JP2022110125A - 炎症メディエーターのレベルを低減するための組成物及び方法 - Google Patents
炎症メディエーターのレベルを低減するための組成物及び方法 Download PDFInfo
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Abstract
Description
Claims (8)
- 結合組織における一種かそれ以上の炎症メディエーターのレベルを低減するために構成された組成物であって、これを必要とする対象動物の結合組織における一種かそれ以上の炎症メディエーターのレベルを低減する量でヒドロキシチロソールおよび3-O-アセチル-11-ケト-β-ボスウェリン酸が相乗的に作用する組み合わせであることを特徴とする組成物。
- 前記一種かそれ以上の炎症メディエーターが腫瘍壊死因子α、プロスタグランジンE2、シクロオキシゲナーゼ-2、および一酸化窒素からなる群から選択される請求項1に記載の組成物。
- 前記ヒドロキシチロソール源がオリーブ抽出物、オリーブの木から得られる生成物、又はオリーブの木から得られる副生物のうちの少なくとも一つであり、
前記3-O-アセチル-11-ケト-β-ボスウェリン酸源がBoswellia serrata抽出物である請求項1又は2に記載の組成物。
- 哺乳類又は鳥類を対象として経口投与用に配合した請求項1~3のいずれか一項に記載の組成物。
- 結合組織における一種かそれ以上の炎症メディエーターのレベルを低減させる方法であって、
これを必要とする対象動物に対しその結合組織における一種かそれ以上の炎症メディエーターのレベルを低減する量でヒドロキシチロソールおよび3-O-アセチル-11-ケト-β-ボスウェリン酸が相乗的に作用する組み合わせで併用された組成物を投与することを特徴とする方法。
- 前記の一種かそれ以上の炎症メディエーターを腫瘍壊死因子α、プロスタグランジンE2、シクロオキシゲナーゼ-2、および一酸化窒素からなる群から選択する請求項5に記載の方法。
- 前記ヒドロキシチロソール源がオリーブ抽出物、オリーブの木から得られる生成物、又はオリーブの木から得られる副生物のうちの少なくとも一つであり、
前記3-O-アセチル-11-ケト-β-ボスウェリン酸源がBoswellia serrata抽出物である請求項5又は6に記載の方法。
- 哺乳類又は鳥類を対象として経口投与用に配合した組成物を投与する請求項5~7のいずれか一項に記載の方法。
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PCT/US2017/028857 WO2018067200A1 (en) | 2016-10-04 | 2017-04-21 | Compositions comprising hydroxytyrosol and boswellic acid |
JP2019516976A JP7079551B2 (ja) | 2016-10-04 | 2017-04-21 | ヒドロキシチロソールおよびボスウェリン酸を有する組成物 |
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EP1315691B2 (en) | 2000-09-01 | 2017-09-13 | Creagri, Inc. | Method of obtaining a hydroxytyrosol-rich composition from vegetation water |
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EP1582512A1 (en) | 2004-03-31 | 2005-10-05 | Cognis IP Management GmbH | Process for obtaining hydroxytyrosol from olive leaves extracts |
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US9101599B2 (en) * | 2008-09-15 | 2015-08-11 | Laila Nutraceuticals | Synergistic anti-inflammatory compositions comprising Boswellia serrata extracts |
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CA2892375A1 (en) * | 2012-11-30 | 2014-06-05 | Darlene E. MCCORD | Hydroxytyrosol and oleuropein compositions for induction of dna damage, cell death and lsd1 inhibition |
EP3522874A1 (en) | 2016-10-04 | 2019-08-14 | Nutramax Laboratories, Inc. | Compositions comprising hydroxytyrosol and boswellic acid |
US10342802B2 (en) | 2016-10-04 | 2019-07-09 | Nutramax Laboratories, Inc. | Compositions comprising hydroxytyrosol and boswellic acid |
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