JP2022158482A - Cosmetic preparation - Google Patents
Cosmetic preparation Download PDFInfo
- Publication number
- JP2022158482A JP2022158482A JP2021063424A JP2021063424A JP2022158482A JP 2022158482 A JP2022158482 A JP 2022158482A JP 2021063424 A JP2021063424 A JP 2021063424A JP 2021063424 A JP2021063424 A JP 2021063424A JP 2022158482 A JP2022158482 A JP 2022158482A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- salt
- cosmetic
- salts
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title abstract description 4
- 150000003839 salts Chemical class 0.000 claims abstract description 50
- 239000002253 acid Substances 0.000 claims abstract description 33
- 150000008062 acetophenones Chemical class 0.000 claims abstract description 19
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 38
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 9
- 229930003268 Vitamin C Natural products 0.000 claims description 9
- 235000019154 vitamin C Nutrition 0.000 claims description 9
- 239000011718 vitamin C Substances 0.000 claims description 9
- 150000003700 vitamin C derivatives Chemical class 0.000 claims description 8
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims description 7
- 239000002738 chelating agent Substances 0.000 claims description 7
- 229940073735 4-hydroxy acetophenone Drugs 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- YRJKYHIIYRGTCC-UHFFFAOYSA-M potassium;2-hydroxy-4-methoxybenzoate Chemical compound [K+].COC1=CC=C(C([O-])=O)C(O)=C1 YRJKYHIIYRGTCC-UHFFFAOYSA-M 0.000 claims description 3
- 238000002845 discoloration Methods 0.000 abstract description 20
- 238000003860 storage Methods 0.000 abstract description 6
- -1 sodium pyrosulfite Chemical class 0.000 description 81
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 27
- 235000014113 dietary fatty acids Nutrition 0.000 description 23
- 239000000194 fatty acid Substances 0.000 description 23
- 229930195729 fatty acid Natural products 0.000 description 23
- 239000003921 oil Substances 0.000 description 18
- 235000019198 oils Nutrition 0.000 description 18
- 239000004166 Lanolin Substances 0.000 description 13
- 229960005070 ascorbic acid Drugs 0.000 description 13
- 235000019388 lanolin Nutrition 0.000 description 13
- 229940039717 lanolin Drugs 0.000 description 13
- 239000000843 powder Substances 0.000 description 13
- 239000004359 castor oil Substances 0.000 description 12
- 235000019438 castor oil Nutrition 0.000 description 12
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 12
- 235000010323 ascorbic acid Nutrition 0.000 description 11
- 239000011668 ascorbic acid Substances 0.000 description 11
- 150000004665 fatty acids Chemical class 0.000 description 11
- 239000011734 sodium Substances 0.000 description 10
- 229910052708 sodium Inorganic materials 0.000 description 10
- 239000001993 wax Substances 0.000 description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 8
- IZZIWIAOVZOBLF-UHFFFAOYSA-N 5-methyloxysalicylic acid Natural products COC1=CC=C(O)C(C(O)=O)=C1 IZZIWIAOVZOBLF-UHFFFAOYSA-N 0.000 description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 7
- 239000006096 absorbing agent Substances 0.000 description 7
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 6
- MRIXVKKOHPQOFK-UHFFFAOYSA-N 4-methoxysalicylic acid Chemical compound COC1=CC=C(C(O)=O)C(O)=C1 MRIXVKKOHPQOFK-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 6
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 6
- 235000010262 sodium metabisulphite Nutrition 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 229940024606 amino acid Drugs 0.000 description 5
- 235000001014 amino acid Nutrition 0.000 description 5
- 150000003863 ammonium salts Chemical class 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 5
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 5
- 229920002545 silicone oil Polymers 0.000 description 5
- 159000000000 sodium salts Chemical class 0.000 description 5
- DSSYKIVIOFKYAU-OIBJUYFYSA-N (S)-camphor Chemical compound C1C[C@]2(C)C(=O)C[C@H]1C2(C)C DSSYKIVIOFKYAU-OIBJUYFYSA-N 0.000 description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 4
- 235000015278 beef Nutrition 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 235000019864 coconut oil Nutrition 0.000 description 4
- 239000003240 coconut oil Substances 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 239000003925 fat Substances 0.000 description 4
- 235000019197 fats Nutrition 0.000 description 4
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- ZQBAKBUEJOMQEX-UHFFFAOYSA-N phenyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OC1=CC=CC=C1 ZQBAKBUEJOMQEX-UHFFFAOYSA-N 0.000 description 4
- 159000000001 potassium salts Chemical class 0.000 description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical group OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 4
- 230000002087 whitening effect Effects 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 3
- 150000005215 alkyl ethers Chemical class 0.000 description 3
- 239000002280 amphoteric surfactant Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000010445 mica Substances 0.000 description 3
- 229910052618 mica group Inorganic materials 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 235000014593 oils and fats Nutrition 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- 239000003760 tallow Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 2
- FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 description 2
- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 2
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- AAUQLHHARJUJEH-UHFFFAOYSA-N 2-hydroxy-5-methoxybenzoic acid Natural products COC1=CC=CC(O)=C1C(O)=O AAUQLHHARJUJEH-UHFFFAOYSA-N 0.000 description 2
- 229940078578 2-o-ethyl ascorbic acid Drugs 0.000 description 2
- ZGSCRDSBTNQPMS-UJURSFKZSA-N 3-O-Ethylascorbic acid Chemical compound CCOC1=C(O)C(=O)O[C@@H]1[C@@H](O)CO ZGSCRDSBTNQPMS-UJURSFKZSA-N 0.000 description 2
- LUJMEECXHPYQOF-UHFFFAOYSA-N 3-hydroxyacetophenone Chemical compound CC(=O)C1=CC=CC(O)=C1 LUJMEECXHPYQOF-UHFFFAOYSA-N 0.000 description 2
- AUZQQIPZESHNMG-UHFFFAOYSA-N 3-methoxysalicylic acid Chemical compound COC1=CC=CC(C(O)=O)=C1O AUZQQIPZESHNMG-UHFFFAOYSA-N 0.000 description 2
- GXRFOOHMMLYYNW-UJURSFKZSA-N 3-o-Ethyl-L-ascorbic acid Chemical compound CCOC1=C(O)[C@@H]([C@@H](O)CO)OC1=O GXRFOOHMMLYYNW-UJURSFKZSA-N 0.000 description 2
- ZCTQGTTXIYCGGC-UHFFFAOYSA-N Benzyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OCC1=CC=CC=C1 ZCTQGTTXIYCGGC-UHFFFAOYSA-N 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- 102000011632 Caseins Human genes 0.000 description 2
- 108010076119 Caseins Proteins 0.000 description 2
- 235000017788 Cydonia oblonga Nutrition 0.000 description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 239000002211 L-ascorbic acid Substances 0.000 description 2
- 235000000069 L-ascorbic acid Nutrition 0.000 description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
- QZXSMBBFBXPQHI-UHFFFAOYSA-N N-(dodecanoyl)ethanolamine Chemical compound CCCCCCCCCCCC(=O)NCCO QZXSMBBFBXPQHI-UHFFFAOYSA-N 0.000 description 2
- 239000005642 Oleic acid Substances 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 235000021314 Palmitic acid Nutrition 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- XKMYWNHZAQUEPY-YZGJEOKZSA-N [(3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] 12-hydroxyoctadecanoate Chemical compound C([C@@H]12)C[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@H]3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)CCCCCCCCCCC(O)CCCCCC)C1 XKMYWNHZAQUEPY-YZGJEOKZSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 2
- 229940053200 antiepileptics fatty acid derivative Drugs 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 229960003237 betaine Drugs 0.000 description 2
- 229940073609 bismuth oxychloride Drugs 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 239000010495 camellia oil Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 229940105990 diglycerin Drugs 0.000 description 2
- 229940008099 dimethicone Drugs 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 2
- 239000010696 ester oil Substances 0.000 description 2
- MMXKVMNBHPAILY-UHFFFAOYSA-N ethyl laurate Chemical compound CCCCCCCCCCCC(=O)OCC MMXKVMNBHPAILY-UHFFFAOYSA-N 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 229940075507 glyceryl monostearate Drugs 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 229940100463 hexyl laurate Drugs 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
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- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 235000000346 sugar Nutrition 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
- 229940117986 sulfobetaine Drugs 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- KWXLCDNSEHTOCB-UHFFFAOYSA-J tetrasodium;1,1-diphosphonatoethanol Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P(=O)([O-])C(O)(C)P([O-])([O-])=O KWXLCDNSEHTOCB-UHFFFAOYSA-J 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 1
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- CIAZJIQGPOGZDS-UHFFFAOYSA-N trimethyl-(methyl-tetradecyl-trimethylsilyloxysilyl)oxysilane Chemical compound CCCCCCCCCCCCCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C CIAZJIQGPOGZDS-UHFFFAOYSA-N 0.000 description 1
- 229940118594 trimethylolpropane triisostearate Drugs 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- SVETUDAIEHYIKZ-IUPFWZBJSA-N tris[(z)-octadec-9-enyl] phosphate Chemical compound CCCCCCCC\C=C/CCCCCCCCOP(=O)(OCCCCCCCC\C=C/CCCCCCCC)OCCCCCCCC\C=C/CCCCCCCC SVETUDAIEHYIKZ-IUPFWZBJSA-N 0.000 description 1
- 229960005066 trisodium edetate Drugs 0.000 description 1
- XPFJYKARVSSRHE-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XPFJYKARVSSRHE-UHFFFAOYSA-K 0.000 description 1
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 235000013799 ultramarine blue Nutrition 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 150000003712 vitamin E derivatives Chemical class 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- 229940105125 zinc myristate Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- GBFLQPIIIRJQLU-UHFFFAOYSA-L zinc;tetradecanoate Chemical compound [Zn+2].CCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCC([O-])=O GBFLQPIIIRJQLU-UHFFFAOYSA-L 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
本発明は、アルコキシサリチル酸またはその塩を含んでなる化粧料に関する。 The present invention relates to cosmetics comprising alkoxysalicylic acid or salts thereof.
アルコキシサリチル酸(またはその塩)には、メラニン生成抑制作用があり、これを含有する皮膚外用剤が優れた美白効果を発揮することが報告されている(例えば、特許文献1)。しかし、アルコキシサリチル酸を含む組成物を、苛酷な条件下で長期にわたって保存した場合、変色することがある。 Alkoxysalicylic acid (or a salt thereof) has a melanin production inhibitory effect, and it has been reported that an external preparation for skin containing this has an excellent whitening effect (for example, Patent Document 1). However, when a composition containing alkoxysalicylic acid is stored under severe conditions for a long period of time, it may become discolored.
アルコキシサリチル酸の変色を抑制する手段として、サポニン等を併用する技術が提案されている(例えば、特許文献2)。また、ピロ亜硫酸ナトリウム等の無機塩と併用することも知られているが、ピロ亜硫酸酸ナトリウムは、不快な臭いを生じさせることもあり、特に、無香料の場合には、配合量に制限がある。 As means for suppressing the discoloration of alkoxysalicylic acid, a technique using saponin or the like in combination has been proposed (eg, Patent Document 2). It is also known that sodium pyrosulfite can be used in combination with inorganic salts such as sodium pyrosulfite, but sodium pyrosulfite may give off an unpleasant odor, and there is a limit to the amount to be added, especially in the case of fragrance-free products. be.
本発明者らは、驚くべきことに、アルコキシサリチル酸またはその塩と、アセトフェノン誘導体とを組み合わせることで、アルコキシサリチル酸またはその塩の変色を抑制することができることを見いだした。本発明はこれらの知見に基づくものである。 The present inventors have surprisingly found that a combination of an alkoxysalicylic acid or a salt thereof and an acetophenone derivative can suppress discoloration of the alkoxysalicylic acid or a salt thereof. The present invention is based on these findings.
したがって、本発明は、アルコキシサリチル酸またはその塩、およびアセトフェノン誘導体を含んでなる化粧料を開示する。 Accordingly, the present invention discloses a cosmetic comprising an alkoxysalicylic acid or a salt thereof and an acetophenone derivative.
本発明によれば、以下の発明が提供される。
[1](A)式(a)で表されるアルコキシサリチル酸またはその塩
(B)式(b)で表されるアセトフェノン誘導体またはその塩
Rbは、それぞれ独立に、水素またはメチル基であり、かつ
nは、0~2である)
を含んでなる、化粧料。
[2]Raが、メチル基またはエチル基である、[1]に記載の化粧料。
[3]前記(A)アルコキシサリチル酸またはその塩が、4-メトキシサリチル酸カリウム塩である、[1]または[2]に記載の化粧料。
[4]前記(B)アセトフェノン誘導体またはその塩が、ヒドロキシアセトフェノンである、[1]~[3]のいずれかに記載の化粧料。
[5]前記(B)アセトフェノン誘導体またはその塩が、4-ヒドロキシアセトフェノンである、[1]~[4]のいずれかに記載の化粧料。
[6]前記(A)アルコキシサリチル酸またはその塩の配合量が、化粧料の総量に対して、0.1~5質量%である、[1]~[5]のいずれかに記載の化粧料。
[7]前記(B)アセトフェノン誘導体またはその塩の配合量が、化粧料の総量に対して、0.005~1質量%である、[1]~[6]に記載の化粧料。
[8](C1)亜硫酸塩またはピロ亜硫酸塩をさらに含んでなる、[1]~[7]のいずれかに記載の化粧料。
[9](C2)ビタミンCまたはビタミンC誘導体をさらに含んでなる、[1]~[8]のいずれかに記載の化粧料。
[10](C3)キレート剤をさらに含んでなる、[1]~[9]のいずれかに記載の化粧料。
[11]前記(B)アセトフェノン誘導体またはその塩の配合量と、前記(C1)亜硫酸塩またはピロ亜硫酸塩、前記(C2)ビタミンCまたはビタミンC誘導体および前記(C3)キレート剤の配合量との合計と、の質量比が1:0.01~1:1である、[7]~[9]のいずれか一項に記載の化粧料。
According to the present invention, the following inventions are provided.
[1] (A) Alkoxysalicylic acid represented by formula (a) or a salt thereof
each R b is independently hydrogen or a methyl group, and n is 0 to 2)
A cosmetic comprising
[2] The cosmetic according to [1], wherein R a is a methyl group or an ethyl group.
[3] The cosmetic according to [1] or [2], wherein (A) the alkoxysalicylic acid or its salt is 4-methoxysalicylic acid potassium salt.
[4] The cosmetic according to any one of [1] to [3], wherein (B) the acetophenone derivative or salt thereof is hydroxyacetophenone.
[5] The cosmetic according to any one of [1] to [4], wherein the (B) acetophenone derivative or salt thereof is 4-hydroxyacetophenone.
[6] The cosmetic according to any one of [1] to [5], wherein the content of (A) alkoxysalicylic acid or a salt thereof is 0.1 to 5% by mass relative to the total amount of the cosmetic. .
[7] The cosmetic according to [1] to [6], wherein the content of (B) the acetophenone derivative or salt thereof is 0.005 to 1% by mass relative to the total amount of the cosmetic.
[8] (C1) The cosmetic according to any one of [1] to [7], further comprising a sulfite or pyrosulfite.
[9] (C2) The cosmetic according to any one of [1] to [8], further comprising vitamin C or a vitamin C derivative.
[10] (C3) The cosmetic according to any one of [1] to [9], further comprising a chelating agent.
[11] The blending amount of the (B) acetophenone derivative or its salt, the blending amount of the (C1) sulfite or pyrosulfite, the (C2) vitamin C or vitamin C derivative, and the (C3) chelating agent. The cosmetic according to any one of [7] to [9], wherein the mass ratio of the total to the is 1:0.01 to 1:1.
本発明によれば保存安定性に優れた化粧料を提供することができる。特に本発明は、苛酷な保存条件下においても、アルコキシサリチル酸またはその塩を含む化粧料の変色を抑制することができる。 According to the present invention, a cosmetic having excellent storage stability can be provided. In particular, the present invention can suppress discoloration of cosmetics containing alkoxysalicylic acid or salts thereof even under severe storage conditions.
本発明は、(A)特定の構造を有するアルコキシサリチル酸またはその塩、および(B)特定の構造を有するアセトフェノン誘導体を含んでなる、化粧料に関するものである。 The present invention relates to a cosmetic comprising (A) an alkoxysalicylic acid having a specific structure or a salt thereof and (B) an acetophenone derivative having a specific structure.
(A)アルコキシサリチル酸またはその塩
本発明による化粧料は、式(a)で表されるアルコキシサリチル酸またはその塩(以下、(A)成分と称することがある。他の成分についても同様である。)を含んでなる。
置換基ORaの位置は特に限定されないが、サリチル酸の3位、4位または5位であることが好ましく、より好ましくは4位である。
(A) Alkoxysalicylic acid or its salt The cosmetic according to the present invention is an alkoxysalicylic acid represented by formula (a) or its salt (hereinafter sometimes referred to as component (A). The same applies to other components. ).
Although the position of the substituent OR a is not particularly limited, it is preferably the 3-, 4- or 5-position of salicylic acid, more preferably the 4-position.
式(a)で表されるアルコキシサリチル酸としては、例えば、3-メトキシサリチル酸、3-エトキシサリチル酸、4-メトキシサリチル酸、4-エトキシサリチル酸、4-プロポキシサリチル酸、4-イソプロポキシサリチル酸、4-ブトキシサリチル酸、5-メトキシサリチル酸、5-エトキシサリチル酸、5-プロポキシサリチル酸等が挙げられ、好ましくは4-メトキシサリチル酸である。 Alkoxysalicylic acids represented by formula (a) include, for example, 3-methoxysalicylic acid, 3-ethoxysalicylic acid, 4-methoxysalicylic acid, 4-ethoxysalicylic acid, 4-propoxysalicylic acid, 4-isopropoxysalicylic acid, and 4-butoxysalicylic acid. , 5-methoxysalicylic acid, 5-ethoxysalicylic acid, 5-propoxysalicylic acid and the like, preferably 4-methoxysalicylic acid.
アルコキシサリチル酸は既知の物質であり、例えば、5-メトキシサリチル酸は「Beil,10227」に、4-メトキシサリチル酸は「Beil,10379」に、それぞれ記載されている方法で容易に合成することができる。また、アルドリッチ社等から試薬として入手できる。 Alkoxysalicylic acids are known substances, and for example, 5-methoxysalicylic acid and 4-methoxysalicylic acid can be easily synthesized by methods described in "Beil, 10227" and "Beil, 10379," respectively. It is also available as a reagent from Aldrich Co. and others.
(A)成分は、式(a)で表されるアルコキシサリチル酸の塩であることも好ましい。塩の種類は、薬理学的に許容される塩であれば特に限定されないが、例えば、ナトリウム塩、カリウム塩、リチウム塩等のアルカリ金属塩;カルシウム塩、マグネシウム塩等のアルカリ土類金属塩;アンモニウム塩;アミノ酸塩等が挙げられ、好ましくはカリウム塩であり、美容効果および入手容易性等の観点から、さらに好ましくは、4-メトキシサリチル酸カリウム塩である。 Component (A) is also preferably a salt of alkoxysalicylic acid represented by formula (a). The type of salt is not particularly limited as long as it is a pharmacologically acceptable salt. Examples include alkali metal salts such as sodium salts, potassium salts and lithium salts; alkaline earth metal salts such as calcium salts and magnesium salts; Ammonium salts; amino acid salts; and the like. Potassium salts are preferred, and potassium 4-methoxysalicylate is more preferred from the viewpoint of cosmetic effects and availability.
(A)成分は、1種または2種以上を配合することができる。(A)成分の配合量は、用途や他の配合成分との兼ね合いに応じて、適宜選択されるが、(A)成分がもつ機能・効果、特に美白効果、を発揮させるためには、化粧料の総量に対して、好ましくは0.1~5質量%であり、より好ましくは0.5~3.5質量%である。 (A) component can be blended 1 type, or 2 or more types. The amount of component (A) is appropriately selected depending on the application and the balance with other ingredients. It is preferably 0.1 to 5% by mass, more preferably 0.5 to 3.5% by mass, based on the total amount of the ingredients.
(B)アセトフェノン誘導体またはその塩
本発明による化粧料は、式(b)で表されるアセトフェノン誘導体またはその塩を含んでなる。
Rbは、それぞれ独立に、水素またはメチル基であり、好ましくは水素である。
nは、0~2であり、好ましくは0または1であり、より好ましくは1である。
置換基(ORb)を有する場合に、置換基の位置は限定されないが、n=1の場合は、アセチル基に対して、パラ位であることが好ましい。
(B) Acetophenone Derivative or Its Salt The cosmetic according to the present invention comprises an acetophenone derivative represented by formula (b) or its salt.
Each Rb is independently hydrogen or a methyl group, preferably hydrogen.
n is 0 to 2, preferably 0 or 1, more preferably 1;
When having a substituent (OR b ), the position of the substituent is not limited, but when n=1, it is preferably para to the acetyl group.
式(b)で表されるアセトフェノン誘導体としては、例えば、アセトフェノン、2-ヒドロキシアセトフェノン、3-ヒドロキシアセトフェノン、4-ヒドロキシアセトフェノン等が挙げられ、好ましくはヒドロキシアセトフェノンであり、より好ましくは4-ヒドロキシアセトフェノンである。 Examples of the acetophenone derivative represented by formula (b) include acetophenone, 2-hydroxyacetophenone, 3-hydroxyacetophenone, 4-hydroxyacetophenone and the like, preferably hydroxyacetophenone, more preferably 4-hydroxyacetophenone. is.
(B)成分は、式(b)で表されるアセトフェノン誘導体の塩であってもよい。塩の種類は、薬理学的に許容される塩であれば特に限定されないが、例えば、ナトリウム塩、カリウム塩、リチウム塩等のアルカリ金属塩;カルシウム塩、マグネシウム塩等のアルカリ土類金属塩;アンモニウム塩;アミノ酸塩等が挙げられ、好ましくはナトリウム塩、カリウム塩、アンモニウム塩であり、より好ましくはナトリウム塩である。 The component (B) may be a salt of the acetophenone derivative represented by formula (b). The type of salt is not particularly limited as long as it is a pharmacologically acceptable salt. Examples include alkali metal salts such as sodium salts, potassium salts and lithium salts; alkaline earth metal salts such as calcium salts and magnesium salts; ammonium salts; amino acid salts; and the like, preferably sodium salts, potassium salts and ammonium salts, more preferably sodium salts.
(B)成分は、1種または2種以上を配合することができる。(B)成分の配合量は、化粧料の総量に対して、好ましくは0.005~1質量%であり、より好ましくは0.01~0.5質量%である。この範囲とすることで、変色を抑制しつつ、(B)成分由来の刺激感を抑制することができる。 (B) component can be blended 1 type(s) or 2 or more types. The blending amount of component (B) is preferably 0.005 to 1% by mass, more preferably 0.01 to 0.5% by mass, based on the total amount of the cosmetic. By setting it as this range, the stimulus derived from (B) component can be suppressed, suppressing a discoloration.
(A)成分は光暴露等の条件下での長期保存により、変色し得ることが知られているが、(A)成分と(B)成分を組み合わせることで、変色を抑制することができる。理論には拘束されないが、これは以下の理由によるものと考えられる。光照射などによって、(A)成分の構造が変化して、変色が起こるものと考えられる。ここで(B)成分が共存すると、その構造変化の中間段階で生じるラジカルを(B)成分がトラップすることで、(A)成分の構造変化を抑制し、変色が抑制されるもの考えられる。
(A)成分の変色抑制を目的に、従来から後述する(C1)~(C3)成分(以下、総称して(C)成分ということがある)と組み合わせることが知られている。(B)成分と(C)成分とでは、(A)成分に対して、異なる作用によって変色抑制を実現するものと考えられるため、(A)成分および(B)成分に、さらに(C)成分を組み合わせることで、相乗効果を発揮すると考えられる。
It is known that component (A) can be discolored by long-term storage under conditions such as exposure to light, but discoloration can be suppressed by combining component (A) and component (B). Without being bound by theory, it is believed that this is due to the following reasons. It is believed that the structure of the component (A) changes due to light irradiation or the like, resulting in discoloration. Here, when the component (B) coexists, the component (B) traps the radicals generated in the intermediate stage of the structural change, thereby suppressing the structural change of the component (A) and suppressing discoloration.
For the purpose of suppressing the discoloration of component (A), it has been conventionally known to combine components (C1) to (C3) (hereinafter sometimes collectively referred to as component (C)) to be described later. Since the components (B) and (C) are thought to suppress discoloration by different actions on the component (A), It is thought that a synergistic effect can be obtained by combining
(C1)亜硫酸塩またはピロ亜硫酸塩
本発明による化粧料は、(C1)亜硫酸塩またはピロ亜硫酸塩をさらに含むことができる。
(C1)成分としては、例えば、亜硫酸ナトリウム、亜硫酸水素ナトリウム、亜硫酸カリウム、亜硫酸カルシウム、ピロ亜硫酸ナトリウム、およびピロ亜硫酸カリウム等が挙げられ、好ましくはピロ亜硫酸塩であり、より好ましくはピロ亜硫酸ナトリウムである。
(C1)成分は、1種または2種以上を配合することができる。亜硫酸塩およびピロ亜硫酸塩は、高配合することで、不快な匂いを生じさせることがあるので、特に無香料化粧品に用いる場合に、配慮することが好ましい。(C1)成分の配合量は、化粧料の総量に対して、好ましくは0.001~0.3質量%であり、より好ましくは0.001~0.2質量%である。この範囲とすることで、(B)成分との相乗効果で効果的に変色を抑制しつつ、ピロ亜硫酸ナトリウム自体の匂いを抑制することができる。
(C1) Sulfite or pyrosulfite The cosmetic according to the present invention may further contain (C1) a sulfite or pyrosulfite.
Examples of component (C1) include sodium sulfite, sodium hydrogen sulfite, potassium sulfite, calcium sulfite, sodium pyrosulfite, and potassium pyrosulfite, preferably pyrosulfite, more preferably sodium pyrosulfite. be.
(C1) component can be blended 1 type, or 2 or more types. When sulfites and pyrosulfites are used in high amounts, they may give off an unpleasant odor, so it is preferable to take this into consideration when using them in fragrance-free cosmetics. The amount of component (C1) to be blended is preferably 0.001 to 0.3% by mass, more preferably 0.001 to 0.2% by mass, relative to the total amount of the cosmetic. Within this range, the odor of sodium pyrosulfite itself can be suppressed while effectively suppressing discoloration through a synergistic effect with the component (B).
(C2)ビタミンCまたはビタミンC誘導体
本発明による化粧料は、(C2)ビタミンCまたはビタミンC誘導体をさらに含むことができる。ビタミンCは、L-アスコルビン酸とも称される。(C2)ビタミンCまたはビタミンC誘導体は、変色抑制に加えて美白剤としての効果も期待できる。
(C2)成分としては、例えば、L-アスコルビン酸、2-O-メチルアスコルビン酸、2-O-エチルアスコルビン酸、2-O-n-プロピルアスコルビン酸、2-O-n-ブチルアスコルビン酸等の2-O-アルキルアスコルビン酸;3-O-メチルアスコルビン酸、3-O-エチルアスコルビン酸、3-O-n-プロピルアスコルビン酸、3-O-イソプロピルアスコルビン酸、3-O-n-ブチルアスコルビン酸、3-O-イソブチルアスコルビン酸等の3-O-アルキルアスコルビン酸;アスコルビン酸モノアルキルエステル類;アスコルビン酸ジアルキルエステル類;アスコルビン酸トリアルキルエステル類;アスコルビン酸トリエステル類;アスコルビン酸グルコシド類等が挙げられる。アスコルビン酸及びその誘導体は、塩の形態であってもよい。このような塩としては、アルカリ金属塩、アルカリ土類金属塩、アンモニウム塩、アルカノールアミン塩、アミノ酸塩等が挙げられる。本発明においては、2-O-エチルアスコルビン酸(ビタミンCエチル)を使用することが好ましい。
(C2)成分は、1種または2種以上を配合することができる。(C2)成分の配合量は、化粧料の総量に対して、好ましくは0.001~0.5質量%であり、より好ましくは0.003~0.2質量%である。この範囲にすることで、(B)成分との相乗効果で効果的に変色を抑制しつつ、(C)成分由来の刺激感や使用感の悪化を抑制することができる。
(C2) Vitamin C or Vitamin C Derivative The cosmetic according to the present invention can further contain (C2) vitamin C or a vitamin C derivative. Vitamin C is also called L-ascorbic acid. (C2) Vitamin C or a vitamin C derivative can be expected to have an effect as a whitening agent in addition to suppressing discoloration.
Component (C2) includes, for example, L-ascorbic acid, 2-O-methylascorbic acid, 2-O-ethylascorbic acid, 2-On-propylascorbic acid, 2-On-butylascorbic acid, and the like. 2-O-alkyl ascorbic acid; 3-O-methyl ascorbic acid, 3-O-ethyl ascorbic acid, 3-O-n-propyl ascorbic acid, 3-O-isopropyl ascorbic acid, 3-O-n-butyl Ascorbic acid, 3-O-alkylascorbic acid such as 3-O-isobutylascorbic acid; Ascorbic acid monoalkyl esters; Ascorbic acid dialkyl esters; Ascorbic acid trialkyl esters; Ascorbic acid triesters; Ascorbic acid glucosides etc. Ascorbic acid and its derivatives may be in the form of salts. Such salts include alkali metal salts, alkaline earth metal salts, ammonium salts, alkanolamine salts, amino acid salts and the like. In the present invention, it is preferred to use 2-O-ethylascorbic acid (vitamin C ethyl).
(C2) component can be blended 1 type(s) or 2 or more types. The blending amount of component (C2) is preferably 0.001 to 0.5% by mass, more preferably 0.003 to 0.2% by mass, based on the total amount of the cosmetic. By setting it to this range, it is possible to effectively suppress discoloration by a synergistic effect with the component (B), while suppressing the stimulating feeling and the feeling of use derived from the component (C).
(C3)キレート剤
本発明による化粧料は、(C3)キレート剤をさらに含むことができる。
(C3)成分としては、例えば、1-ヒドロキシエタン-1,1-ジフォスホン酸、1-ヒドロキシエタン-1,1-ジフォスホン酸四ナトリウム塩、エデト酸二ナトリウム、エデト酸三ナトリウム、エデト酸四ナトリウム、クエン酸ナトリウム、ポリリン酸ナトリウム、メタリン酸ナトリウム、グルコン酸、リン酸、クエン酸、アスコルビン酸、コハク酸、エデト酸、エチレンジアミンヒドロキシエチル三酢酸3ナトリウム、エチレンジアミン四酢酸2ナトリウム等が挙げられる。
(C3)成分は、1種または2種以上を配合することができる。(C3)成分の配合量は、化粧料の総量に対して、好ましくは0.001~0.5質量%であり、より好ましくは0.01~0.3質量%である。この範囲とすることで、(B)成分との相乗効果で効果的に変色を抑制しつつ、(C)成分由来の塗布後のべたつきを抑制することができる。
(C3) Chelating agent The cosmetic according to the present invention may further contain (C3) a chelating agent.
Examples of component (C3) include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, and tetrasodium edetate. , sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, trisodium ethylenediaminehydroxyethyl triacetate, disodium ethylenediaminetetraacetate and the like.
(C3) component can be blended 1 type(s) or 2 or more types. The blending amount of component (C3) is preferably 0.001 to 0.5% by mass, more preferably 0.01 to 0.3% by mass, based on the total amount of the cosmetic. Within this range, the synergistic effect with the component (B) can effectively suppress discoloration while suppressing stickiness after application derived from the component (C).
(B)アセトフェノン誘導体またはその塩の配合量と、(C1)亜硫酸塩またはピロ亜硫酸塩、(C2)ビタミンCまたはビタミンC誘導体および(C3)キレート剤の配合量との合計と、の質量比は、好ましくは1:0.01~1:1であり、より好ましくは1:0.05~1:0.6である。 The mass ratio of (B) the amount of the acetophenone derivative or its salt to the total amount of (C1) the sulfite or pyrosulfite, (C2) vitamin C or the vitamin C derivative and (C3) the chelating agent is , preferably 1:0.01 to 1:1, more preferably 1:0.05 to 1:0.6.
本発明による化粧料には、上記成分以外に、化粧料に通常用いられる成分、例えば、油性成分、紫外線吸収剤、界面活性剤、保湿剤、増粘剤、多価アルコール、粉末成分、合成樹脂エマルジョン、アミノ酸、有機アミン、pH調製剤、酸化防止剤、防腐剤等を必要に応じて適宜配合することができる。 In addition to the above ingredients, the cosmetic according to the present invention may contain ingredients commonly used in cosmetics, such as oily ingredients, ultraviolet absorbers, surfactants, humectants, thickeners, polyhydric alcohols, powder components, and synthetic resins. Emulsions, amino acids, organic amines, pH adjusters, antioxidants, preservatives and the like can be appropriately blended as needed.
油性成分としては、特に限定されるものでなく、例えば、油脂、ロウ類、炭化水素油、高級脂肪酸、高級アルコール、合成エステル油、シリコーン油、シリコーン類等が挙げられる。 The oily component is not particularly limited, and examples thereof include oils and fats, waxes, hydrocarbon oils, higher fatty acids, higher alcohols, synthetic ester oils, silicone oils, and silicones.
油脂としては、例えば、アボガド油、ツバキ油、月見草油、タートル油、マカデミアナッツ油、トウモロコシ油、ミンク油、オリーブ油、ナタネ油、卵黄油、ゴマ油、パーシック油、小麦胚芽油、サザンカ油、ヒマシ油、アマニ油、サフラワー油、綿実油、エノ油、大豆油、落花生油、茶実油、カヤ油、コメヌカ油、シナギリ油、日本キリ油、ホホバ油、胚芽油、トリグリセリン、トリオクタン酸グリセリン、トリイソパルミチン酸グリセリン等の液体油脂;カカオ脂、ヤシ油、馬脂、硬化ヤシ油、パーム油、牛脂、羊脂、硬化牛脂、パーム核油、豚脂、牛骨脂、モクロウ核油、硬化油、牛脚脂、モクロウ、硬化ヒマシ油等の固体油脂等が挙げられる。 Examples of fats and oils include avocado oil, camellia oil, evening primrose oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, Flaxseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, sinagiri oil, Japanese paulownia oil, jojoba oil, germ oil, triglycerin, glycerin trioctanoate, triiso Liquid oils and fats such as glycerol palmitate; cocoa butter, coconut oil, horse fat, hydrogenated coconut oil, palm oil, beef tallow, mutton tallow, hydrogenated beef tallow, palm kernel oil, lard, beef bone fat, Japanese magnolia kernel oil, hydrogenated oil, Solid oils and fats such as beef leg fat, Japanese wax, hardened castor oil, and the like are included.
ロウ類としては、例えば、ミツロウ、カンデリラロウ、綿ロウ、カルナウバロウ、ベイベリーロウ、イボタロウ、鯨ロウ、モンタンロウ、ヌカロウ、ラノリン、カポックロウ、酢酸ラノリン、液状ラノリン、サトウキビロウ、ラノリン脂肪酸イソプロピル、ラウリン酸ヘキシル、還元ラノリン、ジョジョバロウ、硬質ラノリン、セラックロウ、POEラノリンアルコールエーテル、POEラノリンアルコールアセテート、POEコレステロールエーテル、ラノリン脂肪酸ポリエチレングリコール、POE水素添加ラノリンアルコールエーテル等が挙げられる。 Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, wart wax, whale wax, montan wax, bran wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugarcane wax, isopropyl lanolin fatty acid, hexyl laurate, and reduced lanolin. , jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, and the like.
炭化水素油としては、例えば、流動パラフィン、オゾケライト、スクワラン、プリスタン、パラフィン、セレシン、スクワレン、ワセリン、マイクロクリスタリンワックス等の油分が例示される。 Examples of hydrocarbon oils include oils such as liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, vaseline, and microcrystalline wax.
高級脂肪酸としては、例えば、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、ベヘン(ベヘニン)酸、オレイン酸、12-ヒドロキシステアリン酸、ウンデシレン酸、トール酸、イソステアリン酸、リノール酸、リノレイン酸、エイコサペンタエン酸(EPA)、ドコサヘキサエン酸(DHA)等が挙げられる。 Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, toric acid, isostearic acid, linoleic acid, linoleic acid, ethyl Examples include icosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
高級アルコールとしては、例えば、ラウリルアルコール、セチルアルコール、ステアリルアルコール、ベヘニルアルコール、ミリスチルアルコール、オレイルアルコール、セトステアリルアルコール等の直鎖アルコール;モノステアリルグリセリンエーテル(バチルアルコール)、2-デシルテトラデシノール、ラノリンアルコール、コレステロール、フィトステロール、ヘキシルドデカノール、イソステアリルアルコール、オクチルドデカノール等の分枝鎖アルコール等が挙げられる。 Examples of higher alcohols include linear alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, and cetostearyl alcohol; monostearyl glycerin ether (bacyl alcohol), 2-decyltetradecinol, lanolin; Alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, branched chain alcohol such as octyldodecanol, and the like.
合成エステル油としては、例えば、ミリスチン酸イソプロピル、オクタン酸セチル、ミリスチン酸オクチルドデシル、パルミチン酸イソプロピル、ステアリン酸ブチル、ラウリン酸ヘキシル、ミリスチン酸ミリスチル、オレイン酸デシル、ジメチルオクタン酸ヘキシルデシル、乳酸セチル、乳酸ミリスチル、酢酸ラノリン、ステアリン酸イソセチル、イソステアリン酸イソセチル、12-ヒドロキシステアリル酸コレステリル、ジ-2-エチルヘキシル酸エチレングリコール、ジペンタエリスリトール脂肪酸エステル、モノイソステアリン酸N-アルキルグリコール、ジカプリン酸ネオペンチルグリコール、リンゴ酸ジイソステアリル、ジ-2-ヘプチルウンデカン酸グリセリン、トリ-2-エチルヘキシル酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラエチルヘキサン酸ペンタエリスリチル、トリー2-エチルヘキシル酸グリセリン、トリイソステアリン酸トリメチロールプロパン、セチル2-エチルヘキサノエート、2-エチルヘキシルパルミテート、トリミリスチン酸グリセリン、トリ-2-ヘプチルウンデカン酸グリセライド、ヒマシ油脂肪酸メチルエステル、オレイン酸オイル、アセトグリセライド、パルミチン酸2-ヘプチルウンデシル、アジピン酸ジイソブチル、N-ラウロイル-L-グルタミン酸-2-クチルドデシルエステル、アジピン酸ジ-2-ヘプチルウンデシル、エチルラウレート、セバチン酸ジ-2-エチルヘキシル、ミリスチン酸2-ヘキシルデシル、パルミチン酸2-ヘキシルデシル、アジピン酸2-ヘキシルデシル、セバチン酸ジイソプロピル、コハク酸2-エチルヘキシル、酢酸エチル、酢酸ブチル、酢酸アミル、クエン酸トリエチル、クロタミトン(C13H17NO)等が挙げられる。 Synthetic ester oils include, for example, isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, Diisostearyl malate, glyceryl di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexate, trimethylolpropane triisostearate, pentaerythrityl tetraethylhexanoate, glyceryl tri-2-ethylhexate, triisostearate Methylolpropane, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleic oil, acetoglyceride, 2-heptylun palmitate Decyl, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-ctyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, palmitic acid 2-hexyldecyl acid, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate, crotamiton (C 13 H 17 NO) and the like.
シリコーン油としては、例えば、ジメチルポリシロキサン、メチルフェニルポリシロキサン、メチルハイドロジェンポリシロキサン等の鎖状シリコーン油;オクタメチルシクロテトラシロキサン、デカメチルシクロペンタシロキサン、ドデカメチルシクロヘキサシロキサン、テトラメチルテトラハイドロジェンシクロポリシロキサン等の環状シリコーン油、カプリルメチコン、カプリルトリメチコン、ステアリルメチコン等の常温液状のアルキル変性シリコーン油;ジメチルシロキサン・ジフェニルシロキサン・メチル(パーフルオロアルキル)シロキサン共重合体等のフッ素変性シリコーン油等が挙げられる。 Examples of silicone oils include linear silicone oils such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane; octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, tetramethyltetrahydro Cyclic silicone oils such as gencyclopolysiloxane; normal temperature liquid alkyl-modified silicone oils such as capryl methicone, capryl trimethicone, and stearyl methicone; fluorine-modified silicones such as dimethylsiloxane/diphenylsiloxane/methyl (perfluoroalkyl)siloxane copolymers oil and the like.
シリコーン類としては、例えばステアリル変性ジメチコン、ベヘニル変性ジメチコン等のアルキルおよびアルコキシシリコンワックス、3次元網目構造を形成しているシリコ-ン樹脂、シリコーンゴム等が挙げられる。 Examples of silicones include alkyl and alkoxy silicon waxes such as stearyl-modified dimethicone and behenyl-modified dimethicone, silicone resins forming a three-dimensional network structure, and silicone rubbers.
紫外線吸収剤としては、例えば、パラアミノ安息香酸、パラアミノ安息香酸モノグリセリンエステル、N,N-ジプロポキシパラアミノ安息香酸エチルエステル、N,N-ジメチルパラアミノ安息香酸エチルエステル等の安息香酸系紫外線吸収剤;ホモメンチル-N-アセチルアントラニレート等のアントラニル酸系紫外線吸収剤;アミルサリシレート、ホモメンチルサリシレート、オクチルサリシレート、フェニルサリシレート、ベンジルサリシレート、p-イソプロパノールフェニルサリシレート等のサリチル酸系紫外線吸収剤;オクチルメトキシシンナメート、ジ-パラメトキシケイ皮酸-モノ-2-エチルヘキサン酸グリセリル、オクチルシンナメート、エチル-4-イソプロピルシンナメート、メチル-2,5-ジイソプロピルシンナメート、エチル-2,4-ジイソプロピルシンナメート、メチル-2,4-ジイソプロピルシンナメート、プロピル-p-メトキシシンナメート、イソプロピル-p-メトキシシンナメート、イソアミル-p-メトキシシンナメート、オクチル-p-メトキシシンナメート(2-エチルヘキシル-p-メトキシシンナメート)、2-エトキシエチル-p-メトキシシンナメート、シクロヘキシル-p-メトキシシンナメート、エチル-α-シアノ-β-フェニルシンナメート、2-エチルヘキシル-α-シアノ-β-フェニルシンナメート、グリセリルモノ-2-エチルヘキサノイル-ジパラメトキシシンナメート、3,4,5-トリメトキシケイ皮酸-3-メチル-4-[メチルビス(トリメチルシリキシ)シリル]ブチル、トリメトキシケイ皮酸メチルビス(トリメチルシロキシ)シリルイソペンチル等のケイ皮酸系紫外線吸収剤;2,4-ジヒドロキシベンゾフェノン、2,2'-ジヒドロキシ-4-メトキシベンゾフェノン、2,2',4,4'-テトラヒドロキシベンゾフェノン、2-ヒドロキシ-4-メトキシベンゾフェノン、2-ヒドロキシ-4-メトキシベンゾフェノン-5-スルホン酸塩、4-フェニルベンゾフェノン、2-エチルヘキシル-4'-フェニルベンゾフェノン-2-カルボキシレート等のベンゾフェノン系紫外線吸収剤;3-(4'-メチルベンジリデン)-d,l-カンファー、3-ベンジリデン-d,l-カンファー、ウロカニン酸、ウロカニン酸エチルエステル、2,2'-ヒドロキシ-5-メチルフェニルベンゾトリアゾール、2-(2'-ヒドロキシ-5'-t-オクチルフェニル)ベンゾトリアゾール、ジベンザラジン、ジアニソイルメタン、4-メトキシ-4'-t-ブチルジベンゾイルメタン、5-(3,3-ジメチル-2-ノルボルニリデン)-3-ペンタン-2-オンや、ジモルホリノピリダジノン等が挙げられる。 Examples of ultraviolet absorbers include benzoic acid-based ultraviolet absorbers such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerol ester, N,N-dipropoxy para-aminobenzoic acid ethyl ester, and N,N-dimethyl para-aminobenzoic acid ethyl ester; Anthranilic acid UV absorbers such as homomenthyl-N-acetylanthranilate; salicylic acid UV absorbers such as amyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate; octyl methoxycinnamate , glyceryl di-paramethoxycinnamate-mono-2-ethylhexanoate, octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, Methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate mate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono -2-ethylhexanoyl-diparamethoxycinnamate, 3,4,5-trimethoxycinnamate-3-methyl-4-[methylbis(trimethylsiloxy)silyl]butyl, methyl bis(trimethyl trimethoxycinnamate) siloxy) silyl isopentyl and other cinnamic acid UV absorbers; Benzophenone UV absorbers such as hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4′-phenylbenzophenone-2-carboxylate;3 -(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor, urocanic acid, urocanic acid ethyl ester, 2,2'-hydroxy-5-methylphenylbenzotriazole, 2-( 2'-hydroxy-5'-t-octylphenyl)benzotriazole, dibenzalazine, dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5-(3,3-dimethyl-2-norbornylidene)- 3-pentan-2-one, dimorpholinopyridazinone, and the like.
親油性非イオン性界面活性剤としては、例えば、親油性非イオン性界面活性剤としては、例えば、ソルビタンモノオレエート、ソルビタンモノイソステアレート、ソルビタンモノラウレート、ソルビタンモノパルミテート、ソルビタンモノステアレート、ソルビタンセスキオレエート、ペンタ-2-エチルヘキシル酸ジグリセロールソルビタン等のソルビタン脂肪酸エステル類、モノステアリン酸グリセリン、α,α’-オレイン酸ピログルタミン酸グリセリン、モノステアリン酸グリセリンリンゴ酸エステル等のグリセリンまたはポリグリセリンのエステル類、モノステアリン酸プロピレングリコール等のプロピレングリコール脂肪酸エステル類、硬化ヒマシ油誘導体、グリセリンアルキルエーテル等が挙げられる。 Lipophilic nonionic surfactants include, for example, lipophilic nonionic surfactants such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan fatty acid esters such as sorbitan sesquioleate, diglycerol sorbitan penta-2-ethylhexylate, glycerin such as glyceryl monostearate, α,α'-oleic acid pyroglutamic acid glyceryl, glyceryl monostearate malate or Polyglycerin esters, propylene glycol fatty acid esters such as propylene glycol monostearate, hydrogenated castor oil derivatives, glycerin alkyl ethers and the like can be mentioned.
親水性非イオン性界面活性剤としては、例えば、ポリオキシエチレンソルビタンモノオレエート、ポリオキシエチレンソルビタンモノステアレート等のポリオキシエチレンソルビタン脂肪酸エステル類;ポリオキシエチレンソルビットモノラウレート、ポリオキシエチレンソルビットモノオレエート、ポリオキシエチレンソルビットモノステアレート等のポリオキシエチレンソルビット脂肪酸エステル類;ポリオキシエチレングリセリンモノステアレート、ポリオキシエチレングリセリンモノイソステアレート、ポリオキシエチレングリセリントリイソステアレート、等のポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレンモノオレエート、ポリオキシエチレンジステアレート、等のポリオキシエチレン脂肪酸エステル類;ポリオキシエチレンラウリルエーテル、ポリオキシエチレンオレイルエーテル、ポリオキシエチレンステアリルエーテル、ポリオキシエチレン-2-オクチルドデシルエーテル、ポリオキシエチレンコレスタノールエーテル等のポリオキシエチレンアルキルエーテル類;ポリオキシエチレンオクチルフェニルエーテル、ポリオキシエチレンノニルフェニルエーテル、ポリオキシエチレンジノニルフェニルエーテル、等のポリオキシエチレンアルキルフェニルエーテル類;プルロニック等のプルロニック型界面活性剤;ポリオキシエチレンポリオキシプロピレンセチルエーテル、ポリオキシエチレンポリオキシプロピレン-2-デシルテトラデシルエーテル、ポリオキシエチレンポリオキシプロピレンモノブチルエーテル、ポリオキシエチレンポリオキシプロピレン、水添ラノリン、ポリオキシエチレンポリオキシプロピレングリセリンエーテル、PPG-13デシルテトラデセス-24等のポリオキシエチレンポリオキシプロピレンアルキルエーテル類;テトロニック等のテトラポリオキシエチレン・テトラポリオキシプロピレンエチレンジアミン縮合物類;ポリオキシエチレンヒマシ油、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレン硬化ヒマシ油モノイソステアレート、ポリオキシエチレン硬化ヒマシ油トリイソステアレート、ポリオキシエチレン硬化ヒマシ油モノピログルタミン酸モノイソステアリン酸ジエステル、ポリオキシエチレン硬化ヒマシ油マレイン酸エステル等のポリオキシエチレンヒマシ油誘導体またはポリオキシエチレン硬化ヒマシ油誘導体;ヤシ油脂肪酸ジエタノールアミド、ラウリン酸モノエタノールアミド、脂肪酸イソプロパノールアミド等のアルカノールアミドのほか、ポリオキシエチレンプロピレングリコール脂肪酸エステル類、ポリオキシエチレンアルキルアミン類、ポリオキシエチレン脂肪酸アミド、ショ糖脂肪酸エステル、ポリオキシエチレンノニルフェニルホルムアルデヒド縮合物、アルキルエトキシジメチルアミンオキシド、トリオレイルリン酸等が挙げられる。 Examples of hydrophilic nonionic surfactants include polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate and polyoxyethylene sorbitan monostearate; polyoxyethylene sorbit monolaurate, polyoxyethylene sorbit Polyoxyethylene sorbitol fatty acid esters such as monooleate and polyoxyethylene sorbitol monostearate; Polyoxyethylene fatty acid esters such as oxyethylene glycerin fatty acid ester, polyoxyethylene monooleate, polyoxyethylene distearate; polyoxyethylene lauryl ether, polyoxyethylene oleyl ether, polyoxyethylene stearyl ether, polyoxyethylene -polyoxyethylene alkyl ethers such as 2-octyldodecyl ether and polyoxyethylene cholestanol ether; polyoxyethylene alkyl ethers such as polyoxyethylene octylphenyl ether, polyoxyethylene nonylphenyl ether and polyoxyethylene dinonylphenyl ether; Phenyl ethers; pluronic surfactants such as pluronic; polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene-2-decyltetradecyl ether, polyoxyethylene polyoxypropylene monobutyl ether, polyoxyethylene polyoxy Propylene, hydrogenated lanolin, polyoxyethylene polyoxypropylene glycerin ether, polyoxyethylene polyoxypropylene alkyl ethers such as PPG-13 decyltetradeceth-24; tetrapolyoxyethylene/tetrapolyoxypropylene ethylenediamine such as Tetronic Condensates; polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate Acid diesters, polyoxyethylene castor oil derivatives or polyoxyethylene hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil maleate; In addition to alkanolamides such as fatty acid diethanolamide, lauric acid monoethanolamide, and fatty acid isopropanolamide, polyoxyethylene propylene glycol fatty acid esters, polyoxyethylene alkylamines, polyoxyethylene fatty acid amide, sucrose fatty acid ester, polyoxy Ethylene nonylphenyl formaldehyde condensate, alkylethoxydimethylamine oxide, trioleyl phosphate and the like.
アニオン性界面活性剤としては、例えば、ラウリン酸ナトリウム、パルミチン酸ナトリウム等の脂肪酸石鹸、ラウリル硫酸ナトリウム、ラウリル硫酸カリウム、等の高級アルキル硫酸エステル塩;ポリオキシエチレンラウリル硫酸トリエタノールアミン、ポリオキシエチレンラウリル硫酸ナトリウム等のアルキルエーテル硫酸エステル塩;ラウロイルサルコシンナトリウム等のN-アシルサルコシン酸、N-ミリストイル-N-メチルタウリンナトリウム、N-ステアロイル-N-メチルタウリンナトリウム、ヤシ油脂肪酸メチルタウリッドナトリウム、ラウリルメチルタウリッドナトリウム等の高級脂肪酸アミドスルホン酸塩;ポリオキシエチレンオレイルエーテルリン酸ナトリウム、ポリオキシエチレンステアリルエーテルリン酸ナトリウム等のリン酸エステル塩;ジ-2-エチルヘキシルスルホコハク酸ナトリウム、モノラウロイルモノエタノールアミドポリオキシエチレンスルホコハク酸ナトリウム、ラウリルポリプロピレングリコールスルホコハク酸ナトリウム等のスルホコハク酸塩;リニアドデシルベンゼンスルホン酸ナトリウム、リニアドデシルベンゼンスルホン酸トリエタノールアミン等のアルキルベンゼンスルホン酸塩;N-ラウロイルグルタミン酸モノナトリウム、N-ステアロイルグルタミン酸ジナトリウム等のN-アシルグルタミン酸;硬化ヤシ油脂肪酸グリセリン硫酸ナトリウム等の高級脂肪酸エステル硫酸エステル塩のほか、ポリオキシエチレンアルキルエーテルカルボン酸塩、α-オレフィンスルホン酸塩、高級脂肪酸エステルスルホン酸塩、二級アルコール硫酸エステル塩、高級脂肪酸アルキロールアミド硫酸エステル塩、ラウロイルモノエタノールアミドコハク酸ナトリウム、N-パルミトイルアスパラギン酸、ジトリエタノールアミン、ヤシ油脂肪酸コラーゲン加水分解アルカリ塩などが挙げられる。 Examples of anionic surfactants include fatty acid soaps such as sodium laurate and sodium palmitate; higher alkyl sulfate salts such as sodium lauryl sulfate and potassium lauryl sulfate; Alkyl ether sulfate ester salts such as sodium lauryl sulfate; N-acylsarcosic acid such as sodium lauroyl sarcosinate, sodium N-myristoyl-N-methyltaurate, sodium N-stearoyl-N-methyltaurate, sodium cocoate methyl tauride, Higher fatty acid amide sulfonates such as sodium lauryl methyl tauride; Phosphate ester salts such as sodium polyoxyethylene oleyl ether phosphate and sodium polyoxyethylene stearyl ether phosphate; sulfosuccinates such as sodium ethanolamide polyoxyethylene sulfosuccinate and sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzene sulfonates such as sodium linadodecylbenzene sulfonate and triethanolamine linadodecylbenzene sulfonate; monosodium N-lauroyl glutamate, N-acylglutamic acid such as disodium N-stearoylglutamic acid; higher fatty acid esters such as hydrogenated coconut oil fatty acid sodium glycerin sulfate, sulfuric acid ester salts, polyoxyethylene alkyl ether carboxylates, α-olefin sulfonates, higher fatty acid esters sulfonates, secondary alcohol sulfates, higher fatty acid alkylolamide sulfates, sodium lauroyl monoethanolamide succinate, N-palmitoyl aspartic acid, ditriethanolamine, coconut oil fatty acid collagen hydrolyzed alkaline salts, etc. .
カチオン界面活性剤としては、例えば、塩化ステアリルトリメチルアンモニウム、塩化ラウリルトリメチルアンモニウム等のアルキルトリメチルアンモニウム塩、塩化ジステアリルジメチルアンモニウム等のジアルキルジメチルアンモニウム塩;塩化ポリ(N,N'-ジメチル-3,5,-メチレンピペリジニウム)、塩化セチルピリジニウム等のアルキルピリジニウム塩のほか、アルキル四級アンモニウム塩、アルキルジメチルベンジルアンモニウム塩、アルキルイソキノリニウム塩、ジアルキルモリホニウム塩、ポリオキシエチレンアルキルアミン、アルキルアミン塩、ポリアミン脂肪酸誘導体、アミルアルコ-ル脂肪酸誘導体、塩化ベンザルコニウム、塩化ベンゼトニウム、カチオンポリマー、アクリル酸β-N-N-ジメチル-N-エチルアンモニオエチル塩化ビニルピロリドン共重合体等が挙げられる。 Examples of cationic surfactants include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride; dialkyldimethylammonium salts such as distearyldimethylammonium chloride; ,-methylenepiperidinium), alkylpyridinium salts such as cetylpyridinium chloride, alkylquaternary ammonium salts, alkyldimethylbenzylammonium salts, alkylisoquinolinium salts, dialkylmorphonium salts, polyoxyethylenealkylamines, Alkylamine salts, polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride, benzethonium chloride, cationic polymers, β-NN-dimethyl-N-ethylammonioethyl chloride vinylpyrrolidone chloride copolymers, etc. be done.
両性界面活性剤としては、例えば、2-ウンデシル-N,N,N,-(ヒドロキシエチルカルボキシメチル)-2-イミダゾリンナトリウム、2-ココイル-2-イミダゾリニウムヒドロキサイド-1-カルボキシエチロキシ2ナトリウム塩等のイミダゾリン系両性界面活性剤;2-ヘプタデシル-N-カルボキシメチル-N-ヒドロキシエチルイミダゾリニウムベタイン、ラウリルジメチルアミノ酢酸ベタイン、アルキルベタイン、アミドベタイン、スルホベタイン等のベタイン系両性界面活性剤等が挙げられる。 Amphoteric surfactants include, for example, 2-undecyl-N,N,N,-(hydroxyethylcarboxymethyl)-2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy 2 imidazoline-based amphoteric surfactants such as sodium salts; betaine-based amphoteric surfactants such as 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, betaine lauryldimethylaminoacetate, alkylbetaine, amidobetaine, and sulfobetaine agents and the like.
保湿剤としては、例えば、コレステリル-12-ヒドロキシステアレート、乳酸ナトリウム、dl-ピロリドンカルボン酸塩、尿素、ジグリセリンエチレンオキサイド・プロピレンオキサイド付加物等が挙げられ、特にコンドロイチン硫酸やヒアルロン酸等の酸性ムコ多糖類を配合した場合にはアルコキシサリチル酸および/またはその塩の美白効果に対して増強作用がある。 Moisturizing agents include, for example, cholesteryl-12-hydroxystearate, sodium lactate, dl-pyrrolidone carboxylate, urea, diglycerin ethylene oxide/propylene oxide adducts, and particularly acidic agents such as chondroitin sulfate and hyaluronic acid. When mucopolysaccharides are blended, they enhance the whitening effect of alkoxysalicylic acid and/or its salts.
増粘剤としては、例えば、アラビアガム、カラギーナン、トラガントガム、クインスシード(マルメロ)、カゼイン、カゼインナトリウム、デキストリン、ゼラチン、アルギン酸ナトリウム、メチルセルロース、エチルセルロース、カルボキシメチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ポリビニルアルコール、ポリアクリル酸ナトリウム、カルボキシビニルポリマー、グアーガム、キサンタンガム、ケイ酸アルミニウムマグネシウム、ベントナイト、ヘクトライト等が挙げられる。 Thickeners include, for example, gum arabic, carrageenan, tragacanth gum, quince seed (quince), casein, sodium caseinate, dextrin, gelatin, sodium alginate, methylcellulose, ethylcellulose, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, polyvinyl alcohol, Sodium polyacrylate, carboxyvinyl polymer, guar gum, xanthan gum, magnesium aluminum silicate, bentonite, hectorite and the like.
多価アルコールとしては、例えば、エチレングリコール、プロピレングリコール、ジプロピレングリコール、1,3-ブチレングリコール、グリセリン、エリスリトール、トリメチロールプロパン、ペンタエリスリトール、ソルビトール、マルチトール、ジグリセリン、ポリエチレングリコール等が挙げられる。 Examples of polyhydric alcohols include ethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, erythritol, trimethylolpropane, pentaerythritol, sorbitol, maltitol, diglycerin, and polyethylene glycol. .
粉末成分としては、例えば、タルク、カオリン、雲母、絹雲母(セリサイト)、金雲母、合成雲母、炭酸マグネシウム、炭酸カルシウム、ケイ酸アルミニウム、シリカ、ゼオライト、硫酸バリウム、焼成硫酸カルシウム(焼セッコウ)、リン酸カルシウム、弗素アパタイト、ヒドロキシアパタイト、セラミックパウダー、金属石鹸(ミリスチン酸亜鉛、パルミチン酸カルシウム、ステアリン酸アルミニウム等)、窒化ホウ素等の無機粉末;ポリアミド樹脂粉末(ナイロン粉末)、ポリエチレン粉末、ポリメタクリル酸メチル粉末、ポリスチレン粉末、スチレンとアクリル酸の共重合体樹脂粉末、ポリメチシルセスキオキサン粉末、セルロース粉末等の有機粉末;二酸化チタン、酸化亜鉛、酸化鉄(ベンガラ)、チタン酸鉄、黄酸化鉄、黒酸化鉄、カーボンブラック、低次酸化チタン、マンゴバイオレット、コバルトバイオレット、酸化クロム、群青、紺青等の無機顔料;酸化チタンコーティッドマイカ、酸化チタンコーティッドオキシ塩化ビスマス、着色酸化チタンコーティッドマイカ、オキシ塩化ビスマス、魚鱗箔等のパール顔料;アルミニウムパウダー等の金属粉末顔料;赤色201号、赤色202号、橙色203号、黄色205号、黄色401号、青色404号等の有機顔料、赤色3号、黄色4号、緑色3号、青色1号等のジルコニウム、バリウム、アルミニウムレーキ等の有機顔料、クロロフィル、β-カロチン等の天然色素等が挙げられる。 Examples of powder components include talc, kaolin, mica, sericite, phlogopite, synthetic mica, magnesium carbonate, calcium carbonate, aluminum silicate, silica, zeolite, barium sulfate, and calcined calcium sulfate (calcined gypsum). , calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, metal soap (zinc myristate, calcium palmitate, aluminum stearate, etc.), inorganic powder such as boron nitride; polyamide resin powder (nylon powder), polyethylene powder, polymethacrylic acid Organic powders such as methyl powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polymethysilsesquioxane powder, cellulose powder; titanium dioxide, zinc oxide, iron oxide (red iron oxide), iron titanate, yellow oxide Inorganic pigments such as iron, black iron oxide, carbon black, low order titanium oxide, mango violet, cobalt violet, chromium oxide, ultramarine blue, and prussian blue; titanium oxide coated mica, titanium oxide coated bismuth oxychloride, colored titanium oxide coated Pearl pigments such as mica, bismuth oxychloride, and fish scale foil; Metal powder pigments such as aluminum powder; Organic pigments such as Red No. 201, Red No. 202, Orange No. 203, Yellow No. 205, Yellow No. 401, and Blue No. Zirconium such as No. 3, Yellow No. 4, Green No. 3 and Blue No. 1, organic pigments such as barium and aluminum lakes, and natural pigments such as chlorophyll and β-carotene.
合成樹脂エマルジョンとしては、例えば、アクリル樹脂エマルジョン、ポリ酢酸ビニル樹脂エマルジョン等が挙げられる。 Examples of synthetic resin emulsions include acrylic resin emulsions and polyvinyl acetate resin emulsions.
アミノ酸としては、グリシン、ロイシン、フェニルアラニン、チロシン、アスパラギン酸、グルタミン酸、グルタミン酸ナトリウム、アルギニン、ヒスチジン、リジン、シスチン、システイン、アシルサルコシンナトリウム(ラウロイルサルコシンナトリウム)、アシルグルタミン酸塩、グルタチオン、ピロリドンカルボン酸等が挙げられる。 Amino acids include glycine, leucine, phenylalanine, tyrosine, aspartic acid, glutamic acid, sodium glutamate, arginine, histidine, lysine, cystine, cysteine, sodium acyl sarcosinate (sodium lauroyl sarcosinate), acyl glutamate, glutathione, pyrrolidone carboxylic acid, and the like. mentioned.
有機アミンとしては、例えば、モノエタノールアミン、ジエタノールアミン、トリエタノールアミン、モルホリン、トリイソプロパノールアミン、2-アミノ-2-メチル-1,3-プロパンジオール、2-アミノ-2-メチル-1-プロパノール等が挙げられる。 Examples of organic amines include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1-propanol, and the like. is mentioned.
pH調製剤としては、例えば、乳酸-乳酸ナトリウム、クエン酸-クエン酸ナトリウム、コハク酸-コハク酸ナトリウム等の緩衝剤等が挙げられる。
酸化防止剤としては、例えば、トコフェロール類、ジブチルヒドロキシトルエン、ブチルヒドロキシアニソール、没食子酸エステル類等が挙げられる。
防腐剤としては、例えば、フェノキシエタノール、エチルパラベン、ブチルパラベン等が挙げられる。
Examples of pH adjusters include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate.
Examples of antioxidants include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, and gallic acid esters.
Examples of antiseptics include phenoxyethanol, ethylparaben, butylparaben and the like.
その他、カフェイン、タンニン、ベラパミル、トラネキサム酸およびその誘導体、甘草抽出物、グラブリジン、火棘の果実の熱水抽出物、各種生薬、酢酸トコフェロール、グリチルリチン酸およびその誘導体またはその塩等の薬剤;アルブチン等の他の美白剤;グルコース、フルクトース、マンノース、ショ糖、トレハロース等の糖類なども適宜配合することができ、特に酢酸トコフェロール等のビタミンEエステル類を配合した場合には、アルコキシサリチル酸および/またはその塩の美白効果増強作用がある。 In addition, drugs such as caffeine, tannin, verapamil, tranexamic acid and its derivatives, licorice extract, glabridin, hot water extract of thorn fruit, various crude drugs, tocopherol acetate, glycyrrhizic acid and its derivatives or their salts; arbutin sugars such as glucose, fructose, mannose, sucrose, trehalose, etc. can be appropriately added, and in particular when vitamin E esters such as tocopherol acetate are added, alkoxysalicylic acid and/or The salt enhances the whitening effect.
本発明による化粧料は、例えば、ローション、液剤等の可溶化系;乳液、クリーム等の乳化系;メークアップ化粧料等の分散系の他、パック、ゼリー、軟膏等が挙げられる。 Cosmetics according to the present invention include, for example, solubilizing systems such as lotions and liquids; emulsifying systems such as milky lotions and creams; dispersing systems such as make-up cosmetics;
本発明の化粧料は、常法に従って製造することができる。本発明による化粧料が乳化化粧料である場合に、乳化の方法は特に限定されるものではない。 The cosmetic of the present invention can be produced according to a conventional method. When the cosmetic according to the present invention is an emulsified cosmetic, the method of emulsification is not particularly limited.
以下の例に基づいて本発明を具体的に説明するが、本発明はこれらの例に限定されるものではない。含有量は特記しない限り、総量に対する質量%で示す。 The present invention will be specifically described based on the following examples, but the present invention is not limited to these examples. Unless otherwise specified, the content is shown in % by mass with respect to the total amount.
[実施例1~6および比較例1、2]
表1に示される配合で、実施例1~6および比較例1、2の化粧料を調製した。得られた化粧料のpHは表1のとおりである。
Cosmetics of Examples 1 to 6 and Comparative Examples 1 and 2 were prepared with the formulations shown in Table 1. Table 1 shows the pH of the obtained cosmetic.
[色差評価]
実施例および比較例の化粧料を、50mlのサンプル管に入れ、それぞれ、6000Lx以上の高照度環境下で1週間放置後に、色差計(「分光測色計CM-2002」、コニカミノルタ株式会社)を用いて、L、a、およびb値を測色し、測色値から、イオン交換水を用いた場合の測定値との色差ΔEを算出した。得られた結果は表1のとおりである。
[Color difference evaluation]
The cosmetics of Examples and Comparative Examples were placed in a 50 ml sample tube, left for 1 week under a high illumination environment of 6000 Lx or more, and measured with a color difference meter (“Spectrophotometer CM-2002”, Konica Minolta, Inc.). were used to measure the L, a, and b values, and from the colorimetric values, the color difference ΔE from the measured values when ion-exchanged water was used was calculated. The results obtained are shown in Table 1.
[色調官能評価]
上記の高照度環境下後の色調の変化を目視により評価した。評価基準は以下の通りである。得られた結果は表1のとおりである。
A+:変色が全く確認されない。
A:変色がほぼ確認されない。
B:変色がわずかに確認される。
C:変色が確認される。
D:変色が著しい。
[Color tone sensory evaluation]
The change in color tone after the high illumination environment was visually evaluated. Evaluation criteria are as follows. The results obtained are shown in Table 1.
A+: No discoloration is observed.
A: Almost no discoloration is observed.
B: Discoloration is slightly confirmed.
C: Discoloration is confirmed.
D: Remarkable discoloration.
表1の結果から、(A)アルコキシサリチル酸またはその塩、および(b)アセトフェノンの組み合わせを含んでなる化粧料が、高照度環境下での保存後も、色差が抑制され、官能評価においても、変色が抑制されていることがわかった。 From the results in Table 1, the cosmetic containing a combination of (A) alkoxysalicylic acid or a salt thereof and (b) acetophenone exhibited a suppressed color difference even after storage in a high-illuminance environment, and the sensory evaluation showed that It was found that discoloration was suppressed.
Claims (11)
(B)式(b)で表されるアセトフェノン誘導体またはその塩
Rbは、それぞれ独立に、水素またはメチル基であり、かつ
nは、0~2である)
を含んでなる、化粧料。 (A) alkoxysalicylic acid represented by formula (a) or a salt thereof
each R b is independently hydrogen or a methyl group, and n is 0 to 2)
A cosmetic comprising
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