected from the group consisting of) does not contain barley foliage dry powder and Nishinohoshi foliage dry powder, which is a barley variety. As a result, it was found that it exhibits an exceptionally excellent calcium absorption promoting effect. The present invention is a completed invention based on such successful examples and findings.

[6. Blood Cholesterol Elevation Suppressive Action]
In order to solve the above problems, the applicant of the present application has extensively studied various substances, and surprisingly, Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow (hereinafter referred to as "specified variety 6"). At least one barley foliage dry powder selected from the group consisting of) does not contain barley foliage dry powder and Nishinohoshi foliage dry powder, which is a barley variety. As a result, the inventors have found that it exhibits an exceptionally excellent effect of suppressing elevation of blood cholesterol. The present invention is a completed invention based on such successful examples and findings.

The gist of the present invention is as follows.
[1] A green juice for suppressing elevation of blood sugar level, containing dry powder of barley stems and/or leaves of at least one kind selected from the group consisting of shunrai, fiber snow and silky snow.
[2] A green juice for suppressing elevation of blood sugar level, containing as an active ingredient dry powder of stems and/or leaves of at least one kind of barley selected from the group consisting of shunrai, fiber snow and silky snow.
[3] A blood sugar level elevation inhibitor containing dry powder of at least one barley stem and/or leaf selected from the group consisting of shunrai, fiber snow and silky snow.
[4] Antioxidant green juice containing dry powder of stems and/or leaves of at least one kind of barley selected from the group consisting of fiber snow, silky snow, shunrai, ichibanboshi and harushizuku.
[5] Antioxidant green juice containing, as an active ingredient, dry powder of stems and/or leaves of at least one kind of barley selected from the group consisting of fiber snow, silky snow, shunrai, ichibanboshi and harushizuku.
[6] An antioxidant containing dry powder of at least one barley stem and/or leaf selected from the group consisting of fiber snow, silky snow, shunrai, ichibanboshi, and harusizuku.
[7] A green juice for intestinal regulation, containing dry powder of stems and/or leaves of at least one kind of barley selected from the group consisting of shunrai, fiber snow and silky snow.
[8] Green juice for intestinal regulation, containing as an active ingredient dry powder of barley stems and/or leaves of at least one kind selected from the group consisting of shunrai, fiber snow and silky snow.
[9] An intestinal regulator containing dry powder of barley stems and/or leaves of at least one kind selected from the group consisting of shunrai, fiber snow and silky snow.
[10] A green juice for promoting collagen absorption, containing at least one barley stem and/or leaf selected from the group consisting of fiber snow, silky snow, shunrai, ichibanboshi, and harushizuku.
[11] A green juice for promoting collagen absorption, containing, as an active ingredient, dry powder of barley stems and/or leaves of at least one kind selected from the group consisting of fiber snow, silky snow, shunrai, ichibanboshi and harushizuku.
[12] A collagen absorption enhancer containing dry powder of at least one barley stem and/or leaf selected from the group consisting of fiber snow, silky snow, shunrai, ichibanboshi, and harushizuku.
[13] A green juice for promoting calcium absorption, containing dry powder of barley stems and/or leaves of at least one kind selected from the group consisting of Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow.
[14] A green juice for promoting calcium absorption containing, as an active ingredient, dry powder of barley stems and/or leaves of at least one kind selected from the group consisting of harushizuku, shunrai, fiber snow, ichibanboshi and silky snow.
[15] A calcium absorption enhancer containing dry powder of at least one barley stem and/or leaf selected from the group consisting of Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow.
[16] A green juice for inhibiting elevation of blood cholesterol containing dry powder of barley stems and/or leaves of at least one kind selected from the group consisting of Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow.
[17] A green juice for suppressing elevation of blood cholesterol containing, as an active ingredient, dry powder of barley stems and/or leaves of at least one kind selected from the group consisting of Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow.
[18] A blood cholesterol elevation inhibitor containing dry powder of at least one barley stem and/or leaf selected from the group consisting of Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow.

[1. Inhibition of blood sugar level elevation]
According to the present invention 1, by containing the dry powder of barley stems and leaves of the specific variety 1, it is possible to suppress a rapid increase in postprandial blood sugar level, and it is also expected to lower fasting blood sugar level. can. In addition, since the present invention 1 can exhibit the effect of suppressing elevation of blood glucose level even by oral administration, the present invention 1 can be used in a daily usage mode. In addition, "Invention 1" refers to a composition containing dry powder of barley stems and leaves of Specified Variety 1 and having an effect of suppressing an increase in blood sugar level, and green juice for suppressing an increase in blood sugar level and an increase in blood sugar level. Inhibitors are included.

The present invention 1 is most suitable for use before or concurrently with administration of anti-diabetic drugs for diabetic patients or persons at risk of diabetes. Furthermore, according to the present invention 1, diseases related to diabetes and obesity, for example, dyslipidemia, hypertension, metabolic syndrome, arteriosclerosis, hyperlipidemia, gout, high body fat percentage, hyperglycemia, hyperinsulin It can be expected to prevent and treat lifestyle-related diseases such as hypertension, hypercholesterolemia, hypertriglyceridemia, fatty liver, cardiovascular disease, and hyperuricemia.

[2. antioxidant effect]
According to the present invention 2, by containing the dry powder of barley stems and leaves of the specific variety 2, it is possible to provide a composition that has an excellent antioxidant effect and that can be used continuously. In addition, since the composition of the present invention 2 can exhibit antioxidative action even by oral administration, the present invention 2 can be used in a daily usage mode. In addition, "Invention 2" refers to a composition containing dry powder of stems and leaves of barley of specific variety 2 and having an antioxidant action, and includes antioxidant green juice and antioxidant.

[3. intestinal function]
According to the present invention 3, by containing the dry powder of barley stems and leaves of the specific variety 3, the amount of feces is increased, bowel movements such as shortening of the intestinal passage time of ingested products are improved; and the intestinal mucosa is increased, and It can be expected to improve the intestinal environment, such as increasing or activating useful bacteria living in the intestine and improving the intestinal environment such as increasing the volume of feces. In addition, Invention 3 can exhibit an intestinal regulating action even when administered orally, so Invention 3 can be used in a daily usage mode. In addition, "Invention 3" refers to a composition containing dry powder of stems and leaves of barley of specific variety 3 and having an intestinal regulating action, and includes green juice for intestinal regulation and an intestinal regulating agent.

Invention 3 can be expected to have various effects such as amelioration of constipation, stimulation of immunity, suppression of harmful microbial metabolites and harmful enzymes, prevention of lifestyle-related diseases, improvement of allergic predisposition, and the like.

[4. Collagen absorption promoting action]
According to the present invention 4, by containing the dry powder of barley stems and leaves of the specific variety 4, collagen can be efficiently absorbed into the body. In addition, since the composition of the present invention 4 can exhibit a collagen absorption promoting action even by oral administration, the antioxidant green juice of the present invention can be used in a daily usage mode. In addition, "Invention 4" refers to a composition containing dry powder of barley stems and leaves of Specified Variety 4 and having an effect of promoting collagen absorption, and green juice for promoting collagen absorption and a collagen absorption accelerator. included.

Invention 4 is also excellent in palatability such as color and flavor due to the dry powder of barley stems and leaves of specific variety 4 blended. According to the present invention 4, various effects such as beauty, formation of bone and cartilage tissue, and treatment and prevention of joint diseases can be expected through the action of promoting collagen absorption.

The composition of the present invention 4 is an industrially extremely useful composition that has both safety and palatability and has collagen absorption promoting action, and can be expected to be provided to consumers in various forms.

[5. Calcium absorption promoting action]
According to the present invention 5, by containing the dry powder of barley foliage of the specific variety 5, calcium absorption into the body can be efficiently promoted. In addition, since the composition of Invention 5 can exhibit a calcium absorption promoting effect even by oral administration, Invention 5 can be used in a daily usage mode. In addition, "Invention 5" refers to a composition containing dry powder of barley stems and leaves of specific variety 5 and having a calcium absorption promoting effect, and a calcium absorption promoting green juice and a calcium absorption promoting agent. included.

Invention 5 is expected to prevent or treat diseases associated with calcium deficiency, such as bone-related diseases, neurological diseases, arteriosclerosis, hypertension, and overeating.

[6. Blood Cholesterol Elevation Suppressive Action]
According to the present invention 6, by containing the dry powder of barley stems and leaves of the specific variety 6, it is possible to efficiently suppress the increase in blood cholesterol. In addition, since the composition of the present invention 6 can exhibit blood cholesterol elevation suppressing action even by oral administration, the green juice for suppressing blood cholesterol elevation of the present invention can be used in a daily usage mode. is possible. In addition, "Invention 6" refers to a composition containing dry powder of barley stems and leaves of Specified Variety 6 and having an effect of suppressing blood cholesterol elevation, green juice for suppressing blood cholesterol elevation, and blood Including moderate cholesterol-lowering agents.

Invention 6 is a disease caused by elevated blood cholesterol, such as dyslipidemia (hyperlipidemia), high LDL cholesterol, low HDL cholesterol, arteriosclerosis, cerebral infarction, angina pectoris , myocardial infarction, intermittent claudication, cholelithiasis, and nephrotic syndrome.

FIG. 1 is a graph showing the blood glucose level elevation suppression rate (%) of Examples 1 to 3 and Comparative Example 1. FIG. FIG. 2 is a graph showing measurement results of ORAC values (μmol TE/g) of Comparative Example 1 and Examples 1-5. FIG. 3 is a diagram showing the measurement results of the dry stool weight (g) of the control, Comparative Example 1 and Examples 1-3. Numerical values represent mean values. FIG. 4 is a graph showing changes over time in blood Hyp levels in the control group, the example group, and the comparative example group. Numerical values represent mean values. FIG. 5 is a graph showing the AUC of blood Hyp concentration in the control group, the example group and the comparative example group. Numerical values represent mean values. FIG. 6 is a diagram showing changes over time in blood calcium levels in a control group and a test group using a test substance. Numerical values represent mean values. FIG. 7 is a diagram showing AUC of blood calcium concentration in the control group and the test group using the test substance. Numbers and bars represent mean ± standard deviation. FIG. 8 is a diagram showing the blood cholesterol levels of the control group and the test group using the test substance. Numbers and bars represent mean ± standard deviation.

The present invention will be described in detail below.

[1. Dry powder of barley stems and/or leaves]
It is known that there are actually more than 30,000 varieties of barley, and in the present invention, Fiber Snow, Silky Snow, Shunrai, Ichibanboshi and Harushizuku (hereinafter also referred to as "specific varieties") A dry powder of barley stems and/or leaves of at least one cultivar selected from In this specification, "stems and/or leaves" may be referred to as foliage. In addition, the foliage may be a part of a leaf or a stem, or may be the whole.

The specific variety of barley is generally used as a raw material for barley miso, barley tea, shochu, beer, and the like, for example, for polished barley. In the present invention, one of these varieties can be used alone, or two or more can be used in combination. The barley foliage dry powder may be barley leaves, stems or both, and the leaves and stems may each be part or all thereof.

The foliage of barley of a specific variety is preferably harvested before maturity, that is, from the beginning of tillering to the beginning of heading. Barley foliage is preferably processed immediately after harvest. If it takes longer to process, it is stored by means of storage commonly used by those skilled in the art, such as cold storage, to prevent deterioration of the foliage of the barley.

As foliage of the specific variety of barley used in the present invention, various processed products obtained from the foliage, that is, processed products of the specific variety of barley can be used. Examples of such processed products include dry powder of stems and leaves, pulverized stems and leaves and dried powder thereof (hereinafter, dry powder of pulverized product is also referred to as "pulverized powder"), shredded stems and leaves and dried thereof. Powder (hereinafter, dry powder of shredded material is also referred to as "fragmented powder"), squeezed juice of stems and leaves and dried powder thereof (hereinafter, dry powder of squeezed juice is also referred to as "squeezed powder") , foliage extract and its dry powder (hereinafter, the dry powder of the extract is also referred to as "extract powder").

Conventionally known methods can be used to pulverize barley stems and leaves and dry powder them. As such a method, a combination of drying treatment and pulverization treatment can be used for foliage of barley. Either the drying treatment or the pulverizing treatment may be performed first, but the drying treatment is preferably performed first. For dry powderization, this method may be combined with one or more treatments selected from blanching treatment, sterilization treatment, and the like, if necessary. Further, the pulverizing treatment may be performed once, or two or more treatments may be combined, but it is preferable to perform a coarse pulverizing treatment followed by a fine pulverizing treatment for finer pulverizing.

The blanching treatment is a treatment for keeping foliage bright green, and examples of the blanching treatment include hot water treatment and steaming treatment.

The hot water treatment includes, for example, a method of treating barley stems and leaves in hot water or steam at 80 to 100° C., preferably 90 to 100° C., for 60 to 180 seconds, preferably 90 to 120 seconds. Further, in the hot water treatment, it is preferable to use a carbonate such as magnesium carbonate or a hydrogen carbonate such as sodium hydrogen carbonate. can do.

The steaming treatment is preferably an intermittent steaming treatment in which a treatment of steaming the foliage of barley with steam and a treatment of cooling are repeated under normal pressure or pressure. In the intermittent steaming treatment, the steaming treatment is performed for, for example, 20 to 40 seconds, preferably 30 seconds. The cooling treatment after the steaming treatment is preferably performed immediately, and the method is not particularly limited, but immersion in cold water, refrigeration, cooling with cold air, evaporative cooling with hot air, and evaporative cooling with a combination of hot and cold air. etc. are used. Among these, evaporative cooling in which warm air and cold air are combined is preferable. Such a cooling treatment is carried out so that the product temperature of barley foliage is preferably 60° C. or lower, more preferably 50° C. or lower, and even more preferably 40° C. or lower. In order to produce a barley foliage powder rich in nutrients such as vitamins, minerals and chlorophyll, it is preferable to repeat the intermittent steaming treatment 2 to 5 times.

The sterilization treatment is not particularly limited as long as it is a treatment commonly known to those skilled in the art. For example, it is a treatment that physically or chemically kills microorganisms using temperature, pressure, electromagnetic waves, chemicals, etc. can. When blanching is performed in addition to drying and pulverization, blanching is preferably performed before drying. Moreover, when sterilization treatment is performed in addition to the drying treatment and the pulverization treatment, the sterilization treatment is preferably performed after the drying treatment or before or after the pulverization treatment.

Although the drying treatment is not particularly limited, for example, a treatment for drying barley stems and leaves to a moisture content of 10% or less, preferably 5% or less. The drying treatment can be performed by any method known to those skilled in the art, such as hot air drying, high-pressure steam drying, electromagnetic wave drying, and freeze drying. Drying by heating can be carried out, for example, at 40° C. to 140° C., preferably 80° C. to 130° C., at a temperature and time at which the foliage is not discolored by heating.

The pulverization treatment is not particularly limited, but includes, for example, a treatment of pulverizing the plant by any method commonly used by those skilled in the art using a crusher, mill, blender, millstone or other crushing equipment or instrument. The pulverized barley foliage is sieved as necessary, and, for example, those that pass through 30 to 250 mesh are preferably used as the barley foliage powder. By making the particle size less than 250 mesh, the barley foliage powder can be easily handled during further processing, and by making the particle size more than 30 mesh, barley foliage powder and other materials can be easily handled. facilitate uniform mixing with

As a specific method for producing pulverized powder, for example, barley stems and leaves are cut, blanched, then dried to a moisture content of 10% by mass or less, preferably 5% by mass or less, and then dried. A method of pulverizing can be mentioned (see JP-A-2004-000210). In addition to this, for example, barley stems and leaves are cut, blanched, then kneaded, then dried and pulverized (see Japanese Patent Application Laid-Open No. 2002-065204 and Japanese Patent No. 3428956). a method of drying barley foliage, coarsely pulverizing, heating at 110° C. or higher, and further finely pulverizing (see Japanese Patent Application Laid-Open No. 2003-033151 and Japanese Patent No. 3277181).

The method for shredding the foliage of barley is not particularly limited, but methods commonly used by those skilled in the art to shred plants, such as slicing, crushing, and shredding, can be used. As an example of comminution, it may be slurried. Slurrying is carried out by subjecting barley stems and leaves to a mixer, juicer, blender, masscolloider, or the like to make the barley stems and leaves thick and porridge-like (suspension of liquid and solid). By being slurried in this manner, the stems and leaves preferably have an average diameter of 1 mm or less, more preferably 0.5 mm or less, even more preferably 0.1 mm or less, even more preferably 0.5 mm or less, and 80% by mass or more of the pieces. 05 mm or less, and become fluid. The shredded material is processed by freeze-drying, hot-air drying, or the like to obtain a dry powder (shredded powder).

The method for obtaining the squeezed juice of barley foliage is not particularly limited, but examples include a method of squeezing barley foliage or shredded barley foliage, and a method of centrifuging or filtering barley foliage shredded. As an example of a specific method for producing a squeezed liquid, the squeezed liquid is squeezed by mechanical crushing means such as a mixer or juicer, and if necessary, crude solids are removed by means such as sieving or filtration. is obtained. More specifically, the methods described in JP-A-08-245408, JP-A-09-047252, JP-A-5-7471, JP-A-4-341153 and the like can be mentioned. A person skilled in the art can appropriately select and implement the method. The squeezed liquid may be concentrated as necessary, or subjected to a process such as freeze-drying, hot-air drying, or spray-drying to obtain a dry powder (squeezed powder).

The method for obtaining the barley foliage extract is not particularly limited. A method of heating and extracting, etc. can be mentioned. The extract may be concentrated, if necessary, or subjected to a treatment such as freeze drying, hot air drying, or spray drying to obtain a dry powder (extract powder).

The characteristics of the dry powder of barley foliage are not particularly limited, but for example, the angle of repose is preferably 20° to 80°, more preferably 30° to 70°, further preferably 40° to 60°, further preferably 45° to 45°. 55° is even more preferred. The angle of repose is measured by dropping about 50 g of the sample from an altitude of 12 cm into the center of a petri dish with a radius of 4.3 cm using an angle of repose measuring device (AS ONE, ASK-01), and then depositing the sample in a mountain shape. After measuring the height, the angle of repose can be calculated by the following formula from the radius of the petri dish and the height of the deposited sample.
Angle of repose = tan-1 (b/a) x 180 ÷ π (where a = petri dish radius, b = height of deposited sample).

The dry powder of stems and leaves of barley of a specific variety used in the present invention may contain water-insoluble dietary fiber. The water-insoluble dietary fiber contained in the dry powder preferably contains 20% by mass or more, preferably 30% by mass or more in terms of dry mass, 20 to 80% by mass, preferably 30 to 70% by mass, more preferably 35% by mass. It is more preferable to contain up to 60% by mass.

[2. Inhibition of blood sugar level elevation]
TECHNICAL FIELD The present invention relates to a green juice for suppressing an increase in blood sugar level and an agent for suppressing an increase in blood sugar level (Invention 1), which contains dry powder of barley foliage.

The present invention 1 contains at least one or two or more dry barley foliage powders selected from among Shunrai, Fiber Snow, and Silky Snow (specified variety 1) as the substance having an effect of suppressing an increase in blood sugar level.

The present invention 1, by containing the dry powder of barley stems and leaves of the specific variety 1, not only has the effect of suppressing the increase in blood sugar level, but also has a beautiful appearance due to the vivid color and a good flavor. It can be compatible.

The present invention 1 can exhibit an early blood sugar level lowering action in addition to the blood sugar level elevation suppressing action by containing the above-described dry barley foliage powder. However, among these actions, the present invention 1 only needs to exhibit at least the action of suppressing an increase in blood sugar level. The blood glucose level elevation inhibitory action can be evaluated based on the blood glucose level elevation inhibition rate described in the examples below. The rate of suppression of blood glucose level elevation indicated by the present invention 1 is, for example, about 35% or more, preferably about 40% or more, and more preferably about 45% or more. The present invention 1 can be used in various forms for the purpose of obtaining the effect. For example, it may be used for various purposes without adding any special treatment. In addition, according to the present invention 1, it is expected that not only the effects of the blood sugar level-increasing ingredients used at the same time but also the effects of the blood sugar level-increasing ingredients used before or after the use of the present invention 1 are alleviated or reduced. can.

In the solid content of the present invention 1, the content of the dry powder of barley stems and leaves is a dry mass, and the lower limit is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and 1% by mass. More preferably, 10% by mass or more is still more preferable, 20% by mass or more is particularly preferable, and the upper limit is preferably 99.9% by mass or less, more preferably 90% by mass or less, and further 80% by mass or less. preferable. In order to sufficiently exhibit the effect of suppressing elevation of blood sugar level, it is preferable that the content of dry powder of barley foliage is 0.1% by mass. In addition, when present invention 1 contains a large amount of blood sugar level increasing ingredients such as sugar, the amount of dry barley foliage powder used is increased, and other blood sugar level elevation suppressing ingredients different from barley foliage dry powder are further included. In some cases, the amount of dry barley foliage powder used can be reduced.

The daily usage amount of the present invention 1 is not particularly limited, and can be appropriately set according to the usage mode, the usage content of the user, the blood sugar level, etc. It is 1 to 6000 mg/kg, preferably 1 to 4000 mg/kg, more preferably 10 to 3000 mg/kg, still more preferably 10 to 2000 mg/kg, based on the body weight of the person. Similarly, the amount of one use of the present invention 1 is not particularly limited. is 1-2000 mg/kg, more preferably 5-1000 mg/kg.

In addition, the amount of the present invention 1 used once is, for example, in terms of mass of dry barley foliage powder, 0.01 to 30 g, preferably 0.05 to 20 g, more preferably 0.1 to 10 g, especially Preferably, it can be 0.3 to 7 g. Similarly, the daily usage amount of the present invention 1 is, for example, 0.01 to 100 g, preferably 0.05 to 70 g, more preferably 0.5 to 50 g in terms of mass of dry barley foliage powder, Particularly preferably, it can be 1 to 30 g.

The present invention 1 may contain only the dry powder of barley foliage, or may contain other ingredients in addition to the dry powder of barley foliage. Other ingredients include, for example, various excipients, binders, lubricants, stabilizers, diluents, bulking agents, thickeners, emulsifiers, colorants, perfumes, additives and the like. The content of other components can be appropriately selected according to the mode of use of the present invention 1 and the like.

The present invention 1 can be used in various forms for the purpose of obtaining an effect of suppressing elevation of blood sugar level. The present invention 1 can be, for example, an oral or parenteral composition.

One form of the present invention is not particularly limited, and can be any form. Oral forms include, for example, forms suitable for oral use, specifically powders, granules, granules, tablets, rods, plates, blocks, solids, rounds, liquids, Candies, pastes, creams, capsules such as hard capsules and soft capsules, caplets, tablets, gels, jelly, gummies, wafers, biscuits, cookies, cakes, chewables, and syrups , a stick shape, and the like.

The packaging form of the present invention 1 is not particularly limited and can be appropriately selected according to the dosage form etc. Examples include blister packs such as PTP; strip packaging; heat sealing; aluminum pouches; glass containers such as vials; and plastic containers such as ampoules.

Invention 1 is preferably in the form of powder (powder form such as powder, granules, etc.) in which a mixture mixed with water is orally used because it prevents putrefaction and is suitable for long-term storage. In addition, when the present invention 1 is in a solid form such as powder or tablet, as described above, it can be mixed with water to form a liquid and used orally. It may be used orally as a solid, depending on the circumstances.

The present invention 1 is preferably a green juice for suppressing an increase in blood sugar level containing dry powder of stems and leaves of barley of specified variety 1, and suppression of increase in blood sugar level containing dry powder of stems and leaves of barley of specified variety 1 as an active ingredient. Aojiru for green juice is particularly preferred. Moreover, the green juice for suppressing an increase in blood sugar level is preferably in powder form (powder form such as powder and granules).

Since the present invention 1 has a blood sugar level elevation inhibitory action and an early blood sugar level lowering action, its use is useful for people suffering from diabetes, hyperglycemia, obesity, and those at risk thereof. It is useful for maintenance, and is particularly useful for maintaining the health of diabetic patients, those with a fasting blood sugar level of 100 mg/dl or more, and obese people. Obesity as used herein refers to a state in which the BMI (Body Mass Index) is 25 or more, or a waist circumference (waist circumference through the navel) of 85 cm or more for men and 90 cm or more for women. state.

Chronic persistence of high blood sugar levels, such as fasting blood sugar levels of 100 mg/dl or more, causes decreased sensitivity to insulin, resulting in further hyperglycemia. In addition, when a person becomes obese, hypertrophy of adipocytes is observed, and not only adipocytes but also insulin target cells such as muscle cells experience decreased insulin sensitivity at the cellular level. As a result of these, diabetes develops. Furthermore, obesity and decreased insulin sensitivity bring about dyslipidemia and hypertension, which are said to be three major lifestyle-related diseases along with diabetes. Obesity and decreased insulin sensitivity increase triglycerides, inactivating lipolytic enzymes and impairing liver function, leading to the development of dyslipidemia. Furthermore, hypertension develops due to increased circulating blood volume and abnormal glucose metabolism due to obesity and reduced insulin sensitivity. Metabolic syndrome is a condition in which two or more symptoms of these three major lifestyle-related diseases develop, and it is known that arteriosclerosis is caused by abnormal lipid metabolism. In view of the above matters, the present invention 1, in addition to diabetes and obesity, dyslipidemia, hypertension, metabolic syndrome and arteriosclerosis, and further are lifestyle-related diseases related to these: hyperlipidemia, gout, high body fat percentage, hyperglycemia, hyperinsulinemia, hypercholesterolemia, hypertriglyceridemia, fatty liver, cardiovascular disease, hyperuricemia. It can be expected to prevent and treat diseases and the like. Therefore, another aspect of the present invention is a pharmaceutical composition for preventing and treating the above-mentioned diseases caused by elevated blood sugar level, containing dry powder of stems and leaves of barley of specific cultivar 1.

In addition, the present invention 1 contains a large amount of vitamins, minerals, etc. derived from the dry powder of the barley foliage of the specific variety 1, in addition to the effect of suppressing the increase in blood sugar level possessed by the conventional dry powder of foliage of barley. , there is a secondary effect based on these, contributing to the health maintenance of the user.

[3. antioxidant effect]
The present invention relates to an antioxidant green juice containing dry powder of barley foliage and an antioxidant (Invention 2).

Invention 2 contains at least one or two or more of barley stems and leaves dry powder of fiber snow, silky snow, shunrai, ichibanboshi, and harushizuku (specified variety 2) as a substance having an antioxidant effect. do.

Invention 2 contains the dry powder of barley stems and leaves of the specific variety 2, so that it not only has an antioxidant effect, but also has a beautiful appearance due to its vivid color and a good flavor. It is possible.

Invention 2 exhibits an antioxidant action by containing the dry powder of barley foliage. That is, the present invention 2 can alleviate, reduce or eliminate the oxidizing properties of coexisting oxidizing substances. However, the antioxidant action shown by the present invention 2 is not bound by any reasoning, and the present invention 2 may potentiate other substances exhibiting antioxidant action. In addition, invention 2 may not only weaken the oxidizing properties of coexisting oxidizing substances, but also reduce the oxidizing properties of oxidizing substances existing before or after the use of invention 2. The degree of antioxidant activity exhibited by Invention 2, that is, the antioxidant capacity, can be confirmed by examining the SOD activity value, the ORAC value, or both.

The SOD activity value indicates that the amount of diformazan produced by the reaction of O ₂ ⁻ · ^and NO _{2 -TB} present in the reaction system is H by superoxide dismutase (SOD) derived from the test sample. Based on the phenomenon that diformazan is reduced by disproportionation to ₂ O ₂ and O ₂ , the degree of reduction of diformazan is determined as inhibition rate (%).

The ORAC value evaluates the active oxygen absorption capacity (Oxygen Radical Absorbance Capacity) according to the following procedure. That is, the fluorescence intensity of fluorescein was measured over time to determine the process in which the labeling substance fluorescein was degraded by peroxy radicals generated from the radical generator AAPH (2,2'-Azobis (2-amidinopropane) dihydrochloride). Then, a graph was created with the time after the start of measurement on the X axis and the fluorescence intensity of fluorescein at that time on the Y axis, surrounded by the axis of fluorescence intensity, the time axis, and the locus of the graph. Calculate the area under the curve (AUC). The net AUC, which is the AUC in the presence of the test sample minus the AUC in the absence thereof, increases in proportion to the antioxidant capacity of the test sample. ORAC values for test samples are calculated relative to Trolox equivalents per gram of sample (μmol TE/g) based on the net AUC of the standard Trolox.

As for the method for measuring the SOD activity value and the ORAC value, the methods described in "3. SOD-like activity measurement and its results" and "4. ORAC measurement and its results" in Examples described later can be referred to, respectively.

In the solid content of the present invention 2, the content of the dry powder of barley stems and leaves is a dry mass, and the lower limit is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and 1% by mass. More preferably, 10% by mass or more is still more preferable, 20% by mass or more is particularly preferable, and the upper limit is preferably 99.9% by mass or less, more preferably 90% by mass or less, and further 80% by mass or less. preferable. In order to sufficiently exert the antioxidant action, the content of the dry powder of barley stems and leaves is preferably 0.1% by mass.

The daily usage amount of the present invention 2 is not particularly limited, and can be appropriately set according to the mode of use and the content of use by the user. is 1 to 6000 mg/kg, preferably 1 to 4000 mg/kg, more preferably 10 to 3000 mg/kg, still more preferably 10 to 2000 mg/kg. The amount of one use of the present invention 2 is also not particularly limited. is 1-2000 mg/kg, more preferably 5-1000 mg/kg.

In addition, the amount of the present invention 2 used once is, for example, in terms of mass of dry barley foliage powder, 0.01 to 30 g, preferably 0.05 to 20 g, more preferably 0.1 to 10 g, especially Preferably, it can be 0.3 to 7 g. Similarly, the daily usage amount of the present invention 2 is, for example, 0.01 to 100 g, preferably 0.05 to 70 g, more preferably 0.5 to 50 g in terms of mass of dry barley foliage powder, Particularly preferably, it can be 1 to 30 g.

Invention 2 may contain only the dry powder of barley foliage, or may contain other ingredients in addition to the dry powder of barley foliage. Other ingredients include, for example, various excipients, binders, lubricants, stabilizers, diluents, bulking agents, thickeners, emulsifiers, colorants, perfumes, additives and the like. The content of other components can be appropriately selected according to the mode of use of the second invention.

The present invention 2 can be used in various forms for the purpose of obtaining antioxidant action. Invention 2 can be, for example, an oral or parenteral composition.

The form of the present invention 2 is not particularly limited, and may be any form. Oral forms include, for example, forms suitable for oral use, specifically powders, granules, granules, tablets, rods, plates, blocks, solids, rounds, liquids, Candies, pastes, creams, capsules such as hard capsules and soft capsules, caplets, tablets, gels, jelly, gummies, wafers, biscuits, cookies, cakes, chewables, and syrups , a stick shape, and the like.

The packaging form of the present invention 2 is not particularly limited and can be appropriately selected according to the dosage form etc. Examples include blister packs such as PTP; strip packaging; heat sealing; aluminum pouches; glass containers such as vials; and plastic containers such as ampoules.

Invention 2 is preferably in the form of powder (powder form such as powder, granules, etc.) in which a mixture mixed with water is orally used because it prevents putrefaction and is suitable for long-term storage. In addition, when the present invention 2 is in a solid form such as powder or tablet, as described above, it can be mixed with water to form a liquid and used orally. It may be used orally as a solid, depending on the circumstances.

The present invention 2 is preferably an antioxidant green juice containing dry powder of barley stems and leaves of the specific variety 2, and an antioxidant green juice containing the dry powder of barley stems and leaves of the specific variety 2 as an active ingredient. is particularly preferred. Moreover, the antioxidant green juice is preferably in powder form (powder form such as powder and granules).

Since the present invention 2 has an antioxidant effect, its use is useful for maintaining the health of those who are under physical or chemical environmental conditions such as aging and extrinsic stress, in which the generation of active oxygen increases. Useful. Therefore, another aspect of the present invention is a pharmaceutical composition for preventing and treating diseases caused by active oxygen, which contains dry powder of stems and leaves of barley of specific cultivar 2.

In addition, in addition to the antioxidant effect of the conventional dry barley foliage powder, the present invention 2 contains a large amount of vitamins, minerals, etc. derived from the specific variety 2 barley foliage dry powder. is useful for health maintenance.

[4. intestinal function]
TECHNICAL FIELD The present invention relates to a green juice for regulating intestinal function and an intestinal regulating agent (Invention 3) containing dry powder of barley stems and leaves.

Invention 3 contains at least one or two or more dry powders of barley stems and leaves selected from among Shunrai, Fiber Snow and Silky Snow (specified variety 3) as the substance having an intestinal regulation effect.

Invention 3 contains dry powder of barley stems and leaves of the specific variety 3, so that it not only has an intestinal regulation effect, but also has a beautiful appearance due to its vivid color and a good flavor. It is possible.

In Invention 3, the content of the dry powder of barley stems and leaves is not particularly limited as long as the problems of the present invention can be solved. %, preferably 5 wt % or more and 90 wt % or less, more preferably 8 wt % or more and 80 wt % or less, and still more preferably 10 wt % or more and 70 wt % or less. If the content of dry powder of barley foliage is less than 5 wt %, the desired intestinal regulation effect may not be obtained.

The dry powder of barley stems and leaves used in Invention 3 has an excellent intestinal regulation effect. Although the technical scope of the present invention is not bound by any reasoning, for example, by using dry powder of barley stems and leaves, the total amount of feces (amount of dry feces) is increased and the water content in the feces is increased. The amount of wet feces increases due to the water retention effect of forming feces suitable for defecation due to the increased content, and the effect of improving bowel movements can be obtained such that excretion becomes smoother. In addition, an increase in the weight of the cecal tissue and the weight of the cecal content promotes intestinal fermentation, which tends to increase short-chain fatty acids in the cecal content and lower the cecal content pH. Short-chain fatty acids produced by intestinal fermentation suppress cancer cell proliferation, and when the intestinal pH is lowered, they suppress infection with pathogenic bacteria, thereby improving the intestinal environment.

In addition, by improving bowel movement, the growth of bad intestinal bacteria due to constipation can be suppressed, and the intestinal environment can be maintained and improved normally. If the intestinal environment is improved, the action of useful bacteria in the intestines will activate the movement of the intestines, and bowel movements will be improved. As described above, when the present invention 3 is used, the effect of improving bowel movement and the effect of improving the intestinal environment are exhibited in an interactive manner, and as a result, the effect of regulating the intestines can be achieved. In addition, the water retention effect and smooth excretion are also effective, for example, in preventing hemorrhoids. Therefore, another aspect of the present invention is a pharmaceutical composition for preventing and treating diseases caused by bowel movements, which contains dry powder of barley stems and leaves of Specified Variety 3.

Since Invention 3 has an effect of improving bowel movements and an effect of improving the intestinal environment, it can be used in various forms for the purpose of obtaining such effects. The present invention 3 may be used for various purposes without adding special treatment, for example. The amount of dry barley foliage powder contained in Invention 3 is not particularly limited, and is appropriately set, for example, according to the mode of use of the antiflatulent agent.

In the solid content of the present invention 3, the content of the dry powder of barley stems and leaves is a dry mass, and the lower limit is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and 1% by mass. More preferably, 10% by mass or more is still more preferable, 20% by mass or more is particularly preferable, and the upper limit is preferably 99.9% by mass or less, more preferably 90% by mass or less, and further 80% by mass or less. preferable. In order to sufficiently exhibit the intestinal regulating action, the content of dry barley foliage powder is preferably 0.1% by mass.

The daily usage amount of the present invention 3 is not particularly limited, and can be appropriately set according to the mode of use and the content of use by the user. is 1 to 6000 mg/kg, preferably 1 to 4000 mg/kg, more preferably 10 to 3000 mg/kg, still more preferably 10 to 2000 mg/kg. Similarly, the amount of one use of Invention 3 is not particularly limited, for example, it is 0.5 to 3000 mg / kg based on the user's body weight in terms of mass of dry powder of barley stems and leaves, and is preferable. is 1-2000 mg/kg, more preferably 5-1000 mg/kg.

In addition, the amount of present invention 3 used once is, for example, in terms of mass of dry barley foliage powder, 0.01 to 30 g, preferably 0.05 to 20 g, more preferably 0.1 to 10 g, especially Preferably, it can be 0.3 to 7 g. Similarly, the daily usage amount of the present invention 3 is, for example, 0.01 to 100 g, preferably 0.05 to 70 g, more preferably 0.5 to 50 g in terms of mass of dry barley foliage powder, Particularly preferably, it can be 1 to 30 g.

Invention 3 may contain only the dry powder of barley foliage, or may contain other ingredients in addition to the dry powder of barley foliage. Other ingredients include, for example, various excipients, binders, lubricants, stabilizers, diluents, bulking agents, thickeners, emulsifiers, colorants, perfumes, additives and the like. The content of other components can be appropriately selected according to the mode of use of the present invention 3 and the like.

Invention 3 can be used in various forms for the purpose of obtaining an intestinal regulation effect. Invention 3 can be, for example, an oral or parenteral composition.

The form of the present invention 3 is not particularly limited, and may be any form. Oral forms include, for example, forms suitable for oral use, specifically powders, granules, granules, tablets, rods, plates, blocks, solids, rounds, liquids, Candies, pastes, creams, capsules such as hard capsules and soft capsules, caplets, tablets, gels, jelly, gummies, wafers, biscuits, cookies, cakes, chewables, and syrups , a stick shape, and the like.

The packaging form of the present invention 3 is not particularly limited and can be appropriately selected according to the dosage form etc. Examples include blister packs such as PTP; strip packaging; heat sealing; aluminum pouches; glass containers such as vials; and plastic containers such as ampoules.

Invention 3 is preferably in the form of powder (powder form such as powder, granules, etc.) in which a mixture mixed with water is orally used because it prevents putrefaction and is suitable for long-term storage. In addition, when Invention 3 is in a solid form such as powder or tablet, it can be mixed with water to form a liquid and used orally, as described above. It may be used orally as a solid, depending on the circumstances.

Invention 3 is preferably green juice for intestinal regulation containing dry powder of barley stems and leaves of specific variety 3, and green juice for intestinal regulation containing dry powder of barley stems and leaves of specific variety 3 as an active ingredient. is particularly preferred. In addition, the green juice for intestinal regulation is preferably in powder form (powder form such as powder and granules).

Invention 3 uses the dry powder of barley stems and leaves because it contains a large amount of vitamins, minerals, etc. derived from the dry powder of barley stems and leaves of the specific variety 3, in addition to the intestinal regulation effect possessed by the conventional dry powder of barley stems and leaves. That is very useful for health maintenance.

[5. Collagen absorption promotion effect]
TECHNICAL FIELD The present invention relates to a green juice for promoting collagen absorption containing dry powder of barley stems and leaves, and a collagen absorption promoter (Invention 4).

Invention 4 uses at least one or two or more dry powders of barley stems and leaves selected from fiber snow, silky snow, shunrai, ichibanboshi, and harushizuku (specified variety 4) as the substance having collagen absorption promoting action. contains.

Invention 4 contains dry powder of barley stems and leaves of specific cultivar 4, so that it not only has a collagen absorption promoting effect, but also has a beautiful appearance due to its vivid color and a good flavor. It is something that can be done.

In Invention 4, the content of the dry powder of barley stems and leaves is not particularly limited as long as the problems of the present invention can be solved. %, preferably 1 wt % or more and 90 wt % or less, more preferably 3 wt % or more and 85 wt % or less, and still more preferably 5 wt % or more and 80 wt % or less. If the content of the dry powder of stems and leaves of Barley of Specific Variety 4 is less than 1 wt %, the desired effect of promoting absorption of collagen may not be obtained.

The dry powder of barley stems and leaves of the specific variety 4 used in the present invention 4 has an excellent collagen absorption promoting effect. For example, by using the dry powder of stems and leaves of barley of specific cultivar 4, the amount of collagen used in combination can be increased in the body and the bioactivity of collagen can be enhanced.

Invention 4 has a collagen absorption promoting action, and thus can be used in various forms for the purpose of obtaining such action. Invention 4 may be used for various purposes without adding any special treatment.

In the solid content of the present invention 4, the content of the dry powder of barley stems and leaves is a dry mass, and the lower limit is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and 1% by mass. More preferably, 10% by mass or more is still more preferable, 20% by mass or more is particularly preferable, and the upper limit is preferably 99.9% by mass or less, more preferably 90% by mass or less, and further 80% by mass or less. preferable. In order to sufficiently exhibit the action of promoting collagen absorption, the content of the dry barley foliage powder is preferably 0.1% by mass.

The daily usage amount of the present invention 4 is not particularly limited, and can be appropriately set according to the mode of use and the content of use by the user. is 1 to 6000 mg/kg, preferably 1 to 4000 mg/kg, more preferably 10 to 3000 mg/kg, still more preferably 10 to 2000 mg/kg. The amount of one use of the present invention 4 is also not particularly limited. is 1-2000 mg/kg, more preferably 5-1000 mg/kg.

In addition, the amount of the present invention 4 used once is, for example, 0.01 to 30 g, preferably 0.05 to 20 g, more preferably 0.1 to 10 g, in terms of mass of dry powder of barley foliage, especially Preferably, it can be 0.3 to 7 g. Similarly, the daily usage amount of the present invention 4 is, for example, 0.01 to 100 g, preferably 0.05 to 70 g, more preferably 0.5 to 50 g in terms of mass of dry barley foliage powder, Particularly preferably, it can be 1 to 30 g.

Invention 4 may contain only the dry powder of barley foliage, or may contain other ingredients in addition to the dry powder of barley foliage. Other ingredients include, for example, various excipients, binders, lubricants, stabilizers, diluents, bulking agents, thickeners, emulsifiers, colorants, perfumes, additives and the like. The content of other components can be appropriately selected according to the mode of use of the present invention 4 and the like.

Invention 4 can be used in various forms for the purpose of obtaining a collagen absorption promoting effect. Invention 4 can be, for example, an oral or parenteral composition.

The form of the present invention 4 is not particularly limited, and may be any form. Oral forms include, for example, forms suitable for oral use, specifically powders, granules, granules, tablets, rods, plates, blocks, solids, rounds, liquids, Candies, pastes, creams, capsules such as hard capsules and soft capsules, caplets, tablets, gels, jelly, gummies, wafers, biscuits, cookies, cakes, chewables, and syrups , a stick shape, and the like.

The packaging form of the present invention 4 is not particularly limited and can be appropriately selected according to the dosage form etc. Examples include blister packs such as PTP; strip packaging; heat sealing; aluminum pouches; film packaging using plastic or synthetic resin; glass containers such as vials; and plastic containers such as ampoules.

Invention 4 is preferably in the form of powder (powder form such as powder, granules, etc.) in which a mixture mixed with water is orally used because it prevents putrefaction and is suitable for long-term storage. In addition, when the present invention 4 is in a solid form such as powder or tablet, as described above, it can be mixed with water to form a liquid and used orally. It may be used orally as a solid, depending on the circumstances.

Invention 4 is preferably a green juice for promoting collagen absorption containing dry powder of foliage of barley of specific cultivar 4, and green juice for promoting collagen absorption containing dry powder of foliage of barley of specific cultivar 4 as an active ingredient. Juice is particularly preferred. In addition, the green juice for promoting collagen absorption is preferably in powder form (powder form such as powder and granules).

In addition, in order to fully exhibit the physiological activity of collagen, Invention 4 preferably contains collagen together with dry powder of foliage of barley of specific variety 4 . Collagen is not particularly limited in terms of the origin species, its part, molecular weight, etc. For example, collagen derived from mammals obtained from the tails and limbs of cattle and pigs, etc.; collagen from fishes such as tuna, shark, cod, flounder, flounder, sea bream, tilapia, salmon, catfish, sea bass, eel, and the like obtained from fins, skin, and scales. Collagen can be obtained, for example, by enzymatically decomposing gelatin obtained by heating and extracting raw materials derived from mammals, birds, fish, or the like by a known method.

The average molecular weight of collagen is not particularly limited, and is, for example, 500 to 100,000 or less, preferably 1,000 to 50,000. The average molecular weight of collagen may be according to product information provided by the supplier when collagen is a commercial product. In addition, the concentration and amount of collagen to be blended in Invention 4 are not particularly limited, and can be appropriately set according to, for example, the form of the composition and the desired physiologically active effect of collagen. A standard amount of collagen to be used per day for an adult is, for example, 0.01 g to 100 g, preferably 0.1 g to 50 g.

Collagen may be used in combination with Invention 4. In this case, the term "combined use" means that the collagen is used for the purpose of using the collagen at the same time as or before or after the present invention 4. Therefore, the kit containing the present invention 4 and collagen is useful as a kit for purposes such as cosmetic, formation of bone and cartilage tissue, and treatment and prevention of joint diseases. Another aspect of the present invention is a pharmaceutical composition for beauty, formation of bone and cartilage tissue, treatment and prevention of joint diseases, containing dry powder of barley foliage of Specified Variety 4. In particular, a kit containing Invention 4 and a collagen component is useful as a kit for purposes such as treatment and prevention of the above diseases.

Invention 4 contains a large amount of vitamins, minerals, etc. derived from dry powder of barley stems and leaves of specific variety 4, in addition to collagen absorption promoting action possessed by conventional dry powder of stems and leaves of barley, so this is used. Doing so is useful for maintaining good health.

[6. Calcium absorption promoting action]
The present invention relates to a green juice for promoting calcium absorption containing dry powder of barley stems and leaves, and a calcium absorption promoter (Invention 5).

Invention 5 is the drying of barley stems and leaves of any one or two or more of fiber snow, silky snow, shunrai, ichibanboshi and harushizuku (specified variety 5) as the substance having a calcium absorption promoting effect of the invention. Contains at least powder.

Calcium absorption promoting action is not particularly limited as long as it is a generally known action. For example, it refers to the action of increasing or improving calcium absorption in vivo. The action of increasing or maintaining the calcium concentration of the blood, or suppressing or alleviating the decrease in the calcium concentration in the blood.

Invention 5 contains dry powder of barley stems and leaves of the specific variety 5, so that it not only has a calcium absorption promoting effect, but also has a beautiful appearance due to its vivid color and a good flavor. It is something that can be done.

Invention 5 can exhibit a calcium absorption promoting effect by containing the dry powder of stems and leaves of barley of specific variety 5. The degree of calcium absorption promoting action is not particularly limited, and can be evaluated, for example, by measuring and comparing the blood calcium concentration, as described in Examples below. The calcium absorption promoting action shown by the present invention 5 is measured using the MXB method, which is based on the measurement principle that calcium binds to MXB to give a blue color under alkaline conditions. 2, 3 or 5 hours after administration of the present invention 5 This is a calcium absorption promoting effect that is greater than the amount of change in blood calcium concentration when using the same amount of dry powder of foliage of Nishinohoshi as the dry powder of foliage of barley of specific variety 5 contained in .

Specifically, the calcium absorption promoting effect shown by the present invention 5 is such that, for example, the amount of change in blood calcium concentration 2 hours after administration is 1.8 mg/dL or more, preferably 2.0 mg/dL or more. , more preferably 2.2 mg/dL or more, more preferably 2.3 mg/dL or more; similarly, the change in blood calcium concentration 3 hours after administration is 2.4 mg/dL or more, preferably 2.5 mg/dL or more, more preferably 2.6 mg/dL or more, still more preferably 2.7 mg/dL or more; 2 mg/dL or more, preferably 1.3 mg/dL or more, more preferably 1.4 mg/dL or more, and still more preferably 1.5 mg/dL or more. It is preferable that the blood calcium concentration is maintained at 8.0 to 10.0 mg/mL by using Invention 5.

In addition, the calcium absorption promoting effect shown by the present invention 5 is measured by the MXB method, for example, at 0, 0.5, 1, 2, 3 and 5 hours after administration to the user at 200 mg-calcium/kg. It can be expressed using AUC (area under the blood concentration-time curve) calculated based on the blood calcium concentration of . From the viewpoint of AUC, the calcium absorption promoting action shown by Invention 5 is, for example, the same amount of dry powder of Nishinohoshi foliage as the dry powder of barley foliage of the specific variety 5 contained in Invention 5. It is a calcium absorption promoting effect that is greater than the AUC of blood calcium concentration, specifically 8.1 mg/dL·hr, preferably 8.5 mg/dL·hr, more preferably 9.0 mg/dL·hr. dL·hr, more preferably 9.5 mg/dL·hr.

The present invention 5 can be used in various forms for the purpose of obtaining a calcium absorption promoting effect. For example, it may be used for various purposes without adding any special treatment. Invention 5 is expected to promote calcium absorption not only by calcium components such as calcium and calcium-containing substances used at the same time, but also by calcium components used before or after the use of Invention 5. can.

In the solid content of the present invention 5, the content of the dry powder of barley stems and leaves is a dry mass, and the lower limit is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and 1% by mass. More preferably, 10% by mass or more is still more preferable, 20% by mass or more is particularly preferable, and the upper limit is preferably 99.9% by mass or less, more preferably 90% by mass or less, and further 80% by mass or less. preferable. In order to sufficiently exhibit the effect of promoting calcium absorption, the content of dry barley foliage powder is preferably 0.1% by mass.

The daily usage amount of the present invention 5 is not particularly limited, and can be appropriately set according to the mode of use and the content of use by the user. is 1 to 6000 mg/kg, preferably 1 to 4000 mg/kg, more preferably 10 to 3000 mg/kg, still more preferably 10 to 2000 mg/kg. The amount of one use of the present invention 5 is also not particularly limited. is 1-2000 mg/kg, more preferably 5-1000 mg/kg.

In addition, the amount of the present invention 5 used once is, for example, in terms of mass of dry barley foliage powder, 0.01 to 30 g, preferably 0.05 to 20 g, more preferably 0.1 to 10 g, especially Preferably, it can be 0.3 to 7 g. Similarly, the daily usage amount of the present invention 5 is, for example, 0.01 to 100 g, preferably 0.05 to 70 g, more preferably 0.5 to 50 g in terms of mass of dry barley foliage powder, Particularly preferably, it can be 1 to 30 g.

Invention 5 may contain only the dry powder of barley foliage, or may contain other ingredients in addition to the dry powder of barley foliage. Other ingredients include, for example, various excipients, binders, lubricants, stabilizers, diluents, bulking agents, thickeners, emulsifiers, colorants, perfumes, additives and the like. The content of other components can be appropriately selected according to the mode of use of the fifth aspect of the invention.

The present invention 5 can be used in various forms for the purpose of obtaining a calcium absorption promoting effect. Invention 5 can be, for example, an oral or parenteral composition.

The form of the present invention 5 is not particularly limited, and may be any form. Oral forms include, for example, forms suitable for oral use, specifically powders, granules, granules, tablets, rods, plates, blocks, solids, rounds, liquids, Candies, pastes, creams, capsules such as hard capsules and soft capsules, caplets, tablets, gels, jelly, gummies, wafers, biscuits, cookies, cakes, chewables, and syrups , a stick shape, and the like.

The packaging form of the present invention 5 is not particularly limited, and can be appropriately selected according to the dosage form etc. Examples include blister packs such as PTP; strip packaging; heat sealing; aluminum pouches; glass containers such as vials; and plastic containers such as ampoules.

Invention 5 is preferably in the form of powder (powder form such as powder, granules, etc.) in which a mixture mixed with water is orally used because it prevents putrefaction and is suitable for long-term storage. In addition, when the present invention 5 is in a solid form such as powder or tablet, as described above, it can be mixed with water to form a liquid and used orally. It may be used orally as a solid, depending on the circumstances.

Invention 5 is preferably green juice for promoting calcium absorption containing dry powder of foliage of barley of specific cultivar 5, and green juice for promoting calcium absorption containing dry powder of foliage of barley of specific cultivar 5 as an active ingredient. Juice is particularly preferred. In addition, the green juice for promoting calcium absorption is preferably in powder form (powder form such as powder and granules).

Invention 5 is preferably used in combination with a calcium component. In this case, combined use means using a calcium component for the purpose of ingesting calcium at the same time as or before or after the present invention 5.

The calcium component is not particularly limited, and examples thereof include calcium and its salts, natural and synthetic calcium-containing substances, calcium agents, calcium supplements, and the like. Natural calcium-containing materials include, but are not limited to, bones of mammals, birds, fish, and the like, shells of shellfish, crustacean skins, eggshells, and the like. The amount of the calcium component to be used is not particularly limited, and can be appropriately set, for example, in consideration of the degree of calcium deficiency of the user. The daily usage amount of the calcium component is, for example, 200 to 2,000 mg, preferably 400 to 1,500 mg per calcium.

Since the present invention 5 has a calcium absorption promoting action, its use is useful for maintaining the health of people with calcium deficiency and calcium deficiency diseases and those at risk of such diseases, especially osteoporosis and arthritis. Bone-related diseases such as heart disease, hypocalcemia, neurological diseases, arteriosclerosis, hypertension, overeating, etc., and health maintenance for middle-aged, middle-aged and elderly people over 40 years old very useful for

Another aspect of the present invention is for the prevention and treatment of calcium deficiency diseases such as osteoporosis, rickets, hypocalcemia, arteriosclerosis, hypertension, overeating, etc. containing dry powder of barley foliage of specific cultivar 5. is a pharmaceutical composition of In particular, a kit containing the present invention 5 and a calcium component is useful as a kit for purposes such as treatment and prevention of the above-mentioned calcium deficiency diseases.

In addition, Invention 5 contains a large amount of vitamins, minerals, etc. derived from the dry powder of barley foliage of specific variety 5, in addition to the effect of promoting calcium absorption possessed by the conventional dry powder of foliage of barley. There is a secondary effect based on these, and it contributes to the health maintenance of the user.

[7. Blood Cholesterol Elevation Suppressive Action]
TECHNICAL FIELD The present invention relates to a green juice containing dry powder of barley stems and leaves for suppressing elevation of blood cholesterol and an agent for suppressing elevation of blood cholesterol (Invention 6).

Invention 6 is a dry powder of barley stems and leaves of one or more of fiber snow, silky snow, shunrai, ichibanboshi and harushizuku (specified variety 6) as a substance having blood cholesterol elevation inhibitory activity. contains at least

The blood cholesterol elevation inhibitory action is not particularly limited as long as it is an action as is commonly known. It refers to the action of maintaining or reducing the concentration of cholesterol.

Invention 6 contains dry powder of foliage of barley of a specific variety, so that it not only has an effect of suppressing blood cholesterol elevation, but also has a beautiful appearance due to its vivid color and a good flavor. can be compatible.

Invention 6 can exhibit blood cholesterol elevation inhibitory action by containing dry powder of barley stems and leaves of specific cultivar 6 . The degree of blood cholesterol elevation inhibitory action is not particularly limited, and can be evaluated, for example, by measuring and comparing blood cholesterol levels, as described in Examples below. The blood cholesterol elevation inhibitory action of the present invention 6 is obtained by, for example, cholesterol esters being decomposed into free cholesterol and fatty acids by the action of cholesterol esterase, and then the produced cholesterol is subjected to the action of cholesterol oxidase together with the existing free cholesterol. The measurement principle is that DAOS and 4-aminoantipyrine are oxidized and condensed quantitatively by the action of peroxidase to form a blue dye. The same amount of dry powder of Nishinohoshi foliage as the dry powder of barley foliage of the specific variety 6 contained in the present invention 6, which has a fasting blood cholesterol concentration measured using the cholesterol oxidase/DAOS method. This is a blood cholesterol increase inhibitory action to a greater extent than the blood cholesterol concentration when using .

Specifically, the blood cholesterol elevation inhibitory effect shown by the present invention 6 is, for example, compared to the case of using dried powder of foliage of Nishinohoshi, blood cholesterol concentration or blood total cholesterol concentration in fasting is 90% Below, it is preferably 87% or less of blood cholesterol elevation inhibitory action. By using invention 6, it is preferable that the blood cholesterol level is maintained at 130-200 mg/dL and the blood total cholesterol level is maintained at less than 220 mg/dL.

Invention 6 can be used in various forms for the purpose of obtaining an effect of suppressing blood cholesterol elevation. For example, it may be used for various purposes without adding any special treatment. In addition, the present invention 6 alleviates or reduces not only the effects of the blood cholesterol-increasing components such as fat used at the same time, but also the effects of the blood cholesterol-increasing components used before or after the use of the present invention 6. can be expected.

In the solid content of the present invention 6, the content of the dry powder of barley stems and leaves is a dry mass, and the lower limit is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and 1% by mass. More preferably, 10% by mass or more is still more preferable, 20% by mass or more is particularly preferable, and the upper limit is preferably 99.9% by mass or less, more preferably 90% by mass or less, and further 80% by mass or less. preferable. In order to sufficiently exhibit the effect of suppressing elevation of blood cholesterol, it is preferable that the dry powder content of barley foliage is 0.1% by mass. In addition, when Invention 6 contains a large amount of a blood cholesterol-raising component, the amount of dry barley foliage powder used is increased, and when it further contains another blood cholesterol-raising inhibitory component different from the dry powder of barley foliage. can reduce the amount of dry barley foliage powder used.

The daily usage amount of the present invention 6 is not particularly limited, and can be appropriately set according to the mode of use and the details of use by the user. is 1 to 6000 mg/kg, preferably 1 to 4000 mg/kg, more preferably 10 to 3000 mg/kg, still more preferably 10 to 2000 mg/kg. The amount of one use of the present invention 6 is also not particularly limited. is 1-2000 mg/kg, more preferably 5-1000 mg/kg.

In addition, the amount of the present invention 6 used once is, for example, in terms of mass of dry barley foliage powder, 0.01 to 30 g, preferably 0.05 to 20 g, more preferably 0.1 to 10 g, especially Preferably, it can be 0.3 to 7 g. Similarly, the daily usage amount of the present invention 6 is, for example, 0.01 to 100 g, preferably 0.05 to 70 g, more preferably 0.5 to 50 g in terms of mass of dry barley foliage powder, Particularly preferably, it can be 1 to 30 g.

Invention 6 may contain only the dry powder of barley foliage, or may contain other ingredients in addition to the dry powder of barley foliage. Other ingredients include, for example, various excipients, binders, lubricants, stabilizers, diluents, bulking agents, thickeners, emulsifiers, colorants, perfumes, additives and the like. The content of other components can be appropriately selected according to the mode of use of the present invention 6 and the like.

Invention 6 can be used in various forms for the purpose of obtaining an effect of suppressing blood cholesterol elevation. Invention 6 can be, for example, an oral or parenteral composition.

The form of the present invention 6 is not particularly limited, and may be any form. Oral forms include, for example, forms suitable for oral use, specifically powders, granules, granules, tablets, rods, plates, blocks, solids, rounds, liquids, Candies, pastes, creams, capsules such as hard capsules and soft capsules, caplets, tablets, gels, jelly, gummies, wafers, biscuits, cookies, cakes, chewables, and syrups , a stick shape, and the like.

The packaging form of the present invention 6 is not particularly limited and can be appropriately selected according to the dosage form etc. Examples include blister packs such as PTP; strip packaging; heat sealing; aluminum pouches; glass containers such as vials; and plastic containers such as ampoules.

Invention 6 is preferably in the form of powder (powder form such as powder, granules, etc.) in which a mixture mixed with water is orally used because it prevents putrefaction and is suitable for long-term storage. In addition, when the present invention 6 is in a solid form such as powder or tablet, as described above, it can be mixed with water to form a liquid and used orally. It may be used orally as a solid, depending on the circumstances.

Invention 6 is preferably a green juice containing dry powder of barley foliage of specific cultivar 6 for suppressing elevation of blood cholesterol, and blood cholesterol containing dry powder of foliage of barley of specific cultivar 6 as an active ingredient. It is particularly preferable to use a green juice that suppresses growth. In addition, it is preferable that the blood cholesterol elevation suppressing green juice be in powder form (powder form such as powder and granules).

Since the present invention 6 has an inhibitory effect on blood cholesterol elevation, its use is useful for maintaining the health of patients suffering from diseases caused by elevation of blood cholesterol and those at risk thereof. In particular, dyslipidemia (hyperlipidemia), high LDL cholesterol, low HDL cholesterol, arteriosclerosis, cerebral infarction, angina pectoris, myocardial infarction, intermittent claudication, cholelithiasis, nephrotic syndrome, etc. It is very useful for maintaining the health of people suffering from diseases such as , those with a blood total cholesterol concentration of 220 mg/dl or more, obese people, and middle-aged and elderly people over 40 years of age. . Another aspect of the present invention is a pharmaceutical composition for preventing and treating the above-described diseases caused by elevated blood cholesterol, containing dry powder of barley stems and leaves of Specified Cultivar 6. As used herein, obesity refers to a state in which the BMI (Body Mass Index) is 25 or more, or a waist circumference (waist circumference through the navel) of 85 cm or more for men and 90 cm or more for women. It refers to the state of being

In addition, the present invention 6 contains a large amount of vitamins, minerals, etc. derived from the dry powder of the barley foliage of the specific variety 6, in addition to the effect of suppressing blood cholesterol elevation that the conventional dry powder of foliage of barley has. Therefore, there is a secondary effect based on these, and it contributes to the health maintenance of the user.

The present invention will be described in more detail below with reference to Examples, but the present invention is not limited to these Examples, and the present invention can take various aspects as long as the problems of the present invention can be solved. .

[1. Inhibition of blood sugar level elevation]
It was demonstrated as follows that dry powders of stems and leaves of Shunrai, Fiber Snow, and Silky Snow exhibit a particularly remarkable effect of suppressing elevation of blood sugar level.

1. As test substance Examples 1 to 3, Shunrai, Fiber Snow and Silky Snow were used. Moreover, as Comparative Example 1, Ichibanboshi was used.

2. Preparation of test sample As the test sample, the foliage of barley of the above Examples and Comparative Examples was used. This was washed with water to remove adhering mud, etc., and cut into pieces of about 5 to 10 cm in size for pretreatment. The pretreated foliage was blanched only once in hot water at 90-100° C. for 90-120 seconds and then cooled with cold water. Subsequently, the resulting foliage was dried with hot air at 80° C. to 130° C. in a dryer for 20 minutes to 180 minutes until the water content was 5% by mass or less. The dried foliage was pulverized to a size of about 1 mm using a mixer. The obtained foliage of barley was pulverized using a pulverizer so that 90% or more of the foliage passed through a 200-mesh section to obtain pulverized powder of pulverized foliage.

The resulting pulverized stems and leaves and sucrose were each suspended or dissolved in pure water to 200 mg/mL to prepare a test sample. A control sample was prepared by dissolving sucrose alone in pure water to a concentration of 200 mg/mL without using any pulverized stems and leaves.

3. Test procedure First, 7-week-old male SD rats (Kyudo Co., Ltd.) were fasted for 16 hours or more. Thereafter, blood was collected from each rat's tail vein, and the blood glucose level before administration (0 minutes) was measured using Glutest Ace R (Sanwa Kagaku Kenkyusho Co., Ltd.). The groups were divided so that the blood glucose levels before administration (0 minutes) were as uniform as possible.

Then, to each rat, each test sample or control sample was orally administered using a sonde so that each 10 mL / kg body weight (test substance dose per individual is about 0.4 g), blood glucose 30 minutes after administration values were measured. Using the blood glucose levels before (0 minutes) and 30 minutes after administration of the control, the inhibition rate (%) of blood glucose elevation in Examples 1 to 3 and Comparative Example 1 was determined using the following formula. The results are shown in FIG.
Inhibition rate of blood sugar level increase (%) = {1-([blood sugar level 30 minutes after administration of test sample]-[blood sugar level before administration of test sample (0 minutes)]) / ([blood sugar level 30 minutes after administration of control sample value]-[blood glucose level before control sample administration (0 minutes)])}×100

From FIG. 1, it can be seen that the rats ingesting the crushed powder of stems and leaves of Shunrai, Fiber Snow, and Silky Snow in Examples 1 to 3 were more likely to take 30 minutes after administration than the rats ingesting the crushed powder of stems and leaves of Ichibanboshi in Comparative Example 1. It can be seen that the rapid increase in blood sugar level was suppressed in This indicates that pulverized stems and leaves of shunrai, fiber snow and silky snow are useful as green juice for suppressing elevation of blood sugar level and as an agent for suppressing elevation of blood sugar level, especially for prevention of type 2 diabetes characterized by insulin resistance. can be expected to have an effect on

[2. antioxidant effect]
It was demonstrated as follows that dry powders of barley stems and leaves of fiber snow, silky snow, shunrai, ichibanboshi and harushizuku show particularly pronounced antioxidant activity.

1. Fiber snow, silky snow, shunrai, ichibanboshi, and harusizuku were used as test substance examples 1 to 5. As Comparative Example 1, Nishinohoshi was used.

2. Preparation of test sample As the test sample, the foliage of barley of the above Examples and Comparative Examples was used. This was washed with water to remove adhering mud, etc., and cut into pieces of about 5 to 10 cm in size for pretreatment. The pretreated foliage was blanched only once in hot water at 90-100° C. for 90-120 seconds and then cooled with cold water. Subsequently, the resulting foliage was dried with hot air at 80° C. to 130° C. in a dryer for 20 minutes to 180 minutes until the water content was 5% by mass or less. The dried foliage was pulverized to a size of about 1 mm using a mixer. The obtained foliage of barley was pulverized using a pulverizer so that 90% or more of the foliage passed through a 200-mesh section to obtain pulverized powder of pulverized foliage.

The resulting pulverized stems and leaves were adjusted to 60 mg/mL with a phosphate buffer (pH 7.2), vortexed for 1 hour at room temperature, and then centrifuged at 10,000 rpm for 1 minute for 2 hours. The resulting supernatant was used as a test sample.

3. Superoxide dismutase (SOD) kit (NBT reduction method, "SOD Test Wako", manufactured by Wako Pure Chemical Industries, Ltd.) was used to measure SOD-like activity and, as a result, evaluate antioxidant capacity. The SOD activity value (inhibition rate %) of each test sample was measured according to the operation method described in . The test was repeated 2 times, and the average value was used as the measurement result. Table 1 shows the measurement results of the SOD activity value.

As shown in Table 1, in contrast to Comparative Example 2, in which the variety is Nishinohoshi, Examples 1 to 3, in which the varieties are Fiber Snow, Silky Snow, and Shunrai, have higher SOD activity values and greater antioxidant activity. It has been shown.

4. ORAC measurement and its results In order to evaluate the antioxidant capacity from another point of view, the reactive oxygen absorption capacity (ORAC) of the test sample was measured as follows.

A 75 mM phosphate buffer (pH 7.4) was used as the assay buffer. Dilution buffer was prepared by mixing 10 mL of methanol-water-acetic acid (MWA) solution (methanol:water:acetic acid (volume ratio) = 90:9.5:0.5) with 90 mL of assay buffer. A fluorescein solution was prepared by dissolving sodium fluorescein in assay buffer to give a 110.7 nM solution. Trolox solution was prepared by dissolving Trolox in assay buffer to give a 500 μM solution. A Trolox standard solution was prepared by diluting the Trolox solution with dilution buffer. AAPH solution was prepared by dissolving AAPH (2,2'-Azobis(2-amidinopropane) dihydrochloride) in assay buffer to give a 31.7 mM solution.

A dilution solution was prepared by diluting the test sample with assay buffer. The concentration of the test sample in the diluted solution was determined based on the preliminary test results.

It was heated to 37°C in a microplate reader cabinet. The fluorescence detection wavelength was set at an excitation wavelength of 485±20 nm and a detection wavelength of 530±25 nm. 35 μL of sample diluent, dilution buffer (blank) or Trolox standard solution was dispensed into each well of a 96-well plate.

115 μL of fluorescein solution was dispensed into each well and the entire plate was shaken and agitated. Each well was sealed and immediately transferred to a microplate reader heated to 37° C. and warmed in the plate reader for 10 minutes or longer. Fluorescence intensity was measured for each well of the plate (f _0min ). After removing the sealing, 50 μL of AAPH solution was added to each well, and the solutions were mixed by pipetting. After sealing each well, the microplate was quickly transferred to a microplate reader, and fluorescence intensity over time was measured 45 times at 2 minute intervals (90 minutes in total).

By using f 0min and the measured value (f _8min , f _10min ..., f _90min ) after ₈ to 90 minutes from the start of measurement, the ORAC value (μmol TE / L) of the sample is obtained from the following formula. rice field.

Further, the ORAC value (μmol TE/g) was obtained by converting the ORAC value (μmol TE/L) per 1 g of the sample.

Table 2 shows the ORAC values (μmol TE/L) and ORAC values (μmol TE/g) of Comparative Examples and Examples obtained as described above. FIG. 2 shows the ORAC values (μmol TE/g).

As shown in Table 2 and FIG. 2, in contrast to Comparative Example 1 in which the variety is Nishinohoshi, Examples 1 to 5 in which the varieties are Fiber Snow, Silky Snow, Shunrai, Ichibanboshi, and Harushizuku have large ORAC values, It was shown to have greater antioxidant activity.

[3. intestinal function]
It was demonstrated as follows that the dried powders of the stems and leaves of Shunrai, Fiber Snow and Silky Snow exhibit a remarkable intestinal regulating action due to their laxative action.

1. As test substance Examples 1 to 3, Shunrai, Fiber Snow and Silky Snow were used. Moreover, as Comparative Example 1, Ichibanboshi was used.

2. Preparation of Test Feed As test samples, the foliage of barley of Examples 1 to 3 and Comparative Example 1 was used. This was washed with water to remove adhering mud, etc., and cut into pieces of about 5 to 10 cm in size for pretreatment. The pretreated foliage was blanched only once in hot water at 90-100° C. for 90-120 seconds and then cooled with cold water. Subsequently, the resulting foliage was dried with hot air at 80° C. to 130° C. in a dryer for 20 minutes to 180 minutes until the water content was 5% by mass or less. The dried foliage was pulverized to a size of about 1 mm using a mixer. The resulting barley foliage was pulverized using a pulverizer so that 90% or more of the foliage passed through a 200-mesh section to obtain pulverized barley foliage powder.

Each component constituting a fiber-free high-fat diet (NFHF) based on pulverized barley foliage and AIN-76 was added to the feed using a pestle and mortar according to the composition shown in Table 3 below. An NFHF powder feed containing 10 wt% barley stems and leaves was obtained by preparing a uniform component. In addition, NFHF powder feed was obtained as feed containing no pulverized powder of barley foliage.

3. Test animals Six-week-old male Wistar rats (Kyudo Co., Ltd.) were acclimatized by ad libitum intake of MF solid feed (Oriental Yeast Co., Ltd.) and water for 5 days. Seven-week-old male Wistar rats after acclimatization were divided into groups as shown in Table 4 below so that the average body weight was almost uniform. The mice were fed ad libitum. However, in grouping, consideration was given so that there would be no significant difference in the number of stools before the start of the test (days -1 to 0) in each group (priority: body weight > number of stools).

4. Evaluation method and results Before the start of the test (days -1 to 0) and 6 to 7, 13 to 14, 20 to 21, and 27 to 28 days after the start of the test, one day's worth of feces was collected from each group. , the number was measured on each measurement day. The obtained stool was dried in an incubator at 100° C. for 3 days or longer. The dried stool weight was measured and used as the dry stool weight. Fig. 3 summarizes the dry stool weight of each group.

As shown in FIG. 3, the dry stool weight was generally higher in Examples 1 to 3 and Comparative Example 1 than in the control group. Furthermore, surprisingly, the dry stool weight of the groups of Examples 1 to 3 was higher than that of the group of Comparative Example 1. Therefore, when used, the barley foliage of Shunrai, Fiber Snow, and Silky Snow exhibited the effect of promoting an increase in the amount of feces and improving bowel movement, and this effect was demonstrated by the barley foliage of Ichibanboshi, which is a comparative example. It has been shown to be significantly superior to the From these results, it was found that the stems and leaves of barley of Shunrai, Fiber Snow and Silky Snow exhibit remarkable intestinal regulating effects on subjects to which they are used through laxative-improving effects.

[4. Collagen absorption promoting action]
It was demonstrated as follows that the dry powders of stems and leaves of Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow exhibit a particularly remarkable collagen absorption promoting effect.

1. Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow were used as the test substance Examples 1 to 5. As Comparative Example 1, Nishinohoshi was used.

2. Preparation of Test Samples As test samples, the foliage of barley of Examples 1 to 5 and Comparative Example 1 was used. This was washed with water to remove adhering mud, etc., and cut into pieces of about 5 to 10 cm in size for pretreatment. The pretreated foliage was blanched only once in hot water at 90-100° C. for 90-120 seconds and then cooled with cold water. Subsequently, the resulting foliage was dried with hot air at 80° C. to 130° C. in a dryer for 20 minutes to 180 minutes until the water content was 5% by mass or less. The dried foliage was pulverized to a size of about 1 mm using a mixer. The resulting barley foliage was pulverized using a pulverizer so that 90% or more of the foliage passed through a 200-mesh section to obtain pulverized barley foliage powder.

Each component constituting a fiber-free high-fat diet (NFHF) based on ground barley foliage and AIN-76 was added to the feed using a pestle and mortar, according to the composition shown in Table 5 below. An NFHF powder feed containing 10 wt% barley stems and leaves was obtained by preparing a uniform component. Also, NFHF powder feed was obtained without barley foliage.

3. Preparation of Collagen Solution Pig-derived collagen peptide having an average molecular weight of 2000 and fish-derived collagen peptide having an average molecular weight of 2000 were mixed at a blending ratio of 1:1, and passed through a sieve with an opening equivalent to 710 μm. The substance passed through was dissolved in distilled water to prepare a collagen solution so that the collagen content in the test substance solution was 250 mg/mL.

4. Test animals Six-week-old male Wistar rats (Kyudo Co., Ltd.) were acclimatized by ad libitum intake of MF solid feed (Oriental Yeast Co., Ltd.) and water for 5 days. Seven-week-old male Wistar rats after acclimatization were divided into groups as shown in Table 6 below so that the average body weight was almost uniform. The mice were fed ad libitum. However, in grouping, consideration was given so that there would be no significant difference in the number of stools before the start of the test (days -1 to 0) in each group (priority: body weight > number of stools).

5. Administration of the collagen solution After 29 days or more have passed since the start of feeding, the test animals of each group, which had been fasted for 16 hours or more from the previous day, were treated with a probe so that the collagen solution was 20 mL / kg (5,000 g-collagen / kg). Oral gavage was administered using

6. Evaluation method Hydroxyproline (Hyp) accounts for about 11 to 14% of the amino acids that constitute collagen, and is characteristically present in collagen, so it is a substance used as an indicator of collagen absorbability. . Therefore, the blood Hyp concentration was measured as an index of collagen absorbability.

A constant amount of blood was collected from a vein over time before (0 hour) and 1, 2, 3, and 6 hours after administration of the collagen solution. After blood collection, blood samples were allowed to stand at room temperature for 30 minutes or more, and then centrifuged (8000 rpm, 20 minutes, 4°C) to collect serum. Serum was stored at −30° C. until measurement of blood Hyp concentration. The blood HyP concentration was measured using a commercially available kit (Hydroxyproline Assay Kit; Bio Vision). Regarding the measurement results, FIG. 4 is a diagram showing the amount of change in blood Hyp concentration over time (=[measured value at each time]-[measured value at 0 hour]), AUC of blood Hyp concentration (blood concentration- FIG. 5 is a diagram showing the area under the time curve).

7. Results of Evaluation of Collagen Absorption-Promoting Action Blood Hyp concentration was higher in the test group using the test substance than in the control group in both changes over time and AUC. Surprisingly, the example groups (Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow) tended to have higher blood Hyp levels than the comparative example group (Nishinohoshi). Therefore, it has been shown that the dried powders of stems and leaves of Harushizuku, Shunrai, Fiber Snow, Ichibanboshi, and Silky Snow have the effect of increasing the blood Hyp level and thus promoting the absorption of collagen when ingested. rice field.

From the above results, it was clarified that Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow have a collagen absorption promoting effect. That is, dry powders of barley stems and leaves of Harushizuku, Shunrai, Fiber Snow, Ichibanboshi, and Silky Snow are useful materials as green juice for promoting collagen absorption and collagen absorption promoters. It was clarified that by ingesting collagen together, collagen can be efficiently absorbed into the body, and an excellent beauty and health composition can be provided.

[5. Calcium absorption promoting action]
It was demonstrated as follows that dry powders of barley stems and leaves of Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow exhibit a particularly remarkable effect of promoting calcium absorption.

1. Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow were used as the test substance Examples 1 to 5. As Comparative Example 1, Nishinohoshi was used.

2. Preparation of test sample As the test sample, the foliage of barley of the above Examples and Comparative Examples was used. This was washed with water to remove adhering mud, etc., and cut into pieces of about 5 to 10 cm in size for pretreatment. The pretreated foliage was blanched only once in hot water at 90-100° C. for 90-120 seconds and then cooled with cold water. Subsequently, the resulting foliage was dried with hot air at 80° C. to 130° C. in a dryer for 20 minutes to 180 minutes until the water content was 5% by mass or less. The dried foliage was pulverized to a size of about 1 mm using a mixer. The resulting barley foliage was pulverized using a pulverizer so that 90% or more of the foliage passed through a 200-mesh section to obtain pulverized barley foliage powder.

Each component constituting a fiber-free high-fat diet (NFHF) based on ground barley foliage and AIN-76 was added to the feed using a pestle and mortar, according to the composition shown in Table 7 below. An NFHF powder feed containing barley stems and leaves was obtained by preparing a uniform component. Also, NFHF powder feed was obtained without barley foliage.

3. Preparation of Calcium Solution Using pure water as a solvent, DL-calcium lactate pentahydrate (Wako Pure Chemical Industries, Ltd.) was prepared to give a calcium concentration of 20 mg/mL to prepare a calcium solution.

4. Test animals Six-week-old male Wistar rats (Kyudo Co., Ltd.) were acclimatized by ad libitum intake of MF solid feed (Oriental Yeast Co., Ltd.) and water for 5 days. Seven-week-old male Wistar rats after acclimatization were divided into groups as shown in Table 8 below so that the average body weight was almost uniform. The mice were fed ad libitum. However, in grouping, consideration was given so that there would be no significant difference in the number of stools before the start of the test (days -1 to 0) in each group (priority: body weight > number of stools).

5. Administration of calcium solution After 22 days or more from the start of feeding, test animals in each group that had been fasted for 16 hours or more from the previous day were given a calcium solution of 10 mL/kg (200 mg-Ca/kg) using a probe. Administered by oral gavage.

6. Evaluation method Before administration of the calcium solution (0 hour) and 0.5, 1, 2, 3 and 5 hours after administration, a constant amount of blood was collected from a vein over time. After blood collection, blood samples were allowed to stand at room temperature for 30 minutes or more, and then centrifuged (8000 rpm, 20 minutes, 4°C) to collect serum. Serum was stored at −30° C. until measurement of calcium concentration. Using the obtained serum, blood calcium concentration was measured using a commercially available kit, Calcium E-Test Wako (Wako Pure Chemical Industries, Ltd.). Regarding the measurement results, FIG. 6 is a diagram showing the amount of change in blood calcium concentration over time (= [measured value at each time] - [measured value at 0 hour]), and AUC (blood concentration - A diagram showing the area under the time curve) is shown in FIG.

7. Results of Evaluation of Calcium Absorption-Promoting Action With respect to blood calcium concentration, both changes over time and AUC were higher in the test group using the test substance than in the control group. Surprisingly, the example groups (Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow) tended to have higher blood calcium concentrations than the comparative example group (Nishinohoshi). Therefore, it has been shown that the dried powders of stems and leaves of Harushizuku, Shunrai, Fiber snow, Ichibanboshi and Silky snow have the effect of increasing the blood calcium level and promoting calcium absorption when ingested. rice field.

From the above results, it was clarified that Harushizuku, Shunrai, Fiber snow, Ichibanboshi, and Silky snow have a calcium absorption promoting effect. That is, dry powders of barley stems and leaves of Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow are useful materials as green juice for promoting calcium absorption and calcium absorption promoters. It was clarified that calcium can be efficiently absorbed into the body through blood by taking it in combination with calcium.

[6. Blood Cholesterol Elevation Suppressive Action]
It was demonstrated as follows that dry powders of barley stems and leaves of Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow show a remarkably high level of blood cholesterol level.

1. Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow were used as the test substance Examples 1 to 5. As Comparative Example 1, Nishinohoshi was used.

2. Preparation of test sample As the test sample, the foliage of barley of the above Examples and Comparative Examples was used. This was washed with water to remove adhering mud, etc., and cut into pieces of about 5 to 10 cm in size for pretreatment. The pretreated foliage was blanched only once in hot water at 90-100° C. for 90-120 seconds and then cooled with cold water. Subsequently, the resulting foliage was dried with hot air at 80° C. to 130° C. in a dryer for 20 minutes to 180 minutes until the water content was 5% by mass or less. The dried foliage was pulverized to a size of about 1 mm using a mixer. The resulting barley foliage was pulverized using a pulverizer so that 90% or more of the foliage passed through a 200-mesh section to obtain pulverized barley foliage powder.

Each component constituting a fiber-free high-fat diet (NFHF) based on ground barley foliage and AIN-76 was added to the feed using a pestle and mortar, according to the composition shown in Table 9 below. An NFHF powder feed containing 10 wt% barley stems and leaves was obtained by preparing a uniform component. Also, NFHF powder feed was obtained without barley foliage.

3. Test animals Six-week-old male Wistar rats (Kyudo Co., Ltd.) were acclimatized by ad libitum intake of MF solid feed (Oriental Yeast Co., Ltd.) and water for 5 days. Seven-week-old male Wistar rats after acclimatization were divided into groups as shown in Table 10 below so that the average body weight was almost uniform. The rats were fed ad libitum for 28 days. However, in grouping, consideration was given so that there would be no significant difference in the number of stools before the start of the test (days -1 to 0) in each group (priority: body weight > number of stools).

4. Evaluation method On the 29th day after feeding, a certain amount of blood was collected from the vein of rats that had been fasted overnight. After blood collection, blood samples were allowed to stand at room temperature for 30 minutes or more, and then centrifuged (8000 rpm, 20 minutes, 4°C) to collect serum. Serum was stored at −30° C. until measured for cholesterol concentration. Using the obtained sera, blood cholesterol concentrations were measured as total serum cholesterol levels using a commercially available kit, Cholesterol E-Test Wako (Wako Pure Chemical Industries, Ltd.). FIG. 8 shows the measurement results.

5. Results of Evaluation of Blood Cholesterol Elevation Suppressing Action As shown in FIG. 8, blood cholesterol levels were generally lower in the test group using the test substance than in the control group. Surprisingly, the example groups (Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow) tended to have lower blood cholesterol concentrations than the comparative example group (Nishinohoshi). Therefore, it has been shown that the stem and leaf ends of Harushizuku, Shunrai, Fiber Snow, Ichibanboshi, and Silky Snow have the effect of lowering the blood cholesterol level and, in turn, suppressing the increase in blood cholesterol when ingested. rice field.

From the above results, it was clarified that Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow have blood cholesterol elevation inhibitory effects. That is, it was revealed that the barley stems and leaves of Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow are useful materials as a green juice for suppressing elevation of blood cholesterol and as a calcium absorption promoter.

Invention 1 contains dry powder of stems and leaves of barley of specific cultivar 1, which is expected to have a blood sugar level elevation suppressing action and an early blood sugar level lowering action in daily use, and an increase in blood sugar level. It is useful for maintaining the health of those who have anxiety about Therefore, the present invention 1 is useful for diseases related to diabetes and obesity, such as dyslipidemia, hypertension, metabolic syndrome, arteriosclerosis, hyperlipidemia, gout, high body fat percentage, hyperglycemia, and hyperinsulinemia. Lifestyle-related diseases such as hypercholesterolemia, hypertriglyceridemia, fatty liver, cardiovascular disease, and hyperuricemia can be prevented or treated. It contributes to the national economy as a whole, such as reducing labor costs and resolving the decline in the labor force.

Invention 2 contains the dry powder of stems and leaves of barley of specific cultivar 2, so that it has an excellent antioxidative action and exhibits an antioxidative action in a continuous usage mode. Such antioxidant action can be expected to avoid disorders and diseases caused by active oxygen generated in the user's body, and to be used continuously due to the flavor and nutrients derived from raw materials. It can contribute to the health and welfare of human beings by simultaneously preventing oxidation and supplying nutrients.

Invention 3 contains dry powder of stems and leaves of barley of specific cultivar 3, so that it is safer than conventional substances having laxative action and has an intestinal regulation action including an excellent laxative action. and various effects such as treatment and prevention of defecation disorders can be expected.

Invention 4 contains the dry powder of barley stems and leaves of specific cultivar 4, so that it contains a substance exhibiting a superior collagen absorption promotion effect compared to conventional substances that promote collagen absorption. Various effects such as beauty, formation of bone and cartilage tissue, and treatment and prevention of joint diseases can be expected through the action of promoting collagen absorption.

Invention 5 contains dry powder of barley stems and leaves of specific cultivar 5, which can be expected to have a calcium absorption promoting effect in daily use, and is useful for the health of people with calcium deficiency diseases or at risk thereof. Useful for maintenance. Therefore, the present invention 5 is expected to prevent or treat calcium deficiency diseases, for example, bone-related diseases such as osteoporosis and rickets, hypocalcemia, neurological diseases, arteriosclerosis, hypertension, hyperphagia, and other diseases. Since it can be done, it will contribute to the national economy as a whole, such as reducing medical expenses related to these diseases and resolving the decline in the labor force.

Invention 6 contains dried barley foliage powder of specific cultivar 6, which can be expected to have an effect of suppressing blood cholesterol elevation in daily use, and people who are concerned about blood cholesterol elevation. is useful for maintaining the health of Therefore, the present invention 6 can prevent or treat diseases associated with blood cholesterol elevation, such as hyperlipidemia, arteriosclerosis, nephrotic syndrome, etc. It will contribute to the national economy as a whole, such as reducing medical expenses and resolving the decline in the labor force.

The present invention includes food and drink for specified health use, food and drink with nutrient function, food and drink with health function, food and drink for special use, nutritional supplement food and drink, health supplement food and drink, supplements, beauty food and drink, other health food and drink, and pharmaceutical products. It can be used as quasi-products, cosmetics, and pharmaceuticals.

Claims (1)

An antioxidant composition containing spring drops.

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