JP2022095067A - Liquid detergent composition for viruses - Google Patents

Abstract

To provide a liquid detergent composition for viruses that is excellent in antiviral effects and low temperature stability.SOLUTION: A liquid detergent composition for viruses, contains: (A) component: a linear alkylbenzenesulfonic acid or its salt; (B) component: a polyoxyalkylene alkyl ether sulfate or its salt; and (C) component: a nonionic surfactant represented by the following general formula (c), wherein a mass ratio ((A)/(B)) of the content of the (A) component to the content of the (B) component is 0.8 or greater, and the pH at 30°C is 8 or higher. R11-O-[(EO)s/( (A11O)t]-(EO)u -R12...(c) (In the general formula (c), R11 is a C8-22 hydrocarbon group, R12 is a hydrogen atom, a C1-6 alkyl group or a C2-6 alkenyl group, EO is an oxyethylene group, s is 3 to 25, A11O is at least one of PO (oxypropylene group) and BO (oxybutylene group), t is 0 to 6, and u is 0 to 20).SELECTED DRAWING: None

Description

The present invention relates to a liquid detergent composition for a virus, which is excellent in anti-virus effect (virus inactivating effect) and excellent in low temperature stability.

In recent years, viral infections have become a problem throughout the year. Even if you intend to remove the virus, the virus that could not be completely removed may float in the air and infect the virus that remains active.

At home, in order to prevent infection with influenza virus and coronavirus, it is effective to remove the virus and inactivate the virus in textile products in addition to washing hands. Surfactants such as alkylbenzene phonic acid-based surfactants are known to have an antiviral effect against viruses (Patent Documents 1 and 2), but at the same time, improvement in detergency is also required.
The present inventors have achieved antiviral effect and detergency by using linear alkylbenzene phonic acid in combination with polyoxyalkylene alkyl (alkenyl) ether sulfate ester or a salt thereof, and by setting the washing liquid at the time of washing to the alkaline side. We found that both were possible, but on the other hand, it was found that the low temperature stability was reduced. Therefore, by further blending a specific polyoxyalkylene type nonionic surfactant, the problem of low temperature stability could be solved.

Japanese Unexamined Patent Publication No. 2017-218516 Japanese Unexamined Patent Publication No. 2020-040907

Therefore, it is an object of the present invention to provide a liquid detergent composition for a virus, which is excellent in antiviral effect and excellent in low temperature stability.

The present invention has the following aspects.
[1]
(A) Component: Linear alkylbenzene sulfonic acid or a salt thereof, and
(B) Component: Polyoxyalkylene alkyl ether sulfuric acid or a salt thereof,
Ingredient (C): A nonionic surfactant represented by the following general formula (c) and
Contains,
The mass ratio ((A) / (B) ratio) represented by the content of the component (A) to the content of the component (B) is 0.8 or more, and the pH at 30 ° C. is 8 or more. , Liquid detergent composition for viruses R ¹¹ -O- [(EO) _s / (A ¹¹ O) _t ]-(EO) _u -R ¹² ... (c)
(In the general formula (c), R ¹¹ is a hydrocarbon group having 8 to 22 carbon atoms. R ¹² is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkenyl group having 2 to 6 carbon atoms. EO. Is an oxyethylene group. S is a number of 3 to 25 indicating the average number of repetitions of EO. A ¹¹ O represents at least one of PO (oxypropylene group) and BO (oxybutylene group). T represents A ¹¹ It is a number of 0 to 6 indicating the average number of repetitions of O. U is a number of 0 to 20 indicating the average number of repetitions of EO.)

According to the present invention, it is possible to provide a liquid detergent composition for a virus having excellent antiviral effect and excellent low temperature stability.

<Ingredient (A)>
The component (A) is a linear alkylbenzene sulfonic acid and / or a salt thereof.
The component (A) is a component exhibiting an antiviral effect. In addition, the detergency can be improved by using the component (A) and the component (B) described later in combination.

The linear alkylbenzene sulfonic acid preferably has a linear alkyl group having 8 to 18 carbon atoms, and more preferably 10 to 15 carbon atoms.

Examples of the salt of the linear alkylbenzene sulfonic acid include alkali metal salts such as sodium salt and potassium salt; alkaline earth metal salts such as calcium salt and magnesium salt; ammonium salt; alkanolamine salt such as monoethanolamine and diethanolamine. Be done. In particular, sodium salts are preferable because they can easily obtain a thickening effect.

Examples of the component (A) include linear alkyl (10 to 14 carbon atoms) benzenesulfonic acid and sodium salts thereof. Further, as a commercially available product of the component (A), "Rypon LH-200" manufactured by Lion Corporation and the like can be mentioned.

The component (A) may be used alone or in combination of two or more.

The content of the component (A) is preferably 1 to 20% by mass, more preferably 4.5 to 13.5% by mass, still more preferably 8 to 10% by mass, based on the total mass of the liquid detergent composition. .. If it is at least the above lower limit, the virus inactivating effect is excellent. On the other hand, if it is not more than the upper limit, the appearance stability is excellent.
<Ingredient (B)>
The component (B) is polyoxyalkylene alkyl ether sulfuric acid or a salt thereof.

Examples of the polyoxyalkylene alkyl ether sulfate include the compound (B) represented by the following formula (b).

R ²¹ -O- [(EO) _k / (PO) _n ] -SO ₃ ^- M ⁺ ... (b)
In formula (b), R ²¹ is a linear or branched alkyl group having 8 to 20 carbon atoms, EO is an oxyethylene group, PO is an oxypropylene group, and k is the average of EO. It represents the number of repetitions, is a number of 0 or more, n represents the average number of repetitions of PO, is a number of 0 to 6, and M ⁺ is a counter cation.

R ²¹ is preferably a straight-chain or branched-chain alkyl group having 10 to 20 carbon atoms, and more preferably a straight-chain or branched-chain alkyl group having 12 to 14 carbon atoms.

k is preferably 0 to 5, more preferably 0.5 to 5, still more preferably 0.5 to 4, particularly preferably 0.5 to 3.5, and most preferably 1.5 to 2.5.
n is preferably 0 to 3, more preferably 0.
k + n is preferably 0.5 or more, more preferably 0.5 to 5.
(B) When the component has both EO and PO, the EO and PO may be added in a block shape or may be added in a random shape. Examples of the method of adding EO and PO in a block shape include a method of introducing ethylene oxide and then introducing propylene oxide, and a method of introducing propylene oxide and then introducing ethylene oxide. The distribution of the number of added moles of ethylene oxide and propylene oxide is not particularly limited.

Examples of the salt include alkali metal salts with sodium, potassium and the like, alkanolamine salts with monoethanolamine, diethanolamine and the like.

As the component (b), a commercially available product may be used, or a known synthetic method may be used for production. When produced by a known synthetic method, it can be produced by reacting polyoxyalkylene alkyl ether with anhydrous sulfuric acid or by reacting with chlorsulfonic acid.

The component (B) contained in the liquid detergent composition may be one kind or two or more kinds.

The content of the component (B) is preferably 1 to 20% by mass, more preferably 2 to 13.5% by mass, more preferably 6 to 12% by mass, and 8 to 8 to the total mass of the liquid detergent composition. 10% by mass is more preferable. When it is at least the lower limit of the above range, the cleaning performance is high and the virus inactivating effect is high.
<Ingredient (C)>
The component (C) is a nonionic surfactant represented by the following general formula (c) (hereinafter, also referred to as “compound (C)”). The compound represented by the following general formula (c) is a polyoxyalkylene type nonionic surfactant.

R ¹¹ -O-[(EO) _s / (A ¹¹ O) _t ]-(EO) _u -R ¹² ... (c)
(In the general formula (c), R ¹¹ is a hydrocarbon group having 8 to 22 carbon atoms. R ¹² is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkenyl group having 2 to 6 carbon atoms. EO. Is an oxyethylene group. S is a number of 3 to 25 indicating the average number of repetitions of EO. A ¹¹ O represents at least one of PO (oxypropylene group) and BO (oxybutylene group). T represents A ¹¹ It is a number of 0 to 6 indicating the average number of repetitions of O. U is a number of 0 to 20 indicating the average number of repetitions of EO.)
In the general formula (c), the hydrocarbon group of R ¹¹ has 8 to 22 carbon atoms, preferably 10 to 18 and more preferably 12 to 18. The hydrocarbon group of R ¹¹ is a straight chain or a branched chain. Further, the hydrocarbon group of R ¹¹ may or may not have an unsaturated bond.

The carbon atom of R ¹¹ bonded to —O— may be a primary carbon atom or a secondary carbon atom.

When R ¹² is an alkyl group, the number of carbon atoms is 1 to 6, preferably 1 to 3.

When R ¹² is an alkenyl group, the number of carbon atoms is 2 to 6, preferably 2 to 3.

A hydrogen atom is particularly preferable for R ¹² .

s is 3 to 25, preferably 5 to 25, more preferably 7 to 20, and even more preferably 7 to 18.

t is 0 to 6, preferably 0 to 3.

u is 0 to 20, preferably 0 to 15, and more preferably 0 to 10.

s + u is preferably 3 to 30, more preferably 5 to 25, still more preferably 5 to 20, particularly preferably 7 to 20, and most preferably 7 to 18.

If t is non-zero, that is, if compound (C) has EO and PO, EO and BO, or EO and PO and BO, then EO and PO, EO in [(EO) _s / (A ¹¹ O) _t ] The distribution of EO, PO, and BO (in the order of arrangement) is not particularly limited, and these may be arranged in a block shape or randomly. Further, EO may be bound to "R ¹¹ -O-", or PO or BO may be bound to "R ¹¹ -O-". However, if u is not 0, it is A ¹¹ O, ie PO or BO, that binds to − (EO) _u at the end of [(EO) _s / (A ¹¹ O) _t ].

If t is non-zero, compound (C) preferably has EO and PO, or EO and BO.
The content of the component (C) is preferably 1 to 20% by mass, more preferably 3 to 13.5% by mass, still more preferably 4.5 to 6% by mass, based on the total mass of the liquid detergent composition. If it is at least the above lower limit, the cleaning performance is excellent. On the other hand, if it is not more than the upper limit, the sebum cleaning performance is excellent.
The mass ratio represented by the content of the component (A) to the content of the component (B) (hereinafter, also referred to as “(A) / (B) ratio”) is preferably 0.8 or more, and is 0.8. ~ 3 is preferable, 0.9 to 2 is more preferable, and 1 to 1.25 is even more preferable. Within the above range, the virus inactivating effect and the cleaning performance are excellent.
The mass ratio represented by the content of the component (A) to the content of the component (C) (hereinafter, also referred to as “(A) / (C) ratio”) is preferably 0.3 to 4.5. 1.7 to 2.7 is more preferable, and 2 to 2.5 is even more preferable.
Within the above range, the virus inactivating effect and the cleaning performance are excellent.
The mass ratio represented by the content of the component (C) to the content of the component (B) (hereinafter, also referred to as “(C) / (B) ratio”) is preferably 0.2 to 7, and 0. 3 to 3 is more preferable, and 0.4 to 1 is even more preferable. If it is within the above range, the cleaning performance is excellent.
The content of the total surfactant containing the component (A), the component (B) and the component (C) is preferably 5 to 45% by mass, preferably 15 to 30% by mass, based on the total mass of the liquid detergent composition. More preferably, 20 to 25% by mass is further preferable. If it is within the above range, the cleaning performance is excellent.
(PH)
The pH of the liquid detergent composition at 30 ° C. is 8 or more, preferably 8 to 11, more preferably 8.5 to 11, still more preferably 9 to 11, and particularly preferably 9.5 to 11. Within the above range, the detergency of the component (A) and the component (B) is improved. Further, the low temperature stability due to the component (C) can be improved.
The pH of the washing liquid at 30 ° C. is preferably 7 to 11, more preferably 8 to 11, and even more preferably 9 to 11. When the pH of the washing liquid is at least the above lower limit, the washing performance is excellent. When the pH of the washing liquid is not more than the above upper limit value, damage to clothes can be prevented.
The above-mentioned washing liquid means one obtained by dissolving or dispersing the liquid detergent composition in a solvent such as water at the time of washing.

The pH of the liquid detergent composition and the washing liquid can be adjusted by adding a pH adjuster, if necessary.

The pH in the present specification is a value measured by a pH meter (manufactured by DKK-TOA CORPORATION, product name "HM-30G") with a measurement target of 30 ° C.
A pH adjuster is preferable as the pH to be 8 or more.
Examples of the pH adjuster include sodium carbonate, potassium carbonate, sodium hydrogencarbonate, potassium hydrogencarbonate, sodium sesquicarbonate, sodium hydroxide, potassium hydroxide, alkanolamine (for example, monoethanolamine, diethanolamine, triethanolamine, etc.) and the like. Be done. Among these, sodium carbonate, sodium hydroxide, sodium hydrogencarbonate, and alkanolamine are preferable from the viewpoint of pH improving performance in the washing liquid and ease of handling during production. The pH adjuster may be one kind or two or more kinds.
The content of the pH adjuster may be an appropriate amount so as to have a pH of 8 or more at 30 ° C.
When sodium carbonate is blended, it is preferably 0.5 to 5% by mass, more preferably 1 to 2.5% by mass, based on the total mass of the liquid detergent composition. If it is at least the above lower limit, the cleaning performance is excellent. On the other hand, if it is not more than the upper limit, the low temperature stability is excellent.
When sodium hydrogen carbonate is blended, it is preferably 0.5 to 2.5% by mass, more preferably 1 to 1.5% by mass, based on the total mass of the liquid detergent composition. If it is at least the above lower limit, the cleaning performance is excellent. On the other hand, if it is not more than the upper limit, the low temperature stability is excellent.
When alkanolamine is blended, it is preferably 0.1 to 1% by mass, more preferably 0.3 to 0.7% by mass, based on the total mass of the liquid detergent composition. If it is at least the above lower limit, it is possible to prevent the pH from dropping during storage. On the other hand, if it is not more than the upper limit, the appearance stability is excellent.
The water content is preferably 45 to 80% by mass, more preferably 50 to 80% by mass, still more preferably 65 to 75% by mass, based on the total mass of the liquid detergent composition.
<Arbitrary ingredient>
In addition to the above components (A) to (C), components known in the field of liquid detergents may be contained as optional components.

As optional components, for example, surfactants other than the components (A) to (C), hydrotropic agents, organic acids, defoaming agents, metal ion trapping agents (chelating agents), enzymes, alkaline agents, antioxidants, etc. Preservatives, antibacterial agents, texture improvers, stain transfer inhibitors, anticontamination agents, pearl agents, soil release agents, dispersants, flavoring agents, colorants, emulsifying agents, fluorescent agents, extracts and the like can be mentioned. ..
Surfactants other than the components (A) to (C) include anionic surfactants other than the components (A) and (B), nonionic surfactants other than the component (C), cationic surfactants, and amphoteric interfaces. Examples thereof include activators and semi-polar surfactants.
Examples of the anionic surfactant other than the component (A) and the component (B) include a non-soap-based anionic surfactant and a higher fatty acid or a salt thereof.

Examples of the non-soap-based anionic surfactant include α-olefin sulfonic acid or a salt thereof (AOS), a linear or branched alkyl sulfate ester or a salt thereof (AS), an alkane sulfonic acid having an alkyl group, or The salt, α-sulfo fatty acid ester or salt thereof, internal olefin sulfonic acid or salt thereof (IOS), hydroxyalkane sulfonic acid or salt thereof (HAS), alkyl ether carboxylic acid or salt thereof, polyoxyalkylene ether carboxylic acid or salt thereof. Carboxy acid type anionic surfactants such as salts, alkylamide ether carboxylic acids or salts thereof, alkenylamide ether carboxylic acids or salts thereof, acylaminocarboxylic acids or salts thereof; alkyl phosphate esters or salts thereof, polyoxyalkylene alkyllin Examples thereof include a phosphate ester type anionic surfactant such as an acid ester or a salt thereof, a polyoxyalkylene alkylphenyl phosphate ester or a salt thereof, a glycerin fatty acid ester monophosphate ester or a salt thereof.

Examples of the salt form of the non-soap anionic surfactant include alkali metal salts (sodium salt, potassium salt, etc.), alkaline earth metal salts (magnesium salt, etc.), alkanolamine salts (monoethanolamine salt, diethanolamine salt, etc.). ) And so on.

These non-soap-based anionic surfactants may be used alone or in combination of two or more.

The "higher fatty acid" is a fatty acid having 8 to 22 carbon atoms. By containing the higher fatty acid or a salt thereof, the liquid detergent composition can be enhanced in rinsability. By increasing the rinsability, the number of rinsing treatments after the cleaning treatment can be reduced.

When a higher fatty acid or a salt thereof is blended, the liquid stability tends to decrease. Liquid stability can be improved by setting the pH of the liquid detergent composition to more than 7.

As the higher fatty acid, a chain monocarboxylic acid having 8 to 18 carbon atoms is preferable.

The higher fatty acid is represented by the following general formula (i).

R ³¹ -COOH ... (i)
(In the general formula (i), R ³¹ is an aliphatic hydrocarbon group having 7 to 17 carbon atoms.)
In the general formula (i), the aliphatic hydrocarbon group of R ³¹ may be linear or branched. As R ³¹ , a linear or branched alkyl group and a linear or branched alkenyl group are preferable.

The carbon number of R ³¹ is 7 to 17, preferably 11 to 17. When the number of carbon atoms of R ³¹ is equal to or higher than the above lower limit, the effect of preventing recontamination is enhanced. When the number of carbon atoms of R ³¹ is not more than the above upper limit value, the solubility in water is enhanced.

Examples of the salt form in the higher fatty acid salt include an alkali metal salt, an alkaline earth metal salt, an amine salt, an ammonium salt and the like. Examples of the alkali metal salt include sodium salts and potassium salts. Examples of the alkaline earth metal salt include calcium salt and magnesium salt. Examples of the amine salt include alkanolamine salts (monoethanolamine salt, diethanolamine salt, triethanolamine salt, etc.) and the like.

These higher fatty acids or salts thereof may be used alone or in combination of two or more.

Further, the higher fatty acid or a salt thereof may be a mixture having a single chain length or a mixture having two or more chain lengths.

The higher fatty acid or a salt thereof preferably contains coconut fatty acid or a salt thereof.
The content of the higher fatty acid or a salt thereof is preferably 2% by mass or more, more preferably 2.5% by mass or more, based on the total mass of the liquid detergent composition. Further, it is preferably 10% by mass or less, more preferably 7% by mass or less, based on the total mass of the liquid detergent composition. That is, the content of the higher fatty acid or a salt thereof is preferably 2 to 10% by mass, more preferably 2.5 to 7% by mass, based on the total mass of the liquid detergent composition. When the content of the higher fatty acid or a salt thereof is at least the above lower limit, the rinsability is improved.
Examples of the nonionic surfactant other than the component (C) include polyoxyethylene fatty acid methyl ester, an alkylene oxide adduct such as a fatty acid having 8 to 22 carbon atoms or an amine having 8 to 22 carbon atoms, a fatty acid alkanolamine, and a fatty acid alkanol. Examples thereof include amides, polyhydric alcohol fatty acid esters or alkylene oxide adducts thereof, polyhydric alcohol fatty acid ethers, alkylene oxide adducts of hardened castor oil, sugar fatty acid esters, N-alkyl polyhydroxy fatty acid amides, and alkyl glycosides. These nonionic surfactants may be used alone or in combination of two or more.
The polyoxyethylene fatty acid methyl ester is a compound represented by the following general formula (ii).
R ⁴¹ -CO-[(EO) _s / (AO) _t ]-(EO) _u -R ⁴² ... (ii)
In formula (ii), R ⁴¹ is a hydrocarbon group having 7 to 21 carbon atoms, and R ⁴² is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or an alkenyl group having 2 to 6 carbon atoms.
EO is an oxyethylene group, and s is a number of 3 to 25 indicating the average number of EO repetitions.
AO is at least one of PO (oxypropylene group) or BO (oxybutylene group), and t is a number of 0 to 6 indicating the average number of repetitions of AO. u represents the average number of repetitions of EO, and is a number from 0 to 20.
When t is 1 or more, in [(EO) _s / (AO) _t ], the sequence order of EO and AO is not limited except that the terminal is not EO, and may be random polymerization or block polymerization. In the case of block polymerization, three or more blocks may be arranged.
In formula (ii), the hydrocarbon group of R ⁴¹ has 9 to 21 carbon atoms, preferably 9 to 19, and more preferably 9 to 17. The hydrocarbon group may be a straight chain or a branched chain. Further, it may or may not have an unsaturated bond. R ⁴¹ is preferably a straight chain or branched chain alkyl group.
When R ⁴² is an alkyl group, the number of carbon atoms is 1 to 6, preferably 1 to 3. When R ⁴² is an alkenyl group, the number of carbon atoms is 2 to 6, preferably 2 to 3.
s is 3 to 25, preferably 5 to 18, more preferably 10 to 18, and particularly preferably 12 to 18. t is 0 to 6, preferably 0 to 3. u is 0 to 20, preferably 0 to 10. s + u is preferably 3 to 25, more preferably 10 to 20, and particularly preferably 12 to 18.
Mass ratio represented by "total content of nonionic surfactant containing (C) component" to "total content of non-soap-based anionic surfactant containing (A) component and (B) component" (hereinafter, The ratio of "non-soap-based anionic surfactant containing (A) component and (B) component" / "nonionic surfactant containing (C) component") is preferably 0.1 to 9 and 2 to 2. 7 is more preferable, and 3 to 5 is even more preferable. Within the above range, the virus inactivating effect and the cleaning performance are excellent.

Examples of the cationic surfactant include caprylic acid dimethylaminopropylamide, capric acid dimethylaminopropylamide, lauric acid dimethylaminopropylamide, myristic acid dimethylaminopropylamide, palmitic acid dimethylaminopropylamide, stearate dimethylaminopropylamide, and the like. Long-chain aliphatic amide alkyl tertiary amines such as behenic acid dimethylaminopropylamide and oleic acid dimethylaminopropylamide or salts thereof; aliphatic ester alkyl tertiary amines such as palmitate ester propyldimethylamine and stearate ester propyldimethylamine. Or a salt thereof; examples thereof include palmitate diethanolaminopropylamide and stearate diethanolaminopropylamide.

Examples of the salt form of the cationic surfactant include alkali metal salts (sodium salt, potassium salt, etc.), alkaline earth metal salts (magnesium salt, etc.), alkanolamine salts (monoethanolamine salt, diethanolamine salt, etc.), and the like. Can be mentioned.

These cationic surfactants may be used alone or in combination of two or more.

When the cationic surfactant is contained, the content of the cationic surfactant is preferably 0.1 to 10% by mass, more preferably 1 to 5% by mass, based on the total mass of the liquid detergent composition.

Examples of the amphoteric surfactant include an alkyl betaine type, an alkylamide betaine type, an imidazoline type, an alkylaminosulfone type, an alkylaminocarboxylic acid type, an alkylamide carboxylic acid type, an amide amino acid type, and a phosphoric acid type amphoteric surfactant. Can be mentioned.

These amphoteric surfactants may be used alone or in combination of two or more.
When the amphoteric surfactant is contained, the content of the amphoteric surfactant is preferably 0.1 to 10% by mass, more preferably 1 to 5% by mass, based on the total mass of the liquid detergent composition.

Examples of the semi-polar surfactant include alkylamine oxides and alkylamide propyldimethylamine oxides.

These semi-polar surfactants may be used alone or in combination of two or more.

When the semi-polar surfactant is contained, the content of the semi-polar surfactant is preferably 0.1 to 10% by mass, more preferably 1 to 5% by mass, based on the total mass of the liquid detergent composition.
Examples of the hydrotropic agent include monohydric alcohols having 2 to 4 carbon atoms, polyhydric alcohols having 2 to 4 carbon atoms, glycol ether solvents, polyol compounds, alcohols having a methoxy group, alcohols having a phenyl group, and sugar alcohols. , Organic acid salts having a sulfonic acid group and the like.
Examples of the monohydric alcohol having 2 to 4 carbon atoms include ethanol, 1-propanol, 2-propanol, 1-butanol and the like.

Examples of the polyhydric alcohol having 2 to 4 carbon atoms include ethylene glycol, propylene glycol, butylene glycol, dipropylene glycol, isoprene glycol, 1,3-butylene glycol and the like.
Examples of the glycol ether-based solvent include ethylene glycol monobutyl ether, ethylene glycol monohexyl ether, ethylene glycol monophenyl ether, propylene glycol monophenyl ether, diethylene glycol monomethyl ether, and diethylene glycol monobutyl ether (butyl carbitol).
Examples of the polyol compound include polyethylene glycol and the like.
Examples of alcohols having a methoxy group include 3-methoxybutanol, 3-methoxy-3-methylbutanol, 3-methoxy-3-ethylbutanol, 3-methoxy-3-propylbutanol, and 3-methoxy-. 2-Methoxybutanol, 3-methoxy-2-ethylbutanol, 3-methoxy-2-propylbutanol, 3-methoxy-1-methylbutanol, 3-methoxy-1-ethylbutanol, 3-methoxy- 1-propylbutanol, 3-methoxybutyl acetate, 3-methoxy-3-methylbutyl acetate, 3-methoxy-3-ethylbutyl acetate, 3-methoxy-3-propylbutyl acetate, 3-methoxy-2-methylbutyl Acetate, 3-methoxy-2-ethylbutyl acetate, 3-methoxy-2-propylbutyl acetate, 3-methoxy-1-methylbutyl acetate, 3-methoxy-1-ethylbutyl acetate, 3-methoxy-1-propylbutyl Examples include acetate.
Examples of the alcohol having a phenyl group include phenoxyethanol and phenoxyisopropanol.
Examples of the sugar alcohol include glycerin, diglycerin, polyglycerin, sorbitol, erythritol, xylitol, sorbitol (D-sorbitol), mannitol, maltitol, trehalose and the like.
Examples of the organic acid salt having a sulfonic acid group include cumene sulfonic acid or a salt thereof, paratoluene sulfonic acid or a salt thereof, and the like.
One of these solvents may be used alone, or two or more of them may be used in combination as appropriate. It is preferably 1 to 30% by mass with respect to the total mass of the liquid detergent composition.
Examples of the defoaming agent (excluding the nonionic surfactant other than the component (C)) include silicone, propylene oxide adduct of alcohol, fatty acid ester and the like.
Examples of the silicone include silicones such as dimethyl silicone, polyether-modified silicone, and amino-modified silicone. Examples of these silicones include oil type, oil compound type, solution type, emulsion type, self-emulsifying type and the like. These texture improvers may be used alone or in combination of two or more. It is preferably 0.001 to 20% by mass with respect to the total mass of the liquid detergent composition.
Examples of the propylene oxide adduct of alcohol include monoalcohols such as methanol, ethanol, propanol, butanol, pentanol, hexanol, heptanol and octanol with propylene oxide added; diols such as ethanediol and triols such as glycerin. , Tetraol such as erythritol, and polyhydric alcohols such as hexaol such as sorbitol with propylene oxide added. The weight average molecular weight of the propylene oxide adduct of alcohol is preferably 2500 to 5500, more preferably 3000 to 5000. In the present specification, the weight average molecular weight is determined from the molecular weight distribution obtained by GPC (gel permeation chromatography) using polypropylene glycol (weight average molecular weight: 800, 1,200, 2,000, 4,000) as a standard. It is preferably 0.1 to 10% by mass with respect to the total mass of the liquid detergent composition.
Examples of the fatty acid ester include those represented by the following formula (IV).

X ²¹ -COO-Y ²¹ ... (IV)
In the formula, X ²¹ is a branched chain alkyl group having 5 to 21 carbon atoms or a linear alkyl group having 5 to 21 carbon atoms. When X ²¹ is a linear alkyl group, the carbon atom bonded to the carbon atom of the carbonyl group in the formula (IV) is a secondary carbon atom. Y ²¹ is an alkyl group having 3 to 16 carbon atoms or − (R ³¹ O) _m1 −R ³² . R ³¹ is an alkylene group having 2 to 4 carbon atoms. m1 indicates the average number of repetitions of R ³¹ O and is 1 to 5. R ³² is an alkyl group, a phenyl group or a benzyl group having 1 to 16 carbon atoms. Specific examples of the fatty acid ester include 2-ethylhexyl 2-ethylhexanoate (also known as 2-ethylhexyl isooctylate, 2H08). It is preferably 0.01 to 5% by mass with respect to the total mass of the liquid detergent composition.
Examples of the metal ion trapping agent (chelating agent) include acetic acid, adipic acid, glycolic acid, diglycolic acid, monochloroacetic acid, oxydichuccinic acid, carboxymethyloxysuccinic acid, lactic acid, tartrate acid, oxalic acid, malic acid, gluconic acid, and carboxy. Carboacids of acids such as methylsuccinic acid, carboxymethyl tartrate acid or salts thereof; ethylenediaminetetraacetic acid (EDTA), triethylenetetraacetic acid (TTHA), methylglycine diacetic acid (MGDA), 1,3-propane-2-diamine tetra. Acetic acid (PDTA), hydroxyethylethylenediaminetriacetic acid (HEDTA), hydroxyethyliminodiacetic acid (HIDA), hydroxyiminodicosuccinic acid (HIDS), nitrilotriacetic acid (NTA), diethylenetriaminepentaacetic acid (DTPA), propylenediaminetetraacetic acid, Triethylenetetraaminehexaacetic acid, ethyleneglycoldietherdietherdiaminetetraacetic acid, ethylenediaminetetrapropionic acid, cyclohexane-1,2-diaminetetraacetic acid, iminodisuccinic acid, aspartate diacetic acid, β-alaninediacetic acid, hydroxyiminodicosuccinic acid, etc. Aminocarboxylic acids of acids or salts thereof; organic of acids such as 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), N, N, N', N'-tetrakis (phosphonomethyl) ethylenediamine (EDTMP) and salts thereof. Phosphoric acids and the like can be mentioned. Examples of the salt form of the chelating agent include sodium, potassium, calcium, magnesium and the like. These chelating agents may be used alone or in combination of two or more. It is preferably 0.001 to 10% by mass with respect to the total mass of the liquid detergent composition.
Examples of the enzyme include protease, amylase, lipase, cellulase, mannanase and the like. Here, "enzyme" means an enzyme preparation.
As proteases, Pr ogress Uno (registered trademark) 100L, Pr ogress Uno (registered trademark) 101L, Medley (registered trademark) Core210L, Savinase (registered trademark) 16L, Savenase Ultra 16L, which can be obtained from Novozymes as protease preparations. Ultra 16XL, Savenase Evity 16L, Everlase (registered trademark) 16L TypeEX, Everlase 16L, Everlase Ultra 16L, Esperase (registered trademark) 8L, Alcalase (registered trademark) 2.5L, Alcalase (registered trademark) 2.5L, Al .5L, Liquanase Ultra 2.5L, Liquanase Ultra 2.5XL, Coronase® 48L (all trademarks), Purefect® L, Purefect OX, Properase L (all trademarks) available from Genecore. ) And so on.
As amylase, Termamil® 300L, Termamyl Ultra 300L, Duramyl® 300L, Stainzyme® 12L, Steinzyme Plus 12L, Amylase (registered trademark) 12L, Steinzyme Plus 12L, which can be obtained from Novozymes as an amylase preparation. Prime 100L, Medley (registered trademark) Core210L (both trade names), Maxamyl (trade name) available from Genecore, Pluranase Amano (trade name) available from Amano Pharmaceutical Co., Ltd., and Biochemical Industry Co., Ltd. DB-250 (trade name) and the like can be mentioned.
Examples of the lipase include Lipex (registered trademark) 100L, Lipex Evity 100L, and Lipase (registered trademark) 100L (all of which are trade names) available from Novozymes as a lipase preparation.
Examples of the cellulase include Endolase (registered trademark) 5000L, Cellulizeme (registered trademark) 0.4L, Carzyme (registered trademark) 4500L (all trade names), which can be obtained from Novozymes as a cellulase preparation.
Examples of the mannanase include Manaway (registered trademark) 4L (trade name) available from Novozymes as a mannanase preparation.
Among the proteases, among the above, Subtilisin 16L, Subtilisin Ultra 16L, Subtilisin Ultra 16XL, SubtilisEvity 16L, Everlase 16L, Everlase Ultra16L, AlcalaseLaseLaseLaseLalaseLaseLaseLalaseLaseL. 5L, Liquanase Ultra 2.5XL, Coronase 48L, Progless Uno are preferred, Alcalase 2.5L, Everlase 16L, Subtilisin 16L, Subtilisinity 16L, Coronase 48L, Progres in particular. These enzymes may be used alone or in combination of two or more. It is preferably 0.01 to 10% by mass with respect to the total mass of the liquid detergent composition.
Antioxidants include BHT (dibutylhydroxytoluene), BHA (butylhydroxyanisole), vitamin E (tocopherol), sodium erythorbate, methoxyphenol, sulfur dioxide, coffee bean extract (chlorogenic acid), and green tea extract (catechin). ), Rosemary extract and the like. As the antioxidant, one type may be used alone, or two or more types may be used in combination. It is preferably 0.01 to 3% by mass with respect to the total mass of the liquid detergent composition.
Preservatives include Dow Chemical's "Caisson CG" (trade name), Saw Japan's "Actiside MBS" (trade name), Clariant's "NIPACIDE BIT 20" (trade name), and Troy Siam Co. ., Ltd. "Margal KN9" (trade name), "Margal K20" (trade name) and the like can be mentioned. As the preservative, one kind may be used alone, or two or more kinds may be used in combination. It is preferably 0.001 to 1% by mass with respect to the total mass of the liquid detergent composition.
Examples of the antibacterial agent include diphenyl ether antibacterial agents such as diclosan (4,4'-dichloro-2-hydroxydiphenyl ether) and triclosan (5-chloro-2- (2,4-dichlorophenoxy) phenol), and quaternary ammonium salts. Cationic disinfectants such as (benzalconium chloride, alkyltrimethylammonium salt, dialkyldimethylammonium salt, alkylbenzyldimethylammonium salt, alkylpyridinium salt), bis- (2-pyridylthio-1-oxide) zinc, polyhexamethylenebi Examples include guanidine hydrochloride, 8-oxyquinoline, polylysine and the like. These antibacterial agents may be used alone or in combination of two or more. It is preferably 0.001 to 10% by mass with respect to the total mass of the liquid detergent composition.
Examples of the soil release agent include at least one repeating unit selected from the group consisting of an alkylene terephthalate unit and an alkylene isophthalate unit, and a polymer having an oxyalkylene unit. Examples of such polymers include those described in International Publication No. 2017/142012. Examples of commercially available SR agents include the trade name "TexCare SRN-170" manufactured by Clariant AG.
Further, a polymer (P) such as an alkylene oxide adduct of polyalkylene amine can be mentioned. Examples of the alkylene oxide adduct of the polyalkylene amine include those in which the side chain represented by the following formula (p) is bonded to the nitrogen atom of the alkylene amine main chain and the alkylene amine main chain.
-(EO) _a (PO) _b ... Equation (p)
In the formula (p), EO is an oxyethylene group, PO is an oxypropylene group, a is a number of 3 to 60 representing the average number of repetitions of EO, and b is a number of 0 to representing the average number of repetitions of PO. It is a number of 60. Examples of such a polymer (P) include those described in International Publication No. 2017/142012 and Japanese Patent Publication No. 2017-514967. Examples of the polymer (P) include the trade name “Sokalan HP20” manufactured by BASF.

In addition, cationized cellulose described in JP-A-2019-90057 can be mentioned. It is preferably 0.1 to 20% by mass with respect to the total mass of the liquid detergent composition.
Examples of the dispersant include polyacrylic acid and salts thereof, polymethacrylic acid and salts thereof, high molecular weight polycarboxylic acids and salts thereof, and the like. It is preferably 0.01 to 5% by mass with respect to the total mass of the liquid detergent composition.
Examples of the fragrance include a fragrance raw material alone, or a fragrance composition containing a fragrance raw material, a fragrance solvent, a fragrance stabilizer, and the like, and a fragrance usually used in a liquid detergent composition is blended. be able to. Further, a capsule fragrance may be blended. It is preferably 0.01 to 5% by mass with respect to the total mass of the liquid detergent composition.
Examples of the colorant include quinone dyes, triphenylmethane dyes, azo dyes, xanthene dyes, quinoline dyes, pyrene dyes and the like. As used herein, "CI" is an abbreviation for Color Index.

The structure of each dye is described in the "Legal Dye Handbook" (edited by the Japan Cosmetic Industry Liaison Committee) and the Dye Handbook (edited by the Society of Synthetic Organic Chemistry).
Examples of the quinone dye include C.I. I. Solvent Blue 63 (CI Solvent Blue 63, Blue No. 403), C.I. I. Solvent Violet 13 (CI Solvent Violet 13, Purple No. 201), C.I. I. Acid Green 25 (CI Acid Green 25, Green No. 201), C.I. I. Acid Blue 112, C.I. I. Solvent Green 3 (Green No. 202), C.I. I. Vat Blue 6 (CI Bat Blue 6, Blue No. 204), C.I. I. Solvent Blue 11, C.I. I. Solvent Blue 12, C.I. I. Solvent Blue 36, C.I. I. Acid Violet 43 (Purple 401), C.I. I. Acid Blue 41, C.I. I. Acid Blue 62, C.I. I. Acid Blue 78, C.I. I. Direct Green 28 (CI Direct Green 28), C.I. I. Acid Violet 34, C.I. I. Acid Vioret 41, C.I. I. Acid Vioret 51, C.I. I. Acid Blue 23, C.I. I. Acid Blue 25, C.I. I. Acid Blue 27, C.I. I. Acid Blue 40, C.I. I. Acid Blue 43, C.I. I. Acid Blue 45, C.I. I. Acid Blue 80, C.I. I. Acid Blue 126, C.I. I. Acid Blue 127, C.I. I. Acid Blue 129, C.I. I. Acid Blue 138, C.I. I. Acid Blue 143, C.I. I. Acid Blue 182, C.I. I. Acid Blue 183, C.I. I. Acid Blue 203, C.I. I. Acid Blue 204, C.I. I. Acid Blue 205, C.I. I. Acid Green 36, C.I. I. Acid Green 40, C.I. I. Acid Green 41, C.I. I. Acid Green 44, C.I. I. Acid Brown 27 (CI Acid Brown 27), C.I. I. Acid Black 48 (CI Acid Black 48), C.I. I. Acid Black 50, C.I. I. Disperse Red 9 (CI Disperse Red 9), C.I. I. Solvent Violet 14, C.I. I. Disperse Violet 1, C.I. I. Acid Green 27 and the like can be mentioned. In addition, among the above, for Solvent-based (oil-soluble) dyes, water-soluble polymers such as polyethylene glycol and polypropylene glycol are chemically modified at the ends of the chromophore structure to increase the water solubility. But it may be. Specific examples thereof include trade names such as Liquid HP, Liquid Int Blue BL, and Liquid int Blue MC manufactured by Milliken.
Examples of the triphenylmethane dye include Blue No. 1 (CI 42090) and Green No. 3 (CI 42053).
Examples of the azo dye include Yellow No. 4 (CI 19140) and the like.
Examples of the xanthene dye include Red No. 106 (CI Acid Red 52), Red No. 3 (CI Acid Red 51), Red No. 214 (CI Solvent Red 49), and Red No. 215 (Red No. 215). CISolvent Red 49), Red 218 (CISolvent Red 48), Red 223 (CISolvent Red 43), Orange 201 (CISolvent Red 72), Daidai Color 206 (CI Solvent Red 73), Red 104 (1) (CI Acid Red 92), Red 105 (1) (CI Acid Red 94), Red 213 (CI Basic Violet 10), Red 230 (1) (CI Acid Red 87), Red 230 (2) (CI Acid Red 87), Red 231 (C.I. Acid Red 87). I. Acid Red 92), Red No. 232 (CI Acid Red 94), Daidai Color No. 207 (CI Acid Red 95), Yellow No. 201 (CI Acid Yellow 73), Yellow No. 202 (1) (CI Acid Yellow 73), Yellow 202 (2) (CI Acid Yellow 73), Red 401 (CI Acid Violet 9). Here, "CI" is an abbreviation for "color index".
Examples of the quinoline-based dye include Yellow No. 203 (CI Acid Yellow 3) and Yellow No. 204 (CI Solvent Yellow 33).
Examples of the pyrene dye include Green No. 204 (CI Solvent Green 7).
Examples of the fluorescent agent include biphenyl-type fluorescent agents such as 4,4'-bis (2-sulfostilbene) biphenyldi sodium salt, and 4,4'-bis ((4-amino-6-morpholino-1,3,5). -Triazinyl-2) Amino) Stilbene-2, 2'-Disulfonate and other stilbene-type fluorescent agents can be mentioned. These fluorescent agents may be used alone or in combination of two or more. It is preferably 0.01 to 10% by mass with respect to the total mass of the liquid detergent composition.
(viscosity)
The viscosity of the liquid detergent composition at 30 ° C. is preferably 300 to 900 mPa · s, more preferably 400 to 800 mPa · s, still more preferably 500 to 750 mPa · s.

The viscosity of the liquid detergent composition is a value measured under the following conditions using a B-type viscometer.
<< Measurement conditions >>
・ Rotor: No. 2 rotor.
-Rotation speed: 30 rpm.
-Measurement temperature: 30 ° C.
-Reading the viscosity: 30 seconds after the start of rotation of the rotor.
(Production method)
The liquid detergent composition can be produced according to a conventionally known method for producing a liquid detergent composition. For example, after adding each component excluding the pH adjuster to a part of water and mixing, adding a pH adjuster as necessary to adjust the pH, and then adding the rest of the water, the total amount is 100% by mass. It can be manufactured by setting it to%.
(how to use)
The method of use of the present invention is for clothing (for textile products), for hard surfaces (for dishwashing, bathroom, toilet, kitchen, wall / floor, contact lenses, medical equipment, food processing, etc.), It can be used without any particular restrictions.
The washing method of the textile product using the liquid detergent composition of the present invention is not particularly limited, and may be the same as the washing method using a known detergent.
Specifically, a method of washing the cleaning agent composition of the present invention alone or by putting it in water together with a known bleaching agent or a softening agent to make a washing liquid, and then putting a textile product in this washing liquid and washing with a washing machine. Examples include a method in which a textile product is soaked in a liquid for a certain period of time and then washed in a washing machine. Further, the liquid detergent composition may be applied to a dirty portion of the textile product, left as appropriate, and then washed in a washing machine.
The immersion time is preferably 30 minutes or more and 24 hours or less.
The temperature of the immersion liquid at the time of immersion is preferably 10 to 50 ° C.

Examples of textile products in the present invention include clothing, cloths, sheets, curtains, pillowcases and the like. The material of the textile product is not particularly limited, and may be any of natural fibers such as cotton, silk and wool, and chemical fibers such as polyester and polyamide.

The content of the liquid detergent composition in the washing liquid is preferably 0.02 to 0.3% by mass (200 to 3000 ppm) and 0.1 to 0.3% by mass (1000) with respect to the total mass of the washing liquid. ~ 3000ppm) is more preferable.
The amount of the liquid detergent composition added to water is preferably 10 to 30 mL per 10 L of water, for example.

Examples of the virus targeted for the liquid detergent composition of the present embodiment include an enveloped virus and a non-enveloped virus. It is especially effective against enveloped viruses.

Examples of the enveloped virus include influenza virus, coronavirus, rubella virus and the like. Examples of the coronavirus include SARS coronavirus-2 (SARS-CoV-2). SARS coronavirus-2 belongs to the beta coronavirus genus like SARS coronavirus (SARS-CoV) and MERS coronavirus (MERS-CoV), and is a SARS-related coronavirus that causes acute respiratory disease (COVID-19). Is.
Examples of the non-enveloped virus include norovirus, feline calicivirus, poliovirus and the like.
Influenza virus and coronavirus are particularly preferable as the virus to be the target of the liquid detergent composition of the present embodiment.

Hereinafter, the present invention will be described in detail with reference to examples, but the present invention is not limited to the following description. The blending amount in Table 1 is a net conversion value. Water content "balance" means the balance added such that the total of all components contained in the liquid detergent composition is 100% by weight. The "pH of the liquid detergent composition" indicates the pH of each example of the liquid detergent composition and the pH at 30 ° C. in Evaluation 4. Further, the "pH of the washing liquid" indicates the pH at 30 ° C. in the evaluations 1 to 3.
[Ingredients used]
The raw materials used in this example are as follows.
<Ingredient (A)>
A-1: LAS: Linear alkylbenzene sulfonic acid having an alkyl group having 10 to 14 carbon atoms, manufactured by Lion Specialty Chemicals Co., Ltd., trade name "Lypon (registered trademark) LH-200".
<Ingredient (B)>
B-1: AES (2): Polyoxyethylene alkyl ether sulfate (polyoxyethylene alkyl ether sulfate ester salt. (Average number of moles of EO added 2). Trade name: EMAL 270, manufactured by PT. Kao Indonesia Chemicals. )
<Ingredient (C)>
C-1 (AE (7EO)): In the formula (c), R ¹¹ = a linear alkyl group having 12 carbon atoms (C12) and a linear alkyl group having 14 carbon atoms (C14) (C12: C14 by mass ratio). = 70: 30), R ¹² = hydrogen atom, the carbon atom of R ¹¹ to which —O— is bonded is a primary carbon atom, s = 7, t = 0, u = 0. Product name "Leox CL-70" manufactured by Lion Corporation
C-2 (AE (9EO)): In formula (c), R ¹¹ = a linear alkyl group having 12 carbon atoms (C12) and a linear alkyl group having 14 carbon atoms (C14) (C12: C14 by mass ratio). = 70: 30), R ¹² = hydrogen atom, the carbon atom of R ¹¹ to which —O— is bonded is a primary carbon atom, s = 9, t = 0, u = 0. Product name "Leox CL-90" manufactured by Lion Corporation
C-3 (AE (15EO)): In formula (c), R ¹¹ = a linear alkyl group having 12 carbon atoms (C12) and a linear alkyl group having 14 carbon atoms (C14) (C12: C14 by mass ratio). = 70: 30), R ¹² = hydrogen atom, the carbon atom of R ¹¹ to which —O— is bonded is a primary carbon atom, s = 15, t = 0, u = 0. Product name "ECOLAT 24-15 / 85", ETHOXYLATES MANUFACTURING PTE LTD. Made.
<pH adjuster>
-Sodium carbonate: T. Bariwatt Co. , Ltd. Made by the company, product name "Na ₂ CO ₃ ".

-MEA (monoethanolamine): PETRONAS CHEMICALS DERIVATIONES SDN BHD / INEOS N. V. Made by the company, the product name is "Monoethanolamides".
NaOH (48% aqueous solution of sodium hydroxide): MALAY-SINO CHEMICAL INDUSTRIES SDN. BHD. Made by the company, the product name is "Caustic Soda".
-Citric acid: Made by Citric Acid Industries, trade name "Citrus Acid".
-Ethylene oxide adduct of polyethyleneimine: manufactured by BASF, trade name "Sokalan HP20".
-Sodium cumene sulfonate: manufactured by TAYCA CORPORATION, trade name "TAYCA TOX N5040".
-Thickening polymer: Made by Lubirizol, trade name "Novethix HC200".
-MIT / BIT: Made by Thor, product name "Acticide MBS".
-BIT: Troy Siam Co., Ltd. Made by the company, the product name is "Margal K20".
-Protease: DDP Specialty Products Japan Co., Ltd., trade name "Preferenza P300".
-Dichroic glass: Made by BASF, product name "Tinosan HP100".
-Fragrance 1: Made by Givaudan, trade name "COOL Clean".
・ Fragrance 2: Made by Takasago International Corporation, product name "BLOOMING SEASON T15140612"
-Antioxidant (BHT): Made by Japan Chemtech, trade name "Ionol CP"
-Colorant 1 (Blue CI 42090): manufactured by Koyo Kagaku Co., Ltd., trade name "Blue No. 1"
-Colorant 2 (Yellow CI 19140): Saneigen FFI Co., Ltd., trade name "Edible Yellow No. 4"
-Water: Product name "purified water", manufactured by Kanto Chemical Co., Inc.
<Preparation of detergent composition>
A part of water and all the other components were put into a 500 mL beaker according to the blending amount shown in Table 1, and the mixture was sufficiently stirred with a magnet stirrer (manufactured by MITAMURA KOGYO INC.).

Then, an appropriate amount of a pH adjuster was added so that the pH at 30 ° C. became a predetermined value, and then water was added so that the total amount became 100% by mass to obtain a liquid detergent composition.
<Evaluation 1: Antiviral effect (virus inactivating effect)>
The test solution was prepared by diluting the liquid detergent composition of each example in Table 1 with ion-exchanged water so as to be 1167 ppm.
100 μL of influenza A H1N1 virus solution ( ¹⁰⁶ to ¹⁰⁷ PFU / mL) was added to 900 μL of the test solution, and the mixture was reacted at room temperature for 10 minutes. After the reaction, 100 μL of the reaction solution was mixed with 900 μL of SCDLP medium (Soybean-Casein Casein Broth with Lecithin & Polylobate 80), and a 10-fold dilution series was prepared with EMEM (Eagle's minimal essential medium).
After confirming with an inverted microscope that MDCK cells (Madin-Darby canine kidney cells) cultured in a single layer were uniformly distributed on the 96-well microplate, the growth medium was removed. After adding 0.1 mL of EMEM and washing the cell surface, EMEM was removed. This operation was repeated twice to wash the cell surface.
The cell surface was inoculated with 0.1 mL of each of the above dilution series, 8 holes per dilution series. The 96-well microplate after inoculation was placed in a CO ₂ incubator at 34 ° C. and kept warm for 1 hour. The supernatant was removed from the plate, 0.1 mL of EMEM was added to wash the surface, then EMEM was removed, and 0.2 mL of EMEM containing 3 ppm of trypsin was added. Then, the 96-well microplate was placed in a CO ₂ incubator at 34 ° C. and cultured for 4 to 7 days.
The cytopathic effect of each hole was confirmed with an inverted microscope, and after confirming the cytopathic effect, the infectivity titer of the virus was calculated by the Berens-Kelber method, and the inactivation performance was evaluated. In the following evaluation criteria, 〇 was judged as acceptable.

"Evaluation criteria"
〇: Inactivation performance is 99.9% or more ×: Inactivation performance is less than 99.9% <Evaluation 2: Sebum detergency>
In this method, the reflectance of the cloth was measured by using a color difference meter (manufactured by Nippon Denshoku Kogyo Co., Ltd., product name: SE-2000), and the reflectance R was calculated from the hunter whiteness Z by the following formula (1). ..

R = Z / 100 ... (1)
First, the reflectances of 10 wet artificially contaminated cloths (purchased from the Laundry Science Association, hereinafter also referred to as "contaminated cloths") before washing were measured. A Terg-O-Tometer (manufactured by US Testing) was used as a cleaning tester. As the cleaning liquid, a liquid detergent composition for clothing was dissolved in 900 mL of 5 ° DH hard water at 30 ° C. so as to be 1167 ppm.

In the washing tank, 10 contaminated cloths and a charge cloth (a knitted cloth cut into small pieces, thoroughly washed and rinsed and dried) were put in, and a washing liquid was put in. The amount of the charge cloth was set so that the bath ratio was 30 times or 10 times.

After washing at a rotation speed of 120 rpm and a temperature of 30 ° C. for 10 minutes, rinsing was performed twice for 3 minutes with 900 mL of 2 ° DH hard water at 30 ° C. It was dried. The reflectance R of the contaminated cloth after drying (hereinafter, also referred to as a washing cloth) is measured using a 460 nm filter, and the washing rate (unit:%. Rounded to the nearest whole number) is calculated by the following formula (2). did. In the formula, K represents the absorption coefficient, S represents the scattering coefficient, and R represents the reflectance. The standard white cloth is the original white cloth (raw cloth) that has not been soiled, and the reflectance R of the standard white cloth is calculated to be 80. The larger the value of the cleaning rate obtained by the following formula (2), the higher the cleaning power. In the following evaluation criteria, ◎ and ○ were accepted.
Cleaning rate (%) = (contaminated cloth K / S-cleaning cloth K / S) / (contaminated cloth K / S-uncontaminated cloth K / S) × 100 ... (2)
K / S = (1-R / 100) ² / (2R / 100)
"Evaluation criteria"
The average cleaning rate of 10 contaminated cloths is as follows.
⊚: 75% or more 〇: 70% or more and less than 75% ×: less than 70% <Evaluation 3: Protein detergency>
The cleaning rate was calculated by the same method as in Evaluation 2 using EMPA117 contaminated cloth (purchased from Nippon Materials Co., Ltd.) instead of the wet artificial contaminated cloth in Evaluation 2 described above.
In the following evaluation criteria, ◎ and ○ were accepted.

"Evaluation criteria"
The average cleaning rate of 10 contaminated cloths is as follows.
⊚: 65% or more 〇: 57% or more and less than 65% ×: less than 57% <Evaluation 4: Low temperature stability>
30 mL of the liquid detergent composition of each example was taken in a cylindrical glass bottle, and the lid was closed and sealed. In this state, it was left in a constant temperature bath at 10 ° C. and stored for 1 month.
Then, it was taken out from the constant temperature bath, the transparency uniformity and fluidity of the liquid detergent were visually observed, and the appearance stability of the liquid detergent was evaluated based on the following criteria.

In the following evaluation criteria, ◎ and ○ were accepted.
"Evaluation criteria"
⊚: Transparent and uniform, showing fluidity.
〇: Although it is opaque, it became transparent and uniform by leaving it in a constant temperature bath at 25 ° C for one day.
X: A precipitate was observed at the bottom of the glass bottle, and the precipitate did not disappear even when the glass bottle was shaken lightly. Alternatively, the liquid detergent is opaque and uniform, and even if it is left in a constant temperature bath at 25 ° C. for one day, it does not become transparent and uniform.

As shown in Table 1, all of the examples showed excellent virus inactivating effect, detergency and low temperature stability.

Claims (13)

(A) Component: Linear alkylbenzene sulfonic acid or a salt thereof, and
(B) Component: Polyoxyalkylene alkyl ether sulfuric acid or a salt thereof,
Ingredient (C): A nonionic surfactant represented by the following general formula (c) and
Contains,
The mass ratio ((A) / (B) ratio) represented by the content of the component (A) to the content of the component (B) is 0.8 or more.
The pH at 30 ° C. is 8 or higher.
Liquid Detergent Composition for Viruses R ¹¹ -O- [(EO) _s / (A ¹¹ O) _t ]-(EO) _u -R ¹² ... (c)
(In the general formula (c), R ¹¹ is a hydrocarbon group having 8 to 22 carbon atoms. R ¹² is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkenyl group having 2 to 6 carbon atoms. EO. Is an oxyethylene group. S is a number of 3 to 25 indicating the average number of repetitions of EO. A ¹¹ O represents at least one of PO (oxypropylene group) and BO (oxybutylene group). T represents A ¹¹ It is a number of 0 to 6 indicating the average number of repetitions of O. U is a number of 0 to 20 indicating the average number of repetitions of EO.) Further, it contains a pH adjuster for adjusting the pH at 30 ° C. to 8 or more.
The liquid cleaning agent composition for a virus according to claim 1, wherein the pH adjuster is at least one selected from the group of sodium carbonate, sodium hydroxide, sodium hydrogencarbonate, and alkanolamine. The mass ratio ((A) / (C) ratio) represented by the content of the component (A) to the content of the component (C) is 0.3 to 4.5, claim 1 or 2. The liquid detergent composition for viruses according to. The mass ratio ((C) / (B) ratio) represented by the content of the component (C) to the content of the component (B) is 0.2 to 7, any of claims 1 to 3. The liquid detergent composition for a virus according to item 1. The liquid detergent composition for a virus according to any one of claims 1 to 4, wherein the content of the total surfactant is 5 to 45% by mass with respect to the total mass of the liquid detergent composition. Further, α-olefin sulfonic acid or a salt thereof (AOS), a linear or branched alkyl sulfate ester or a salt thereof (AS), an alkane sulfonic acid having an alkyl group or a salt thereof, an α-sulfo fatty acid ester or a salt thereof. Salt, internal olefin sulfonic acid or salt thereof (IOS), hydroxyalcan sulfonic acid or salt thereof (HAS), alkyl ether sulfonic acid or salt thereof, polyoxyalkylene ether carboxylic acid or salt thereof, alkylamide ether carboxylic acid or salt thereof The liquid cleaning agent composition for a virus according to any one of claims 1 to 5, which contains at least one selected from the group consisting of alkenylamide ether carboxylic acid or a salt thereof, a higher fatty acid or a salt thereof. Further, polyoxyethylene fatty acid methyl ester, alkylene oxide adduct of fatty acid having 8 to 22 carbon atoms or amine having 8 to 22 carbon atoms, fatty acid alkanolamine, fatty acid alkanolamide, polyhydric alcohol fatty acid ester or alkylene oxide adduct thereof, Any of claims 1 to 6, which contains at least one selected from the group consisting of polyhydric alcohol fatty acid ether, alkylene oxide adduct of hardened castor oil, sugar fatty acid ester, N-alkylpolyhydroxyfatty acid amide, and alkylglycoside. The liquid cleaning agent composition for a virus according to item 1. The mass ratio represented by "the total content of the nonionic surfactant containing the component (C)" to "the total content of the non-soap-based anionic surfactant containing the component (A) and the component (B)". (Ratio of "non-soap-based anionic surfactant containing (A) component and (B) component" / "nonionic surfactant containing (C) component") is 0.1 to 9, claim 1 to 9. 7. The liquid detergent composition for a virus according to any one of 7. The liquid detergent composition for a virus according to any one of claims 1 to 8, further comprising at least one selected from the group consisting of a cationic surfactant, an amphoteric surfactant, and a semipolar surfactant. thing. In addition, it contains a hydrotrope,
The hydrotropic agent is a group consisting of cumene sulfonic acid or a salt thereof, paratoluene sulfonic acid or a salt thereof, ethanol, 2-propanol, ethylene glycol, propylene glycol, dipropylene glycol, glycerin, diethylene glycol monobutyl ether, polyethylene glycol and phenoxyethanol. The liquid cleaning agent composition for a virus according to any one of claims 1 to 9, which is one or more selected from the above. Further, a claim comprising any one or more selected from the group consisting of antifoaming agents, metal ion scavengers, enzymes, antioxidants, antibacterial agents, soil release agents, dispersants, flavoring agents, and fluorescent agents. The liquid detergent composition for a virus according to any one of 1 to 10. The liquid detergent composition for a virus according to any one of claims 1 to 11, which has a viscosity at 30 ° C. of 300 to 900 mPa · s. The liquid detergent composition for a virus according to any one of claims 1 to 12, wherein the pH of the washing liquid at 30 ° C. is 7 to 11.