JP2022136905A - Sterilizing liquid - Google Patents
Sterilizing liquid Download PDFInfo
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- JP2022136905A JP2022136905A JP2021036732A JP2021036732A JP2022136905A JP 2022136905 A JP2022136905 A JP 2022136905A JP 2021036732 A JP2021036732 A JP 2021036732A JP 2021036732 A JP2021036732 A JP 2021036732A JP 2022136905 A JP2022136905 A JP 2022136905A
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- calcium hydroxide
- edta
- solution
- benzalkonium chloride
- calcium
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- 230000001954 sterilising effect Effects 0.000 title claims abstract description 37
- 239000007788 liquid Substances 0.000 title abstract description 18
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims abstract description 36
- 239000000920 calcium hydroxide Substances 0.000 claims abstract description 35
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims abstract description 35
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims abstract description 26
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 16
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 16
- 229920006395 saturated elastomer Polymers 0.000 claims description 6
- 239000000645 desinfectant Substances 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 20
- 230000000694 effects Effects 0.000 abstract description 11
- 230000002087 whitening effect Effects 0.000 abstract description 4
- KHJWSKNOMFJTDN-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;sodium Chemical compound [Na].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KHJWSKNOMFJTDN-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 24
- 239000000243 solution Substances 0.000 description 14
- 229910000019 calcium carbonate Inorganic materials 0.000 description 12
- 235000010216 calcium carbonate Nutrition 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 8
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 8
- 229910001424 calcium ion Inorganic materials 0.000 description 8
- 239000013522 chelant Substances 0.000 description 8
- 239000007864 aqueous solution Substances 0.000 description 5
- 229910002092 carbon dioxide Inorganic materials 0.000 description 4
- 239000001569 carbon dioxide Substances 0.000 description 3
- 230000000249 desinfective effect Effects 0.000 description 3
- 230000008023 solidification Effects 0.000 description 3
- 238000007711 solidification Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000005416 organic matter Substances 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
本発明は、除菌液に関し、より詳細には、温度等の環境に影響されずに除菌効果を保持可能な除菌液に関する。 TECHNICAL FIELD The present invention relates to a sterilizing liquid, and more particularly to a sterilizing liquid capable of maintaining a sterilizing effect without being affected by the environment such as temperature.
従来、安全性が高く、食品用、医療用等に広く使用されている除菌剤として、水酸化カルシウムや塩化ベンザルコニウムがあるが（例えば、特許文献１、２参照）、これらにはいくつかの問題点がある。 Conventionally, there are calcium hydroxide and benzalkonium chloride as disinfectants that are highly safe and widely used for food, medical, etc. (see, for example, Patent Documents 1 and 2). There is some problem.
例えば、ノズルから水酸化カルシウム水溶液を噴霧した場合、以下の反応式に示すように、当該ノズルの先端に残った液や先端から滴り落ちる水滴が大気中の二酸化炭素と反応して炭酸カルシウムとなり、ノズルの先端や乾燥部に析出して固形化し、ノズルを詰まらせたり白色の粉が発生するという問題があった。
Ｃａ（ＯＨ）２＋ＣＯ２→ＣａＣＯ３＋Ｈ２Ｏ↑
For example, when an aqueous solution of calcium hydroxide is sprayed from a nozzle, as shown in the following reaction formula, the liquid remaining at the tip of the nozzle and water droplets dripping from the tip react with carbon dioxide in the atmosphere to form calcium carbonate. There was a problem that it precipitated and solidified at the tip of the nozzle and the drying part, clogging the nozzle and generating white powder.
Ca(OH) 2 + CO2 → CaCO3 + H2O ↑
また、塩化ベンザルコニウムについては、冬期の低温下や有機物汚染環境下において、除菌効果が著しく減衰するという問題があった。 In addition, benzalkonium chloride has a problem that its sterilization effect is remarkably attenuated under low temperature in winter or under an environment contaminated with organic substances.
本発明は、上記問題点に鑑みてなされたものであり、低温下や有機物汚染環境下でも高い除菌効果を発揮することができ、かつ、乾燥下でも固形化や白色化するのを防ぐことができる除菌液を提供することを課題とする。 The present invention has been made in view of the above problems, and is capable of exhibiting a high sterilization effect even at low temperatures or in environments contaminated with organic matter, and preventing solidification and whitening even under drying. An object of the present invention is to provide a sterilizing solution capable of
上記課題を解決するために、本発明の除菌液は、
水酸化カルシウムと、エチレンジアミン四酢酸四ナトリウム（ＥＤＴＡ－４Ｎａ）と、塩化ベンザルコニウムと、を含むことを特徴とする。
In order to solve the above problems, the disinfectant solution of the present invention is
It is characterized by containing calcium hydroxide, tetrasodium ethylenediaminetetraacetate (EDTA-4Na), and benzalkonium chloride.
本発明によれば、水酸化カルシウムにより除菌液の液性をアルカリ性とすることで、低温下や有機物汚染環境下であっても塩化ベンザルコニウムの除菌効果を保持することができる。また、エチレンジアミン四酢酸四ナトリウムが液中のカルシウムイオンとキレート結合することで、水酸化カルシウムが大気中や水中に存在する二酸化炭素と反応して炭酸カルシウムを生成するのを阻止することができ、固形化や白色化を防止することができる。また、塩化ベンザルコニウムと水酸化カルシウムとの相乗効果により、高い除菌効果を発揮することができる。 According to the present invention, the sterilization effect of benzalkonium chloride can be maintained even at low temperatures or in environments contaminated with organic substances by making the sterilization solution alkaline with calcium hydroxide. In addition, tetrasodium ethylenediaminetetraacetate forms a chelate bond with calcium ions in the liquid, which prevents calcium hydroxide from reacting with carbon dioxide present in the air or water to form calcium carbonate. Solidification and whitening can be prevented. Moreover, the synergistic effect of benzalkonium chloride and calcium hydroxide can exhibit a high sterilization effect.
上記発明において、前記除菌液における前記水酸化カルシウムの濃度は飽和濃度であることを特徴とする。 In the above invention, the concentration of the calcium hydroxide in the sterilization liquid is a saturated concentration.
本発明によれば、除菌液を強アルカリ性とすることができ、除菌効果を高めることできる。 According to the present invention, the sterilization liquid can be made strongly alkaline, and the sterilization effect can be enhanced.
上記発明において、前記除菌液における前記塩化ベンザルコニウムの含有量は０．０３～０．０５重量％であることを特徴とする。 In the above invention, the content of the benzalkonium chloride in the disinfecting liquid is 0.03 to 0.05% by weight.
本発明によれば、除菌効果と安全性を高めることできる。 According to the present invention, sterilization effect and safety can be enhanced.
上記発明において、前記除菌液における前記エチレンジアミン四酢酸四ナトリウムと前記水酸化カルシウムとのモル比が１：１であることを特徴とする。 The above invention is characterized in that the molar ratio of the tetrasodium ethylenediaminetetraacetate and the calcium hydroxide in the sterilizing solution is 1:1.
本発明によれば、エチレンジアミン四酢酸四ナトリウムが液中のカルシウムイオンを全て取り込んで効率的にキレート結合することができる。 According to the present invention, tetrasodium ethylenediaminetetraacetate can take in all the calcium ions in the liquid and efficiently chelate them.
以下、本発明の実施形態について詳細に説明する。 BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, embodiments of the present invention will be described in detail.
本発明に係る除菌液は、水酸化カルシウムと、ＥＤＴＡ－４Ｎａ（エチレンジアミン四酢酸四ナトリウム）と、塩化ベンザルコニウムと、を混合したものである。 The disinfectant solution according to the present invention is a mixture of calcium hydroxide, EDTA-4Na (tetrasodium ethylenediaminetetraacetate), and benzalkonium chloride.
当該除菌液における水酸化カルシウムの濃度は飽和濃度である。除菌液中の水酸化カルシウムの濃度を高めることで、当該除菌液の液性を強アルカリ性とし、除菌効果を高めることできる。水酸化カルシウムの飽和水溶液は、温度２５℃において、水酸化カルシウム濃度が０．１７質量％であり、ｐＨは１２．４である。 The concentration of calcium hydroxide in the sterilization solution is the saturated concentration. By increasing the concentration of calcium hydroxide in the sterilization liquid, the liquid property of the sterilization liquid is made strongly alkaline, and the sterilization effect can be enhanced. A saturated aqueous solution of calcium hydroxide has a calcium hydroxide concentration of 0.17% by mass and a pH of 12.4 at a temperature of 25°C.
また、当該除菌液における塩化ベンザルコニウムの含有量は０．０３～０．０５重量％である。これにより、医薬部外品規格を満たし、安全性と除菌効果を保つことができる。 Moreover, the content of benzalkonium chloride in the sterilization liquid is 0.03 to 0.05% by weight. As a result, it is possible to meet the standards for quasi-drugs and maintain safety and sterilization effects.
ＥＤＴＡ－４Ｎａはキレート剤である。アルカリ性の水酸化カルシウム水溶液中のカルシウムイオンをキレートする場合には、アルカリ性と相性の良いＥＤＴＡ－４Ｎａを用いるのが好ましい。ＥＤＴＡ－４Ｎａとカルシウムイオンとは１：１のモル比で結合するため、水酸化カルシウム水溶液中のカルシウムイオンをキレートするのに必要なＥＤＴＡ－４Ｎａの量は、水酸化カルシウムのモル量と同モル量となる。 EDTA-4Na is a chelating agent. When chelating calcium ions in an alkaline aqueous solution of calcium hydroxide, it is preferable to use EDTA-4Na, which has good compatibility with alkalinity. Since EDTA-4Na and calcium ions bind at a molar ratio of 1:1, the amount of EDTA-4Na required to chelate calcium ions in the aqueous calcium hydroxide solution is the same molar amount as the molar amount of calcium hydroxide. amount.
除菌液中のＥＤＴＡ－４Ｎａと水酸化カルシウムとのモル比が１：１となるように混合することで、ＥＤＴＡ－４Ｎａが除菌液中のカルシウムイオンを全て取り込んで効率的にキレート結合することができる。これにより、除菌液中にカルシウムイオンが存在しなくなるため、噴射ノズルの先端等に付着した除菌液が固化したり白色化するのを防ぐことができる。 By mixing EDTA-4Na and calcium hydroxide in the sterilization solution at a molar ratio of 1:1, EDTA-4Na takes in all the calcium ions in the sterilization solution and efficiently chelates them. be able to. As a result, calcium ions do not exist in the sterilizing liquid, so that the sterilizing liquid adhering to the tip of the injection nozzle or the like can be prevented from solidifying or turning white.
以下、１トンの除菌液を生成する場合の各成分の量を示す。
（１）水（水道水又は精製水：純水）：１０００Ｌ＝１０００ｋｇ
（２）水酸化カルシウム飽和水溶液：２５℃において水の重量の０．０１７４％＝１．７４ｋｇ
（３）ＥＤＴＡ－４Ｎａ：水酸化カルシウムを炭酸カルシウムに換算した試算値から量を計算する。
ＥＤＴＡ－４Ｎａのキレート価は２６８ｍｇＣａＣＯ３／ｇであるため、水酸化カルシウムを炭酸カルシウムの量に換算すると、
１．７４ｋｇ（キレートする量）÷７４．１（水酸化カルシウムの分子量）×１００．１（炭酸カルシウムの分子量）＝２．３５ｋｇ
水酸化カルシウムを炭酸カルシウムに換算した上記値をキレート価で割ると、
２．３５ｋｇ÷０．２６８＝８．７７ｋｇ
よって、ＥＤＴＡ－４Ｎａの量は８．７７ｋｇとなる。。
（４）塩化ベンザルコニウム：１００％溶液 ５００ｇ
Below, the amount of each component when producing 1 ton of the sterilizing solution is shown.
(1) Water (tap water or purified water: pure water): 1000 L = 1000 kg
(2) Saturated aqueous solution of calcium hydroxide: 0.0174% of the weight of water at 25°C = 1.74 kg
(3) EDTA-4Na: Calculate the amount from a trial calculation of calcium hydroxide converted to calcium carbonate.
Since the chelate value of EDTA-4Na is 268 mgCaCO 3 /g, when calcium hydroxide is converted to the amount of calcium carbonate,
1.74 kg (amount to be chelated) ÷ 74.1 (molecular weight of calcium hydroxide) × 100.1 (molecular weight of calcium carbonate) = 2.35 kg
Dividing the above value obtained by converting calcium hydroxide to calcium carbonate by the chelate value,
2.35kg/0.268=8.77kg
Therefore, the amount of EDTA-4Na is 8.77 kg. .
(4) Benzalkonium chloride: 500 g of 100% solution
以上説明したように、水酸化カルシウムと、ＥＤＴＡ－４Ｎａと、塩化ベンザルコニウムと、を混合して除菌液を生成することで、水酸化カルシウムにより除菌液の液性がアルカリ性となるため、低温下や有機物汚染環境下であっても塩化ベンザルコニウムの除菌効果を保持することができる。また、ＥＤＴＡ－４Ｎａが液中のカルシウムイオンとキレート結合することで、水酸化カルシウムが大気中や水中に存在する二酸化炭素と反応して炭酸カルシウムを生成するのを阻止することができ、固形化や白色化を防止することができる。また、塩化ベンザルコニウムと水酸化カルシウムとの相乗効果により、高い除菌効果を発揮することができる。 As described above, by mixing calcium hydroxide, EDTA-4Na, and benzalkonium chloride to produce a disinfecting solution, the liquidity of the disinfecting solution becomes alkaline due to calcium hydroxide. , the sterilization effect of benzalkonium chloride can be maintained even at low temperatures or in environments contaminated with organic matter. In addition, EDTA-4Na forms a chelate bond with calcium ions in the liquid, which prevents calcium hydroxide from reacting with carbon dioxide present in the air or water to form calcium carbonate, resulting in solidification. and whitening can be prevented. Moreover, the synergistic effect of benzalkonium chloride and calcium hydroxide can exhibit a high sterilization effect.
また、塩化ベンザルコニウムは医薬部外品認可品であり、水酸化カルシウム及びＥＤＴＡ－４Ｎａは医薬部外品添加物認可品であるため、本発明に係る除菌液を医薬部外品として市場に流通させることができる。 In addition, benzalkonium chloride is a quasi-drug approved product, and calcium hydroxide and EDTA-4Na are quasi-drug additive approved products. can be distributed to
以下、１トンの除菌液を生成する場合の各成分の量を示す。
（１）水（水道水又は精製水：純水）：１０００Ｌ＝１０００ｋｇ
（２）水酸化カルシウム飽和水溶液：２５℃において水の重量の０．１７４％＝１．７４ｋｇ
（３）ＥＤＴＡ－４Ｎａ：水酸化カルシウムを炭酸カルシウムに換算した試算値から量を計算する。
ＥＤＴＡ－４Ｎａのキレート価は２６８ｍｇＣａＣＯ３／ｇであるため、水酸化カルシウムを炭酸カルシウムの量に換算すると、
１．７４ｋｇ（キレートする量）÷７４．１（水酸化カルシウムの分子量）×１００．１（炭酸カルシウムの分子量）＝２．３５ｋｇ
水酸化カルシウムを炭酸カルシウムに換算した上記値をキレート価で割ると、
２．３５ｋｇ÷０．２６８＝８．７７ｋｇ
よって、ＥＤＴＡ－４Ｎａの量は８．７７ｋｇとなる。
（４）塩化ベンザルコニウム：１００％溶液 ５００ｇ
Below, the amount of each component when producing 1 ton of the sterilizing solution is shown.
(1) Water (tap water or purified water: pure water): 1000 L = 1000 kg
(2) Saturated aqueous solution of calcium hydroxide: 0.0% of the weight of water at 25°C . 1 74% = 1.74kg
(3) EDTA-4Na: Calculate the amount from a trial calculation of calcium hydroxide converted to calcium carbonate.
Since the chelate value of EDTA-4Na is 268 mgCaCO3/g, when calcium hydroxide is converted to the amount of calcium carbonate,
1.74 kg (amount to be chelated) ÷ 74.1 (molecular weight of calcium hydroxide) × 100.1 (molecular weight of calcium carbonate) = 2.35 kg
Dividing the above value obtained by converting calcium hydroxide to calcium carbonate by the chelate value,
2.35kg/0.268=8.77kg
Therefore, the amount of EDTA-4Na is 8.77 kg.
(4) Benzalkonium chloride: 500 g of 100% solution
Claims (4)
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009007326A (en) * | 2007-05-25 | 2009-01-15 | Rohto Pharmaceut Co Ltd | Flunisolide-containing composition for mucosal application |
| JP2009221177A (en) * | 2008-03-18 | 2009-10-01 | Andes Denki Kk | Antibacterial-and-antifungal composition and applied goods thereof |
| JP2017122229A (en) * | 2011-06-02 | 2017-07-13 | エコラボ ユーエスエー インコーポレイティド | Use of glycerin short-chain aliphatic ether compounds |
| CN110915804A (en) * | 2019-12-20 | 2020-03-27 | 苏州市科渠金属制品有限公司 | Organic dye mildew preventive |
| KR102200507B1 (en) * | 2019-12-11 | 2021-01-08 | 주식회사 아워홈 | Composition for Antiviral disinfectants |
-
2021
- 2021-03-08 JP JP2021036732A patent/JP2022136905A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009007326A (en) * | 2007-05-25 | 2009-01-15 | Rohto Pharmaceut Co Ltd | Flunisolide-containing composition for mucosal application |
| JP2009221177A (en) * | 2008-03-18 | 2009-10-01 | Andes Denki Kk | Antibacterial-and-antifungal composition and applied goods thereof |
| JP2017122229A (en) * | 2011-06-02 | 2017-07-13 | エコラボ ユーエスエー インコーポレイティド | Use of glycerin short-chain aliphatic ether compounds |
| KR102200507B1 (en) * | 2019-12-11 | 2021-01-08 | 주식회사 아워홈 | Composition for Antiviral disinfectants |
| CN110915804A (en) * | 2019-12-20 | 2020-03-27 | 苏州市科渠金属制品有限公司 | Organic dye mildew preventive |
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