JP2022088787A - 時計遺伝子の発現を制御するビフィズス菌 - Google Patents
時計遺伝子の発現を制御するビフィズス菌 Download PDFInfo
- Publication number
- JP2022088787A JP2022088787A JP2020200815A JP2020200815A JP2022088787A JP 2022088787 A JP2022088787 A JP 2022088787A JP 2020200815 A JP2020200815 A JP 2020200815A JP 2020200815 A JP2020200815 A JP 2020200815A JP 2022088787 A JP2022088787 A JP 2022088787A
- Authority
- JP
- Japan
- Prior art keywords
- bifidobacteria
- clock
- present
- strain
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000186000 Bifidobacterium Species 0.000 title claims abstract description 45
- 230000014509 gene expression Effects 0.000 title claims abstract description 23
- 101150038243 CLOCK gene Proteins 0.000 title abstract description 28
- 230000001105 regulatory effect Effects 0.000 title abstract description 3
- 241001608472 Bifidobacterium longum Species 0.000 claims abstract description 16
- 229940009291 bifidobacterium longum Drugs 0.000 claims abstract description 15
- 235000013305 food Nutrition 0.000 claims abstract description 11
- 241000894007 species Species 0.000 claims abstract 2
- 108090000623 proteins and genes Proteins 0.000 claims description 14
- 101150074181 PER2 gene Proteins 0.000 abstract description 21
- 238000013518 transcription Methods 0.000 abstract description 19
- 230000035897 transcription Effects 0.000 abstract description 19
- 230000001737 promoting effect Effects 0.000 abstract description 16
- 235000013361 beverage Nutrition 0.000 abstract description 7
- 238000000034 method Methods 0.000 abstract description 5
- 230000027288 circadian rhythm Effects 0.000 abstract description 3
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 238000011156 evaluation Methods 0.000 description 11
- 241000894006 Bacteria Species 0.000 description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 8
- 239000002609 medium Substances 0.000 description 8
- 229920001091 Poly(octyl cyanoacrylate) Polymers 0.000 description 7
- DNORZUSMZSZZKU-UHFFFAOYSA-N ethyl 2-[5-(4-chlorophenyl)pentyl]oxirane-2-carboxylate Chemical compound C=1C=C(Cl)C=CC=1CCCCCC1(C(=O)OCC)CO1 DNORZUSMZSZZKU-UHFFFAOYSA-N 0.000 description 7
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 101000973177 Homo sapiens Nuclear factor interleukin-3-regulated protein Proteins 0.000 description 5
- 238000011529 RT qPCR Methods 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 235000013336 milk Nutrition 0.000 description 5
- 239000008267 milk Substances 0.000 description 5
- 210000004080 milk Anatomy 0.000 description 5
- 238000003757 reverse transcription PCR Methods 0.000 description 5
- 101150032765 ARNTL gene Proteins 0.000 description 4
- 101150102464 Cry1 gene Proteins 0.000 description 4
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 4
- 102100022163 Nuclear factor interleukin-3-regulated protein Human genes 0.000 description 4
- 239000012911 assay medium Substances 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 4
- 235000014655 lactic acid Nutrition 0.000 description 4
- 239000004310 lactic acid Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 102000007469 Actins Human genes 0.000 description 3
- 108010085238 Actins Proteins 0.000 description 3
- 108700039887 Essential Genes Proteins 0.000 description 3
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 3
- 229960001948 caffeine Drugs 0.000 description 3
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 3
- 235000015140 cultured milk Nutrition 0.000 description 3
- 238000012258 culturing Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 235000013861 fat-free Nutrition 0.000 description 3
- 239000012091 fetal bovine serum Substances 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 238000002123 RNA extraction Methods 0.000 description 2
- 238000011530 RNeasy Mini Kit Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 235000014121 butter Nutrition 0.000 description 2
- 238000010804 cDNA synthesis Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 201000010897 colon adenocarcinoma Diseases 0.000 description 2
- 208000029742 colonic neoplasm Diseases 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000010606 normalization Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 101100447432 Danio rerio gapdh-2 gene Proteins 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 101150112014 Gapdh gene Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 208000001145 Metabolic Syndrome Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010062519 Poor quality sleep Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- LFYJSSARVMHQJB-QIXNEVBVSA-N bakuchiol Chemical compound CC(C)=CCC[C@@](C)(C=C)\C=C\C1=CC=C(O)C=C1 LFYJSSARVMHQJB-QIXNEVBVSA-N 0.000 description 1
- 238000010876 biochemical test Methods 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 235000014510 cooky Nutrition 0.000 description 1
- 230000036757 core body temperature Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000008713 feedback mechanism Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 235000008446 instant noodles Nutrition 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000008268 mayonnaise Substances 0.000 description 1
- 235000010746 mayonnaise Nutrition 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000009024 positive feedback mechanism Effects 0.000 description 1
- 230000023603 positive regulation of transcription initiation, DNA-dependent Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 235000021067 refined food Nutrition 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000004460 silage Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Polymers & Plastics (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Non-Alcoholic Beverages (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2020200815A JP2022088787A (ja) | 2020-12-03 | 2020-12-03 | 時計遺伝子の発現を制御するビフィズス菌 |
PCT/JP2021/035381 WO2022118525A1 (ja) | 2020-12-03 | 2021-09-27 | 時計遺伝子の発現を制御するビフィズス菌 |
TW110136155A TW202228742A (zh) | 2020-12-03 | 2021-09-29 | 抑制時鐘基因表現之雙歧乳酸桿菌 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2020200815A JP2022088787A (ja) | 2020-12-03 | 2020-12-03 | 時計遺伝子の発現を制御するビフィズス菌 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2022088787A true JP2022088787A (ja) | 2022-06-15 |
JP2022088787A5 JP2022088787A5 (zh) | 2022-07-13 |
Family
ID=81852707
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020200815A Pending JP2022088787A (ja) | 2020-12-03 | 2020-12-03 | 時計遺伝子の発現を制御するビフィズス菌 |
Country Status (3)
Country | Link |
---|---|
JP (1) | JP2022088787A (zh) |
TW (1) | TW202228742A (zh) |
WO (1) | WO2022118525A1 (zh) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5112706B2 (ja) * | 2007-01-25 | 2013-01-09 | キッコーマン株式会社 | 機能性組成物 |
JP5943342B2 (ja) * | 2012-03-02 | 2016-07-05 | 国立研究開発法人産業技術総合研究所 | 概日リズム改善剤 |
-
2020
- 2020-12-03 JP JP2020200815A patent/JP2022088787A/ja active Pending
-
2021
- 2021-09-27 WO PCT/JP2021/035381 patent/WO2022118525A1/ja active Application Filing
- 2021-09-29 TW TW110136155A patent/TW202228742A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
WO2022118525A1 (ja) | 2022-06-09 |
TW202228742A (zh) | 2022-08-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Yang et al. | Antioxidant and immune-enhancing effects of probiotic Lactobacillus plantarum 200655 isolated from kimchi | |
Song et al. | Probiotic characteristics of Lactobacillus brevis B13-2 isolated from kimchi and investigation of antioxidant and immune-modulating abilities of its heat-killed cells | |
KR102028744B1 (ko) | 면역증강 활성, 항산화 활성 및 소화액 내성을 갖는 락토바실러스 플란타룸 hy7717 균주 및 그의 용도 | |
US10405569B2 (en) | Lanctobacillus plantarum HAC01 strain having anti-inflammatory efficacy and metabolic disease alleviating efficacy and use thereof | |
KR101494279B1 (ko) | 지방세포 분화 유도에 관여하는 유전자의 발현을 억제함으로써 지방세포 분화 억제 효능을 갖는 락토바실러스 플란타룸 케이와이1032 및 이를 유효성분으로 함유하는 제품 | |
Han et al. | Antioxidant and anti-inflammatory effect of probiotic Lactobacillus plantarum KU15149 derived from Korean homemade diced-radish kimchi | |
CA2810698A1 (en) | Aryl hydrocarbon receptor-activating probiotics for preventing inflammation | |
TWI787665B (zh) | 保加利亞乳桿菌tci904、其培養上清液、其組合物及其用於減少體重的用途 | |
Yoon et al. | Multifunctional probiotic and functional properties of Lactiplantibacillus plantarum LRCC5314, isolated from kimchi | |
JP6829144B2 (ja) | 心理状態改善剤 | |
Maheshwari et al. | Characterization of potential probiotic bacteria from ‘panchamirtham’; A Southern Indian ethinic fermented fruit mix | |
KR102005617B1 (ko) | 항콜레스테롤 활성이 우수한 신규 락토바실러스 플란타룸 f.m.b #31 균주 및 이의 용도 | |
WO2022118525A1 (ja) | 時計遺伝子の発現を制御するビフィズス菌 | |
WO2022050303A1 (ja) | 筋萎縮遺伝子の発現を抑制するビフィズス菌 | |
KR101844778B1 (ko) | 비타민 b2 생합성능이 매우 우수한 락토바실러스 플란타룸 hy7715 및 이를 유효성분으로 함유하는 제품 | |
JP2021180619A (ja) | 整腸用茶発酵組成物及びその製造方法 | |
EP3547851B1 (en) | L. salivarius sgl03:probiotic activities and production of antimicrobial proteins | |
JP2021065133A (ja) | ビフィズス菌増殖用組成物 | |
WO2022091667A1 (ja) | Igf-1の産生を促進するビフィドバクテリウム属に属するビフィズス菌 | |
KR102292475B1 (ko) | 비피도박테리움 애니멀리스 서브스페시스 락티스 hy8002를 유효성분으로 함유하는 니코틴 금단증상 개선용 식품조성물 | |
RU2805505C2 (ru) | Консорциум штаммов бифидобактерий, используемый для приготовления бифидосодержащей продукции | |
KR102678153B1 (ko) | 인지능력 또는 기억력 개선 효능을 갖는 라틸락토바실러스 커베터스 WiKim0094 및 이의 용도 | |
EP4036214A1 (en) | Novel lactococcus lactis strains, compositions comprising them, and use thereof in prevention and treatment of intestinal cancer | |
JP2009242430A (ja) | 加齢に伴う代謝異常疾患の予防・改善・治療剤 | |
LeBegue | The Pharmabiotic for Phenylketonuria: Development of a Novel Therapeutic |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220630 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20230721 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20240521 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20240717 |