JP2022028975A5 - - Google Patents
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- Publication number
- JP2022028975A5 JP2022028975A5 JP2021202092A JP2021202092A JP2022028975A5 JP 2022028975 A5 JP2022028975 A5 JP 2022028975A5 JP 2021202092 A JP2021202092 A JP 2021202092A JP 2021202092 A JP2021202092 A JP 2021202092A JP 2022028975 A5 JP2022028975 A5 JP 2022028975A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- salt
- ophthalmic composition
- chondroitin sulfate
- pranoprofen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000003839 salts Chemical class 0.000 claims 6
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 4
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 4
- 229940059329 chondroitin sulfate Drugs 0.000 claims 4
- TVQZAMVBTVNYLA-UHFFFAOYSA-N Pranoprofen Chemical compound C1=CC=C2CC3=CC(C(C(O)=O)C)=CC=C3OC2=N1 TVQZAMVBTVNYLA-UHFFFAOYSA-N 0.000 claims 3
- 229960003101 pranoprofen Drugs 0.000 claims 3
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims 2
- BYJAVTDNIXVSPW-UHFFFAOYSA-N tetryzoline Chemical compound N1CCN=C1C1C2=CC=CC=C2CCC1 BYJAVTDNIXVSPW-UHFFFAOYSA-N 0.000 claims 2
- 229940042585 tocopherol acetate Drugs 0.000 claims 2
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 239000000043 antiallergic agent Substances 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000035807 sensation Effects 0.000 claims 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims 1
- 229960000337 tetryzoline Drugs 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
Claims (4)
(A)プラノプロフェン、及び/又は薬学的に許容されるその塩
(B)ブチル基含有フェノール
(C)酢酸トコフェロール、コンドロイチン硫酸、及びコンドロイチン硫酸の塩からなる群より選択される少なくとも1種
ただし、下記(1)~(2)である場合を除く。
(1)プラノプロフェン又はその塩と、抗アレルギー剤、抗炎症剤及び水溶性ビタミンからなる群から選択される少なくとも1種の化合物とを含有する、組成物。
(2)プラノプロフェン及びその塩からなる群より選択される少なくとも1種と、ジブチルヒドロキシトルエン及びブチルヒドロキシアニソールからなる群より選択される少なくとも1種と、サルファ剤とを含有する、組成物 An ophthalmic composition for improving a foreign body sensation containing the following components (A), (B), and (C).
(A) Pranoprofen and / or its pharmaceutically acceptable salt
(B) Butyl group-containing phenol
(C) At least one selected from the group consisting of tocopherol acetate , chondroitin sulfate , and a salt of chondroitin sulfate .
However, the cases (1) and (2) below are excluded.
(1) A composition containing pranoprofen or a salt thereof and at least one compound selected from the group consisting of antiallergic agents, anti-inflammatory agents and water-soluble vitamins.
(2) A composition containing at least one selected from the group consisting of pranoprofen and a salt thereof, at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole, and a sulfa drug.
(i)酢酸トコフェロール(i) Tocopherol acetate
(iii)コンドロイチン硫酸、及び/又はコンドロイチン硫酸の塩(iii) Chondroitin sulfate and / or salt of chondroitin sulfate
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2022057713A JP2022079633A (en) | 2015-10-15 | 2022-03-30 | Ophthalmic composition for improved foreign matter feeling |
JP2023076355A JP2023093761A (en) | 2015-10-15 | 2023-05-02 | Ophthalmic composition for improved foreign matter feeling |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015203994 | 2015-10-15 | ||
JP2015203994 | 2015-10-15 | ||
JP2015256235 | 2015-12-28 | ||
JP2015256235 | 2015-12-28 | ||
JP2016203154A JP2017119669A (en) | 2015-10-15 | 2016-10-14 | Ophthalmic composition for improved foreign matter feeling |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016203154A Division JP2017119669A (en) | 2015-10-15 | 2016-10-14 | Ophthalmic composition for improved foreign matter feeling |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022057713A Division JP2022079633A (en) | 2015-10-15 | 2022-03-30 | Ophthalmic composition for improved foreign matter feeling |
JP2023076355A Division JP2023093761A (en) | 2015-10-15 | 2023-05-02 | Ophthalmic composition for improved foreign matter feeling |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2022028975A JP2022028975A (en) | 2022-02-16 |
JP2022028975A5 true JP2022028975A5 (en) | 2022-04-08 |
Family
ID=59271468
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016203154A Withdrawn JP2017119669A (en) | 2015-10-15 | 2016-10-14 | Ophthalmic composition for improved foreign matter feeling |
JP2021202092A Withdrawn JP2022028975A (en) | 2015-10-15 | 2021-12-13 | Ophthalmic composition for improved foreign matter feeling |
JP2022057713A Pending JP2022079633A (en) | 2015-10-15 | 2022-03-30 | Ophthalmic composition for improved foreign matter feeling |
JP2023076355A Pending JP2023093761A (en) | 2015-10-15 | 2023-05-02 | Ophthalmic composition for improved foreign matter feeling |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016203154A Withdrawn JP2017119669A (en) | 2015-10-15 | 2016-10-14 | Ophthalmic composition for improved foreign matter feeling |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022057713A Pending JP2022079633A (en) | 2015-10-15 | 2022-03-30 | Ophthalmic composition for improved foreign matter feeling |
JP2023076355A Pending JP2023093761A (en) | 2015-10-15 | 2023-05-02 | Ophthalmic composition for improved foreign matter feeling |
Country Status (1)
Country | Link |
---|---|
JP (4) | JP2017119669A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6687781B1 (en) * | 2019-03-08 | 2020-04-28 | ロート製薬株式会社 | Ophthalmic composition with suppressed irritation |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3021312B2 (en) * | 1994-03-15 | 2000-03-15 | 千寿製薬株式会社 | Method for stabilizing pranoprofen and stable aqueous solution of pranoprofen |
ITMI981586A1 (en) * | 1998-07-10 | 2000-01-10 | Giorgio Panin | VITAMIN AND ITS ESTERS FOR USE IN TOPICAL TREATMENT OF MUCOSA DISORDERS |
JP2005239682A (en) * | 2004-02-27 | 2005-09-08 | Taisho Pharmaceut Co Ltd | Ophthalmic agent |
JP4919666B2 (en) * | 2005-01-26 | 2012-04-18 | ロート製薬株式会社 | Planoprofen-containing composition |
JP2007169232A (en) * | 2005-12-26 | 2007-07-05 | Lion Corp | Ophthalmic composition |
JP6009141B2 (en) * | 2009-10-09 | 2016-10-19 | ロート製薬株式会社 | Aqueous composition |
JP5580944B2 (en) * | 2011-12-27 | 2014-08-27 | 千寿製薬株式会社 | Dibutylhydroxytoluene-containing preparation and method for stabilizing dibutylhydroxytoluene |
JP6148957B2 (en) * | 2012-10-02 | 2017-06-14 | ロート製薬株式会社 | Planoprofen-containing aqueous composition |
JP6452283B2 (en) * | 2012-11-06 | 2019-01-16 | ロート製薬株式会社 | Eye foreign substance feeling improving agent |
JP6315755B2 (en) * | 2013-10-02 | 2018-04-25 | ロート製薬株式会社 | Foreign eye feel relief eye drops |
TW201540292A (en) * | 2014-03-10 | 2015-11-01 | Senju Pharma Co | Method for stabilizing dibutylhydroxytoluene |
-
2016
- 2016-10-14 JP JP2016203154A patent/JP2017119669A/en not_active Withdrawn
-
2021
- 2021-12-13 JP JP2021202092A patent/JP2022028975A/en not_active Withdrawn
-
2022
- 2022-03-30 JP JP2022057713A patent/JP2022079633A/en active Pending
-
2023
- 2023-05-02 JP JP2023076355A patent/JP2023093761A/en active Pending
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