JP2022132558A - ゴニオトキシンのネオサキシトキシンへの分取スケール変換 - Google Patents

ゴニオトキシンのネオサキシトキシンへの分取スケール変換 Download PDF

Info

Publication number
JP2022132558A
JP2022132558A JP2022115732A JP2022115732A JP2022132558A JP 2022132558 A JP2022132558 A JP 2022132558A JP 2022115732 A JP2022115732 A JP 2022115732A JP 2022115732 A JP2022115732 A JP 2022115732A JP 2022132558 A JP2022132558 A JP 2022132558A
Authority
JP
Japan
Prior art keywords
neostx
toxins
neosaxitoxin
gtx1
saxitoxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022115732A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022132558A5 (https=
Inventor
イアン セルウッド、アンドリュー
Ian Selwood Andrew
ヒンケル、ルーロフ ファン
Van Ginkel Roelof
アラン ウォー、クレイグ
Alan Waugh Craig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cawthron Institute Trust Board
Original Assignee
Cawthron Institute Trust Board
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2018/057274 external-priority patent/WO2020058750A1/en
Application filed by Cawthron Institute Trust Board filed Critical Cawthron Institute Trust Board
Publication of JP2022132558A publication Critical patent/JP2022132558A/ja
Publication of JP2022132558A5 publication Critical patent/JP2022132558A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C12N1/125—Unicellular algae isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/02—Photobioreactors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/14—Bags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/22—Transparent or translucent parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/89—Algae ; Processes using algae

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2022115732A 2018-09-21 2022-07-20 ゴニオトキシンのネオサキシトキシンへの分取スケール変換 Pending JP2022132558A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/IB2018/057274 WO2020058750A1 (en) 2018-09-21 2018-09-21 A semisynthetic method of preparing neosaxitoxin
IBPCT/IB2018/057274 2018-09-21
PCT/IB2019/058019 WO2020058949A1 (en) 2018-09-21 2019-09-23 Preparative scale conversion of gonyautoxins to neosaxitoxin
JP2020567588A JP7110403B2 (ja) 2018-09-21 2019-09-23 ゴニオトキシンのネオサキシトキシンへの分取スケール変換

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2020567588A Division JP7110403B2 (ja) 2018-09-21 2019-09-23 ゴニオトキシンのネオサキシトキシンへの分取スケール変換

Publications (2)

Publication Number Publication Date
JP2022132558A true JP2022132558A (ja) 2022-09-08
JP2022132558A5 JP2022132558A5 (https=) 2023-05-02

Family

ID=81000600

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022115732A Pending JP2022132558A (ja) 2018-09-21 2022-07-20 ゴニオトキシンのネオサキシトキシンへの分取スケール変換

Country Status (3)

Country Link
EP (1) EP3853231A4 (https=)
JP (1) JP2022132558A (https=)
CN (1) CN117964629A (https=)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012521408A (ja) * 2009-03-24 2012-09-13 プロテウス エセ．ア． 生物学的に活性な藻類毒素の工業的精製法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012521408A (ja) * 2009-03-24 2012-09-13 プロテウス エセ．ア． 生物学的に活性な藻類毒素の工業的精製法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10, JPN6021051347, 2000, pages 1787 - 1789, ISSN: 0005489205 *
SUZUKI,T. ET AL., MARINE AND FRESH-WATER HARMFUL ALGAE PROCEEDINGS OF THE 16TH INTERNATIONAL CONFERENCE ON HARMFUL A, JPN6021051349, 2014, pages 34 - 39, ISSN: 0005489204 *
TOXINS, vol. 8, no. 11, JPN6021051345, 2016, ISSN: 0005489206 *
天然有機化合物討論会講演要旨集, vol. 41, JPN6021051342, 1999, pages 403 - 408, ISSN: 0005489207 *

Also Published As

Publication number Publication date
EP3853231A1 (en) 2021-07-28
CN117964629A (zh) 2024-05-03
EP3853231A4 (en) 2022-05-11

Similar Documents

Publication Publication Date Title
JP7110403B2 (ja) ゴニオトキシンのネオサキシトキシンへの分取スケール変換
Höger et al. Analytical and functional characterization of microcystins [Asp3] MC-RR and [Asp3, Dhb7] MC-RR: consequences for risk assessment?
CA2754154C (en) Method for the industrial purification of biologically active phycotoxins
O’Brien et al. Improving yields of deuterated, methyl labeled protein by growing in H2O
CN104276973B (zh) 一种羟基肉桂酸胺类生物碱及其制备和应用
JP2022132558A (ja) ゴニオトキシンのネオサキシトキシンへの分取スケール変換
AU2026201265A1 (en) Preparative scale conversion of gonyautoxins to neosaxitoxin
CN106795207B (zh) 芋螺毒素多肽κ-CPTx-bt105、其制备方法及应用
US12018034B2 (en) Semisynthetic methods of preparing GTX1,4 and neosaxitoxin
US20230145895A1 (en) Preparation of neosaxitoxin
CN109206486B (zh) 一种硫酸多黏菌素b的杂质及其制备方法
US20250019384A1 (en) Preparation of neosaxitoxin
Mosin et al. Studying the influence of heavy and deuterium depleted types of water on biological objects
RU2408576C2 (ru) СПОСОБ ПОЛУЧЕНИЯ ИНДИВИДУАЛЬНЫХ Nε-НИТРОЗО- Nε-[(2-ХЛОРЭТИЛ)КАРБАМОИЛ]-L-ЛИЗИНА И Nε-[(2-ХЛОРЭТИЛ)-N-НИТРОЗОКАРБАМОИЛ]-L-ЛИЗИНА
Rodriguez et al. Bioactivity-Guided Isolation of Putative Bioactive Peptides from Bacillus spizizenii ATCC 6633
WO2016049864A1 (zh) 芋螺毒素多肽κ-CPTx-btl01、其制备方法及应用
CN107949567B (zh) 三种芋螺毒素肽、其制备方法及应用
Mosin et al. Research the Influence of Deuterium Depleted and Heavy Types of Water on Biological Objects
Liu et al. On the isomerisation of cefozopran in solution
RU2451024C1 (ru) Анализ арг-х протеолиза и его ингибирования в негистоновых и гистоновых белках супрамолекулярных структур клеточных ядер растений
Li et al. Simultaneous RP-HPLC determination of six platycosides: Application to an enzymatic preparation study
CN103374057A (zh) 一种对甘氨酸转运子具有抑制活性的新化合物

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220921

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230421

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230919

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20231213

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240318

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20240521

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240918

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20240918

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20241108