JP2022050307A - Virus inactivation coat composition, virus inactivation method of virus inactivation object and virus inactivation coat material - Google Patents

Abstract

To provide a virus inactivation coat composition capable of sustaining a virus inactivation effect for a long term, in a virus inactivation object.SOLUTION: A virus inactivation coat composition comprises glue, alkylamine oxide, virus trapping agent, alcohol of 1 to 3 carbon atoms and water, and the viral trapping agent is at least one selected from sialic acid, sulfatide, angiotensin converting enzyme II and C-type lectin, when relative to 100 pts.mass of the glue, alkylamine oxide is contained in an amount of 0.1 pt.mass or more and 2.0 pts.mass or less, the virus trapping agent is contained in the amount of 0.1 pt.mass or more and 1.0 pt.mass or less, and when a total amount of the glue, the alcohol and the water is set to 100 mass%, the glue is in the amount of 2.0 mass% or more and 9.0 mass% or less, and the amount of the alcohol is 2.5 mass% or more and 7.5 mass% or less, and the water is contained in the amount of 83.5 mass% or more and 95.5 mass% or less.SELECTED DRAWING: None

Description

The present invention relates to a virus inactivating coat composition, a virus inactivating method for a virus inactivating object, and a virus inactivating coating material.

Patent Document 1 describes (a) ethanol in an amount of 7 to 25% by mass, and (b) one or more surfactants selected from nonionic surfactants, amphoteric surfactants and cationic surfactants. A sterilizing composition containing 02 to 0.7% by mass is described.

Japanese Unexamined Patent Publication No. 2011-236204

However, when virus inactivation is performed using the sterilization composition of Patent Document 1, there is a problem that the virus inactivating effect is not sustained in the virus inactivating object.

Therefore, an object of the present invention is to provide a virus inactivating coat composition having a long-term sustainable virus inactivating effect in a virus inactivating object.

The virus-inactivating coat composition of the present invention contains glue, an alkylamine oxide, a virus trapping agent, alcohol and water having 1 to 3 carbon atoms, and the virus trapping agent includes sialic acid, sulfatide, angiotensin converting enzyme II and It is at least one selected from C-type lectin, and the amount of the above alkylamine oxide is 0.1 part by mass or more and 2.0 parts by mass or less with respect to 100 parts by mass of the glue, and the virus trapping agent is 0. When the amount of the glue is 1 part by mass or more and 1.0 part by mass or less, and the total of the glue, the alcohol and the water is 100% by mass, the glue is 2.0% by mass or more and 9.0% by mass or less. In terms of amount, the alcohol is contained in an amount of 2.5% by mass or more and 7.5% by mass or less, and the water is contained in an amount of 83.5% by mass or more and 95.5% by mass or less.

According to the virus inactivating coat composition of the present invention, the virus inactivating effect can be sustained for a long period of time in the virus inactivating object.

An embodiment (embodiment) for carrying out the present invention will be described in detail. The present invention is not limited to the contents described in the following embodiments. In addition, the components described below include those that can be easily assumed by those skilled in the art and those that are substantially the same. Furthermore, the configurations described below can be combined as appropriate. Further, various omissions, substitutions or changes of the configuration can be made without departing from the gist of the present invention.

<Virus inactivating coat composition of embodiment>
The virus inactivating coat composition of the embodiment contains glue, an alkylamine oxide, sialic acid, an alcohol having 1 to 3 carbon atoms, and water. Further, in the virus inactivating coat composition of the embodiment, the amount of the alkylamine oxide is 0.1 part by mass or more and 2.0 parts by mass or less, and the amount of the sialic acid is 0.1 with respect to 100 parts by mass of the glue. It is contained in an amount of 1 part by mass or more and 1.0 part by mass or less. Further, in the virus inactivating coat composition of the embodiment, when the total of the glue, the alcohol and the water is 100% by mass, the amount of the glue is 2.0% by mass or more and 9.0% by mass or less. , The alcohol is contained in an amount of 2.5% by mass or more and 7.5% by mass or less, and the water is contained in an amount of 83.5% by mass or more and 95.5% by mass or less.

In addition, in this specification, virus inactivation means killing a virus (losing infectivity). Examples of the virus include enveloped viruses such as coronavirus and influenza virus.

The virus inactivating coat composition of the embodiment containing the above component in the above specific amount is applied to the surface of the virus inactivating object and used. The applied virus inactivating coat composition of the embodiment forms a virus inactivating coat layer on the surface of the virus inactivating object. Since the virus inactivating coat layer can exist stably for a long period of time, the virus inactivating effect can be sustained for a long period of time. Moreover, since the virus inactivating coat layer is not sticky, it does not affect the use of the virus inactivating object. Further, since the virus inactivating coat layer is colorless and transparent when it does not contain the aqueous dye described later, it does not spoil the aesthetic appearance of the virus inactivating object. Further, since the virus inactivating coat composition of the embodiment does not discolor the metal, even when the virus inactivating object is composed of the metal, the appearance of the virus inactivating object is not spoiled.

The virus inactivated coat layer formed from the virus inactivated coat composition of the embodiment is water soluble and can be removed by wiping with water. After a certain period of time has passed from the formation of the virus inactivated coat layer, stains may adhere to the surface of the virus inactivated coat layer. The stain may reduce the virus inactivating effect. In such a case, the virus inactivating coat layer can be removed by wiping with water, and a new virus inactivating coat layer can be provided by using the virus inactivating coat composition of the embodiment.

The virus inactivated coat composition of the embodiment is less likely to cause precipitation and is excellent in storage stability. For example, the virus inactivated coat composition of the embodiment can be suitably stored in a closed container without deterioration at 5 ° C. or higher and 60 ° C. or lower.

The virus inactivated coat composition of the embodiment comprises glue. It is considered that glue constitutes a network structure in the virus inactivated coat layer and can stably retain alkylamine oxides and sialic acid in the network. Therefore, according to the virus inactivating coat layer using the virus inactivating coat composition of the embodiment, it is considered that the virus inactivating effect lasts for a long period of time. By using glue, a virus-inactivated coat layer that is not sticky, is colorless and transparent when it does not contain the aqueous dye described later, and is difficult to deteriorate can be formed. Further, since the glue is contained in the above amount, the virus inactivating coat composition of the embodiment is excellent in storage stability, and a virus inactivating coat layer having a suitable thickness can be formed. Further, from the viewpoint of uniformly forming a virus inactivating coat layer having a more suitable thickness, the virus inactivating coat composition of the embodiment is obtained when the total of the glue, the alcohol and the water is 100% by mass. In addition, the glue is 2.0% by mass or more and 3.0% by mass or less, the alcohol is 2.5% by mass or more and 7.5% by mass or less, and the water is 89.5% by mass or more and 95% by mass. It is preferably contained in an amount of 5.5% by mass or less.

The virus inactivated coat composition of the embodiment comprises an alkylamine oxide. Alkyl amine oxides can damage the envelope of enveloped viruses and detoxify and detoxify them. Alkylamine oxide is preferably used because it can detoxify and detoxify viruses even in a small amount and has good compatibility with glue. The alkylamine oxide also has a role of improving the coatability of the virus inactivating coat composition of the embodiment.

As the alkylamine oxide, for example, a compound represented by the following formula (1) is preferably used. The alkylamine oxide may be used alone or in combination of two or more.

In the above formula (1), R ¹ represents an alkyl group or an alkenyl group having 8 to 16 carbon atoms which may be partitioned by an amide group, and R ² and R ³ are independently having 1 carbon atom. An alkyl group of ~ 3 or a hydroxyalkyl group having 1 to 3 carbon atoms is shown.

In the above formula (1), R ¹ is preferably an alkyl group having 8 to 14 carbon atoms or an alkanoylaminopropyl group having 8 to 14 carbon atoms, and R ¹ is an alkyl group having 8 to 14 carbon atoms. It is more preferable that R ² and R ³ are methyl groups.

Specific examples of the alkylamine oxide include N-decyl-N, N-dimethylamine oxide, N-lauryl-N, N-dimethylamine oxide, N-myristyl-N, N-dimethylamine oxide, and N-cap. Examples thereof include loylaminopropyl-N, N-dimethylamine oxide, N-lauroylaminopropyl-N, N-dimethylamine oxide, and N-myristylloylaminopropyl-N, N-dimethylamine oxide. Of these, N-lauryl-N, N-dimethylamine oxide, N-decyl-N, N-dimethylamine oxide, and N-myristyl-N, N-dimethylamine oxide are particularly preferable.

Since the alkylamine oxide is contained in the above amount, the virus inactivating coat layer formed by using the virus inactivating coat composition of the embodiment can maintain the virus inactivating effect for a long period of time. In addition, the stickiness of the virus inactivated coat layer can be suppressed.

The virus inactivated coat composition of the embodiment comprises sialic acid. Sialic acid can bind to hemagglutinin present on the surface of a virus (such as influenza virus) and capture the virus. That is, it can be said that sialic acid is one kind of virus scavenger, and the virus inactivating coat composition of the embodiment contains sialic acid as a virus scavenger. If the sialic acid contained in the virus inactivating coat layer provided on the virus inactivating object captures the virus, then even if there is a person who touches the virus inactivating object, the virus is transferred to that person. It becomes difficult. In addition, when sialic acid traps the virus, the movement of the virus is suppressed while the alkylamine oxide detoxifies and detoxifies the virus. Therefore, the virus can be reliably detoxified and detoxified.

Sialic acid is a general term for neuraminic acid. Sialic acid may be used alone or in combination of two or more. Examples of sialic acid include N-acetylneuraminic acid and N-glycolylneuramine.

Since the sialic acid is contained in the above amount, the virus inactivated coat layer formed by using the virus inactivated coat composition of the embodiment can preferably capture the virus. Further, since sialic acid is contained in the above amount, the storage stability of the virus inactivated coat composition of the embodiment can be improved.

The virus inactivated coat composition of the embodiment contains an alcohol having 1 to 3 carbon atoms. Alcohol can improve the coatability of the virus inactivated coat composition of the embodiment. In addition, the storage stability of the virus inactivated coat composition of the embodiment can be enhanced.

Examples of the alcohol having 1 to 3 carbon atoms include methanol, ethanol, 1-propanol and 2-propanol. Alcohol may be used alone or in combination of two or more.

When the alcohol is contained in the above amount, other components in the virus inactivating coat composition of the embodiment do not precipitate, which is preferable in terms of storage stability.

The virus inactivated coat composition of the embodiment comprises water. As the water, ion-exchanged water or distilled water from which the metal component has been removed is preferably used.

Further, the virus inactivating coat composition of the embodiment may contain a siloxane compound having a group containing a polyalkylene oxide structure as an anti-repellent agent. When such an anti-repellent agent is contained, it can be applied to a virus inactivated object without repelling. Therefore, it is possible to eliminate a site where the virus inactivating coat composition of the embodiment is repelled and cannot be applied to form a virus inactivating coat layer, that is, a site where the virus cannot be inactivated. Further, when the virus inactivated coat layer is formed, it is considered that the repellent inhibitor gradually volatilizes from the layer and the influence of the addition is reduced.

In the above siloxane compound, examples of the polyalkylene oxide structure include a polyethylene oxide structure (-[CH ₂ CH ₂ O] _n- ) and a polypropylene oxide structure (-[CH ₂ CH ₂ CH ₂ O] _n- ). The siloxane compound may be a trisiloxane compound or a tetrasiloxane compound, and is preferably a trisiloxane compound. Specifically, the above-mentioned siloxane compound is Poly (oxy-1,2-ethanediyl) ,. alpha. -Methyl-. omega. -[3- [1,3,3,3-tetramethyl-1-[(trimethylsilyl) oxygen] -1-disiloxanyl] propoxy]-(CAS 27306-78-1, flash point 214 ° C. of a single substance). preferable. The above-mentioned anti-repellency agent may be used alone or in combination of two or more.

The anti-repellent agent is preferably contained in an amount of 0.3 parts by mass or more and 3.0 parts by mass or less with respect to 100 parts by mass in total of glue, alkylamine oxide, sialic acid, alcohol and water. The anti-repellency agent is effective only when a small amount is added in this way, and it is preferable to add it within a range that does not impair the target function.

Further, the virus inactivated coat composition of the embodiment may contain a water-soluble dye or a coumarin derivative as a colorant. When such a colorant is contained, it can be easily confirmed whether or not it can be applied to the virus inactivating object or whether or not the virus inactivating coat layer can be formed. If it contains a water-soluble dye, it can be visually confirmed. When a coumarin derivative is contained, it can be confirmed by the fluorescence emitted when irradiated with ultraviolet rays. When the appearance color of the virus inactivated object may change, a water-soluble dye is preferably used, and when it is preferable that the appearance color of the virus inactivated object does not change, a coumarin derivative is preferably used.

The water-soluble dye is not particularly limited as long as it can be dissolved in the virus-inactivating coat composition of the embodiment, but for example, Basic Blue 12 (CAS 2381-85-3), Basic Blue 17 (CAS 92-31-9) and the like. , A green dye such as Acid Green 3 (CAS 4680-78-8), and a red dye such as Acid Red 52 (CAS 3520-42-1) are preferably used. The water-soluble dye may be used alone or in combination of two or more.

Coumarin is a compound having 2H-chromen-2-one as a basic skeleton. Examples of the coumarin derivative include compounds in which an electron donating group is introduced at the 7-position of the basic skeleton. Examples of the electron donating group include a dimethylamino group, a diethylamino group and a dipropylamino group. Further, a methyl group, an ethyl group, an n-propyl group and an isopropyl group may be present at the 4-position of the basic skeleton. Of these, a coumarin derivative having a diethylamino group at the 7-position of the basic skeleton and a methyl group at the 4-position of the basic skeleton is preferably used. The above coumarin derivative may be used alone or in combination of two or more.

The colorant is preferably contained in an amount of 0.01 parts by mass or more and 1.0 parts by mass or less with respect to 100 parts by mass in total of glue, alkylamine oxide, sialic acid, alcohol and water.

The virus inactivated coat composition of the embodiment may further contain other components. Other components include, for example, titanium oxide. When other components are contained, the other components may be contained in an amount of 0.1 parts by mass or more and 5.0 parts by mass or less with respect to 100 parts by mass of the glue.

The virus inactivated coat composition of the embodiment can be prepared by appropriately mixing the above-mentioned components in the above-mentioned amounts.

The virus inactivating coat composition of the embodiment is suitably used for virus inactivation of a virus inactivating object. Examples of the virus inactivated object include products made of metal, plastic, glass, pottery, wood, leather and the like. Such products include doorknobs, handrails, countertops, furniture, household goods, and watch bands (watch bands made of metal or leather). In the virus inactivating method of a virus inactivating object, specifically, the above-mentioned virus inactivating coat composition is applied to the surface of the virus inactivating object to form a virus inactivating coat layer. After the virus inactivating coat composition of the embodiment is applied to the surface of the virus inactivating object, when alcohol and water evaporate to some extent, a virus inactivating coat layer is formed. This virus inactivating coat layer is non-greasy, colorless and transparent when it does not contain an aqueous dye, and can stably exist on the surface of the virus inactivating object. As a result, the virus inactivating effect can be sustained for a long period of time in the virus inactivating object.

Further, when the virus inactivating coat composition of the embodiment contains an anti-repellent agent, the layer can be reliably formed at the site where the virus inactivating coat layer is desired to be formed in the virus inactivating object. Further, when the virus inactivating coat composition of the embodiment contains a colorant, it can be easily confirmed whether the layer can be formed at the site where the virus inactivating coat layer is desired to be formed in the virus inactivating object. ..

When applying the virus inactivating coat composition of the embodiment, it is preferable to carry out at 15 ° C. or higher and 25 ° C. Specifically, the above composition may be applied to the surface of the virus inactivating object with a cloth or brush impregnated with the virus inactivating coat composition of the embodiment, using a sprayer or a sprayer. , The above composition may be applied. Alternatively, the virus inactivating coat composition of the embodiment may be poured on the surface of the virus inactivating object, and the excess composition on the surface may be wiped with a cloth and applied. Further, the virus inactivating coat composition of the embodiment may be placed in a container with a sponge cap, and the composition may be applied via the sponge of the sponge cap.

When reapplying the virus inactivated coat composition of the embodiment, first, the virus inactivated coat layer already formed is removed by wiping with water. Then, as described above, a new virus inactivated coat layer is provided. Even if the virus inactivating effect is reduced due to dirt on the surface of the virus inactivating coat layer, the virus inactivating effect is exhibited again by the newly provided virus inactivating coat layer.

<Modified example of the virus inactivated coat composition of the embodiment>
In the virus inactivating coat composition of the above-described embodiment, the case where sialic acid is contained as a virus scavenger has been described. In contrast, the modified virus inactivated coat composition contains sulfatide, angiotensin converting enzyme II or C-type lectin as a virus scavenger instead of sialic acid. Examples of the C-type lectin include DC-SIGN, L-SIGN, MR and MGL. These virus scavengers may be used alone or in combination of two or more. In addition, sialic acid may be used in combination with sulfatide, angiotensin converting enzyme II or C-type lectin. Sulfatide, like sialic acid, can bind to hemagglutinin, which is present on the surface of viruses, especially influenza virus, and can capture the virus. On the other hand, the angiotensin converting enzyme II or C-type lectin can bind to hemagglutinin present on the surface of the new coronavirus (SARS-Cov-2) among the viruses and capture the virus. Therefore, the virus scavenger contained in the virus inactivating coat layer provided on the virus inactivating object can capture the virus, and even if there is a person who subsequently touches the virus inactivating object, that person It becomes difficult for the virus to transfer to. In addition, when the virus scavenger captures the virus, the movement of the virus is suppressed while the alkylamine oxide detoxifies and detoxifies the virus. Therefore, the virus can be reliably detoxified and detoxified even by the virus inactivating coat composition of the modified example.

The virus inactivating coat composition of the modified example is the same as the virus inactivating coat composition of the above-described embodiment except that the virus scavenger other than sialic acid is contained as the virus scavenger. When two or more kinds of virus scavengers are used in combination, the total amount is preferably 0.1 part by mass or more and 1.0 part by mass or less with respect to 100 parts by mass of glue. When the virus catching agent is contained in the above amount, the virus inactivating coat layer formed by using the virus inactivating coat composition of the modified example can suitably catch the virus.

<Virus inactivated coating material of Embodiments 1 to 4>
In the virus inactivating coat material of the first embodiment, the substrate is impregnated with the virus inactivating coat composition containing glue, alkylamine oxide, sialic acid, alcohol having 1 to 3 carbon atoms and water, and the virus is inactivated. In the activated coat composition, the amount of the alkylamine oxide is 0.1 part by mass or more and 2.0 parts by mass or less, and the amount of sialic acid is 0.1 part by mass or more and 1.0 part by mass with respect to 100 parts by mass of the glue. The substrate is a paper, non-woven fabric, woven fabric, knitted fabric or porous structure. In the virus inactivating coat composition, when the total of the glue, the alcohol and the water is 100% by mass, the glue is added in an amount of 2.0% by mass or more and 9.0% by mass or less. It is preferable that the water is contained in an amount of 2.5% by mass or more and 7.5% by mass or less and 83.5% by mass or more and 95.5% by mass or less.

In the virus inactivating coating material of the first embodiment, the virus inactivating coating composition may further contain the anti-repellent agent. The anti-repellent agent is preferably contained in an amount of 0.3 parts by mass or more and 3.0 parts by mass or less with respect to 100 parts by mass in total of glue, alkylamine oxide, sialic acid, alcohol and water. Further, in the virus inactivating coat material of the first embodiment, the virus inactivating coat composition may further contain the coloring agent. The colorant is preferably contained in an amount of 0.01 parts by mass or more and 1.0 parts by mass or less with respect to 100 parts by mass in total of glue, alkylamine oxide, sialic acid, alcohol and water.

Specifically, the virus inactivating coat material is produced by impregnating a substrate with the virus inactivating coat composition of the above-described embodiment. Alcohol and water can evaporate after the virus inactivated coating material is prepared. Therefore, in the virus inactivated coating material of the first embodiment, the amounts of alcohol and water may be smaller than immediately after the preparation.

When the virus inactivating coating material is brought into contact with the virus inactivating object, the virus inactivating coating composition impregnated in the substrate is applied to the surface of the virus inactivating object to form a virus inactivating coat layer. can. After the virus inactivating coat composition is applied to the surface of the virus inactivating object, when alcohol and water evaporate to some extent, a virus inactivating coat layer is formed. This virus inactivating coat layer exerts a virus inactivating effect for a long period of time on a virus inactivating object. Further, when the virus inactivating coat composition contains an anti-repellent agent, the layer can be reliably formed at the site where the virus inactivating coat layer is desired to be formed in the virus inactivating object. Further, when the virus inactivating coat composition contains a colorant, it can be easily confirmed whether the layer can be formed at the site where the virus inactivating coat layer is desired to be formed in the virus inactivating object.

Specifically, the virus-inactivated coating material of the first embodiment may be an individually packaged package, or may be a package containing a plurality of the virus-inactivated coating materials. Examples of the individually wrapped package include a package containing one virus-inactivated coating material in a bag. Such a package can be manufactured, for example, by surrounding the virus-inactivated coating material with a rectangular film and heat-sealing the ends. Examples of the package containing a plurality of the packages include a package in which a plurality of flatly folded virus-inactivated coating materials are laminated and stored in a bag. Such a package can also be manufactured, for example, by surrounding the virus-inactivated coating material with a rectangular film and heat-sealing the ends. In the case of a package containing a plurality of packages, the film constituting the package should be provided with an opening for taking out the virus inactivated coating material, and a lid material for opening and closing the opening should be provided. Is preferable. According to this, it is easy to take out the virus inactivated coating material one by one, and it is possible to prevent the virus inactivating coating material from deteriorating by closing the opening even after opening. Further, as a package containing a plurality of substances, there is also a package in which a virus-inactivated coating material wound in a roll shape is packed in a cylindrical container.

In the virus inactivating coat material of the second embodiment, the adhesive layer, the base material, and the virus inactivating coat layer are laminated in this order, and the virus inactivating coat layer is based on 100 parts by mass of glue. It contains alkylamine oxide in an amount of 0.1 parts by mass or more and 2.0 parts by mass or less, and sialic acid in an amount of 0.1 parts by mass or more and 1.0 parts by mass or less. The substrate is made of, for example, resin, paper, cloth, metal, or the like.

In the virus inactivating coat material of the second embodiment, the virus inactivating coat layer may further contain the anti-repellent agent. Further, in the virus inactivating coat material of the second embodiment, the virus inactivating coat layer may further contain the coloring agent.

The virus inactivated coat layer is specifically obtained by evaporating water and alcohol from the virus inactivated coat composition of the above-described embodiment. Therefore, the amount of alcohol and water in the virus inactivating coat material of the second embodiment is usually smaller than that in the virus inactivating coat composition.

The virus inactivating coating material can be attached to a virus inactivating object via an adhesive layer. The virus inactivating coat layer on the surface of the virus inactivating coating material exerts a virus inactivating effect for a long period of time on the virus inactivating object. Further, when the virus inactivating coat layer contains an anti-repellent agent, the layer can be reliably attached to the virus inactivating object at the site where the virus inactivating coat layer is desired to be formed. Further, when the virus inactivating coat layer contains a colorant, it can be easily confirmed whether the layer is attached to the site where the virus inactivating coat layer is desired to be formed in the virus inactivating object.

Specifically, the virus inactivated coating material of the second embodiment may be a roll wound in a roll shape. Further, in the virus inactivated coating material of the second embodiment, a peeling layer may be further laminated on the adhesive layer side. In this case, the virus inactivating coating material can be attached to the virus inactivating object by the peeling layer and the exposed adhesive layer.

The virus inactivating coat material of the third embodiment has a base material and a virus inactivating coat layer laminated on the base material and transferable to the surface of the virus inactivating object, and the virus inactivating coat layer is the same. , The amount of alkylamine oxide is 0.1 parts by mass or more and 2.0 parts by mass or less, and the amount of virus is 0.1 parts by mass or more and 1.0 parts by mass or less with respect to 100 parts by mass of glue.

In the virus inactivating coat material of the third embodiment, the virus inactivating coat layer may further contain the anti-repellent agent. Further, in the virus inactivating coat material of the second embodiment, the virus inactivating coat layer may further contain the coloring agent.

The virus inactivated coat layer is specifically obtained by evaporating water and alcohol from the virus inactivated coat composition of the above-described embodiment. Therefore, the amount of alcohol and water in the virus inactivating coat material of the third embodiment is usually smaller than that in the virus inactivating coat composition.

When the virus inactivating object is wetted with water and brought into contact with the virus inactivating coat layer, the virus inactivating coat layer is partially dissolved. Next, a part of the dissolved virus inactivated coat layer is solidified on the surface of the virus inactivated object, and the virus inactivated coat layer is transferred. This virus inactivating coat layer exerts a virus inactivating effect for a long period of time on a virus inactivating object. Further, when the virus inactivating coat layer contains an anti-repellent agent, the layer can be reliably transferred to the site where the virus inactivating coat layer is desired to be formed in the virus inactivating object. Further, when the virus inactivating coat layer contains a colorant, it can be easily confirmed whether the layer is transferred to the site where the virus inactivating coat layer is desired to be formed in the virus inactivating object.

The virus inactivating coating material of the fourth embodiment is a rod-shaped molded body, and the amount of alkylamine oxide is 0.1 part by mass or more and 2.0 parts by mass or less with respect to 100 parts by mass of the molded body glue. It contains sialic acid in an amount of 0.1 part by mass or more and 1.0 part by mass or less.

In the virus inactivated coating material of the fourth embodiment, the molded product may further contain the anti-repellency agent. Further, in the virus inactivated coating material of the second embodiment, the molded product may further contain the coloring agent.

The virus inactivating coat material is specifically obtained by evaporating water and alcohol from the virus inactivated coat composition of the above-described embodiment. Therefore, the amount of alcohol and water in the virus inactivating coat material of the fourth embodiment is usually smaller than that in the virus inactivating coat composition.

When the virus inactivating object is wetted with water and the virus inactivating coating material is rubbed, the virus inactivating coating material is partially dissolved. Next, a virus inactivating coat layer is formed from a part of the dissolved virus inactivating coating material on the surface of the virus inactivating object. This virus inactivating coat layer exerts a virus inactivating effect for a long period of time on a virus inactivating object. Further, when the molded product contains an anti-repellent agent, the layer can be reliably formed at the site where the virus inactivating coat layer is desired to be formed in the virus inactivating object. Further, when the molded product contains a colorant, it can be easily confirmed in the virus inactivating object whether the layer is formed at the site where the virus inactivating coat layer is desired to be formed.

Specifically, the virus inactivated coating material of the fourth embodiment may be contained in a pay-out container such as a glue stick container, a lipstick container, or the like.

<Variation example of virus inactivated coating material of Embodiments 1 to 4>
In the virus inactivating coating materials of the above-mentioned embodiments 1 to 4, a case where sialic acid is contained as a virus scavenger has been described. In contrast, the modified virus inactivating coat material contains sulfatide, angiotensin converting enzyme II or C-type lectin as a virus scavenger instead of sialic acid. Examples of the C-type lectin include DC-SIGN, L-SIGN, MR and MGL. These virus scavengers may be used alone or in combination of two or more. In addition, sialic acid may be used in combination with sulfatide, angiotensin converting enzyme II or C-type lectin. Sulfatide, like sialic acid, can bind to hemagglutinin, which is present on the surface of viruses, especially influenza virus, and can capture the virus. On the other hand, the angiotensin converting enzyme II or C-type lectin can bind to hemagglutinin present on the surface of the new coronavirus (SARS-Cov-2) among the viruses and capture the virus. Therefore, the virus scavenger contained in the virus inactivating coat layer provided on the virus inactivating object can capture the virus, and even if there is a person who subsequently touches the virus inactivating object, that person It becomes difficult for the virus to transfer to. In addition, when the virus scavenger captures the virus, the movement of the virus is suppressed while the alkylamine oxide detoxifies and detoxifies the virus. Therefore, the virus can be reliably detoxified and detoxified even by the virus inactivating coating material of the modified example.

The virus inactivating coating material of the modified example is the same as the virus inactivating coating material of the above-mentioned embodiments 1 to 4 except that the virus scavenger other than sialic acid is contained as the virus scavenger. When two or more kinds of virus scavengers are used in combination, the total amount is preferably 0.1 part by mass or more and 1.0 part by mass or less with respect to 100 parts by mass of glue. The virus inactivating coat material of the modified example can be produced by using the virus inactivated coat composition of the modified example instead of the virus inactivated coat composition of the embodiment.

Based on the above, the present invention relates to the following.
[1] Glue, alkylamine oxide, virus trapping agent, alcohol having 1 to 3 carbon atoms and water are contained, and the virus trapping agent is at least selected from sialic acid, sulfatide, angiotensin converting enzyme II and C-type lectin. It is one kind, and the amount of the alkylamine oxide is 0.1 part by mass or more and 2.0 parts by mass or less, and the virus trapping agent is 0.1 part by mass or more and 1.0 part by mass with respect to 100 parts by mass of the glue. When the total of the glue, the alcohol and the water is 100% by mass, the glue is contained in an amount of 2.0% by mass or more and 9.0% by mass or less, and the alcohol is added in an amount of 2.0% by mass or less. A virus inactivating coat composition containing the above water in an amount of 83.5% by mass or more and 95.5% by mass or less in an amount of 5% by mass or more and 7.5% by mass or less.
According to the virus inactivating coat composition of the above [1], the virus inactivating effect can be sustained for a long period of time in the virus inactivating object.
[2] Further, as an anti-repellent agent, a siloxane compound having a group containing a polyalkylene oxide structure is contained, with respect to a total of 100 parts by mass of the glue, the alkylamine oxide, the virus scavenger, the alcohol and the water. The virus inactivating coat composition according to claim 1, which contains the anti-repellant agent in an amount of 0.3 parts by mass or more and 3.0 parts by mass or less.
According to the virus inactivating coat composition of the above [2], the layer can be more reliably formed at the site where the virus inactivating coat layer is desired to be formed in the virus inactivating object.
[3] Further, the colorant contains a water-soluble dye or a coumarin derivative, and the colorant is added to 100 parts by mass in total of the glue, the alkylamine oxide, the virus scavenger, the alcohol and the water. The virus inactivating coat composition according to [1] or [2], which is contained in an amount of 01 parts by mass or more and 1.0 part by mass or less.
According to the virus inactivating coat composition of the above [3], it can be easily confirmed whether or not the layer can be formed at the site where the virus inactivating coat layer is desired to be formed in the virus inactivating object.
[4] The virus inactivating object is coated with the virus inactivating coat composition according to any one of [1] to [3] on the surface of the virus inactivating object to form a virus inactivating coat layer. Virus inactivation method.
According to the virus inactivating method of the virus inactivating object of the above [4], the virus inactivating effect can be exhibited for a long period of time in the virus inactivating object.
[5] The substrate is impregnated with a virus inactivating coat composition containing glue, an alkylamine oxide, a virus scavenger, alcohol having 1 to 3 carbon atoms and water, and the virus scavenger is sialic acid or sulfatide. , At least one selected from angiotensin converting enzyme II and C-type scavenger, and the virus inactivating coat composition contains 0.1 parts by mass or more of the alkylamine oxide with respect to 100 parts by mass of the glue. The virus scavenger is contained in an amount of 0 parts by mass or less and 0.1 parts by mass or more and 1.0 part by mass or less, and the substrate is a paper, a non-woven fabric, a woven cloth, a knitted fabric or a porous structure. Virus inactivating coating material.
[6] The virus inactivating coat material according to [5], wherein the virus inactivating coat composition further contains a siloxane compound having a group containing a polyalkylene oxide structure as an anti-repellent agent.
[7] The virus inactivating coating material according to [5] or [6], wherein the virus inactivating coating composition further contains a water-soluble dye or a coumarin derivative as a coloring agent.
[8] The adhesive layer, the base material, and the virus inactivated coat layer are laminated in this order, and the virus inactivated coat layer contains 0.1 mass of alkylamine oxide with respect to 100 parts by mass of glue. The virus trapping agent is contained in an amount of 0.1 parts by mass or more and 1.0 part by mass or less in an amount of 2 parts or more and 2.0 parts by mass or less, and the virus trapping agent includes sialic acid, sulfatide, angiotensin converting enzyme II and C. -A virus inactivated coating material, which is at least one selected from typelectins.
[9] It has a base material and a virus inactivating coat layer laminated on the base material and transferable to the surface of a virus inactivating object, and the virus inactivating coat layer is based on 100 parts by mass of glue. , Alkylamine oxide is contained in an amount of 0.1 parts by mass or more and 2.0 parts by mass or less, and a virus trapping agent is contained in an amount of 0.1 parts by mass or more and 1.0 parts by mass or less. , A virus inactivated coating material, which is at least one selected from sulfatide, angiotensin converting enzyme II and C-type lectin.
[10] The virus inactivating coat material according to [8] or [9], wherein the virus inactivating coat layer further contains a siloxane compound having a group containing a polyalkylene oxide structure as an anti-repellent agent.
[11] The virus inactivating coating material according to any one of [8] to [10], wherein the virus inactivating coating layer further contains a water-soluble dye or a coumarin derivative as a coloring agent.
[12] It is a rod-shaped molded body, and the above-mentioned molded body contains a virus scavenger in an amount of 0.1 part by mass or more and 2.0 parts by mass or less of alkylamine oxide with respect to 100 parts by mass of glue. The virus scavenger is contained in an amount of 0.1 part by mass or more and 1.0 part by mass or less, and the virus scavenger is at least one selected from sialic acid, sulfatide, angiotensin converting enzyme II and C-type lectin, a virus inactivating coat. Material.
[13] The virus-inactivated coating material according to [12], wherein the molded product further contains a siloxane compound having a group containing a polyalkylene oxide structure as an anti-repellent agent.
[14] The virus inactivated coating material according to [12] or [13], wherein the molded product further contains a water-soluble dye or a coumarin derivative as a colorant.
According to the virus inactivating coating materials of the above [5] to [13], the virus inactivating effect can be sustained for a long period of time in the virus inactivating object.

[Example]
Hereinafter, the present invention will be described in more detail based on Examples, but the present invention is not limited to these Examples.

[Example 1-1]
Glue (trade name: powder glue, manufactured by Fujikura Applied Chemicals Co., Ltd.), lauryldimethylamine oxide aqueous solution (trade name: Unisafe (registered trademark) A-LM, manufactured by Nichiyu Co., Ltd.), N-acetylneuraminic acid (Nakalitesk) A virus inactivating coat composition was prepared using ethanol and water (manufactured by Co., Ltd.).
Here, the prepared virus inactivating coat composition contained 1.0 part by mass of alkylamine oxide and 0.1 part by mass of sialic acid with respect to 100 parts by mass of glue. When the total of glue, alcohol and water is 100% by mass, the amount of glue is 2.0% by mass, the amount of alcohol is 5.0% by mass, and the amount of water is 93.0% by mass. It was included (Table 1).

[Examples 1-2 to 1-4]
As shown in Table 1, a virus inactivated coat composition was prepared in the same manner as in Example 1-1 except that the amount of glue was changed.

[Examples 2-1 to 2-2]
As shown in Table 1, a virus-inactivated coat composition was prepared in the same manner as in Example 1-1 except that the amount of alkylamine oxide was changed.

[Example 3-1]
As shown in Table 1, a virus-inactivated coat composition was prepared in the same manner as in Example 1-1 except that the amount of sialic acid was changed.

[Comparative Example 1-1]
A coat composition was prepared in the same manner as in Example 1-1 except that polyethylene glycol (polyethylene glycol 4000, manufactured by Tokyo Chemical Industry Co., Ltd.) was used instead of glue.

In Table 1, the amount (parts by mass) of the alkylamine oxide and sialic acid is the amount with respect to 100 parts by mass of glue or polyethylene glycol. The amount (% by mass) of glue or polyethylene glycol, alcohol and water is the amount when the total of glue or polyethylene glycol, alcohol and water is 100% by mass.

[Evaluation method and its results]
[Virus inactivation test]
(1) The virus infectivity titer of the virus inactivated coat composition obtained in Example 1-1 was determined by the TCID ₅₀ method. Specifically, the virus inactivating coat composition obtained in Example 1-1 was applied onto a glass piece (50 mm × 50 mm square) and dried at room temperature for 1 hour to form a virus inactivated coat layer. did. Immediately after the formation of the virus-inactivated coat layer, 0.4 mL of a solution containing influenza virus was attached onto the virus-inactivated coat layer, a sterile film was layered, and the mixture was allowed to stand for a certain period of time. Next, a piece of glass was placed in a sterilization pack containing a physiological saline solution with the sterilization film on top of each other, and the residual virus was suspended. Then, the above-mentioned physiological saline was diluted, the residual virus was cultured, and after 5 days, the morphological change of the cells was observed. As a control, a piece of glass that did not form a virus-inactivated coat layer was used. From this, the virus infection titer was calculated.
In addition, the virus infectivity titer was also determined when the virus inactivated coat layer was formed and then allowed to stand at room temperature for one month. That is, 0.4 mL of a solution containing influenza virus was adhered on a virus inactivated coat layer that had been allowed to stand at room temperature for one month, a sterilized film was layered, and the mixture was allowed to stand for a certain period of time. Next, a piece of glass was placed in a sterilization pack containing a physiological saline solution with the sterilization film on top of each other, and the residual virus was suspended. Then, the above-mentioned physiological saline was diluted, the residual virus was cultured, and after 5 days, the morphological change of the cells was observed. As a control, a piece of glass that did not form a virus-inactivated coat layer was used. From this, the virus infection titer was calculated.
(2) The virus infectivity titer was determined in the same manner as in (1) above, except that a solution containing a pig-infected coronavirus was used instead of the influenza virus.
(3) Instead of the virus inactivating coat composition obtained in Example 1-1, the virus inactivating obtained in Examples 1-2 to 1-4, 2-1, 2-2, 3-1 The virus infectivity titer was determined in the same manner as in (1) and (2) above except that the coat composition was used.
(4) The virus inactivated coat compositions obtained in Examples 1-1 to 1-4, 2-1 and 2-2, 3-1 all had an influenza virus and an influenza virus based on the obtained virus infectivity titer. It was found that the pig-infected coronavirus can be sufficiently inactivated. Specifically, it was found that both the virus inactivated coat layer immediately after formation and the virus inactivated coat layer left at room temperature for 1 month can sufficiently inactivate influenza virus and pig-infected coronavirus. As described above, it was found that the virus inactivating coat layer can sustain the virus inactivating effect for a long period of time.

[Formation and removal of virus inactivated coat layer]
(1) Using a cloth impregnated with the virus inactivating coat composition obtained in Example 1-1 on the surface of a desk having a matte surface, the virus inactivating coat composition is applied at room temperature. Was dried for 1 hour to form a virus-inactivated coat layer. Due to the formation of the virus inactivated coat layer, the desk surface was glossy. Also, even if I touched the surface, it was not sticky.
After that, when the virus inactivated coat layer was wiped with a cloth moistened with water, the desk surface returned to the original matte appearance. It was found that the virus inactivated coat layer could be removed.
(2) Instead of the virus inactivating coat composition obtained in Example 1-1, the virus inactivating obtained in Examples 1-2 to 1-4, 2-1, 2-2, 3-1 The virus inactivated coat layer was formed and removed in the same manner as in (1) above except that the coat composition was used.
In each case, the desk surface was glossy due to the formation of the virus inactivating coat layer. Also, even if I touched the surface, it was not sticky. After that, when the virus inactivated coat layer was wiped with a cloth moistened with water, the desk surface returned to the original matte appearance. It was found that the virus inactivated coat layer could be removed.
(3) Coat in the same manner as in (1) above, except that the coat composition obtained in Comparative Example 1-1 was used instead of the virus inactivated coat composition obtained in Example 1-1. Layers were formed and removed.
Due to the formation of the coat layer, the desk surface was glossy. However, it was sticky to the touch. After that, when the coat layer was wiped with a cloth moistened with water, the desk surface returned to the original matte appearance. It was found that the coat layer could be removed.

[Formation of virus inactivated coat layer by spraying]
(1) The virus inactivating coat composition obtained in Example 1-1 was applied onto the surface of a desk having a matte surface by spraying, and dried at room temperature for 1 hour to obtain a virus inactivating coat layer. Was formed. The desk surface was glossy, indicating that the virus-inactivated coat layer was uniformly formed.
(2) Instead of the virus inactivating coat composition obtained in Example 1-1, the virus inactivating obtained in Examples 1-2 to 1-4, 2-1, 2-2, 3-1 The virus inactivated coat layer was formed in the same manner as in (1) above except that the coat composition was used.
Even when the virus inactivated coat composition obtained in Examples 1-2, 2-1 and 2-2, 3-1 was used, the desk surface was glossy and the virus inactivated coat layer was uniformly formed. It turned out that it was done.
On the other hand, when the virus inactivated coat composition obtained in Examples 1-3 and 1-4 was used, it was found that the desk surface was glossy and the virus inactivated coat layer was formed. Unevenness was seen on the surface of the layer. It is considered that there is no problem with the virus inactivating effect.

[Example 4-1]
The non-woven fabric was impregnated with the virus inactivated coat composition of Example 1-1 to prepare a virus inactivated coat material. Therefore, the virus inactivating coat material contains a virus inactivating coat composition containing glue, an alkylamine oxide, sialic acid, an alcohol having 1 to 3 carbon atoms and water, and the virus inactivating coat composition. Contained alkylamine oxide in an amount of 1.0 part by mass and sialic acid in an amount of 0.1 part by mass with respect to 100 parts by mass of glue. Next, a package was prepared by laminating a plurality of virus-inactivated coating materials that were folded flat and housed in a bag. Specifically, the virus-inactivated coating material was surrounded by a rectangular film, and the end portion was heat-sealed. Here, the film constituting the package was provided with an opening for taking out the virus inactivated coating material, and a lid material was provided to cover the opening so as to be openable and closable. Further, the film was a laminated film in which a first resin film, an aluminum foil, and a second resin film having a heat-sealing property were laminated in this order.
The virus inactivated coating material was taken out from the package. Next, a virus inactivating coat composition was applied on the surface of a desk having a matte surface using a virus inactivating coating material to form a virus inactivating coating layer. The desk surface was glossy, indicating that the virus-inactivated coat layer was uniformly formed.

[Example 4-2]
A virus-inactivated coat material was prepared in which an adhesive layer, a base material, and a virus-inactivated coat layer were laminated in this order. The virus-inactivated coating material was a roll-shaped scroll. Further, the virus inactivated coat layer was formed by evaporating water and alcohol using the virus inactivated coat composition of Example 1-1. Therefore, the virus-inactivated coat layer contained 1.0 part by mass of alkylamine oxide and 0.1 part by mass of sialic acid with respect to 100 parts by mass of glue.
A virus inactivated coat layer was attached via an adhesive layer on the surface of a desk having a matte surface. The desk surface was glossy, indicating that the virus-inactivated coat layer was uniformly formed.

[Example 4-3]
A virus-inactivated coat material was prepared in which a peeling layer, an adhesive layer, a base material, and a virus-inactivated coat layer were laminated in this order. The virus inactivated coat layer was formed by evaporating water and alcohol using the virus inactivated coat composition of Example 1-1. Therefore, the virus-inactivated coat layer contained 1.0 part by mass of alkylamine oxide and 0.1 part by mass of sialic acid with respect to 100 parts by mass of glue.
The peeling layer was peeled off on the surface of the desk having a matte surface, and the virus inactivating coat layer was attached via the exposed adhesive layer. The desk surface was glossy, indicating that the virus-inactivated coat layer was uniformly formed.

[Example 4-4]
A virus inactivating coat material having a base material and a virus inactivating coat layer laminated on the base material and transferable to the surface of the virus inactivating object was prepared. The virus inactivated coat layer was formed by evaporating water and alcohol using the virus inactivated coat composition of Example 1-1. Therefore, the virus-inactivated coat layer contained 1.0 part by mass of alkylamine oxide and 0.1 part by mass of sialic acid with respect to 100 parts by mass of glue.
The surface of the desk having a matte surface was wetted with water, the virus inactivated coat layer was brought into contact with the desk, and the virus inactivated coat layer was transferred to the surface of the desk. The desk surface was glossy, indicating that the virus-inactivated coat layer was uniformly formed.

[Example 4-5]
It is a rod-shaped molded product, and a virus inactivated coating material containing glue, an alkylamine oxide and sialic acid was prepared. The virus inactivating coat material was formed by evaporating water and alcohol using the virus inactivating coat composition of Example 1-1. Therefore, the virus inactivating coating material contained 1.0 part by mass of alkylamine oxide and 0.1 part by mass of sialic acid with respect to 100 parts by mass of glue. Then, the rod-shaped virus inactivated coating material was housed in a pay-out container.
When the surface of the desk having a matte surface was moistened with water and the virus inactivated coating material paid out from the tip of the container was rubbed, a virus inactivating coat layer was formed on the surface of the desk. The desk surface was glossy, indicating that the virus-inactivated coat layer was uniformly formed.

[Example 5-1]
Instead of lauryldimethylamine oxide aqueous solution (trade name: Unisafe (registered trademark) A-LM, manufactured by Nichiyu Co., Ltd.), decyldimethylamine oxide aqueous solution (trade name: Cadenax (registered trademark) DM10D-W, Lion Specialty. A virus-inactivated coat composition was prepared in the same manner as in Example 1-1 except that (Chemicals Co., Ltd.) was used.

[Example 5-2]
Instead of lauryldimethylamine oxide aqueous solution (trade name: Unisafe (registered trademark) A-LM, manufactured by Nichiyu Co., Ltd.), tetradecyldimethylamine oxide aqueous solution (trade name: Cadenax (registered trademark) DM14D-N, Lion Specialty -A virus inactivating coat composition was prepared in the same manner as in Example 1-1 except that (manufactured by Chemicals Co., Ltd.) was used.

[Example 6-1]
Virus inactivation in the same manner as in Example 1-1, except that sulfatides (product number: 131305P, manufactured by Merck Group) was used instead of N-acetylneuraminic acid (manufactured by Nacalai Tesque Co., Ltd.). A coat composition was prepared.

[Example 6-2]
Other than using N-acetylneuraminic acid (manufactured by Nakaraitesk Co., Ltd.), angiotensin converting enzyme II (catalog number: SAE0064, product name: Angiotensin Converting Enzyme-2, ACE2, manufactured by Merck Co., Ltd.) A virus inactivating coat composition was prepared in the same manner as in Example 1-1.

[Evaluation method and its results]
[Virus inactivation test]
The virus-inactivated coat composition obtained in Examples 5-1, 5-2, 6-1 and 6-2 is virus-inert, similarly to the virus-inactivated coat composition obtained in Example 1-1. An activation test was performed. That is, instead of the virus inactivated coat composition obtained in Example 1-1, the virus inactivated coat composition obtained in Examples 5-1, 5-2, 6-1 and 6-2 was used. The virus infectivity titer was determined in the same manner as in (1) and (2) of the above [virus inactivation test] except that the virus was inactivated.
The virus inactivated coat compositions obtained in Examples 5-1, 5-2, 6-1 and 6-2 were sufficiently free of influenza virus and pig-infected coronavirus from the obtained virus infectivity titers. It turned out that it could be activated. Specifically, it was found that both the virus inactivated coat layer immediately after formation and the virus inactivated coat layer left at room temperature for 1 month can sufficiently inactivate influenza virus and pig-infected coronavirus. As described above, it was found that the virus inactivating coat layer can sustain the virus inactivating effect for a long period of time.

[Formation and removal of virus inactivated coat layer]
The virus-inactivated coat composition obtained in Examples 5-1, 5-2, 6-1 and 6-2 is virus-inert, similarly to the virus-inactivated coat composition obtained in Example 1-1. The activated coat layer was formed and removed. That is, instead of the virus inactivated coat composition obtained in Example 1-1, the virus inactivated coat composition obtained in Examples 5-1, 5-2, 6-1 and 6-2 was used. The coat layer was formed and removed in the same manner as in (1) of the above [Formation and removal of virus inactivated coat layer].
In each case, the desk surface was glossy due to the formation of the virus inactivating coat layer. Also, even if I touched the surface, it was not sticky. After that, when the virus inactivated coat layer was wiped with a cloth moistened with water, the desk surface returned to the original matte appearance. It was found that the virus inactivated coat layer could be removed.

[Formation of virus inactivated coat layer by spraying]
The virus-inactivated coat composition obtained in Examples 5-1, 5-2, 6-1 and 6-2 was sprayed in the same manner as in the virus-inactivated coat composition obtained in Example 1-1. A virus-inactivated coat layer was formed. That is, instead of the virus inactivated coat composition obtained in Example 1-1, the virus inactivated coat composition obtained in Examples 5-1, 5-2, 6-1 and 6-2 was used. The coat layer was formed and removed in the same manner as in (1) of the above-mentioned [Formation of virus inactivated coat layer by mist blowing].
In each case, the desk surface was glossy, and it was found that the virus inactivated coat layer was uniformly formed.

[Example 7-1]
Glue (trade name: powder glue, manufactured by Fujikura Applied Chemicals Co., Ltd.), lauryldimethylamine oxide aqueous solution (trade name: Unisafe (registered trademark) A-LM, manufactured by NOF Corporation), N-acetylneuraminic acid (Nacalai Tesque) (Manufactured by Co., Ltd.), Poly (oxy-1,2-ethanediyl) as an anti-repellent agent ,. alpha. -Methyl-. omega. -[3- [1,3,3,3-tetramethyl-1-[(trimethylsilyl) oxy] -1-disiloxanyl] ropoxy]-(CAS 27306-78-1) (Shin-Etsu Silicone, product name: KP-110, Shin-Etsu) A virus inactivated coat composition was prepared using ethanol and water (manufactured by Kagaku Kogyo Co., Ltd.).
Here, the prepared virus inactivating coat composition contained 1.0 part by mass of alkylamine oxide and 0.1 part by mass of sialic acid with respect to 100 parts by mass of glue. When the total of glue, alcohol and water is 100% by mass, the amount of glue is 2.0% by mass, the amount of alcohol is 5.0% by mass, and the amount of water is 93.0% by mass. It was included.
Further, the anti-repellent agent was contained in an amount of 0.3 parts by mass with respect to 100 parts by mass in total of glue, alkylamine oxide, sialic acid, alcohol and water.

[Example 7-2]
The same as in Example 7-1, except that the anti-repellent agent was used in an amount of 1.0 part by mass with respect to 100 parts by mass in total of glue, alkylamine oxide, sialic acid, alcohol and water. To prepare a virus inactivating coat composition.

[Example 7-3]
The same as in Example 7-1, except that the anti-repellent agent was used in an amount of 3.0 parts by mass with respect to 100 parts by mass in total of glue, alkylamine oxide, sialic acid, alcohol and water. To prepare a virus inactivating coat composition.

[Example 8-1]
Glue (trade name: powder glue, manufactured by Fujikura Applied Chemicals Co., Ltd.), lauryldimethylamine oxide aqueous solution (trade name: Unisafe (registered trademark) A-LM, manufactured by NOF Corporation), N-acetylneuraminic acid (Nacalai Tesque) (Manufactured by Co., Ltd.), Poly (oxy-1,2-ethanediyl) as an anti-repellent agent ,. alpha. -Methyl-. omega. -[3- [1,3,3,3-tetramethyl-1-[(trimethylsilyl) oxy] -1-disiloxanyl] ropoxy]-(CAS 27306-78-1) (Shin-Etsu Silicone, product name: KP-110, Shin-Etsu) A virus inactivating coat composition was prepared using Basic Blue 12 (CAS 2381-85-3) (product code: N0317, manufactured by Tokyo Chemical Industry Co., Ltd.), ethanol and water as a colorant (manufactured by Kagaku Kogyo Co., Ltd.). did.
Here, the prepared virus inactivating coat composition contained 1.0 part by mass of alkylamine oxide and 0.1 part by mass of sialic acid with respect to 100 parts by mass of glue. When the total of glue, alcohol and water is 100% by mass, the amount of glue is 2.0% by mass, the amount of alcohol is 5.0% by mass, and the amount of water is 93.0% by mass. It was included.
Further, the anti-repellent agent was contained in an amount of 0.3 parts by mass with respect to 100 parts by mass in total of glue, alkylamine oxide, sialic acid, alcohol and water.
Further, the colorant was contained in an amount of 0.01 part by mass with respect to 100 parts by mass in total of glue, alkylamine oxide, sialic acid, alcohol and water.

[Example 8-2]
The same as in Example 8-1 except that the colorant was used in an amount of 1.0 part by mass with respect to a total of 100 parts by mass of glue, alkylamine oxide, sialic acid, alcohol and water. To prepare a virus-inactivated coat composition.

[Example 8-3]
As the colorant, instead of Basic Blue 12 (CAS 2381-85-3) (product code: N0317, manufactured by Tokyo Chemical Industry Co., Ltd.), Acid Green 3 (CAS 4680-78-8) (product code: G0176, Tokyo) A virus-inactivated coat composition was prepared in the same manner as in Example 8-1 except that (manufactured by Kasei Kogyo Co., Ltd.) was used.

[Example 8-4]
As the colorant, instead of Basic Blue 12 (CAS 2381-85-3) (product code: N0317, manufactured by Tokyo Chemical Industry Co., Ltd.), Acid Red 52 (CAS 3520-42-1) (product code: A0600, Tokyo) A virus inactivated coat composition was prepared in the same manner as in Example 8-1 except that (manufactured by Kasei Kogyo Co., Ltd.) was used.

[Example 8-5]
Instead of Basic Blue 12 (CAS 2381-85-3) (product code: N0317, manufactured by Tokyo Chemical Industry Co., Ltd.) as the colorant, it has a diethylamino group at the 7-position of the basic skeleton and 4 of the basic skeleton. A virus-inactivated coat composition was prepared in the same manner as in Example 8-1 except that a coumarin derivative having a methyl group at the position (trade name: M0631, manufactured by Tokyo Chemical Industry Co., Ltd.) was used.

[Example 8-6]
Glue (trade name: powder glue, manufactured by Fujikura Applied Chemical Industry Co., Ltd.), lauryldimethylamine oxide aqueous solution (trade name: Unisafe (registered trademark) A-LM, manufactured by Nichiyu Co., Ltd.), N-acetylneuraminic acid (Nakalitesk) A virus-inactivated coat composition was prepared using Basic Blue 12 (CAS 2381-85-3) (product code: N0317, manufactured by Tokyo Chemical Industry Co., Ltd.), ethanol and water as a colorant (manufactured by Tokyo Chemical Industry Co., Ltd.).
Here, the prepared virus inactivating coat composition contained 1.0 part by mass of alkylamine oxide and 0.1 part by mass of sialic acid with respect to 100 parts by mass of glue. When the total of glue, alcohol and water is 100% by mass, the amount of glue is 2.0% by mass, the amount of alcohol is 5.0% by mass, and the amount of water is 93.0% by mass. It was included.
Further, the colorant was contained in an amount of 0.01 part by mass with respect to 100 parts by mass in total of glue, alkylamine oxide, sialic acid, alcohol and water.

[Example 8-7]
Instead of Basic Blue 12 (CAS 2381-85-3) (product code: N0317, manufactured by Tokyo Chemical Industry Co., Ltd.) as the colorant, it has a diethylamino group at the 7-position of the basic skeleton and 4 of the basic skeleton. A virus-inactivated coat composition was prepared in the same manner as in Examples 8-6 except that a coumarin derivative having a methyl group at the position (trade name: M0631, manufactured by Tokyo Chemical Industry Co., Ltd.) was used.

[Evaluation method and its results]
[Virus inactivation test]
The virus-inactivated coat compositions obtained in Examples 7-1 to 7-3 and 8-1 to 8-7 are virus-inactive, similarly to the virus-inactivated coat compositions obtained in Example 1-1. An activation test was performed. That is, instead of the virus inactivated coat composition obtained in Example 1-1, the virus inactivated coat composition obtained in Examples 7-1 to 7-3 and 8-1 to 8-7 was used. The virus infectivity titer was determined in the same manner as in (1) and (2) of the above [virus inactivation test] except that the virus was inactivated.
The virus inactivated coat compositions obtained in Examples 7-1 to 7-3 and 8-1 to 8-7 were sufficiently incompatible with influenza virus and pig-infected coronavirus from the obtained virus infectious titers. It turned out that it could be activated. Specifically, it was found that both the virus inactivated coat layer immediately after formation and the virus inactivated coat layer left at room temperature for 1 month can sufficiently inactivate influenza virus and pig-infected coronavirus. As described above, it was found that the virus inactivating coat layer can sustain the virus inactivating effect for a long period of time.

[Formation of virus inactivated coat layer (repelling prevention performance and confirmation of virus inactivated coat layer formation)]
(1) The virus inactivated coat composition was applied onto the surface of a desk having a matte white surface using a cloth impregnated with the virus inactivated coat composition obtained in Example 8-1. It was dried at room temperature for 1 hour to form a virus inactivated coat layer. It was found that the virus inactivated coat layer was uniformly formed. Specifically, since it contains a colorant, a colored virus-inactivated coat layer was obtained. It was found that the virus inactivated coat layer was uniformly formed by the color uniformity of the desk surface.
(2) The above (1) except that the virus inactivated coat composition obtained in Examples 8-2 to 8-7 was used instead of the virus inactivated coat composition obtained in Example 8-1. ), The virus inactivated coat layer was formed.
It was also found that the virus inactivated coat layer was uniformly formed even when the virus inactivated coat composition obtained in Examples 8-2 to 8-5 was used. Specifically, in Examples 8-2 to 8-4, a colored virus-inactivated coat layer was obtained because it contained a colorant. It was found that the virus inactivated coat layer was uniformly formed by the color uniformity of the desk surface. Further, in Examples 8-5, a colorless and transparent virus-inactivated coat layer was obtained. When the surface of the desk was exposed to black light, it was found that the virus inactivated coat layer was uniformly formed due to the uniformity of fluorescence.
On the other hand, when the virus inactivated coat composition obtained in Example 8-6 was also used, a colored virus inactivated coat layer was obtained. It was found that the virus inactivated coat layer was uniformly formed by the color uniformity of the desk surface. However, it was found that in Examples 8-1 to 8-4, the color of the surface of the desk was more uniform and the virus inactivated coat layer was formed more uniformly.
Also, when the virus inactivated coat composition obtained in Example 8-7 was used, a colorless and transparent virus inactivated coat layer was obtained. When the surface of the desk was exposed to black light, it was found that the virus inactivated coat layer was uniformly formed due to the uniformity of fluorescence. However, it was found that in Examples 8-5, the fluorescence on the surface of the desk was more uniform, and the virus inactivated coat layer was formed more uniformly.
Although the repellent inhibitor and the colorant were used in Examples 8-1 to 8-5, the repellent inhibitor was also used in Examples 7-1 to 7-3 in which the repellent inhibitor was used without using the colorant. By using it, it is considered that the virus inactivated coat layer can be formed more uniformly.

Claims (14)

Contains glue, alkylamine oxides, virus scavengers, alcohol with 1-3 carbon atoms and water.
The virus scavenger is at least one selected from sialic acid, sulfatide, angiotensin converting enzyme II and C-type lectin.
The amount of the alkylamine oxide is 0.1 parts by mass or more and 2.0 parts by mass or less, and the amount of the virus scavenger is 0.1 parts by mass or more and 1.0 parts by mass or less with respect to 100 parts by mass of the glue. Including,
When the total of the glue, the alcohol and the water is 100% by mass, the glue is 2.0% by mass or more and 9.0% by mass or less, and the alcohol is 2.5% by mass or more and 7.5% by mass. The water is contained in an amount of 83.5% by mass or more and 95.5% by mass or less in an amount of mass% or less.
Virus inactivated coat composition. Further, as an anti-repellent agent, a siloxane compound having a group containing a polyalkylene oxide structure is contained.
The repellent inhibitor is contained in an amount of 0.3 parts by mass or more and 3.0 parts by mass or less with respect to a total of 100 parts by mass of the glue, the alkylamine oxide, the virus scavenger, the alcohol and the water.
The virus inactivating coat composition according to claim 1. In addition, it contains a water-soluble dye or coumarin derivative as a colorant and contains
The colorant is contained in an amount of 0.01 parts by mass or more and 1.0 part by mass or less with respect to 100 parts by mass in total of the glue, the alkylamine oxide, the virus scavenger, the alcohol and the water.
The virus inactivated coat composition according to claim 1 or 2. The virus inactivating coat composition according to any one of claims 1 to 3 is applied to the surface of the virus inactivating object to form a virus inactivating coat layer. Method. The substrate is impregnated with a virus inactivating coat composition containing glue, an alkylamine oxide, a virus scavenger, an alcohol having 1 to 3 carbon atoms and water.
The virus scavenger is at least one selected from sialic acid, sulfatide, angiotensin converting enzyme II and C-type lectin.
In the virus inactivating coat composition, the amount of the alkylamine oxide is 0.1 part by mass or more and 2.0 parts by mass or less, and the amount of the virus scavenger is 0.1 part by mass or more with respect to 100 parts by mass of the glue. Including in an amount of 1.0 part by mass or less,
The substrate is paper, non-woven fabric, woven fabric, knitted fabric or porous structure.
Virus inactivated coating material. The virus inactivated coat composition further comprises a siloxane compound having a group containing a polyalkylene oxide structure as an anti-repellent agent.
The virus inactivated coating material according to claim 5. The virus inactivated coat composition further comprises a water-soluble dye or a coumarin derivative as a colorant.
The virus inactivated coating material according to claim 5 or 6. The adhesive layer, the base material, and the virus inactivated coat layer are laminated in this order.
In the virus inactivating coat layer, the amount of alkylamine oxide is 0.1 parts by mass or more and 2.0 parts by mass or less, and the virus scavenger is 0.1 parts by mass or more and 1.0 part by mass with respect to 100 parts by mass of glue. Including in less than a part
The virus scavenger is at least one selected from sialic acid, sulfatide, angiotensin converting enzyme II and C-type lectin.
Virus inactivated coating material. It has a substrate and a virus inactivated coat layer laminated on the substrate and transferable to the surface of the virus inactivated object.
In the virus inactivating coat layer, the amount of alkylamine oxide is 0.1 parts by mass or more and 2.0 parts by mass or less, and the virus scavenger is 0.1 parts by mass or more and 1.0 part by mass with respect to 100 parts by mass of glue. Including in less than a part
The virus scavenger is at least one selected from sialic acid, sulfatide, angiotensin converting enzyme II and C-type lectin.
Virus inactivated coating material. The virus inactivated coat layer further contains a siloxane compound having a group containing a polyalkylene oxide structure as an anti-repellent agent.
The virus inactivated coating material according to claim 8 or 9. The virus inactivated coat layer further comprises a water-soluble dye or coumarin derivative as a colorant.
The virus inactivated coating material according to any one of claims 8 to 10. It is a molded body molded into a rod shape,
The molded body contains 0.1 parts by mass or more and 2.0 parts by mass or less of the alkylamine oxide and 0.1 parts by mass or more and 1.0 part by mass or less of the virus scavenger with respect to 100 parts by mass of the glue. Including in quantity
The virus scavenger is at least one selected from sialic acid, sulfatide, angiotensin converting enzyme II and C-type lectin.
Virus inactivated coating material. The molded product further contains a siloxane compound having a group containing a polyalkylene oxide structure as an anti-repellent agent.
The virus inactivated coating material according to claim 12. The molded product further contains a water-soluble dye or a coumarin derivative as a colorant.
The virus inactivated coating material according to claim 12 or 13.