JP2021534398A5 - - Google Patents

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Publication number
JP2021534398A5
JP2021534398A5 JP2021507759A JP2021507759A JP2021534398A5 JP 2021534398 A5 JP2021534398 A5 JP 2021534398A5 JP 2021507759 A JP2021507759 A JP 2021507759A JP 2021507759 A JP2021507759 A JP 2021507759A JP 2021534398 A5 JP2021534398 A5 JP 2021534398A5
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JP
Japan
Prior art keywords
antibody
protein
matrix
conditions
affinity matrix
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JP2021507759A
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English (en)
Japanese (ja)
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JP7527273B2 (ja
JP2021534398A (ja
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Priority claimed from PCT/US2019/046769 external-priority patent/WO2020037182A1/en
Publication of JP2021534398A publication Critical patent/JP2021534398A/ja
Publication of JP2021534398A5 publication Critical patent/JP2021534398A5/ja
Priority to JP2024117397A priority Critical patent/JP2024156725A/ja
Application granted granted Critical
Publication of JP7527273B2 publication Critical patent/JP7527273B2/ja
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JP2021507759A 2018-08-17 2019-08-16 多量体タンパク質の量および純度を決定するための方法およびクロマトグラフィーシステム Active JP7527273B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024117397A JP2024156725A (ja) 2018-08-17 2024-07-23 多量体タンパク質の量および純度を決定するための方法およびクロマトグラフィーシステム

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862719323P 2018-08-17 2018-08-17
US62/719,323 2018-08-17
PCT/US2019/046769 WO2020037182A1 (en) 2018-08-17 2019-08-16 Method and chromatography system for determining amount and purity of a multimeric protein

Related Child Applications (1)

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JP2024117397A Division JP2024156725A (ja) 2018-08-17 2024-07-23 多量体タンパク質の量および純度を決定するための方法およびクロマトグラフィーシステム

Publications (3)

Publication Number Publication Date
JP2021534398A JP2021534398A (ja) 2021-12-09
JP2021534398A5 true JP2021534398A5 (https=) 2022-08-18
JP7527273B2 JP7527273B2 (ja) 2024-08-02

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ID=67851218

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JP2021507759A Active JP7527273B2 (ja) 2018-08-17 2019-08-16 多量体タンパク質の量および純度を決定するための方法およびクロマトグラフィーシステム
JP2024117397A Pending JP2024156725A (ja) 2018-08-17 2024-07-23 多量体タンパク質の量および純度を決定するための方法およびクロマトグラフィーシステム

Family Applications After (1)

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JP2024117397A Pending JP2024156725A (ja) 2018-08-17 2024-07-23 多量体タンパク質の量および純度を決定するための方法およびクロマトグラフィーシステム

Country Status (14)

Country Link
US (2) US12152056B2 (https=)
EP (1) EP3837552A1 (https=)
JP (2) JP7527273B2 (https=)
KR (2) KR102795000B1 (https=)
CN (2) CN118641770A (https=)
AU (1) AU2019322895B2 (https=)
BR (1) BR112021002724A2 (https=)
CA (1) CA3109362A1 (https=)
EA (1) EA202190459A1 (https=)
IL (2) IL325196A (https=)
MX (1) MX2021001915A (https=)
MY (1) MY207066A (https=)
SG (1) SG11202101369XA (https=)
WO (1) WO2020037182A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY207066A (en) * 2018-08-17 2025-01-28 Regeneron Pharma Method and chromatography system for determining amount and purity of a multimeric protein
WO2020252260A1 (en) * 2019-06-13 2020-12-17 Regeneron Pharmaceuticals, Inc. Methods for removing undesired components during multistage chromatographic processes
WO2022234412A1 (en) 2021-05-03 2022-11-10 Lupin Limited A process for purification of fc-fusion proteins
WO2026075981A1 (en) * 2024-10-01 2026-04-09 Regeneron Pharmaceuticals, Inc. Methods of analyzing heterodimeric proteins

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EP0826696B1 (de) 1996-09-03 2002-05-29 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Verwendung bi-und trispezifischer Antikörper zur Induktion einer Tumorimmunität
US7691645B2 (en) * 2001-01-09 2010-04-06 Agilent Technologies, Inc. Immunosubtraction method
SG149759A1 (en) * 2007-07-10 2009-02-27 Millipore Corp Media for affinity chromatography
SG177202A1 (en) * 2008-09-15 2012-01-30 Emd Millipore Corp Methods for quantifying protein leakage from protein based affinity chromatography resins
MY192182A (en) 2009-06-26 2022-08-04 Regeneron Pharma Readily isolated bispecific antibodies with native immunoglobulin format
WO2012057676A1 (en) 2010-10-27 2012-05-03 Ge Healthcare Bio-Sciences Ab Chromatography system with guard columns
US20130248451A1 (en) * 2010-12-03 2013-09-26 Ge Healthcare Bio-Sciences Ab System and process for biopolymer chromatography
EP2500073A1 (en) 2011-03-17 2012-09-19 ChromaCon AG Method for identification and purification of multi-specific polypeptides
EP2656892A1 (en) 2012-04-23 2013-10-30 Merck Patent GmbH Chromatography method
KR20150008171A (ko) 2012-05-10 2015-01-21 자임워크스 인코포레이티드 단일군 일가 항체 구조물 및 그의 용도
AU2014226126B2 (en) * 2013-03-08 2019-02-14 Genzyme Corporation Continuous purification of therapeutic proteins
JP2015052533A (ja) * 2013-09-06 2015-03-19 株式会社日立製作所 クロマトグラフィー装置およびクロマトグラフィー方法
JP2016538275A (ja) 2013-11-04 2016-12-08 グレンマーク ファーマシューティカルズ， エセ．アー． Ｔ細胞再標的化ヘテロ二量体免疫グロブリン（ｈｅｔｅｒｏ−ｄｉｍｅｒｉｃ ｉｍｍｕｎｏｇｌｏｂｕｌｉｎ）の製造
AR101262A1 (es) * 2014-07-26 2016-12-07 Regeneron Pharma Plataforma de purificación para anticuerpos biespecíficos
WO2016149088A1 (en) * 2015-03-13 2016-09-22 Bristol-Myers Squibb Company Use of alkaline washes during chromatography to remove impurities
JP6962819B2 (ja) * 2015-04-10 2021-11-05 アディマブ， エルエルシー 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法
GB201602156D0 (en) * 2016-02-05 2016-03-23 Jones Philip C And Boku University Of Natural Resources And Life Sciences Heterodimers and purification thereof
MY207066A (en) * 2018-08-17 2025-01-28 Regeneron Pharma Method and chromatography system for determining amount and purity of a multimeric protein

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