JP2022060323A - Mold sterilizing agent composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a mold sterilizing agent composition that can exhibit an excellent mold sterilizing effect on the mold present in a living environment such as a bath room.

SOLUTION: A mold sterilizing agent composition contains (a) a compound represented by general formula (a-1), (b) at least one selected from the following (b1)-(b3) compounds, and water. (b1): an aliphatic alcohol having carbon atoms of 3 or more and 10 or less. (b2): an aliphatic diol having carbon atoms of 3 or more and 10 or less (excluding (b3) component). (b3): an aliphatic glyceryl ether having carbon atoms of 4 or more and 10 or less. (In the formula, R^1a is a bivalent hydrocarbon group having carbon atoms of 1 or more and 4 or less; each of r and l is an integer of 0 or 1, where if l is 0, r is an integer of 1. A is an alkylene group having carbon atoms of 2 or more and 4 or less).

SELECTED DRAWING: None

COPYRIGHT: (C)2022,JPO&INPIT

Description

The present invention relates to an antifungal composition.

Since Japan is hot and humid, the environment around water such as bathrooms is humid, and the presence of soap scum stains and sebum stains promotes the growth of microorganisms such as fungi, which are derived from fungi such as pink stains and mold stains. It is easy to get dirty. These stains are generally killed with a strong disinfectant such as hypochlorite, but it is difficult to use easily because there is a concern that chlorine will be generated and a unique odor is involved. .. For this reason, in general, in order to avoid the generation of stains derived from these bacteria as much as possible, it is necessary to perform frequent cleaning on a daily basis or long-term cleaning. In addition, isothiazolin-based compounds, nitroalcohol-based compounds, nitrile-based compounds, dithiol-based compounds, phenol-based compounds, phenylurea-based compounds, carbamate-based compounds, sulfamide-based compounds, phthalimide-based compounds, pyridine-based compounds, guanidine-based compounds, and triazole-based compounds. , Thiazol-based compounds, benzoimidazole-based compounds, and other antifungal agents have also been used, but the effects of the antifungal agents are temporary, and the growth of the mold cannot be permanently prevented. ..

Therefore, a method for sterilizing molds before breeding has been studied. Patent Document 1 and Patent Document 2 disclose a technique having an effect on mold killing in which the bactericidal activity of a cationic fungicide is enhanced by a glucol ether compound.

Patent Document 3 describes that a bactericidal treatment agent for a hard surface containing a phenolic bactericidal agent and an alcohol acts effectively against fungi.

Patent Document 4 discloses a composition for microbial killing in which an aromatic alcohol such as benzyl alcohol and a glycol ether solvent are used in combination as a microbial killing agent.

Japanese Unexamined Patent Publication No. 2017-39646 Japanese Unexamined Patent Publication No. 2013-001771 Japanese Unexamined Patent Publication No. 2017-48182 JP-A-2015-140331A

The present invention provides a mold-killing composition capable of exerting an excellent mold-killing effect on mold existing in a living environment such as a bathroom.

The present invention is one or more selected from (a) a compound represented by the following general formula (a-1) [hereinafter referred to as (a) component] and (b) the following compounds (b1) to (b3). [Hereinafter referred to as (b) component], and a fungicide composition containing water.
(B1): Aliphatic alcohol having 3 or more and 10 or less carbon atoms (b2): Aliphatic diol having 3 or more and 10 or less carbon atoms (however, the component (b3) is excluded)
(B3): Aliphatic glyceryl ether having 4 or more and 10 or less carbon atoms

(In the formula, R ^1a is a divalent hydrocarbon group having 1 or more carbon atoms and 4 or less carbon atoms, and r and l are 0 or an integer of 1, but when l is 0, r is an integer of 1. A is an alkylene group having 2 or more and 4 or less carbon atoms.)

The present invention also relates to a mold-killing method in which the mold-killing agent composition is brought into contact with a surface of an object in which fungi are present for 30 seconds or longer.

According to the present invention, there is provided a mold-killing agent composition capable of exerting an excellent mold-killing effect on mold existing in a living environment such as a bathroom.

[Moldicide composition]
The reason why the mold-killing agent composition of the present invention can exert an excellent mold-killing effect on mold is not always clear, but it is presumed as follows. The mold has a thick cell wall outside the cell membrane. The cell wall of mold is composed of a polysaccharide layer composed of glucan, chitin and the like, a melanin layer, a hydrophobin layer and the like. Due to the presence of this cell wall, it is considered that the problem is that mold has a lower permeability of the fungicide into the cell than general bacteria such as Escherichia coli, and a sufficient mold-killing effect cannot be obtained in a short time. .. However, the fungicide composition of the present invention, in combination with the component (b) that promotes structural changes in the polysaccharide layer, enhances the permeability of the component (a), which is a fungicide, to achieve a fungicide effect in a short time. It is presumed that it made it possible to obtain.

<(A) component>
The component (a) of the present invention is a compound represented by the following general formula (a-1).

(In the formula, R ^1a is a divalent hydrocarbon group having 1 or more carbon atoms and 4 or less carbon atoms, and r and l are 0 or an integer of 1, but when l is 0, r is an integer of 1. A is an alkylene group having 2 or more and 4 or less carbon atoms.)

The carbon number of R ^1a is preferably 4 or less, more preferably 2 or less, from the viewpoint of compounding stability.
For r and l, it is preferable that r is 1 and l is 0 from the viewpoint of the fungicide effect.

Specifically, the component (a) includes benzyl alcohol (molecular weight: 108), phenoxyethanol (molecular weight: 138), 2-phenylethanol (molecular weight: 122), 3-phenyl-1-propanol (molecular weight: 136), and One or more selected from cinnamyl alcohol (molecular weight: 134) is preferable, one or more selected from benzyl alcohol, phenoxyethanol, and 2-phenylethanol is more preferable, and one or more selected from benzyl alcohol and phenoxyethanol are further preferable. preferable.

<(B) component>
The component (b) of the present invention is one or more selected from the following compounds (b1) to (b3).
(B1): Aliphatic alcohol having 3 or more and 10 or less carbon atoms (b2): Aliphatic diol having 3 or more and 10 or less carbon atoms (however, the component (b3) is excluded)
(B3): Aliphatic glyceryl ether having 4 or more and 10 or less carbon atoms

The component (b) has a logP value of preferably 0 or more, more preferably 0.5 or more, and preferably from the viewpoint of compounding stability, from the viewpoint of antifungal effect and distribution from the aqueous phase to the cells. A compound having 3 or less, more preferably 2 or less is preferable.

In the present invention, the logP value is a coefficient indicating the affinity of the organic compound for water and 1-octanol. The 1-octanol / water partition coefficient P is the partition equilibrium when a trace amount of the compound is dissolved as a solute in the solvent of the two-component phase of 1-octanol and water, and is the ratio of the equilibrium concentration of the compound in each solvent. It is generally shown in the form of their loglogP for the base 10. The logP values of many compounds have been reported, and many values are listed in databases available from Daylight Chemical Information Systems, Inc. (Daylight CIS), etc., which can be referred to. If there is no actually measured logP value, it can be calculated by the program "CLOGP" etc. available from Daylight CIS. This program outputs the value of "calculated logP (ClogP)" calculated by Hansch, Leo's fragment approach together with the actually measured logP value, if any.

The fragment approach is based on the chemical structure of the compound and takes into account the number of atoms and the type of chemical bond (cf. A. Leo, Comprehensive Medicinal Chemistry, Vol. 4, C. Hansch, P.G. Sammens, J.B. Taylor and C.A. Ramsden, Eds., P.295, Pergamon Press, 1990). This LogP value can be used in place of the measured logP value when selecting a compound. In the present invention, if there is an actually measured value of logP, it is used, and if not, the LogP value calculated by the program CLOGP v4.01 is used.

Examples of the aliphatic alcohol having 3 or more and 10 or less carbon atoms, which is (b1), include 1-propanol (molecular weight: 60, logP: 0.55), 2-propanol (molecular weight: 60, logP: 0.38), and 1 -Hexanol (molecular weight: 102, logP: 1.80), 1-pentanol (molecular weight: 88, logP: 1.39), 3-pentanol (molecular weight: 88, logP: 1.36), 1-butanol (molecular weight: 88, logP: 1.36) Molecular weight: 74, logP: 0.97), 2-butanol (molecular weight: 74, logP: 0.87), tert-butanol (molecular weight: 74, logP: 0.60), 1-heptanol (molecular weight: 116, logP) : 2.22), and 1 or more selected from 1-octanol (molecular weight: 130.23, logP: 2.64) can be mentioned. One or more selected from 2-propanol, 1-butanol, 2-butanol, tert-butanol, 1-pentanol, 3-pentanol, 1-hexanol, and 1-heptanol is preferable, and 1-butanol and 2-butanol are preferable. , 1-pentanol, and 3-pentanol are more preferred.

The aliphatic diol having 3 or more carbon atoms and 10 or less carbon atoms according to (b2) is preferably a compound represented by the following general formula (b-2) from the viewpoint of an antifungal effect.
R ^1c -CH (OH)-(CH ₂ ) _m -CH ₂ OH (b-2)
(In the formula, R ^1c is a hydrogen atom or an alkyl group or an alkenyl group having 1 or more and 8 or less carbon atoms, and m is 0 or an integer of 1 or more and 6 or less. However, the total number of carbon atoms in the compound is 3 or more and 10 or more. It is as follows.)

From the viewpoint of the killing effect, R ^1c is preferably a hydrogen atom or an alkyl group or alkenyl group having 2 or more and 8 or less carbon atoms, more preferably an alkyl group or alkenyl group having 3 or more and 8 or less carbon atoms, and 4 or more and 8 carbon atoms. The following alkyl or alkenyl groups are more preferred.
m is preferably 1 or less from the viewpoint of the mold-killing effect.

Specifically, (b2) is 1,2-hexanediol (molecular weight: 118, logP: 0.85), 1,2-pentanediol (molecular weight: 104, logP: 0.43), propylene glycol (molecular weight). : 76, logP: 0.40), 1,6-hexanediol (molecular weight: 118, logP: 0.60), 1,2-butanediol (molecular weight: 90, logP: 0.01), 1,4- Butanediol (molecular weight: 90, logP: -0.23), 1,3-butanediol (molecular weight: 90, logP: 0-0.37), 1,5-pentanediol (molecular weight: 104, logP: 0) .19), 1,2-octanediol (molecular weight: 146, logP: 1.68), and 1,8-octanediol (molecular weight: 146, logP: 1.44). From the viewpoint of achieving both a mold-killing effect and compounding stability, one or more selected from 1,2-hexanediol, 1,2-pentanediol, propylene glycol, and 1,6-hexanediol is preferable, and 1,2-hexanediol is preferable. More preferably, one or more selected from hexanediol and 1,2-pentanediol.

The aliphatic glyceryl ether having 4 or more and 10 or less carbon atoms according to (b3) is preferably a compound represented by the following general formula (b-3) from the viewpoint of an antifungal effect.
R ^2c O-CH ₂ -CH (OH) -CH ₂ OH (b-3)
(In the formula, R ^2c is a hydrocarbon group having 1 or more carbon atoms, preferably 4 or more, and 7 or less, preferably 6 or less, preferably an alkyl group or an alkenyl group.)

Specific examples of (b3) include one or more selected from hexyl glyceryl ether (molecular weight: 176, logP: 1.11) and cyclohexyl glyceryl ether (molecular weight: 174, logP: 0.58). From the viewpoint of mold-killing effect, hexyl glyceryl ether is preferable.

The component (b) is preferably one or more selected from the compounds of (b1) and (b2), and more preferably (b1), from the viewpoint of achieving both an antifungal effect and compounding stability.

<Composition, etc.>
In the mold-killing agent composition of the present invention, the component (a) is preferably 0.1% by mass or more, more preferably 1% by mass or more, still more preferably 1.4% by mass or more, from the viewpoint of the mold-killing effect. From the viewpoint of compounding stability, the content is preferably 10% by mass or less, more preferably 3% by mass or less, and further preferably 2% by mass or less.

In the mold-killing agent composition of the present invention, the component (b) is preferably 0.1% by mass or more, more preferably 1.0% by mass or more, still more preferably 3% by mass or more, from the viewpoint of the killing effect. From the viewpoint of compounding stability, the content is preferably 10% by mass or less, more preferably 8% by mass or less, and further preferably 6% by mass or less.

In the fungicide composition of the present invention, the total of the content of the component (a) and the content of the component (b) is preferably 1.0% by mass or more, more preferably 3 from the viewpoint of the fungicide effect. It is 0.0% by mass or more, more preferably 5.0% by mass or more, and from the viewpoint of compounding stability, it is preferably 15% by mass or less, more preferably 10% by mass or less, still more preferably 8% by mass or less.

In the fungicide composition of the present invention, the mass ratio (a) / (b) of the content of the component (a) to the content of the component (b) is 0.1 or more, further 0.2 or more, and further. You can select from 0.3 or more, 50 or less, 10 or less, and 5 or less.

In the fungicide composition of the present invention, the molar ratio (a) / (b) of the content of the component (a) to the content of the component (b) is 0.05 or more, further 0.1 or more, and further. You can select from 0.2 or more, 50 or less, 15 or less, and 10 or less.

From the viewpoint of the fungicide effect, the fungicide composition of the present invention can contain a water-soluble inorganic salt [hereinafter referred to as (c) component] as the component (c).
Here, the inorganic salt of the component (c) that is water-soluble means that 5 g or more is dissolved in 100 g of deionized water at 25 ° C.

The component (c) is alkali metal sulfate, alkaline earth metal sulfate, ammonium sulfate, alkali metal sulfite, alkaline earth metal sulfite, alkali metal halide, alkaline earth metal halide, alkali metal nitrate, alkali. One selected from earth metal nitrate, alkali metal carbonate, alkaline earth metal carbonate, alkali metal phosphate, alkaline earth metal phosphate, alkali metal thiocyanate, and alkaline earth metal thiocitanoate. The above-mentioned water-soluble inorganic salts are mentioned, and from the viewpoint of mold-killing effect and compounding stability, alkali metal sulfates, alkaline earth metal sulfates, alkali metal nitrates, alkaline earth metal nitrates, alkali metal halides, and alkalis. One or more water-soluble inorganic salts selected from earth metal halides are preferable, and one or more water-soluble inorganic salts selected from alkali metal sulfates, alkali metal nitrates, and alkali metal halides are more preferable, and alkali metals. One or more water-soluble inorganic salts selected from sulfates and alkali metal halides are more preferable.

The component (c) is more specifically sodium sulfate, lithium sulfate, potassium sulfate, cesium sulfate, ammonium sulfate, sodium sulfite, sodium chloride, potassium chloride, sodium nitrate, sodium carbonate, disodium hydrogen phosphate, and thiosian acid. One or more selected from sodium is mentioned, and one or more selected from sodium sulfate, potassium sulfate, sodium nitrate, sodium chloride and potassium chloride are preferable from the viewpoint of sizing effect and compounding stability, and sodium sulfate and potassium sulfate are preferable. And one or more selected from potassium chloride are more preferable.

In the mold-killing agent composition of the present invention, the component (c) is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, still more preferably 1.0% by mass, from the viewpoint of the killing effect. As described above, from the viewpoint of compounding stability, the content is preferably 10% by mass or less, more preferably 5% by mass or less, still more preferably 2% by mass or less.

In the fungicide composition of the present invention, the mass ratio (a) / (c) of the content of the component (a) to the content of the component (c) is 0.1 or more, further 0.2 or more, and further. You can select from 0.5 or more, 10 or less, 7 or less, and 5 or less.

In the fungicide composition of the present invention, the molar ratio (a) / (c) of the content of the component (a) to the content of the component (c) is 0.1 or more, further 0.3 or more, and further. You can select from 0.5 or more, 20 or less, 12 or less, and 8 or less.

In the fungicide composition of the present invention, the mass ratio (b) / (c) of the content of the component (b) to the content of the component (c) is 0.1 or more, further 0.3 or more, and further. You can select from 0.5 or more, 10 or less, 6 or less, and 4 or less.

In the fungicide composition of the present invention, the molar ratio (b) / (c) of the content of the component (b) to the content of the component (c) is 0.05 or more, further 0.1 or more, and further. You can select from 0.2 or more, 8 or less, 5 or less, and 3 or less.

The fungicide composition of the present invention can contain a surfactant [excluding the component (a) and the component (b)] [hereinafter referred to as the component (d)] as the component (d).
The component (d) is used from the viewpoint of imparting cleaning performance, but the content is preferably 10% by mass or less, more preferably 8% by mass or less, still more preferably 6% by mass or less, from the viewpoint of mold-killing effect. Is desirable.
Examples of the component (d) include a surfactant selected from nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants.

Examples of the nonionic surfactant include a polyoxyalkylene alkyl ether having an alkyl group having 10 or more and 18 or less carbon atoms, a polyoxyalkylene alkenyl ether having an alkenyl group having 10 or more and 18 or less carbon atoms, and 10 or more and 18 or less carbon atoms. Polyoxyalkylene sorbitan fatty acid ester having a fatty acid group, an alkyl glycoside having an alkyl group having 8 or more and 18 or less carbon atoms, an alkyl polyglycoside having an alkyl group having 8 or more and 18 or less carbon atoms, and a fatty acid group having 8 or more carbon atoms and 18 or less carbon atoms. Examples thereof include sucrose fatty acid esters having sucrose, alkyl polyglyceryl ethers having an alkyl group having 8 or more carbon atoms and 18 or less carbon atoms, and the like. Among them, from the viewpoint of detergency, a polyoxyethylene alkyl ether having an alkyl group having 10 or more and 16 or less carbon atoms and an average number of moles of ethylene oxide added of 1 or more and 15 or less is preferable.

Examples of the anionic surfactant include an anionic surfactant having one or more hydrocarbon groups and one or more groups selected from the group consisting of a sulfonic acid group, a sulfate ester group and a carboxylic acid group. .. Examples of the anionic surfactant include alkyl or alkenylbenzenesulfonic acid or a salt thereof, polyoxyalkylene alkyl or alkenyl ether sulfate ester or a salt thereof, alkyl or alkenylsulfate ester or a salt thereof, fatty acid or a salt thereof and the like. From the viewpoint of detergency, the anionic surfactant is preferably one or more selected from the group consisting of polyoxyalkylene alkyl or alkenyl ether sulfate ester or a salt thereof and a fatty acid or a salt thereof. The oxyalkylene group of the polyoxyalkylene alkyl or alkenyl ether sulfate ester or a salt thereof is preferably an oxyethylene group. The average number of moles of oxyalkylene groups added to the polyoxyalkylene alkyl or alkenyl ether sulfate ester salt is preferably 1 or more and 10 or less. Examples of the fatty acid or a salt thereof include a fatty acid having 10 or more carbon atoms and 18 or less carbon atoms or a salt thereof. The alkyl group or alkenyl group of the anionic surfactant preferably has 10 or more and 18 or less carbon atoms. The salt is preferably an alkali metal salt such as a sodium salt or a potassium salt.

Examples of the cationic surfactant include a quaternary ammonium salt-type cationic surfactant. As the quaternary ammonium salt-type cationic surfactant, one or two of the groups bonded to the nitrogen atom are hydrocarbon groups having 8 or more and 16 or less carbon atoms, and the rest have 1 or more and 3 or less carbon atoms. Examples thereof include a quaternary ammonium salt-type cationic surfactant which is a group selected from the group consisting of an alkyl group, a hydroxyalkyl group having 1 or more and 3 or less carbon atoms, and an arylalkyl group (benzyl group or the like). Of these, a quaternary ammonium salt-type cationic surfactant having bactericidal performance is preferable, and a quaternary ammonium salt-type cationic surfactant having a benzyl group is preferable from the viewpoint of bactericidal performance.

As the amphoteric tenside agent, an amphoteric tenside agent having an alkyl group having 8 or more carbon atoms and 22 or less carbon atoms is preferable from the viewpoint of foaming. Further, in this amphoteric surfactant, the number of carbon atoms of the alkyl group is preferably 10 or more, more preferably 11 or more, and preferably 18 or less, further preferably 13 or less. As the amphoteric tenside, one or more amphoteric tensides selected from the group consisting of alkylbetaine, alkylamide betaine, alkylsulfobetaine, alkylhydroxysulfobetaine, alkylamide hydroxysulfobetaine, and alkylamino fatty acid salt can be used. It is preferable from the viewpoint of detergency and foaming. Among them, amphoteric tensides selected from the group consisting of alkyl (8 or more carbon atoms, 22 or less) amidopropyl betaine and alkyl (8 or more carbon atoms, 22 or less carbon atoms) hydroxysulfobetaine are preferable, and further (3-lauramidopropyl). ) An amphoteric tenside selected from the group consisting of dimethylbetaine and lauryldimethylhydroxysulfobetaine is more preferable. Further, two or more kinds of amphoteric surfactants listed here may be mixed and used.

The component (d) is preferably one or more selected from anionic surfactants, cationic surfactants, and amphoteric surfactants from the viewpoint of detergency and foaming. Further, the component (d) is preferably one or more selected from an anionic surfactant, a nonionic surfactant, and an amphoteric surfactant from the viewpoint of an ester-killing effect, and is preferably polyoxyalkylene alkyl (carbon number 10 or more 18). Or alkenyl (10 or more and 18 or less carbon atoms) ether sulfate ester or its salt, fatty acid (10 or more and 18 or less carbon atoms) or its salt, alkyl (8 or more and 18 or less carbon atoms) glycoside, polyoxyalkylene alkyl (10 or more carbon atoms) More preferably, one or more selected from 10 or more and 18 or less) or alkenyl (10 or more and 18 or less carbon atoms) ether and alkyl (8 or more and 22 or less carbon atoms) amide propyl betaine, and polyoxyalkylene alkyl (10 or more and 18 carbon atoms). One or more selected from alkenyl (10 or more and 18 or less carbon atoms) ether sulfate ester or a salt thereof, alkyl (8 or more and 18 or less carbon atoms) glycoside, and alkyl (8 or more and 22 or less carbon atoms) amide propyl betaine. More preferably, from the viewpoint of compounding stability, polyoxyalkylene alkyl (10 or more and 18 or less carbon atoms) or alkenyl (10 or more and 18 or less carbon atoms) ether sulfate ester or a salt thereof, and alkyl (8 or more and 22 or less carbon atoms). More preferably, one or more selected from amidpropyl betaine.

When the mold-killing agent composition of the present invention contains the component (d), the component (d) is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, from the viewpoint of cleaning performance. It is more preferably 1.0% by mass or more, preferably 10% by mass or less, more preferably 8% by mass or less, still more preferably 6% by mass or less.

In order to increase the added value of the product, the mold-killing agent composition of the present invention may be optionally blended with a fragrance, a dye, a preservative, an antioxidant and the like (provided that the above (a) to (d) are added. ) Excluding ingredients).

The fungicide composition of the present invention contains water. That is, the balance other than the components (a) to (b) and the optional components is water. The mold-killing agent composition of the present invention contains water, preferably 50% by mass or more, more preferably 60% by mass or more, still more preferably 70% by mass or more, still more preferably 80% by mass or more, and preferably 99. It is contained in an amount of% by mass or less, more preferably 95% by mass or less. As the water, it is preferable to use ion-exchanged water, sterile ion-exchanged water, or the like.

The fungicide composition of the present invention is a fungicide composition that does not require a strong alkali or strong acid. That is, the antifungal composition of the present invention can obtain a good antifungal effect even if it is a liquid near neutrality. The fungicide composition of the present invention has a pH at 25 ° C. of preferably 2 or more, more preferably 4 or more, still more preferably 6 or more, and from the viewpoint of ease of handling and irritation to the hand skin. It is preferably less than 12, more preferably less than 10, and even more preferably less than 8.

The antifungal composition of the present invention is suitably used for cleaning hard surfaces such as bathrooms, bathtubs, washbasins, tiles, dressing rooms, washbasins, mirrors, sinks around kitchens, countertops, and water taps. It is suitably used for bathrooms. Here, the term "for bathroom" refers not only to bathrooms but also to articles having other hard surfaces existing in the bathroom, such as bathtubs and washbasins.

The mold-killing agent composition of the present invention has an excellent mold-killing action on mold. For example, for fungi of the genera Cladosporium, Aspergillus, Candida, Penicillium, Alternaria, Phoma, and Aureobasidium. It shows a high genus killing effect for the representative genus.
Also, Saccharomyces, Rhodotorula, Pichia fungi, Pseudomonas aeruginosa, Pseudomonas putida and other Pseudomonas bacteria, Escherichia coli, Alcaligenes faec ), Klebsiellapneumoniae, Proteus vulgaris, Serratia marcescense, Methylobacterium and other gram-negative bacteria; also against gram-positive bacteria such as Staphylococcus aureus. Shows a high bactericidal effect.

[Mold killing method]
The mold-killing method of the present invention is a mold-killing method in which the mold-killing agent composition of the present invention is brought into contact with the surface of an object in which fungi are present for 30 seconds or longer.
In the present invention, after the antifungal composition of the present invention is brought into contact with the target surface, the surface can be washed. Further, in the present invention, the target surface can be cleaned with a cleaning article in which the mold-killing agent composition of the present invention is supported on a substrate.
As the target surface, a hard surface such as a bathroom, a bathtub, a washbasin, a tile, a dressing room, a washbasin, a mirror, a sink around the kitchen, a countertop, and a water supply is suitable.

Specifically, the mold-killing method of the present invention is such that the mold-killing agent composition of the present invention is brought into contact with the target surface with a stock solution, or the mold-killing agent composition is brought into contact with a target surface without being diluted with a stock solution. That is, a cleaning method in which the fungicide composition is brought into contact with the surface of the object without being diluted is preferably mentioned. Further, there is a mold killing method in which the mold killing agent composition is brought into contact with the surface of the target to which the fungus adheres without diluting. As a method of contacting with the target surface, a method of applying to the target surface is preferable.
Contacting the target surface without diluting the mold-killing agent composition means that the mold-killing agent composition is intentionally diluted with water or the like and then not brought into contact with the target surface. For example, when the mold-killing agent composition is brought into contact with the target surface to which water droplets or the like are attached, or when the mold-killing agent composition is brought into contact with the target surface and then water droplets are attached to the target surface, the killing is performed. It can be understood that the mold composition is brought into contact with the target surface without being diluted.
In the mold-killing method of the present invention, the mold-killing agent composition may be directly applied or sprayed from a bottle in order to bring the mold-killing agent composition into contact with the target surface with a stock solution, and the bottle may be, for example, a squeeze bottle, a spray bottle or the like. Can be mentioned.
Further, when the cleaning article impregnated with the fungicide composition of the present invention is used, the fungicide composition of the present invention may be separately used while being sprayed on the object to be cleaned or the cleaning article. Clean a larger area according to the method of use.

However, a concentrated composition containing the component (a), the component (b), and the optional component of the present invention is prepared, and the concentrated composition is diluted with water to prepare the mold-killing agent composition of the present invention. , May be in contact with the target surface. That is, a concentrated composition containing the component (a), the component (b), and the optional component of the present invention is diluted with water to prepare the mold-killing agent composition of the present invention, and the mold-killing agent composition is diluted. It may be a dilution method in which the surface of the object is brought into contact with the surface of the object without using it.

From the viewpoint of the fungal killing effect, the leaving time for contacting the surface of the object in which the fungus is present is preferably 30 seconds or longer, preferably 1 minute or longer, more preferably 2 minutes or longer, still more preferably 3. Minutes or more, more preferably 4 minutes or more, still more preferably 5 minutes or more, and from the viewpoint of efficient cleaning, preferably 30 minutes or less, more preferably 20 minutes or less, still more preferably 10 minutes or less. Is.
After leaving it, it is usually rinsed with water. When rinsing, mechanical force (physical force) may be applied by hand or simply rinsing with a stream of water.
The temperature when left to stand may be room temperature, for example, 10 ° C. or higher and 30 ° C. or lower.

The fungicide compositions shown in Tables 1 and 2 were prepared using the following compounding ingredients, and the following items were evaluated. The results are shown in Tables 1 and 2. The mold-killing agent compositions shown in Tables 1 and 2 are prepared by adding sodium hydrogen phosphate and sodium dihydrogen phosphate to ion-exchanged water, respectively, to prepare a 10 mM phosphate buffered aqueous solution (pH 7.8) containing the component (a). The component (b) and the component (b') were added in the blending amounts shown in the table and dissolved at room temperature (25 ° C.). The mass% of the compounding components in Tables 1 and 2 are all numerical values based on the effective amount.

<Ingredients>
(A) Ingredients-Benzyl alcohol: manufactured by Tokyo Chemical Industry Co., Ltd., molecular weight 108
-Phenoxyethanol: manufactured by Nippon Emulsorium Co., Ltd., molecular weight 138

(B) Ingredients-2-butanol: molecular weight 74, logP0.87, manufactured by Wako Pure Chemical Industries, Ltd., first grade, (b1)
1-Butanol: Molecular weight 74, logP0.97, manufactured by Tokyo Chemical Industry Co., Ltd., (b1)
1,2-Hexanediol: molecular weight 118, logP0.85, manufactured by Tokyo Chemical Industry Co., Ltd., (b2)
-Cyclohexylglycerin: molecular weight 174, logP0.58, manufactured by ADEKA Corporation, (b3)
1-Propanol: molecular weight 60, logP0.55, manufactured by Wako Pure Chemical Industries, Ltd., special grade, (b1)
2-propanol: molecular weight 60, logP0.38, manufactured by Wako Pure Chemical Industries, Ltd., first grade, (b1)
-Tert-Butyl: molecular weight 74, logP0.60, manufactured by Tokyo Chemical Industry Co., Ltd., (b1)
1-Pentanol: molecular weight 88, logP1.39, manufactured by Tokyo Chemical Industry Co., Ltd., (b1)
-3-Pentanol: Molecular weight 88, logP1.36, manufactured by Tokyo Chemical Industry Co., Ltd., (b1)
1-Hexanol: molecular weight 102, logP1.80, manufactured by Tokyo Chemical Industry Co., Ltd., (b1)
1-Heptanol: molecular weight 116, logP2.22, manufactured by Wako Pure Chemical Industries, Ltd., special grade, (b1)
1,2-pentanediol: molecular weight 104, logP0.43, manufactured by Tokyo Chemical Industry Co., Ltd., (b2)
-Hexyl glycerin: molecular weight 176, logP1.11, manufactured by ADEKA Corporation, (b3)

(B') component (comparative component of (b) component)
-Ethanol: molecular weight 46, manufactured by Wako Pure Chemical Industries, Ltd., special grade-methanol: molecular weight 32, manufactured by Wako Pure Chemical Industries, Ltd., for high performance liquid chromatography graph

<Mold-killing evaluation method>
After culturing the environmental isolate Cladosporium sp. PA-4 of the genus Cladosporium, which is a living environment priority, on a potato dextrose plate agar plate (Potato Dextrose Agar reagent manufactured by Becton Dickinson was prepared according to the Noh book) at 25 ° C for 7 days. 4 mL of spore recovery solution (0.05% Tween80 solution manufactured by Wako Pure Chemical Industries, Ltd. prepared with physiological saline manufactured by Otsuka Pharmaceutical Factory Co., Ltd.) was dropped onto the agar plate, and a conlarge stick (Nissui) was added. The bacterial solution was recovered by gently rubbing it with a pharmaceutical company (manufactured by Pharmaceutical Co., Ltd.). After that, the collected hyphae were filtered using Miracross (manufactured by CALBIOCHEM) to remove hyphae, and the obtained liquid was centrifuged (10,000 rpm, 25 ° C., 5 min) to remove the supernatant. These operations were repeated two or three times, and the bacterial concentration was adjusted to 3.0 to 7.0 × ¹⁰⁷ CFU / mL to prepare a test spore solution.

Using the antifungal composition shown in Tables 1 and 2 as the test solution, 10 μL of the prepared test spore solution was mixed with 1 mL of the test solution, contacted at 25 ° C. for 5 minutes, and then 100 μL was separated. The test solution was inactivated by suspending it in 900 μL of LP diluted solution (prepared according to Noh book by Nissui Pharmaceutical Co., Ltd.). After further diluting this with LP diluted solution, it was applied to a potato dextrose plate agar medium (Potato Dextrose Agar reagent manufactured by Becton Dickinson was prepared according to the Noh book) and cultured at 25 ° C for 4 days from the number of colonies obtained. The number of surviving bacteria was calculated.

In addition, use physiological saline (manufactured by Otsuka Pharmaceutical Factory, Inc.) instead of the test solution to mix 10 μL of the bacterial solution with 1 mL of the test solution, contact for 5 minutes, and then mix with the LP diluted solution. ) Was used as the target operation, and the logarithmic difference between the number of surviving bacteria after the target operation and the number of surviving bacteria after contact with the test solution was calculated and used as an index of bactericidal performance. The results are shown in Tables 1 and 2.

<Appearance evaluation>
The appearance of each moldicide composition shown in Tables 1 and 2 immediately after preparation after being left at 20 ° C. for 12 hours was evaluated according to the following criteria. The results are shown in Tables 1 and 2.
Transparent: The composition is a clear, clear solution.
Separation: The composition is a liquid separated into two layers.
White turbidity: The composition is a turbid, cloudy liquid.

In the table, those having a ΔLog-reduced number of bacteria of 4.5 or more indicate a detection limit value, which means that the number of surviving bacteria is extremely small after being killed by the fungicide composition.

Claims (3)

(A) A compound represented by the following general formula (a-1) [hereinafter referred to as (a) component], (b) one or more selected from the following compounds (b1) [hereinafter referred to as (b) component ], And a fungicide composition containing water.
(A) Contains 0.1% by mass or more and 10% by mass or less of the component.
(B) Contains 0.1% by mass or more and 10% by mass or less of the component, and
The mass ratio (a) / (b) between the content of the component (a) and the content of the component (b) is 0.1 or more and 50 or less.
Moldicide composition.
(B1): One or more fatty alcohols selected from 1-propanol, 1-hexanol, 1-pentanol, 3-pentanol, 1-butanol, tert-butanol, 1-heptanol, and 1-octanol.

(In the formula, R ^1a is a divalent hydrocarbon group having 1 or more carbon atoms and 4 or less carbon atoms, and r and l are 0 or an integer of 1, but when l is 0, r is an integer of 1. A is an alkylene group having 2 or more and 4 or less carbon atoms.) (B) The component is one or more aliphatic alcohols selected from 1-hexanol, 1-pentanol, 3-pentanol, and 1-octanol, and
The fungicide composition according to claim 1, wherein the component (b) is contained in an amount of 0.1% by mass or more and less than 3% by mass. A fungicide method in which the fungicide composition according to claim 1 or 2 is brought into contact with the surface of a target in which fungi are present for 30 seconds or longer.