JP2022158482A - Cosmetic preparation - Google Patents

Abstract

To provide a cosmetic preparation which is suppressed in discoloration of alkoxysalicylic acid or a salt thereof even under harsh storage conditions, and has excellent storage stability.SOLUTION: A cosmetic preparation contains (A) alkoxysalicylic acid having a specific structure or a salt thereof, and (B) an acetophenone derivative having a specific structure or a salt thereof.SELECTED DRAWING: None

Description

The present invention relates to cosmetics comprising alkoxysalicylic acid or salts thereof.

Alkoxysalicylic acid (or a salt thereof) has a melanin production inhibitory effect, and it has been reported that an external preparation for skin containing this has an excellent whitening effect (for example, Patent Document 1). However, when a composition containing alkoxysalicylic acid is stored under severe conditions for a long period of time, it may become discolored.

As means for suppressing the discoloration of alkoxysalicylic acid, a technique using saponin or the like in combination has been proposed (eg, Patent Document 2). It is also known that sodium pyrosulfite can be used in combination with inorganic salts such as sodium pyrosulfite, but sodium pyrosulfite may give off an unpleasant odor, and there is a limit to the amount to be added, especially in the case of fragrance-free products. be.

JP-A-6-40886 JP-A-8-217660

The present inventors have surprisingly found that a combination of an alkoxysalicylic acid or a salt thereof and an acetophenone derivative can suppress discoloration of the alkoxysalicylic acid or a salt thereof. The present invention is based on these findings.

Accordingly, the present invention discloses a cosmetic comprising an alkoxysalicylic acid or a salt thereof and an acetophenone derivative.

（式中、Ｒ^ａは、炭素数１～６のアルキル基である）、および
（Ｂ）式（ｂ）で表されるアセトフェノン誘導体またはその塩

（式中、
Ｒ^ｂは、それぞれ独立に、水素またはメチル基であり、かつ
ｎは、０～２である）
を含んでなる、化粧料。
［２］Ｒ^ａが、メチル基またはエチル基である、［１］に記載の化粧料。
［３］前記（Ａ）アルコキシサリチル酸またはその塩が、４－メトキシサリチル酸カリウム塩である、［１］または［２］に記載の化粧料。
［４］前記（Ｂ）アセトフェノン誘導体またはその塩が、ヒドロキシアセトフェノンである、［１］～［３］のいずれかに記載の化粧料。
［５］前記（Ｂ）アセトフェノン誘導体またはその塩が、４－ヒドロキシアセトフェノンである、［１］～［４］のいずれかに記載の化粧料。
［６］前記（Ａ）アルコキシサリチル酸またはその塩の配合量が、化粧料の総量に対して、０．１～５質量％である、［１］～［５］のいずれかに記載の化粧料。
［７］前記（Ｂ）アセトフェノン誘導体またはその塩の配合量が、化粧料の総量に対して、０．００５～１質量％である、［１］～［６］に記載の化粧料。
［８］（Ｃ１）亜硫酸塩またはピロ亜硫酸塩をさらに含んでなる、［１］～［７］のいずれかに記載の化粧料。
［９］（Ｃ２）ビタミンＣまたはビタミンＣ誘導体をさらに含んでなる、［１］～［８］のいずれかに記載の化粧料。
［１０］（Ｃ３）キレート剤をさらに含んでなる、［１］～［９］のいずれかに記載の化粧料。
［１１］前記（Ｂ）アセトフェノン誘導体またはその塩の配合量と、前記（Ｃ１）亜硫酸塩またはピロ亜硫酸塩、前記（Ｃ２）ビタミンＣまたはビタミンＣ誘導体および前記（Ｃ３）キレート剤の配合量との合計と、の質量比が１：０．０１～１：１である、［７］～［９］のいずれか一項に記載の化粧料。 According to the present invention, the following inventions are provided.
[1] (A) Alkoxysalicylic acid represented by formula (a) or a salt thereof

(Wherein, R ^a is an alkyl group having 1 to 6 carbon atoms), and (B) an acetophenone derivative represented by formula (b) or a salt thereof

(In the formula,
each R ^b is independently hydrogen or a methyl group, and n is 0 to 2)
A cosmetic comprising
[2] The cosmetic according to [1], wherein R ^a is a methyl group or an ethyl group.
[3] The cosmetic according to [1] or [2], wherein (A) the alkoxysalicylic acid or its salt is 4-methoxysalicylic acid potassium salt.
[4] The cosmetic according to any one of [1] to [3], wherein (B) the acetophenone derivative or salt thereof is hydroxyacetophenone.
[5] The cosmetic according to any one of [1] to [4], wherein the (B) acetophenone derivative or salt thereof is 4-hydroxyacetophenone.
[6] The cosmetic according to any one of [1] to [5], wherein the content of (A) alkoxysalicylic acid or a salt thereof is 0.1 to 5% by mass relative to the total amount of the cosmetic. .
[7] The cosmetic according to [1] to [6], wherein the content of (B) the acetophenone derivative or salt thereof is 0.005 to 1% by mass relative to the total amount of the cosmetic.
[8] (C1) The cosmetic according to any one of [1] to [7], further comprising a sulfite or pyrosulfite.
[9] (C2) The cosmetic according to any one of [1] to [8], further comprising vitamin C or a vitamin C derivative.
[10] (C3) The cosmetic according to any one of [1] to [9], further comprising a chelating agent.
[11] The blending amount of the (B) acetophenone derivative or its salt, the blending amount of the (C1) sulfite or pyrosulfite, the (C2) vitamin C or vitamin C derivative, and the (C3) chelating agent. The cosmetic according to any one of [7] to [9], wherein the mass ratio of the total to the is 1:0.01 to 1:1.

According to the present invention, a cosmetic having excellent storage stability can be provided. In particular, the present invention can suppress discoloration of cosmetics containing alkoxysalicylic acid or salts thereof even under severe storage conditions.

Specific description of the invention

The present invention relates to a cosmetic comprising (A) an alkoxysalicylic acid having a specific structure or a salt thereof and (B) an acetophenone derivative having a specific structure.

式中、Ｒ^ａは、炭素数１～６のアルキル基であり、直鎖であっても分岐であってもよい。Ｒ^ａとしては、例えば、メチル基、エチル基、ｎ－プロピル基、イソプロピル基、ｎ－ブチル基、イソブチル基、ｔｅｒ－ブチル基、ｓｅｃ－ブチル基等が挙げられ、好ましくは、メチル基またはエチル基である。
置換基ＯＲ^ａの位置は特に限定されないが、サリチル酸の３位、４位または５位であることが好ましく、より好ましくは４位である。 (A) Alkoxysalicylic acid or its salt The cosmetic according to the present invention is an alkoxysalicylic acid represented by formula (a) or its salt (hereinafter sometimes referred to as component (A). The same applies to other components. ).

In the formula, R ^a is an alkyl group having 1 to 6 carbon atoms and may be linear or branched. Examples of R ^a include methyl group, ethyl group, n-propyl group, isopropyl group, n-butyl group, isobutyl group, ter-butyl group, sec-butyl group and the like, preferably methyl group or ethyl group. is the base.
Although the position of the substituent OR ^a is not particularly limited, it is preferably the 3-, 4- or 5-position of salicylic acid, more preferably the 4-position.

Alkoxysalicylic acids represented by formula (a) include, for example, 3-methoxysalicylic acid, 3-ethoxysalicylic acid, 4-methoxysalicylic acid, 4-ethoxysalicylic acid, 4-propoxysalicylic acid, 4-isopropoxysalicylic acid, and 4-butoxysalicylic acid. , 5-methoxysalicylic acid, 5-ethoxysalicylic acid, 5-propoxysalicylic acid and the like, preferably 4-methoxysalicylic acid.

Alkoxysalicylic acids are known substances, and for example, 5-methoxysalicylic acid and 4-methoxysalicylic acid can be easily synthesized by methods described in "Beil, 10227" and "Beil, 10379," respectively. It is also available as a reagent from Aldrich Co. and others.

Component (A) is also preferably a salt of alkoxysalicylic acid represented by formula (a). The type of salt is not particularly limited as long as it is a pharmacologically acceptable salt. Examples include alkali metal salts such as sodium salts, potassium salts and lithium salts; alkaline earth metal salts such as calcium salts and magnesium salts; Ammonium salts; amino acid salts; and the like. Potassium salts are preferred, and potassium 4-methoxysalicylate is more preferred from the viewpoint of cosmetic effects and availability.

(A) component can be blended 1 type, or 2 or more types. The amount of component (A) is appropriately selected depending on the application and the balance with other ingredients. It is preferably 0.1 to 5% by mass, more preferably 0.5 to 3.5% by mass, based on the total amount of the ingredients.

式中、
Ｒ^ｂは、それぞれ独立に、水素またはメチル基であり、好ましくは水素である。
ｎは、０～２であり、好ましくは０または１であり、より好ましくは１である。
置換基（ＯＲ^ｂ）を有する場合に、置換基の位置は限定されないが、ｎ＝１の場合は、アセチル基に対して、パラ位であることが好ましい。 (B) Acetophenone Derivative or Its Salt The cosmetic according to the present invention comprises an acetophenone derivative represented by formula (b) or its salt.

During the ceremony,
Each ^Rb is independently hydrogen or a methyl group, preferably hydrogen.
n is 0 to 2, preferably 0 or 1, more preferably 1;
When having a substituent (OR ^b ), the position of the substituent is not limited, but when n=1, it is preferably para to the acetyl group.

Examples of the acetophenone derivative represented by formula (b) include acetophenone, 2-hydroxyacetophenone, 3-hydroxyacetophenone, 4-hydroxyacetophenone and the like, preferably hydroxyacetophenone, more preferably 4-hydroxyacetophenone. is.

The component (B) may be a salt of the acetophenone derivative represented by formula (b). The type of salt is not particularly limited as long as it is a pharmacologically acceptable salt. Examples include alkali metal salts such as sodium salts, potassium salts and lithium salts; alkaline earth metal salts such as calcium salts and magnesium salts; ammonium salts; amino acid salts; and the like, preferably sodium salts, potassium salts and ammonium salts, more preferably sodium salts.

(B) component can be blended 1 type(s) or 2 or more types. The blending amount of component (B) is preferably 0.005 to 1% by mass, more preferably 0.01 to 0.5% by mass, based on the total amount of the cosmetic. By setting it as this range, the stimulus derived from (B) component can be suppressed, suppressing a discoloration.

It is known that component (A) can be discolored by long-term storage under conditions such as exposure to light, but discoloration can be suppressed by combining component (A) and component (B). Without being bound by theory, it is believed that this is due to the following reasons. It is believed that the structure of the component (A) changes due to light irradiation or the like, resulting in discoloration. Here, when the component (B) coexists, the component (B) traps the radicals generated in the intermediate stage of the structural change, thereby suppressing the structural change of the component (A) and suppressing discoloration.
For the purpose of suppressing the discoloration of component (A), it has been conventionally known to combine components (C1) to (C3) (hereinafter sometimes collectively referred to as component (C)) to be described later. Since the components (B) and (C) are thought to suppress discoloration by different actions on the component (A), It is thought that a synergistic effect can be obtained by combining

(C1) Sulfite or pyrosulfite The cosmetic according to the present invention may further contain (C1) a sulfite or pyrosulfite.
Examples of component (C1) include sodium sulfite, sodium hydrogen sulfite, potassium sulfite, calcium sulfite, sodium pyrosulfite, and potassium pyrosulfite, preferably pyrosulfite, more preferably sodium pyrosulfite. be.
(C1) component can be blended 1 type, or 2 or more types. When sulfites and pyrosulfites are used in high amounts, they may give off an unpleasant odor, so it is preferable to take this into consideration when using them in fragrance-free cosmetics. The amount of component (C1) to be blended is preferably 0.001 to 0.3% by mass, more preferably 0.001 to 0.2% by mass, relative to the total amount of the cosmetic. Within this range, the odor of sodium pyrosulfite itself can be suppressed while effectively suppressing discoloration through a synergistic effect with the component (B).

(C2) Vitamin C or Vitamin C Derivative The cosmetic according to the present invention can further contain (C2) vitamin C or a vitamin C derivative. Vitamin C is also called L-ascorbic acid. (C2) Vitamin C or a vitamin C derivative can be expected to have an effect as a whitening agent in addition to suppressing discoloration.
Component (C2) includes, for example, L-ascorbic acid, 2-O-methylascorbic acid, 2-O-ethylascorbic acid, 2-On-propylascorbic acid, 2-On-butylascorbic acid, and the like. 2-O-alkyl ascorbic acid; 3-O-methyl ascorbic acid, 3-O-ethyl ascorbic acid, 3-O-n-propyl ascorbic acid, 3-O-isopropyl ascorbic acid, 3-O-n-butyl Ascorbic acid, 3-O-alkylascorbic acid such as 3-O-isobutylascorbic acid; Ascorbic acid monoalkyl esters; Ascorbic acid dialkyl esters; Ascorbic acid trialkyl esters; Ascorbic acid triesters; Ascorbic acid glucosides etc. Ascorbic acid and its derivatives may be in the form of salts. Such salts include alkali metal salts, alkaline earth metal salts, ammonium salts, alkanolamine salts, amino acid salts and the like. In the present invention, it is preferred to use 2-O-ethylascorbic acid (vitamin C ethyl).
(C2) component can be blended 1 type(s) or 2 or more types. The blending amount of component (C2) is preferably 0.001 to 0.5% by mass, more preferably 0.003 to 0.2% by mass, based on the total amount of the cosmetic. By setting it to this range, it is possible to effectively suppress discoloration by a synergistic effect with the component (B), while suppressing the stimulating feeling and the feeling of use derived from the component (C).

(C3) Chelating agent The cosmetic according to the present invention may further contain (C3) a chelating agent.
Examples of component (C3) include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, and tetrasodium edetate. , sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, trisodium ethylenediaminehydroxyethyl triacetate, disodium ethylenediaminetetraacetate and the like.
(C3) component can be blended 1 type(s) or 2 or more types. The blending amount of component (C3) is preferably 0.001 to 0.5% by mass, more preferably 0.01 to 0.3% by mass, based on the total amount of the cosmetic. Within this range, the synergistic effect with the component (B) can effectively suppress discoloration while suppressing stickiness after application derived from the component (C).

The mass ratio of (B) the amount of the acetophenone derivative or its salt to the total amount of (C1) the sulfite or pyrosulfite, (C2) vitamin C or the vitamin C derivative and (C3) the chelating agent is , preferably 1:0.01 to 1:1, more preferably 1:0.05 to 1:0.6.

In addition to the above ingredients, the cosmetic according to the present invention may contain ingredients commonly used in cosmetics, such as oily ingredients, ultraviolet absorbers, surfactants, humectants, thickeners, polyhydric alcohols, powder components, and synthetic resins. Emulsions, amino acids, organic amines, pH adjusters, antioxidants, preservatives and the like can be appropriately blended as needed.

The oily component is not particularly limited, and examples thereof include oils and fats, waxes, hydrocarbon oils, higher fatty acids, higher alcohols, synthetic ester oils, silicone oils, and silicones.

Examples of fats and oils include avocado oil, camellia oil, evening primrose oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, Flaxseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, sinagiri oil, Japanese paulownia oil, jojoba oil, germ oil, triglycerin, glycerin trioctanoate, triiso Liquid oils and fats such as glycerol palmitate; cocoa butter, coconut oil, horse fat, hydrogenated coconut oil, palm oil, beef tallow, mutton tallow, hydrogenated beef tallow, palm kernel oil, lard, beef bone fat, Japanese magnolia kernel oil, hydrogenated oil, Solid oils and fats such as beef leg fat, Japanese wax, hardened castor oil, and the like are included.

Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, wart wax, whale wax, montan wax, bran wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugarcane wax, isopropyl lanolin fatty acid, hexyl laurate, and reduced lanolin. , jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, and the like.

Examples of hydrocarbon oils include oils such as liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, vaseline, and microcrystalline wax.

Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, toric acid, isostearic acid, linoleic acid, linoleic acid, ethyl Examples include icosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

Examples of higher alcohols include linear alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, and cetostearyl alcohol; monostearyl glycerin ether (bacyl alcohol), 2-decyltetradecinol, lanolin; Alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, branched chain alcohol such as octyldodecanol, and the like.

Synthetic ester oils include, for example, isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, Diisostearyl malate, glyceryl di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexate, trimethylolpropane triisostearate, pentaerythrityl tetraethylhexanoate, glyceryl tri-2-ethylhexate, triisostearate Methylolpropane, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleic oil, acetoglyceride, 2-heptylun palmitate Decyl, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-ctyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, palmitic acid 2-hexyldecyl acid, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate, crotamiton (C ₁₃ H ₁₇ NO) and the like.

Examples of silicone oils include linear silicone oils such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane; octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, tetramethyltetrahydro Cyclic silicone oils such as gencyclopolysiloxane; normal temperature liquid alkyl-modified silicone oils such as capryl methicone, capryl trimethicone, and stearyl methicone; fluorine-modified silicones such as dimethylsiloxane/diphenylsiloxane/methyl (perfluoroalkyl)siloxane copolymers oil and the like.

Examples of silicones include alkyl and alkoxy silicon waxes such as stearyl-modified dimethicone and behenyl-modified dimethicone, silicone resins forming a three-dimensional network structure, and silicone rubbers.

Examples of ultraviolet absorbers include benzoic acid-based ultraviolet absorbers such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerol ester, N,N-dipropoxy para-aminobenzoic acid ethyl ester, and N,N-dimethyl para-aminobenzoic acid ethyl ester; Anthranilic acid UV absorbers such as homomenthyl-N-acetylanthranilate; salicylic acid UV absorbers such as amyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate; octyl methoxycinnamate , glyceryl di-paramethoxycinnamate-mono-2-ethylhexanoate, octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, Methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate mate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono -2-ethylhexanoyl-diparamethoxycinnamate, 3,4,5-trimethoxycinnamate-3-methyl-4-[methylbis(trimethylsiloxy)silyl]butyl, methyl bis(trimethyl trimethoxycinnamate) siloxy) silyl isopentyl and other cinnamic acid UV absorbers; Benzophenone UV absorbers such as hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4′-phenylbenzophenone-2-carboxylate;3 -(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor, urocanic acid, urocanic acid ethyl ester, 2,2'-hydroxy-5-methylphenylbenzotriazole, 2-( 2'-hydroxy-5'-t-octylphenyl)benzotriazole, dibenzalazine, dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5-(3,3-dimethyl-2-norbornylidene)- 3-pentan-2-one, dimorpholinopyridazinone, and the like.

Lipophilic nonionic surfactants include, for example, lipophilic nonionic surfactants such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan fatty acid esters such as sorbitan sesquioleate, diglycerol sorbitan penta-2-ethylhexylate, glycerin such as glyceryl monostearate, α,α'-oleic acid pyroglutamic acid glyceryl, glyceryl monostearate malate or Polyglycerin esters, propylene glycol fatty acid esters such as propylene glycol monostearate, hydrogenated castor oil derivatives, glycerin alkyl ethers and the like can be mentioned.

Examples of hydrophilic nonionic surfactants include polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate and polyoxyethylene sorbitan monostearate; polyoxyethylene sorbit monolaurate, polyoxyethylene sorbit Polyoxyethylene sorbitol fatty acid esters such as monooleate and polyoxyethylene sorbitol monostearate; Polyoxyethylene fatty acid esters such as oxyethylene glycerin fatty acid ester, polyoxyethylene monooleate, polyoxyethylene distearate; polyoxyethylene lauryl ether, polyoxyethylene oleyl ether, polyoxyethylene stearyl ether, polyoxyethylene -polyoxyethylene alkyl ethers such as 2-octyldodecyl ether and polyoxyethylene cholestanol ether; polyoxyethylene alkyl ethers such as polyoxyethylene octylphenyl ether, polyoxyethylene nonylphenyl ether and polyoxyethylene dinonylphenyl ether; Phenyl ethers; pluronic surfactants such as pluronic; polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene-2-decyltetradecyl ether, polyoxyethylene polyoxypropylene monobutyl ether, polyoxyethylene polyoxy Propylene, hydrogenated lanolin, polyoxyethylene polyoxypropylene glycerin ether, polyoxyethylene polyoxypropylene alkyl ethers such as PPG-13 decyltetradeceth-24; tetrapolyoxyethylene/tetrapolyoxypropylene ethylenediamine such as Tetronic Condensates; polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate Acid diesters, polyoxyethylene castor oil derivatives or polyoxyethylene hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil maleate; In addition to alkanolamides such as fatty acid diethanolamide, lauric acid monoethanolamide, and fatty acid isopropanolamide, polyoxyethylene propylene glycol fatty acid esters, polyoxyethylene alkylamines, polyoxyethylene fatty acid amide, sucrose fatty acid ester, polyoxy Ethylene nonylphenyl formaldehyde condensate, alkylethoxydimethylamine oxide, trioleyl phosphate and the like.

Examples of anionic surfactants include fatty acid soaps such as sodium laurate and sodium palmitate; higher alkyl sulfate salts such as sodium lauryl sulfate and potassium lauryl sulfate; Alkyl ether sulfate ester salts such as sodium lauryl sulfate; N-acylsarcosic acid such as sodium lauroyl sarcosinate, sodium N-myristoyl-N-methyltaurate, sodium N-stearoyl-N-methyltaurate, sodium cocoate methyl tauride, Higher fatty acid amide sulfonates such as sodium lauryl methyl tauride; Phosphate ester salts such as sodium polyoxyethylene oleyl ether phosphate and sodium polyoxyethylene stearyl ether phosphate; sulfosuccinates such as sodium ethanolamide polyoxyethylene sulfosuccinate and sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzene sulfonates such as sodium linadodecylbenzene sulfonate and triethanolamine linadodecylbenzene sulfonate; monosodium N-lauroyl glutamate, N-acylglutamic acid such as disodium N-stearoylglutamic acid; higher fatty acid esters such as hydrogenated coconut oil fatty acid sodium glycerin sulfate, sulfuric acid ester salts, polyoxyethylene alkyl ether carboxylates, α-olefin sulfonates, higher fatty acid esters sulfonates, secondary alcohol sulfates, higher fatty acid alkylolamide sulfates, sodium lauroyl monoethanolamide succinate, N-palmitoyl aspartic acid, ditriethanolamine, coconut oil fatty acid collagen hydrolyzed alkaline salts, etc. .

Examples of cationic surfactants include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride; dialkyldimethylammonium salts such as distearyldimethylammonium chloride; ,-methylenepiperidinium), alkylpyridinium salts such as cetylpyridinium chloride, alkylquaternary ammonium salts, alkyldimethylbenzylammonium salts, alkylisoquinolinium salts, dialkylmorphonium salts, polyoxyethylenealkylamines, Alkylamine salts, polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride, benzethonium chloride, cationic polymers, β-NN-dimethyl-N-ethylammonioethyl chloride vinylpyrrolidone chloride copolymers, etc. be done.

Amphoteric surfactants include, for example, 2-undecyl-N,N,N,-(hydroxyethylcarboxymethyl)-2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy 2 imidazoline-based amphoteric surfactants such as sodium salts; betaine-based amphoteric surfactants such as 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, betaine lauryldimethylaminoacetate, alkylbetaine, amidobetaine, and sulfobetaine agents and the like.

Moisturizing agents include, for example, cholesteryl-12-hydroxystearate, sodium lactate, dl-pyrrolidone carboxylate, urea, diglycerin ethylene oxide/propylene oxide adducts, and particularly acidic agents such as chondroitin sulfate and hyaluronic acid. When mucopolysaccharides are blended, they enhance the whitening effect of alkoxysalicylic acid and/or its salts.

Thickeners include, for example, gum arabic, carrageenan, tragacanth gum, quince seed (quince), casein, sodium caseinate, dextrin, gelatin, sodium alginate, methylcellulose, ethylcellulose, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, polyvinyl alcohol, Sodium polyacrylate, carboxyvinyl polymer, guar gum, xanthan gum, magnesium aluminum silicate, bentonite, hectorite and the like.

Examples of polyhydric alcohols include ethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, erythritol, trimethylolpropane, pentaerythritol, sorbitol, maltitol, diglycerin, and polyethylene glycol. .

Examples of powder components include talc, kaolin, mica, sericite, phlogopite, synthetic mica, magnesium carbonate, calcium carbonate, aluminum silicate, silica, zeolite, barium sulfate, and calcined calcium sulfate (calcined gypsum). , calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, metal soap (zinc myristate, calcium palmitate, aluminum stearate, etc.), inorganic powder such as boron nitride; polyamide resin powder (nylon powder), polyethylene powder, polymethacrylic acid Organic powders such as methyl powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polymethysilsesquioxane powder, cellulose powder; titanium dioxide, zinc oxide, iron oxide (red iron oxide), iron titanate, yellow oxide Inorganic pigments such as iron, black iron oxide, carbon black, low order titanium oxide, mango violet, cobalt violet, chromium oxide, ultramarine blue, and prussian blue; titanium oxide coated mica, titanium oxide coated bismuth oxychloride, colored titanium oxide coated Pearl pigments such as mica, bismuth oxychloride, and fish scale foil; Metal powder pigments such as aluminum powder; Organic pigments such as Red No. 201, Red No. 202, Orange No. 203, Yellow No. 205, Yellow No. 401, and Blue No. Zirconium such as No. 3, Yellow No. 4, Green No. 3 and Blue No. 1, organic pigments such as barium and aluminum lakes, and natural pigments such as chlorophyll and β-carotene.

Examples of synthetic resin emulsions include acrylic resin emulsions and polyvinyl acetate resin emulsions.

Amino acids include glycine, leucine, phenylalanine, tyrosine, aspartic acid, glutamic acid, sodium glutamate, arginine, histidine, lysine, cystine, cysteine, sodium acyl sarcosinate (sodium lauroyl sarcosinate), acyl glutamate, glutathione, pyrrolidone carboxylic acid, and the like. mentioned.

Examples of organic amines include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1-propanol, and the like. is mentioned.

Examples of pH adjusters include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate.
Examples of antioxidants include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, and gallic acid esters.
Examples of antiseptics include phenoxyethanol, ethylparaben, butylparaben and the like.

In addition, drugs such as caffeine, tannin, verapamil, tranexamic acid and its derivatives, licorice extract, glabridin, hot water extract of thorn fruit, various crude drugs, tocopherol acetate, glycyrrhizic acid and its derivatives or their salts; arbutin sugars such as glucose, fructose, mannose, sucrose, trehalose, etc. can be appropriately added, and in particular when vitamin E esters such as tocopherol acetate are added, alkoxysalicylic acid and/or The salt enhances the whitening effect.

Cosmetics according to the present invention include, for example, solubilizing systems such as lotions and liquids; emulsifying systems such as milky lotions and creams; dispersing systems such as make-up cosmetics;

The cosmetic of the present invention can be produced according to a conventional method. When the cosmetic according to the present invention is an emulsified cosmetic, the method of emulsification is not particularly limited.

The present invention will be specifically described based on the following examples, but the present invention is not limited to these examples. Unless otherwise specified, the content is shown in % by mass with respect to the total amount.

[Examples 1 to 6 and Comparative Examples 1 and 2]
Cosmetics of Examples 1 to 6 and Comparative Examples 1 and 2 were prepared with the formulations shown in Table 1. Table 1 shows the pH of the obtained cosmetic.

[Color difference evaluation]
The cosmetics of Examples and Comparative Examples were placed in a 50 ml sample tube, left for 1 week under a high illumination environment of 6000 Lx or more, and measured with a color difference meter (“Spectrophotometer CM-2002”, Konica Minolta, Inc.). were used to measure the L, a, and b values, and from the colorimetric values, the color difference ΔE from the measured values when ion-exchanged water was used was calculated. The results obtained are shown in Table 1.

[Color tone sensory evaluation]
The change in color tone after the high illumination environment was visually evaluated. Evaluation criteria are as follows. The results obtained are shown in Table 1.
A+: No discoloration is observed.
A: Almost no discoloration is observed.
B: Discoloration is slightly confirmed.
C: Discoloration is confirmed.
D: Remarkable discoloration.

From the results in Table 1, the cosmetic containing a combination of (A) alkoxysalicylic acid or a salt thereof and (b) acetophenone exhibited a suppressed color difference even after storage in a high-illuminance environment, and the sensory evaluation showed that It was found that discoloration was suppressed.

Claims (11)

(A) alkoxysalicylic acid represented by formula (a) or a salt thereof

(Wherein, R ^a is an alkyl group having 1 to 6 carbon atoms), and (B) an acetophenone derivative represented by formula (b) or a salt thereof

(In the formula,
each R ^b is independently hydrogen or a methyl group, and n is 0 to 2)
A cosmetic comprising The cosmetic according to claim 1, wherein Ra is ^a methyl group or an ethyl group. 3. The cosmetic according to claim 1, wherein the (A) alkoxysalicylic acid or a salt thereof is 4-methoxysalicylic acid potassium salt. The cosmetic according to any one of claims 1 to 3, wherein the (B) acetophenone derivative or salt thereof is hydroxyacetophenone. The cosmetic according to any one of claims 1 to 4, wherein (B) the acetophenone derivative or a salt thereof is 4-hydroxyacetophenone. The cosmetic according to any one of claims 1 to 5, wherein the amount of (A) alkoxysalicylic acid or a salt thereof is 0.1 to 5% by mass relative to the total amount of the cosmetic. The cosmetic according to any one of claims 1 to 6, wherein the content of (B) the acetophenone derivative or salt thereof is 0.005 to 1% by mass relative to the total amount of the cosmetic. (C1) The cosmetic according to any one of claims 1 to 7, further comprising a sulfite or pyrosulfite. (C2) The cosmetic according to any one of claims 1 to 8, further comprising vitamin C or a vitamin C derivative. (C3) The cosmetic according to any one of claims 1 to 9, further comprising a chelating agent. the total amount of the (B) acetophenone derivative or its salt, the (C1) sulfite or pyrosulfite, the (C2) vitamin C or vitamin C derivative, and the (C3) chelating agent; The cosmetic according to any one of claims 7 to 9, wherein the mass ratio of is 1:0.01 to 1:1.